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Items: 1 to 50 of 51

1.

Safinamide Modulates Striatal Glutamatergic Signaling in a Rat Model of Levodopa-Induced Dyskinesia.

Gardoni F, Morari M, Kulisevsky J, Brugnoli A, Novello S, Pisanò CA, Caccia C, Mellone M, Melloni E, Padoani G, Sosti V, Vailati S, Keywood C.

J Pharmacol Exp Ther. 2018 Dec;367(3):442-451. doi: 10.1124/jpet.118.251645. Epub 2018 Oct 5.

PMID:
30291173
2.

NMDA receptor GluN2D subunit participates to levodopa-induced dyskinesia pathophysiology.

Mellone M, Zianni E, Stanic J, Campanelli F, Marino G, Ghiglieri V, Longhi A, Thiolat ML, Li Q, Calabresi P, Bezard E, Picconi B, Di Luca M, Gardoni F.

Neurobiol Dis. 2019 Jan;121:338-349. doi: 10.1016/j.nbd.2018.09.021. Epub 2018 Sep 24.

PMID:
30261285
3.

PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells.

Georgilis A, Klotz S, Hanley CJ, Herranz N, Weirich B, Morancho B, Leote AC, D'Artista L, Gallage S, Seehawer M, Carroll T, Dharmalingam G, Wee KB, Mellone M, Pombo J, Heide D, Guccione E, Arribas J, Barbosa-Morais NL, Heikenwalder M, Thomas GJ, Zender L, Gil J.

Cancer Cell. 2018 Jul 9;34(1):85-102.e9. doi: 10.1016/j.ccell.2018.06.007.

4.

Corrigendum: A miRNA-145/TGF-β1 negative feedback loop regulates the cancer-associated fibroblast phenotype.

Melling GE, Flannery SE, Abidin SA, Clemmens H, Prajapati P, Hinsley EE, Hunt S, Catto JWF, Coletta RD, Mellone M, Thomas GJ, Parkinson EK, Prime SS, Paterson IC, Buttle DJ, Lambert DW.

Carcinogenesis. 2018 Jul 4. doi: 10.1093/carcin/bgy083. [Epub ahead of print] No abstract available.

PMID:
29982353
5.

Quantitative proteomic profiling of primary cancer-associated fibroblasts in oesophageal adenocarcinoma.

Manousopoulou A, Hayden A, Mellone M, Garay-Baquero DJ, White CH, Noble F, Lopez M, Thomas GJ, Underwood TJ, Garbis SD.

Br J Cancer. 2018 May;118(9):1200-1207. doi: 10.1038/s41416-018-0042-9. Epub 2018 Mar 29.

PMID:
29593339
6.

The Colorectal Cancer Microenvironment: Strategies for Studying the Role of Cancer-Associated Fibroblasts.

Bhome R, Mellone M, Emo K, Thomas GJ, Sayan AE, Mirnezami AH.

Methods Mol Biol. 2018;1765:87-98. doi: 10.1007/978-1-4939-7765-9_6.

7.

A miRNA-145/TGF-β1 negative feedback loop regulates the cancer-associated fibroblast phenotype.

Melling GE, Flannery SE, Abidin SA, Clemmens H, Prajapati P, Hinsley EE, Hunt S, Catto JWF, Coletta RD, Mellone M, Thomas GJ, Parkinson EK, Prime SS, Paterson IC, Buttle DJ, Lambert DW.

Carcinogenesis. 2018 May 28;39(6):798-807. doi: 10.1093/carcin/bgy032.

PMID:
29506142
8.

Glutamatergic mechanisms in L-DOPA-induced dyskinesia and therapeutic implications.

Mellone M, Gardoni F.

J Neural Transm (Vienna). 2018 Aug;125(8):1225-1236. doi: 10.1007/s00702-018-1846-8. Epub 2018 Jan 31.

PMID:
29387966
9.

Publisher Correction: Anti-AMPA GluA3 antibodies in Frontotemporal dementia: a new molecular target.

