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Items: 1 to 50 of 165

1.

A Validation Study on IDO Immune Biomarkers for Survival Prediction in Non-small Cell Lung Cancer: Radiation Dose Fractionation Effect in Early Stage Disease.

Wang W, Huang L, Jin JY, Pi W, Ellsworth SG, Jolly S, Mellor AL, Machtay M, Kong FS.

Clin Cancer Res. 2019 Aug 30. pii: clincanres.1202.2019. doi: 10.1158/1078-0432.CCR-19-1202. [Epub ahead of print]

PMID:
31471311
2.

Adoptive CD8+ T cell therapy against cancer:Challenges and opportunities.

Jiang X, Xu J, Liu M, Xing H, Wang Z, Huang L, Mellor AL, Wang W, Wu S.

Cancer Lett. 2019 Oct 10;462:23-32. doi: 10.1016/j.canlet.2019.07.017. Epub 2019 Jul 26.

PMID:
31356845
3.

IDO2 is critical for IDO1-mediated T-cell regulation and exerts a non-redundant function in inflammation.

Metz R, Smith C, DuHadaway JB, Chandler P, Baban B, Merlo LMF, Pigott E, Keough MP, Rust S, Mellor AL, Mandik-Nayak L, Muller AJ, Prendergast GC.

Int Immunol. 2019 Mar 5;31(3):181-182. doi: 10.1093/intimm/dxz003. No abstract available.

PMID:
31222337
4.

Immune control by amino acid catabolism during tumorigenesis and therapy.

Lemos H, Huang L, Prendergast GC, Mellor AL.

Nat Rev Cancer. 2019 Mar;19(3):162-175. doi: 10.1038/s41568-019-0106-z. Review.

PMID:
30696923
5.

Metabolic requirements for expanding and arming a clone army.

Mellor AL, Huang L.

Nat Immunol. 2019 Feb;20(2):118-120. doi: 10.1038/s41590-018-0299-4. No abstract available.

PMID:
30664763
6.

Indoleamine 2,3-Dioxygenase and Tolerance: Where Are We Now?

Mellor AL, Lemos H, Huang L.

Front Immunol. 2017 Oct 27;8:1360. doi: 10.3389/fimmu.2017.01360. eCollection 2017. Review.

7.

IDO Immune Status after Chemoradiation May Predict Survival in Lung Cancer Patients.

Wang W, Huang L, Jin JY, Jolly S, Zang Y, Wu H, Yan L, Pi W, Li L, Mellor AL, Kong FS.

Cancer Res. 2018 Feb 1;78(3):809-816. doi: 10.1158/0008-5472.CAN-17-2995. Epub 2017 Nov 8.

8.

Soluble CD83 Inhibits T Cell Activation by Binding to the TLR4/MD-2 Complex on CD14+ Monocytes.

Horvatinovich JM, Grogan EW, Norris M, Steinkasserer A, Lemos H, Mellor AL, Tcherepanova IY, Nicolette CA, DeBenedette MA.

J Immunol. 2017 Mar 15;198(6):2286-2301. doi: 10.4049/jimmunol.1600802. Epub 2017 Feb 13.

9.

Virus Infections Incite Pain Hypersensitivity by Inducing Indoleamine 2,3 Dioxygenase.

Huang L, Ou R, Rabelo de Souza G, Cunha TM, Lemos H, Mohamed E, Li L, Pacholczyk G, Randall J, Munn DH, Mellor AL.

PLoS Pathog. 2016 May 11;12(5):e1005615. doi: 10.1371/journal.ppat.1005615. eCollection 2016 May.

10.

Deletion of LRP5 and LRP6 in dendritic cells enhances antitumor immunity.

Hong Y, Manoharan I, Suryawanshi A, Shanmugam A, Swafford D, Ahmad S, Chinnadurai R, Manicassamy B, He Y, Mellor AL, Thangaraju M, Munn DH, Manicassamy S.

Oncoimmunology. 2015 Dec 14;5(4):e1115941. eCollection 2016 Apr.

11.

STING Promotes the Growth of Tumors Characterized by Low Antigenicity via IDO Activation.

