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Items: 1 to 50 of 314

1.

Safinamide Modulates Striatal Glutamatergic Signaling in a Rat Model of Levodopa-Induced Dyskinesia.

Gardoni F, Morari M, Kulisevsky J, Brugnoli A, Novello S, Pisanò CA, Caccia C, Mellone M, Melloni E, Padoani G, Sosti V, Vailati S, Keywood C.

J Pharmacol Exp Ther. 2018 Dec;367(3):442-451. doi: 10.1124/jpet.118.251645. Epub 2018 Oct 5.

PMID:
30291173
2.

Relationship between low levels of circulating TRAIL and atheromatosis progression in patients with chronic kidney disease.

Arcidiacono MV, Rimondi E, Maietti E, Melloni E, Tisato V, Gallo S, Valdivielso JM, Fernández E, Betriu À, Voltan R, Zauli G, Volpato S, Secchiero P.

PLoS One. 2018 Sep 11;13(9):e0203716. doi: 10.1371/journal.pone.0203716. eCollection 2018.

3.

TRAIL and Ceruloplasmin Inverse Correlation as a Representative Crosstalk between Inflammation and Oxidative Stress.

Tisato V, Gallo S, Melloni E, Celeghini C, Passaro A, Zauli G, Secchiero P, Bergamini C, Trentini A, Bonaccorsi G, Valacchi G, Zuliani G, Cervellati C.

Mediators Inflamm. 2018 Jul 26;2018:9629537. doi: 10.1155/2018/9629537. eCollection 2018.

4.

Corticolimbic Connectivity Mediates the Relationship between Adverse Childhood Experiences and Symptom Severity in Borderline Personality Disorder.

Vai B, Sforzini L, Visintini R, Riberto M, Bulgarelli C, Ghiglino D, Melloni E, Bollettini I, Poletti S, Maffei C, Benedetti F.

Neuropsychobiology. 2017;76(2):105-115. doi: 10.1159/000487961. Epub 2018 Jun 1.

PMID:
29860262
5.

Unexpected role of the L-domain of calpastatin during the autoproteolytic activation of human erythrocyte calpain.

De Tullio R, Franchi A, Martines A, Averna M, Pedrazzi M, Melloni E, Sparatore B.

Biosci Rep. 2018 Apr 20;38(2). pii: BSR20180147. doi: 10.1042/BSR20180147. Print 2018 Apr 26.

6.

Cell protection from Ca2+-overloading by bioactive molecules extracted from olive pomace.

Averna M, Casazza AA, Martines A, Pedrazzi M, Franchi A, De Tullio R, Perego P, Melloni E.

Nat Prod Res. 2018 Jan 4:1-7. doi: 10.1080/14786419.2017.1422181. [Epub ahead of print]

PMID:
29298502
7.

Safinamide Differentially Modulates In Vivo Glutamate and GABA Release in the Rat Hippocampus and Basal Ganglia.

Morari M, Brugnoli A, Pisanò CA, Novello S, Caccia C, Melloni E, Padoani G, Vailati S, Sardina M.

J Pharmacol Exp Ther. 2018 Feb;364(2):198-206. doi: 10.1124/jpet.117.245100. Epub 2017 Nov 22.

PMID:
29167350
8.

A Homer 1 gene variant influences brain structure and function, lithium effects on white matter, and antidepressant response in bipolar disorder: A multimodal genetic imaging study.

Benedetti F, Poletti S, Locatelli C, Mazza E, Lorenzi C, Vitali A, Riberto M, Brioschi S, Vai B, Bollettini I, Melloni E, Aggio V, Falini A, De Bartolomeis A, Colombo C.

Prog Neuropsychopharmacol Biol Psychiatry. 2018 Feb 2;81:88-95. doi: 10.1016/j.pnpbp.2017.10.011. Epub 2017 Oct 27.

PMID:
29079138
9.

The γ-secretase inhibitors enhance the anti-leukemic activity of ibrutinib in B-CLL cells.

Secchiero P, Voltan R, Rimondi E, Melloni E, Athanasakis E, Tisato V, Gallo S, Rigolin GM, Zauli G.

Oncotarget. 2017 Jul 22;8(35):59235-59245. doi: 10.18632/oncotarget.19494. eCollection 2017 Aug 29.

10.