Borroni B, Stanic J, Verpelli C, Mellone M, Bonomi E, Alberici A, Bernasconi P, Culotta L, Zianni E, Archetti S, Manes M, Gazzina S, Ghidoni R, Benussi L, Stuani C, Di Luca M, Sala C, Buratti E, Padovani A, Gardoni F.

Sci Rep. 2018 Jan 5;8(1):272. doi: 10.1038/s41598-017-18750-8.

10.

Exosomal microRNAs derived from colorectal cancer-associated fibroblasts: role in driving cancer progression.

Bhome R, Goh RW, Bullock MD, Pillar N, Thirdborough SM, Mellone M, Mirnezami R, Galea D, Veselkov K, Gu Q, Underwood TJ, Primrose JN, De Wever O, Shomron N, Sayan AE, Mirnezami AH.

Aging (Albany NY). 2017 Dec 28;9(12):2666-2694. doi: 10.18632/aging.101355.

11.

Targeting the Myofibroblastic Cancer-Associated Fibroblast Phenotype Through Inhibition of NOX4.

Hanley CJ, Mellone M, Ford K, Thirdborough SM, Mellows T, Frampton SJ, Smith DM, Harden E, Szyndralewiez C, Bullock M, Noble F, Moutasim KA, King EV, Vijayanand P, Mirnezami AH, Underwood TJ, Ottensmeier CH, Thomas GJ.

J Natl Cancer Inst. 2018 Jan 1;110(1). doi: 10.1093/jnci/djx121.

12.

Rabphilin 3A: A novel target for the treatment of levodopa-induced dyskinesias.

Stanic J, Mellone M, Napolitano F, Racca C, Zianni E, Minocci D, Ghiglieri V, Thiolat ML, Li Q, Longhi A, De Rosa A, Picconi B, Bezard E, Calabresi P, Di Luca M, Usiello A, Gardoni F.

Neurobiol Dis. 2017 Dec;108:54-64. doi: 10.1016/j.nbd.2017.08.001. Epub 2017 Aug 18.

13.

Anti-AMPA GluA3 antibodies in Frontotemporal dementia: a new molecular target.

Borroni B, Stanic J, Verpelli C, Mellone M, Bonomi E, Alberici A, Bernasconi P, Culotta L, Zianni E, Archetti S, Manes M, Gazzina S, Ghidoni R, Benussi L, Stuani C, Di Luca M, Sala C, Buratti E, Padovani A, Gardoni F.

Sci Rep. 2017 Jul 27;7(1):6723. doi: 10.1038/s41598-017-06117-y. Erratum in: Sci Rep. 2018 Jan 5;8(1):272.

14.

Novel splice-switching oligonucleotide promotes BRCA1 aberrant splicing and susceptibility to PARP inhibitor action.

Smith LD, Leme de Calais F, Raponi M, Mellone M, Buratti E, Blaydes JP, Baralle D.

Int J Cancer. 2017 Apr 1;140(7):1564-1570. doi: 10.1002/ijc.30574. Epub 2017 Jan 30.

15.

Induction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosis.

Mellone M, Hanley CJ, Thirdborough S, Mellows T, Garcia E, Woo J, Tod J, Frampton S, Jenei V, Moutasim KA, Kabir TD, Brennan PA, Venturi G, Ford K, Herranz N, Lim KP, Clarke J, Lambert DW, Prime SS, Underwood TJ, Vijayanand P, Eliceiri KW, Woelk C, King EV, Gil J, Ottensmeier CH, Thomas GJ.

Aging (Albany NY). 2016 Dec 15;9(1):114-132. doi: 10.18632/aging.101127.

16.

Profiling the MicroRNA Payload of Exosomes Derived from Ex Vivo Primary Colorectal Fibroblasts.

Bhome R, Goh R, Pickard K, Mellone M, Sayan AE, Mirnezami A.

Methods Mol Biol. 2017;1509:115-122.

17.

Authentication and characterisation of a new oesophageal adenocarcinoma cell line: MFD-1.