Lemos H, Mohamed E, Huang L, Ou R, Pacholczyk G, Arbab AS, Munn D, Mellor AL.

Cancer Res. 2016 Apr 15;76(8):2076-81. doi: 10.1158/0008-5472.CAN-15-1456. Epub 2016 Mar 10.

12.

IDO in the Tumor Microenvironment: Inflammation, Counter-Regulation, and Tolerance.

Munn DH, Mellor AL.

Trends Immunol. 2016 Mar;37(3):193-207. doi: 10.1016/j.it.2016.01.002. Epub 2016 Jan 31. Review.

13.

The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment.

Sharma MD, Shinde R, McGaha TL, Huang L, Holmgaard RB, Wolchok JD, Mautino MR, Celis E, Sharpe AH, Francisco LM, Powell JD, Yagita H, Mellor AL, Blazar BR, Munn DH.

Sci Adv. 2015 Nov 6;1(10):e1500845. doi: 10.1126/sciadv.1500845. eCollection 2015 Nov.

14.

Amino acid metabolism inhibits antibody-driven kidney injury by inducing autophagy.

Chaudhary K, Shinde R, Liu H, Gnana-Prakasam JP, Veeranan-Karmegam R, Huang L, Ravishankar B, Bradley J, Kvirkvelia N, McMenamin M, Xiao W, Kleven D, Mellor AL, Madaio MP, McGaha TL.

J Immunol. 2015 Jun 15;194(12):5713-24. doi: 10.4049/jimmunol.1500277. Epub 2015 May 15.

15.

Canonical wnt signaling in dendritic cells regulates Th1/Th17 responses and suppresses autoimmune neuroinflammation.

Suryawanshi A, Manoharan I, Hong Y, Swafford D, Majumdar T, Taketo MM, Manicassamy B, Koni PA, Thangaraju M, Sun Z, Mellor AL, Munn DH, Manicassamy S.

J Immunol. 2015 Apr 1;194(7):3295-304. doi: 10.4049/jimmunol.1402691. Epub 2015 Feb 20.

16.

β-catenin promotes regulatory T-cell responses in tumors by inducing vitamin A metabolism in dendritic cells.

Hong Y, Manoharan I, Suryawanshi A, Majumdar T, Angus-Hill ML, Koni PA, Manicassamy B, Mellor AL, Munn DH, Manicassamy S.

Cancer Res. 2015 Feb 15;75(4):656-665. doi: 10.1158/0008-5472.CAN-14-2377. Epub 2015 Jan 7.

17.

Alkylating agent melphalan augments the efficacy of adoptive immunotherapy using tumor-specific CD4+ T cells.

Lu X, Ding ZC, Cao Y, Liu C, Habtetsion T, Yu M, Lemos H, Salman H, Xu H, Mellor AL, Zhou G.

J Immunol. 2015 Feb 15;194(4):2011-21. doi: 10.4049/jimmunol.1401894. Epub 2015 Jan 5.

18.

STING, nanoparticles, autoimmune disease and cancer: a novel paradigm for immunotherapy?

Lemos H, Huang L, McGaha T, Mellor AL.

Expert Rev Clin Immunol. 2015 Jan;11(1):155-65. doi: 10.1586/1744666X.2015.995097. Epub 2014 Dec 18. Review.

19.

TLR2-dependent activation of β-catenin pathway in dendritic cells induces regulatory responses and attenuates autoimmune inflammation.

Manoharan I, Hong Y, Suryawanshi A, Angus-Hill ML, Sun Z, Mellor AL, Munn DH, Manicassamy S.

J Immunol. 2014 Oct 15;193(8):4203-13. doi: 10.4049/jimmunol.1400614. Epub 2014 Sep 10.

20.

Cytosolic DNA sensing via the stimulator of interferon genes adaptor: Yin and Yang of immune responses to DNA.

Lemos H, Huang L, McGaha TL, Mellor AL.

Eur J Immunol. 2014 Oct;44(10):2847-53. doi: 10.1002/eji.201344407. Epub 2014 Aug 25. Review.

21.

The indoleamine 2,3-dioxygenase pathway controls complement-dependent enhancement of chemo-radiation therapy against murine glioblastoma.