Night sleep influences white matter microstructure in bipolar depression.

Benedetti F, Melloni EMT, Dallaspezia S, Bollettini I, Locatelli C, Poletti S, Colombo C.

J Affect Disord. 2017 Aug 15;218:380-387. doi: 10.1016/j.jad.2017.05.008. Epub 2017 May 8.

PMID:
28500983
11.

Clock genes associate with white matter integrity in depressed bipolar patients.

Bollettini I, Melloni EM, Aggio V, Poletti S, Lorenzi C, Pirovano A, Vai B, Dallaspezia S, Colombo C, Benedetti F.

Chronobiol Int. 2017;34(2):212-224. doi: 10.1080/07420528.2016.1260026. Epub 2016 Dec 20.

PMID:
27996307
12.

Ibrutinib synergizes with MDM-2 inhibitors in promoting cytotoxicity in B chronic lymphocytic leukemia.

Voltan R, Rimondi E, Melloni E, Rigolin GM, Casciano F, Arcidiacono MV, Celeghini C, Cuneo A, Zauli G, Secchiero P.

Oncotarget. 2016 Oct 25;7(43):70623-70638. doi: 10.18632/oncotarget.12139.

13.

Abnormal activation of calpain and protein kinase Cα promotes a constitutive release of matrix metalloproteinase 9 in peripheral blood mononuclear cells from cystic fibrosis patients.

Averna M, Bavestrello M, Cresta F, Pedrazzi M, De Tullio R, Minicucci L, Sparatore B, Salamino F, Pontremoli S, Melloni E.

Arch Biochem Biophys. 2016 Aug 15;604:103-12. doi: 10.1016/j.abb.2016.06.015. Epub 2016 Jun 25.

PMID:
27349634
14.

Metformin combined with sodium dichloroacetate promotes B leukemic cell death by suppressing anti-apoptotic protein Mcl-1.

Voltan R, Rimondi E, Melloni E, Gilli P, Bertolasi V, Casciano F, Rigolin GM, Zauli G, Secchiero P.

Oncotarget. 2016 Apr 5;7(14):18965-77. doi: 10.18632/oncotarget.7879.

15.

Design, Synthesis, and Biological Characterization of Novel Mitochondria Targeted Dichloroacetate-Loaded Compounds with Antileukemic Activity.

Trapella C, Voltan R, Melloni E, Tisato V, Celeghini C, Bianco S, Fantinati A, Salvadori S, Guerrini R, Secchiero P, Zauli G.

J Med Chem. 2016 Jan 14;59(1):147-56. doi: 10.1021/acs.jmedchem.5b01165. Epub 2015 Dec 23.

PMID:
26653539
16.

Kinetic Profiles of Inflammatory Mediators in the Conjunctival Sac Fluid of Patients upon Photorefractive Keratectomy.

Tisato V, Perri P, Rimondi E, Melloni E, Lamberti G, Milani D, Secchiero P, Zauli G.

Mediators Inflamm. 2015;2015:942948. doi: 10.1155/2015/942948. Epub 2015 Oct 7.

17.

Physiological Roles of Calpain 1 Associated to Multiprotein NMDA Receptor Complex.

Averna M, Pellegrini M, Cervetto C, Pedrazzi M, Bavestrello M, De Tullio R, Salamino F, Pontremoli S, Melloni E.

PLoS One. 2015 Oct 2;10(10):e0139750. doi: 10.1371/journal.pone.0139750. eCollection 2015.

18.

The p53 transcriptional pathway is preserved in ATMmutated and NOTCH1mutated chronic lymphocytic leukemias.

Athanasakis E, Melloni E, Rigolin GM, Agnoletto C, Voltan R, Vozzi D, Piscianz E, Segat L, Dal Monego S, Cuneo A, Secchiero P, Zauli G.

Oncotarget. 2014 Dec 30;5(24):12635-45.

19.

Interaction between calpain-1 and HSP90: new insights into the regulation of localization and activity of the protease.

Averna M, De Tullio R, Pedrazzi M, Bavestrello M, Pellegrini M, Salamino F, Pontremoli S, Melloni E.

PLoS One. 2015 Jan 9;10(1):e0116738. doi: 10.1371/journal.pone.0116738. eCollection 2015.

20.

