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Items: 8


Inhibition of ileal bile acid uptake protects against nonalcoholic fatty liver disease in high-fat diet-fed mice.

Rao A, Kosters A, Mells JE, Zhang W, Setchell KD, Amanso AM, Wynn GM, Xu T, Keller BT, Yin H, Banton S, Jones DP, Wu H, Dawson PA, Karpen SJ.

Sci Transl Med. 2016 Sep 21;8(357):357ra122. doi: 10.1126/scitranslmed.aaf4823.


Saturated fat and cholesterol are critical to inducing murine metabolic syndrome with robust nonalcoholic steatohepatitis.

Mells JE, Fu PP, Kumar P, Smith T, Karpen SJ, Anania FA.

J Nutr Biochem. 2015 Mar;26(3):285-92. doi: 10.1016/j.jnutbio.2014.11.002. Epub 2014 Dec 6.


Adiponectin modulates focal adhesion disassembly in activated hepatic stellate cells: implication for reversing hepatic fibrosis.

Kumar P, Smith T, Rahman K, Mells JE, Thorn NE, Saxena NK, Anania FA.

FASEB J. 2014 Dec;28(12):5172-83. doi: 10.1096/fj.14-253229. Epub 2014 Aug 25.


The role of gastrointestinal hormones in hepatic lipid metabolism.

Mells JE, Anania FA.

Semin Liver Dis. 2013 Nov;33(4):343-57. doi: 10.1055/s-0033-1358527. Epub 2013 Nov 12. Review.


Glp-1 analog, liraglutide, ameliorates hepatic steatosis and cardiac hypertrophy in C57BL/6J mice fed a Western diet.

Mells JE, Fu PP, Sharma S, Olson D, Cheng L, Handy JA, Saxena NK, Sorescu D, Anania FA.

Am J Physiol Gastrointest Liver Physiol. 2012 Jan 15;302(2):G225-35. doi: 10.1152/ajpgi.00274.2011. Epub 2011 Oct 28.


GLP-1 analogs reduce hepatocyte steatosis and improve survival by enhancing the unfolded protein response and promoting macroautophagy.

Sharma S, Mells JE, Fu PP, Saxena NK, Anania FA.

PLoS One. 2011;6(9):e25269. doi: 10.1371/journal.pone.0025269. Epub 2011 Sep 21.


Adiponectin inhibits leptin signalling via multiple mechanisms to exert protective effects against hepatic fibrosis.

Handy JA, Fu PP, Kumar P, Mells JE, Sharma S, Saxena NK, Anania FA.

Biochem J. 2011 Dec 15;440(3):385-95. doi: 10.1042/BJ20102148.


Adiponectin activation of AMPK disrupts leptin-mediated hepatic fibrosis via suppressors of cytokine signaling (SOCS-3).

Handy JA, Saxena NK, Fu P, Lin S, Mells JE, Gupta NA, Anania FA.

J Cell Biochem. 2010 Aug 1;110(5):1195-207. doi: 10.1002/jcb.22634. Erratum in: J Cell Biochem. 2011 Feb;112(2):734.

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