Li M, Bolduc AR, Hoda MN, Gamble DN, Dolisca SB, Bolduc AK, Hoang K, Ashley C, McCall D, Rojiani AM, Maria BL, Rixe O, MacDonald TJ, Heeger PS, Mellor AL, Munn DH, Johnson TS.

J Immunother Cancer. 2014 Jul 7;2:21. doi: 10.1186/2051-1426-2-21. eCollection 2014.

22.

T cell costimulation molecules CD80/86 inhibit osteoclast differentiation by inducing the IDO/tryptophan pathway.

Bozec A, Zaiss MM, Kagwiria R, Voll R, Rauh M, Chen Z, Mueller-Schmucker S, Kroczek RA, Heinzerling L, Moser M, Mellor AL, David JP, Schett G.

Sci Transl Med. 2014 May 7;6(235):235ra60. doi: 10.1126/scitranslmed.3007764.

23.

Activation of the STING adaptor attenuates experimental autoimmune encephalitis.

Lemos H, Huang L, Chandler PR, Mohamed E, Souza GR, Li L, Pacholczyk G, Barber GN, Hayakawa Y, Munn DH, Mellor AL.

J Immunol. 2014 Jun 15;192(12):5571-8. doi: 10.4049/jimmunol.1303258. Epub 2014 May 5.

24.

Immunosuppressive myeloid cells induced by chemotherapy attenuate antitumor CD4+ T-cell responses through the PD-1-PD-L1 axis.

Ding ZC, Lu X, Yu M, Lemos H, Huang L, Chandler P, Liu K, Walters M, Krasinski A, Mack M, Blazar BR, Mellor AL, Munn DH, Zhou G.

Cancer Res. 2014 Jul 1;74(13):3441-53. doi: 10.1158/0008-5472.CAN-13-3596. Epub 2014 Apr 29.

25.

Indoleamine 2,3-dioxygenase (IDO) activity during the primary immune response to influenza infection modifies the memory T cell response to influenza challenge.

Sage LK, Fox JM, Mellor AL, Tompkins SM, Tripp RA.

Viral Immunol. 2014 Apr;27(3):112-23. doi: 10.1089/vim.2013.0105. Epub 2014 Apr 4.

26.

Marginal zone CD169+ macrophages coordinate apoptotic cell-driven cellular recruitment and tolerance.

Ravishankar B, Shinde R, Liu H, Chaudhary K, Bradley J, Lemos HP, Chandler P, Tanaka M, Munn DH, Mellor AL, McGaha TL.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4215-20. doi: 10.1073/pnas.1320924111. Epub 2014 Mar 3.

27.

IDO2 is critical for IDO1-mediated T-cell regulation and exerts a non-redundant function in inflammation.

Metz R, Smith C, DuHadaway JB, Chandler P, Baban B, Merlo LM, Pigott E, Keough MP, Rust S, Mellor AL, Mandik-Nayak L, Muller AJ, Prendergast GC.

Int Immunol. 2014 Jul;26(7):357-67. doi: 10.1093/intimm/dxt073. Epub 2014 Jan 8. Erratum in: Int Immunol. 2019 Mar 5;31(3):181-182.

28.

Metabolic control of tumour progression and antitumour immunity.

Huang L, Mellor AL.

Curr Opin Oncol. 2014 Jan;26(1):92-9. doi: 10.1097/CCO.0000000000000035. Review.

29.

GCN2-dependent metabolic stress is essential for endotoxemic cytokine induction and pathology.

Liu H, Huang L, Bradley J, Liu K, Bardhan K, Ron D, Mellor AL, Munn DH, McGaha TL.

Mol Cell Biol. 2014 Feb;34(3):428-38. doi: 10.1128/MCB.00946-13. Epub 2013 Nov 18.

30.

Cutting edge: DNA sensing via the STING adaptor in myeloid dendritic cells induces potent tolerogenic responses.

Huang L, Li L, Lemos H, Chandler PR, Pacholczyk G, Baban B, Barber GN, Hayakawa Y, McGaha TL, Ravishankar B, Munn DH, Mellor AL.

J Immunol. 2013 Oct 1;191(7):3509-13. doi: 10.4049/jimmunol.1301419. Epub 2013 Aug 28.