Garcia E, Hayden A, Birts C, Britton E, Cowie A, Pickard K, Mellone M, Choh C, Derouet M, Duriez P, Noble F, White MJ, Primrose JN, Strefford JC, Rose-Zerilli M, Thomas GJ, Ang Y, Sharrocks AD, Fitzgerald RC, Underwood TJ; OCCAMS consortium.

Sci Rep. 2016 Sep 7;6:32417. doi: 10.1038/srep32417.

18.

A miR-335/COX-2/PTEN axis regulates the secretory phenotype of senescent cancer-associated fibroblasts.

Kabir TD, Leigh RJ, Tasena H, Mellone M, Coletta RD, Parkinson EK, Prime SS, Thomas GJ, Paterson IC, Zhou D, McCall J, Speight PM, Lambert DW.

Aging (Albany NY). 2016 Aug;8(8):1608-35. doi: 10.18632/aging.100987.

19.

Fibroblast activation and senescence in oral cancer.

Prime SS, Cirillo N, Hassona Y, Lambert DW, Paterson IC, Mellone M, Thomas GJ, James EN, Parkinson EK.

J Oral Pathol Med. 2017 Feb;46(2):82-88. doi: 10.1111/jop.12456. Epub 2016 May 30. Review.

PMID:
27237745
20.

LRRK2 phosphorylation level correlates with abnormal motor behaviour in an experimental model of levodopa-induced dyskinesias.

Stanic J, Mellone M, Cirnaru MD, Perez-Carrion M, Zianni E, Di Luca M, Gardoni F, Piccoli G.

Mol Brain. 2016 May 11;9(1):53. doi: 10.1186/s13041-016-0234-2.

21.

Ring finger protein 10 is a novel synaptonuclear messenger encoding activation of NMDA receptors in hippocampus.

Dinamarca MC, Guzzetti F, Karpova A, Lim D, Mitro N, Musardo S, Mellone M, Marcello E, Stanic J, Samaddar T, Burguière A, Caldarelli A, Genazzani AA, Perroy J, Fagni L, Canonico PL, Kreutz MR, Gardoni F, Di Luca M.

Elife. 2016 Mar 15;5:e12430. doi: 10.7554/eLife.12430.

22.

A subset of myofibroblastic cancer-associated fibroblasts regulate collagen fiber elongation, which is prognostic in multiple cancers.

Hanley CJ, Noble F, Ward M, Bullock M, Drifka C, Mellone M, Manousopoulou A, Johnston HE, Hayden A, Thirdborough S, Liu Y, Smith DM, Mellows T, Kao WJ, Garbis SD, Mirnezami A, Underwood TJ, Eliceiri KW, Thomas GJ.

Oncotarget. 2016 Feb 2;7(5):6159-74. doi: 10.18632/oncotarget.6740.

23.

Modulation of serotonergic transmission by eltoprazine in L-DOPA-induced dyskinesia: Behavioral, molecular, and synaptic mechanisms.

Ghiglieri V, Mineo D, Vannelli A, Cacace F, Mancini M, Pendolino V, Napolitano F, di Maio A, Mellone M, Stanic J, Tronci E, Fidalgo C, Stancampiano R, Carta M, Calabresi P, Gardoni F, Usiello A, Picconi B.

Neurobiol Dis. 2016 Feb;86:140-53. doi: 10.1016/j.nbd.2015.11.022. Epub 2015 Nov 27.

PMID:
26639853
24.

Erratum: mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype.

Herranz N, Gallage S, Mellone M, Wuestefeld T, Klotz S, Hanley CJ, Raguz S, Acosta JC, Innes AJ, Banito A, Georgilis A, Montoya A, Wolter K, Dharmalingam G, Faull P, Carroll T, Martínez-Barbera JP, Cutillas P, Reisinger F, Heikenwalder M, Miller RA, Withers D, Zender L, Thomas GJ, Gil J.

Nat Cell Biol. 2015 Oct;17(10):1370. doi: 10.1038/ncb3243. No abstract available.