The anti-leukemic activity of sodium dichloroacetate in p53mutated/null cells is mediated by a p53-independent ILF3/p21 pathway.

Agnoletto C, Brunelli L, Melloni E, Pastorelli R, Casciano F, Rimondi E, Rigolin GM, Cuneo A, Secchiero P, Zauli G.

Oncotarget. 2015 Feb 10;6(4):2385-96.

21.

Evaluation of the effects of a new intravaginal gel, containing purified bovine colostrum, on vaginal blood flow and vaginal atrophy in ovariectomized rat.

Vailati S, Melloni E, Riscassi E, Behr Roussel D, Sardina M.

Sex Med. 2013 Dec;1(2):35-43. doi: 10.1002/sm2.8.

22.

Role of calpain-1 in the early phase of experimental ALS.

Stifanese R, Averna M, De Tullio R, Pedrazzi M, Milanese M, Bonifacino T, Bonanno G, Salamino F, Pontremoli S, Melloni E.

Arch Biochem Biophys. 2014 Nov 15;562:1-8. doi: 10.1016/j.abb.2014.08.006. Epub 2014 Aug 21.

PMID:
25151305
23.

Differential regulation of the calpain-calpastatin complex by the L-domain of calpastatin.

De Tullio R, Averna M, Pedrazzi M, Sparatore B, Salamino F, Pontremoli S, Melloni E.

Biochim Biophys Acta. 2014 Nov;1843(11):2583-91. doi: 10.1016/j.bbamcr.2014.07.002. Epub 2014 Jul 12.

24.

Sodium dichloroacetate exhibits anti-leukemic activity in B-chronic lymphocytic leukemia (B-CLL) and synergizes with the p53 activator Nutlin-3.

Agnoletto C, Melloni E, Casciano F, Rigolin GM, Rimondi E, Celeghini C, Brunelli L, Cuneo A, Secchiero P, Zauli G.

Oncotarget. 2014 Jun 30;5(12):4347-60.

25.

Inverse correlation between circulating levels of TNF-related apoptosis-inducing ligand and 17β-estradiol.

Zauli G, Tisato V, Melloni E, Volpato S, Cervellati C, Bonaccorsi G, Radillo O, Marci R, Secchiero P.

J Clin Endocrinol Metab. 2014 Apr;99(4):E659-64. doi: 10.1210/jc.2013-4193. Epub 2014 Jan 21.

PMID:
24446659
26.

Calpain inhibition promotes the rescue of F(508)del-CFTR in PBMC from cystic fibrosis patients.

Averna M, Pedrazzi M, Minicucci L, De Tullio R, Cresta F, Salamino F, Pontremoli S, Melloni E.

PLoS One. 2013 Jun 13;8(6):e66089. doi: 10.1371/journal.pone.0066089. Print 2013.

27.

Memofilm project: "Man's memory. Cinema against the pathologies of memory".

Savorani G, Pini E, Tondi L, Ribani V, Tedesco R, Melloni E, Bertolucci G.

J Am Geriatr Soc. 2013 May;61(5):826-8. doi: 10.1111/jgs.12248. No abstract available.

PMID:
23672549
28.

The MDM2 inhibitor Nutlin-3 attenuates streptozotocin-induced diabetes mellitus and increases serum level of IL-12p40.

Secchiero P, Toffoli B, Melloni E, Agnoletto C, Monasta L, Zauli G.

Acta Diabetol. 2013 Dec;50(6):899-906. doi: 10.1007/s00592-013-0476-8. Epub 2013 Apr 25.

PMID:
23615706
29.

C-Reactive protein downregulates TRAIL expression in human peripheral monocytes via an Egr-1-dependent pathway.

Secchiero P, Rimondi E, di Iasio MG, Agnoletto C, Melloni E, Volpi I, Zauli G.

Clin Cancer Res. 2013 Apr 15;19(8):1949-59. doi: 10.1158/1078-0432.CCR-12-3027. Epub 2013 Mar 6.

30.

Release of a specific set of proinflammatory adipokines by differentiating 3T3-L1 cells.

Melloni E, Zauli G, Celeghini C, Volpi I, Secchiero P.

Nutrition. 2013 Jan;29(1):332-7. doi: 10.1016/j.nut.2012.07.013.

PMID:
23237655
31.