31.

Indoleamine 2,3-dioxygenase 1 (ido1) is involved in the control of mouse caput epididymis immune environment.

Jrad-Lamine A, Henry-Berger J, Damon-Soubeyrand C, Saez F, Kocer A, Janny L, Pons-Rejraji H, Munn DH, Mellor AL, Gharbi N, Cadet R, Guiton R, Aitken RJ, Drevet JR.

PLoS One. 2013 Jun 20;8(6):e66494. doi: 10.1371/journal.pone.0066494. Print 2013.

32.

Induction and role of indoleamine 2,3 dioxygenase in mouse models of influenza a virus infection.

Huang L, Li L, Klonowski KD, Tompkins SM, Tripp RA, Mellor AL.

PLoS One. 2013 Jun 13;8(6):e66546. doi: 10.1371/journal.pone.0066546. Print 2013.

33.

An inherently bifunctional subset of Foxp3+ T helper cells is controlled by the transcription factor eos.

Sharma MD, Huang L, Choi JH, Lee EJ, Wilson JM, Lemos H, Pan F, Blazar BR, Pardoll DM, Mellor AL, Shi H, Munn DH.

Immunity. 2013 May 23;38(5):998-1012. doi: 10.1016/j.immuni.2013.01.013. Epub 2013 May 16.

34.

Inhibition of indoleamine 2,3-dioxygenase enhances the T-cell response to influenza virus infection.

Fox JM, Sage LK, Huang L, Barber J, Klonowski KD, Mellor AL, Tompkins SM, Tripp RA.

J Gen Virol. 2013 Jul;94(Pt 7):1451-61. doi: 10.1099/vir.0.053124-0. Epub 2013 Apr 11.

35.

B7h (ICOS-L) maintains tolerance at the fetomaternal interface.

Riella LV, Dada S, Chabtini L, Smith B, Huang L, Dakle P, Mfarrej B, D'Addio F, Adams LT, Kochupurakkal N, Vergani A, Fiorina P, Mellor AL, Sharpe AH, Yagita H, Guleria I.

Am J Pathol. 2013 Jun;182(6):2204-13. doi: 10.1016/j.ajpath.2013.02.014. Epub 2013 Apr 8.

36.

Constitutively CD40-activated B cells regulate CD8 T cell inflammatory response by IL-10 induction.

Koni PA, Bolduc A, Takezaki M, Ametani Y, Huang L, Lee JR, Nutt SL, Kamanaka M, Flavell RA, Mellor AL, Tsubata T, Shimoda M.

J Immunol. 2013 Apr 1;190(7):3189-96. doi: 10.4049/jimmunol.1203364. Epub 2013 Feb 25.

37.

Indoleamine 2,3 dioxygenase and metabolic control of immune responses.

Munn DH, Mellor AL.

Trends Immunol. 2013 Mar;34(3):137-43. doi: 10.1016/j.it.2012.10.001. Epub 2012 Oct 25. Review.

38.

Amino acid catabolism: a pivotal regulator of innate and adaptive immunity.

McGaha TL, Huang L, Lemos H, Metz R, Mautino M, Prendergast GC, Mellor AL.

Immunol Rev. 2012 Sep;249(1):135-57. doi: 10.1111/j.1600-065X.2012.01149.x. Review.

39.

Polyfunctional CD4⁺ T cells are essential for eradicating advanced B-cell lymphoma after chemotherapy.

Ding ZC, Huang L, Blazar BR, Yagita H, Mellor AL, Munn DH, Zhou G.

Blood. 2012 Sep 13;120(11):2229-39. doi: 10.1182/blood-2011-12-398321. Epub 2012 Aug 2.

40.

Altered tryptophan metabolism as a paradigm for good and bad aspects of immune privilege in chronic inflammatory diseases.

Li L, Huang L, Lemos HP, Mautino M, Mellor AL.

Front Immunol. 2012 May 11;3:109. doi: 10.3389/fimmu.2012.00109. eCollection 2012.

41.

Engineering DNA nanoparticles as immunomodulatory reagents that activate regulatory T cells.