PMID:
26419804
25.

Alpha-Synuclein Produces Early Behavioral Alterations via Striatal Cholinergic Synaptic Dysfunction by Interacting With GluN2D N-Methyl-D-Aspartate Receptor Subunit.

Tozzi A, de Iure A, Bagetta V, Tantucci M, Durante V, Quiroga-Varela A, Costa C, Di Filippo M, Ghiglieri V, Latagliata EC, Wegrzynowicz M, Decressac M, Giampà C, Dalley JW, Xia J, Gardoni F, Mellone M, El-Agnaf OM, Ardah MT, Puglisi-Allegra S, Björklund A, Spillantini MG, Picconi B, Calabresi P.

Biol Psychiatry. 2016 Mar 1;79(5):402-414. doi: 10.1016/j.biopsych.2015.08.013. Epub 2015 Aug 20.

PMID:
26392130
26.

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype.

Herranz N, Gallage S, Mellone M, Wuestefeld T, Klotz S, Hanley CJ, Raguz S, Acosta JC, Innes AJ, Banito A, Georgilis A, Montoya A, Wolter K, Dharmalingam G, Faull P, Carroll T, Martínez-Barbera JP, Cutillas P, Reisinger F, Heikenwalder M, Miller RA, Withers D, Zender L, Thomas GJ, Gil J.

Nat Cell Biol. 2015 Sep;17(9):1205-17. doi: 10.1038/ncb3225. Epub 2015 Aug 17. Erratum in: Nat Cell Biol. 2015 Oct;17(10):1370.

27.

NMDA receptor GluN2A/GluN2B subunit ratio as synaptic trait of levodopa-induced dyskinesias: from experimental models to patients.

Mellone M, Stanic J, Hernandez LF, Iglesias E, Zianni E, Longhi A, Prigent A, Picconi B, Calabresi P, Hirsch EC, Obeso JA, Di Luca M, Gardoni F.

Front Cell Neurosci. 2015 Jul 6;9:245. doi: 10.3389/fncel.2015.00245. eCollection 2015.

28.

Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease.

Bastide MF, Meissner WG, Picconi B, Fasano S, Fernagut PO, Feyder M, Francardo V, Alcacer C, Ding Y, Brambilla R, Fisone G, Jon Stoessl A, Bourdenx M, Engeln M, Navailles S, De Deurwaerdère P, Ko WK, Simola N, Morelli M, Groc L, Rodriguez MC, Gurevich EV, Quik M, Morari M, Mellone M, Gardoni F, Tronci E, Guehl D, Tison F, Crossman AR, Kang UJ, Steece-Collier K, Fox S, Carta M, Angela Cenci M, Bézard E.

Prog Neurobiol. 2015 Sep;132:96-168. doi: 10.1016/j.pneurobio.2015.07.002. Epub 2015 Jul 21. Review.

PMID:
26209473
29.

Cancer-associated fibroblasts predict poor outcome and promote periostin-dependent invasion in oesophageal adenocarcinoma.

Underwood TJ, Hayden AL, Derouet M, Garcia E, Noble F, White MJ, Thirdborough S, Mead A, Clemons N, Mellone M, Uzoho C, Primrose JN, Blaydes JP, Thomas GJ.

J Pathol. 2015 Feb;235(3):466-77. doi: 10.1002/path.4467.

30.

Zinc transporter-1: a novel NMDA receptor-binding protein at the postsynaptic density.

Mellone M, Pelucchi S, Alberti L, Genazzani AA, Di Luca M, Gardoni F.

J Neurochem. 2015 Jan;132(2):159-68. doi: 10.1111/jnc.12968. Epub 2015 Jan 4.

31.

Molecular profiling of the invasive tumor microenvironment in a 3-dimensional model of colorectal cancer cells and ex vivo fibroblasts.

Bullock MD, Mellone M, Pickard KM, Sayan AE, Mitter R, Primrose JN, Packham GK, Thomas G, Mirnezami AH.