Sorafenib inhibits in vitro osteoclastogenesis by down-modulating Mcl-1.

Rimondi E, Secchiero P, Melloni E, Grill V, Zauli G.

Invest New Drugs. 2013 Jun;31(3):780-6. doi: 10.1007/s10637-012-9903-x. Epub 2012 Nov 16.

PMID:
23154882
32.

Merkel-cell polyomavirus (MCPyV) is rarely associated to B-chronic lymphocytic leukemia (1 out of 50) samples and occurs late in the natural history of the disease.

Comar M, Cuneo A, Maestri I, Melloni E, Pozzato G, Soffritti O, Secchiero P, Zauli G.

J Clin Virol. 2012 Dec;55(4):367-9. doi: 10.1016/j.jcv.2012.08.011. Epub 2012 Sep 7.

PMID:
22959215
33.

Potentiation of NMDA receptor-dependent cell responses by extracellular high mobility group box 1 protein.

Pedrazzi M, Averna M, Sparatore B, Patrone M, Salamino F, Marcoli M, Maura G, Cervetto C, Frattaroli D, Pontremoli S, Melloni E.

PLoS One. 2012;7(8):e44518. doi: 10.1371/journal.pone.0044518. Epub 2012 Aug 31.

34.

The sorafenib plus nutlin-3 combination promotes synergistic cytotoxicity in acute myeloid leukemic cells irrespectively of FLT3 and p53 status.

Zauli G, Celeghini C, Melloni E, Voltan R, Ongari M, Tiribelli M, di Iasio MG, Lanza F, Secchiero P.

Haematologica. 2012 Nov;97(11):1722-30. doi: 10.3324/haematol.2012.062083. Epub 2012 Jun 11.

35.

Clinical severity of β-thalassaemia/Hb E disease is associated with differential activities of the calpain-calpastatin proteolytic system.

Sukati S, Svasti S, Stifanese R, Averna M, Panutdaporn N, Penglong T, Melloni E, Fucharoen S, Katzenmeier G.

PLoS One. 2012;7(5):e37133. doi: 10.1371/journal.pone.0037133. Epub 2012 May 16.

36.

MCL1 down-regulation plays a critical role in mediating the higher anti-leukaemic activity of the multi-kinase inhibitor Sorafenib with respect to Dasatinib.

Secchiero P, Melloni E, Voltan R, Norcio A, Celeghini C, Zauli G.

Br J Haematol. 2012 May;157(4):510-4. doi: 10.1111/j.1365-2141.2012.09042.x. Epub 2012 Feb 8. No abstract available.

PMID:
22313359
37.

SOCS1 is significantly up-regulated in Nutlin-3-treated p53wild-type B chronic lymphocytic leukemia (B-CLL) samples and shows an inverse correlation with miR-155.

di Iasio MG, Norcio A, Melloni E, Zauli G.

Invest New Drugs. 2012 Dec;30(6):2403-6. doi: 10.1007/s10637-011-9786-2. Epub 2012 Jan 13.

PMID:
22238073
38.

Evidence for alteration of calpain/calpastatin system in PBMC of cystic fibrosis patients.

Averna M, Stifanese R, De Tullio R, Minicucci L, Cresta F, Palena S, Salamino F, Pontremoli S, Melloni E.

Biochim Biophys Acta. 2011 Dec;1812(12):1649-57. doi: 10.1016/j.bbadis.2011.09.013. Epub 2011 Sep 29.

39.

Decreased levels of soluble TNF-related apoptosis-inducing ligand (TRAIL) in the conjunctival sac fluid of patients with diabetes affected by proliferative retinopathy.

Secchiero P, Perri P, Melloni E, Martini A, Lamberti G, Sebastiani A, Zauli G.

Diabet Med. 2011 Oct;28(10):1277-8. doi: 10.1111/j.1464-5491.2010.03202.x. No abstract available.

PMID:
21923698
40.

Fine tuning of protein kinase C (PKC) isoforms in cancer: shortening the distance from the laboratory to the bedside.

Bosco R, Melloni E, Celeghini C, Rimondi E, Vaccarezza M, Zauli G.

Mini Rev Med Chem. 2011 Mar;11(3):185-99. Review.

PMID:
21534929
41.

miR-34a induces the downregulation of both E2F1 and B-Myb oncogenes in leukemic cells.