Huang L, Lemos HP, Li L, Li M, Chandler PR, Baban B, McGaha TL, Ravishankar B, Lee JR, Munn DH, Mellor AL.

J Immunol. 2012 May 15;188(10):4913-20. doi: 10.4049/jimmunol.1103668. Epub 2012 Apr 18.

42.

Tolerance to apoptotic cells is regulated by indoleamine 2,3-dioxygenase.

Ravishankar B, Liu H, Shinde R, Chandler P, Baban B, Tanaka M, Munn DH, Mellor AL, Karlsson MC, McGaha TL.

Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3909-14. doi: 10.1073/pnas.1117736109. Epub 2012 Feb 21.

43.

Opposing biological functions of tryptophan catabolizing enzymes during intracellular infection.

Divanovic S, Sawtell NM, Trompette A, Warning JI, Dias A, Cooper AM, Yap GS, Arditi M, Shimada K, Duhadaway JB, Prendergast GC, Basaraba RJ, Mellor AL, Munn DH, Aliberti J, Karp CL.

J Infect Dis. 2012 Jan 1;205(1):152-61. doi: 10.1093/infdis/jir621. Epub 2011 Oct 11.

44.

Highlights of 10 years of immunology in Nature Reviews Immunology.

Medzhitov R, Shevach EM, Trinchieri G, Mellor AL, Munn DH, Gordon S, Libby P, Hansson GK, Shortman K, Dong C, Gabrilovich D, Gabryšová L, Howes A, O'Garra A.

Nat Rev Immunol. 2011 Sep 23;11(10):693-702. doi: 10.1038/nri3063. Review.

45.

Physiologic control of IDO competence in splenic dendritic cells.

Baban B, Chandler PR, Johnson BA 3rd, Huang L, Li M, Sharpe ML, Francisco LM, Sharpe AH, Blazar BR, Munn DH, Mellor AL.

J Immunol. 2011 Sep 1;187(5):2329-35. doi: 10.4049/jimmunol.1100276. Epub 2011 Aug 3.

46.

Meeting report of the first conference of the International Placenta Stem Cell Society (IPLASS).

Parolini O, Alviano F, Betz AG, Bianchi DW, Götherström C, Manuelpillai U, Mellor AL, Ofir R, Ponsaerts P, Scherjon SA, Weiss ML, Wolbank S, Wood KJ, Borlongan CV.

Placenta. 2011 Oct;32 Suppl 4:S285-90. doi: 10.1016/j.placenta.2011.04.017. Epub 2011 May 14.

47.

Physiologic control of the functional status of Foxp3+ regulatory T cells.

Mellor AL, Munn DH.

J Immunol. 2011 Apr 15;186(8):4535-40. doi: 10.4049/jimmunol.1002937. Review.

48.

Leishmania major attenuates host immunity by stimulating local indoleamine 2,3-dioxygenase expression.

Makala LH, Baban B, Lemos H, El-Awady AR, Chandler PR, Hou DY, Munn DH, Mellor AL.

J Infect Dis. 2011 Mar 1;203(5):715-25. doi: 10.1093/infdis/jiq095. Epub 2011 Jan 31.

49.

Deficient tryptophan catabolism along the kynurenine pathway reveals that the epididymis is in a unique tolerogenic state.

Jrad-Lamine A, Henry-Berger J, Gourbeyre P, Damon-Soubeyrand C, Lenoir A, Combaret L, Saez F, Kocer A, Tone S, Fuchs D, Zhu W, Oefner PJ, Munn DH, Mellor AL, Gharbi N, Cadet R, Aitken RJ, Drevet JR.

J Biol Chem. 2011 Mar 11;286(10):8030-42. doi: 10.1074/jbc.M110.172114. Epub 2010 Dec 28.

50.

Reprogrammed foxp3(+) regulatory T cells provide essential help to support cross-presentation and CD8(+) T cell priming in naive mice.

Sharma MD, Hou DY, Baban B, Koni PA, He Y, Chandler PR, Blazar BR, Mellor AL, Munn DH.

Immunity. 2010 Dec 14;33(6):942-54. doi: 10.1016/j.immuni.2010.11.022. Epub 2010 Dec 9.

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