Zauli G, Voltan R, di Iasio MG, Bosco R, Melloni E, Sana ME, Secchiero P.

Clin Cancer Res. 2011 May 1;17(9):2712-24. doi: 10.1158/1078-0432.CCR-10-3244. Epub 2011 Mar 2.

42.

Calpain digestion and HSP90-based chaperone protection modulate the level of plasma membrane F508del-CFTR.

Averna M, Stifanese R, Grosso R, Pedrazzi M, De Tullio R, Salamino F, Sparatore B, Pontremoli S, Melloni E.

Biochim Biophys Acta. 2011 Jan;1813(1):50-9. doi: 10.1016/j.bbamcr.2010.11.008. Epub 2010 Nov 24.

43.

Dasatinib plus Nutlin-3 shows synergistic antileukemic activity in both p53 wild-type and p53 mutated B chronic lymphocytic leukemias by inhibiting the Akt pathway.

Zauli G, Voltan R, Bosco R, Melloni E, Marmiroli S, Rigolin GM, Cuneo A, Secchiero P.

Clin Cancer Res. 2011 Feb 15;17(4):762-70. doi: 10.1158/1078-0432.CCR-10-2572. Epub 2010 Nov 24.

44.

The negative prognostic value of TRAIL overexpression in oral squamous cell carcinomas does not preclude the potential therapeutic use of recombinant TRAIL.

Carinci F, Monasta L, Rubini C, Stramazzotti D, Palmieri A, Melloni E, Knowles A, Ronfani L, Zauli G, Secchiero P.

Invest New Drugs. 2012 Apr;30(2):810-8. doi: 10.1007/s10637-010-9586-0. Epub 2010 Nov 18. No abstract available.

PMID:
21086019
45.

Human bone marrow mesenchymal stem cells display anti-cancer activity in SCID mice bearing disseminated non-Hodgkin's lymphoma xenografts.

Secchiero P, Zorzet S, Tripodo C, Corallini F, Melloni E, Caruso L, Bosco R, Ingrao S, Zavan B, Zauli G.

PLoS One. 2010 Jun 16;5(6):e11140. doi: 10.1371/journal.pone.0011140.

46.

Role of calpain in the regulation of CFTR (cystic fibrosis transmembrane conductance regulator) turnover.

Averna M, Stifanese R, Grosso R, Pedrazzi M, De Tullio R, Salamino F, Pontremoli S, Melloni E.

Biochem J. 2010 Sep 1;430(2):255-63. doi: 10.1042/BJ20100344.

PMID:
20557290
47.

The oncogene DEK promotes leukemic cell survival and is downregulated by both Nutlin-3 and chlorambucil in B-chronic lymphocytic leukemic cells.

Secchiero P, Voltan R, di Iasio MG, Melloni E, Tiribelli M, Zauli G.

Clin Cancer Res. 2010 Mar 15;16(6):1824-33. doi: 10.1158/1078-0432.CCR-09-3031. Epub 2010 Mar 9.

48.

Perifosine plus nutlin-3 combination shows a synergistic anti-leukaemic activity.

Voltan R, Celeghini C, Melloni E, Secchiero P, Zauli G.

Br J Haematol. 2010 Mar;148(6):957-61. doi: 10.1111/j.1365-2141.2009.08018.x. Epub 2009 Dec 1. No abstract available.

PMID:
19958355
49.

Adaptive modifications in the calpain/calpastatin system in brain cells after persistent alteration in Ca2+ homeostasis.

Stifanese R, Averna M, De Tullio R, Pedrazzi M, Beccaria F, Salamino F, Milanese M, Bonanno G, Pontremoli S, Melloni E.

J Biol Chem. 2010 Jan 1;285(1):631-43. doi: 10.1074/jbc.M109.031674. Epub 2009 Oct 30.

50.

The expression levels of the pro-apoptotic XAF-1 gene modulate the cytotoxic response to Nutlin-3 in B chronic lymphocytic leukemia.

Secchiero P, di Iasio MG, Melloni E, Voltan R, Celeghini C, Tiribelli M, Dal Bo M, Gattei V, Zauli G.

Leukemia. 2010 Feb;24(2):480-3. doi: 10.1038/leu.2009.215. Epub 2009 Oct 22. No abstract available.

PMID:
19847196

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