J Vis Exp. 2014 Apr 29;(86). doi: 10.3791/51475.

32.

Suppression of Hedgehog signalling promotes pro-tumourigenic integrin expression and function.

Moutasim KA, Mellows T, Mellone M, Lopez MA, Tod J, Kiely PC, Sapienza K, Greco A, Neill GW, Violette S, Weinreb PH, Marshall JF, Ottensmeier CH, Sayan AE, Jenei V, Thomas GJ.

J Pathol. 2014 Jun;233(2):196-208. doi: 10.1002/path.4342. Epub 2014 Apr 29.

PMID:
24573955
33.

Tau pathology is present in vivo and develops in vitro in sensory neurons from human P301S tau transgenic mice: a system for screening drugs against tauopathies.

Mellone M, Kestoras D, Andrews MR, Dassie E, Crowther RA, Stokin GB, Tinsley J, Horne G, Goedert M, Tolkovsky AM, Spillantini MG.

J Neurosci. 2013 Nov 13;33(46):18175-89. doi: 10.1523/JNEUROSCI.4933-12.2013.

34.

Modulation of NMDA receptor at the synapse: promising therapeutic interventions in disorders of the nervous system.

Mellone M, Gardoni F.

Eur J Pharmacol. 2013 Nov 5;719(1-3):75-83. doi: 10.1016/j.ejphar.2013.04.054. Epub 2013 Jul 18. Review.

PMID:
23872417
35.

Pleiotropic actions of miR-21 highlight the critical role of deregulated stromal microRNAs during colorectal cancer progression.

Bullock MD, Pickard KM, Nielsen BS, Sayan AE, Jenei V, Mellone M, Mitter R, Primrose JN, Thomas GJ, Packham GK, Mirnezami AH.

Cell Death Dis. 2013 Jun 20;4:e684. doi: 10.1038/cddis.2013.213. Erratum in: Cell Death Dis. 2013;4:e748. Mirenzami, AH [corrected to Mirnezami, AH].

36.

Progression of genotype-specific oral cancer leads to senescence of cancer-associated fibroblasts and is mediated by oxidative stress and TGF-β.

Hassona Y, Cirillo N, Lim KP, Herman A, Mellone M, Thomas GJ, Pitiyage GN, Parkinson EK, Prime SS.

Carcinogenesis. 2013 Jun;34(6):1286-95. doi: 10.1093/carcin/bgt035. Epub 2013 Jan 27.

PMID:
23358854
37.

PIR2/Rnf144B regulates epithelial homeostasis by mediating degradation of p21WAF1 and p63.

Conforti F, Yang AL, Piro MC, Mellone M, Terrinoni A, Candi E, Tucci P, Thomas GJ, Knight RA, Melino G, Sayan BS.

Oncogene. 2013 Oct;32(40):4758-65. doi: 10.1038/onc.2012.497. Epub 2012 Nov 5.

PMID:
23128396
38.

Neuroprotective effects of human mesenchymal stem cells on neural cultures exposed to 6-hydroxydopamine: implications for reparative therapy in Parkinson's disease.

Cova L, Bossolasco P, Armentero MT, Diana V, Zennaro E, Mellone M, Calzarossa C, Cerri S, Deliliers GL, Polli E, Blandini F, Silani V.

Apoptosis. 2012 Mar;17(3):289-304. doi: 10.1007/s10495-011-0679-9.

PMID:
22160861
39.

Transplantation of undifferentiated human mesenchymal stem cells protects against 6-hydroxydopamine neurotoxicity in the rat.

Blandini F, Cova L, Armentero MT, Zennaro E, Levandis G, Bossolasco P, Calzarossa C, Mellone M, Giuseppe B, Deliliers GL, Polli E, Nappi G, Silani V.

Cell Transplant. 2010;19(2):203-17. doi: 10.3727/096368909X479839. Epub 2009 Nov 10.

PMID:
19906332
40.

Human papilloma virus-dependent HMGA1 expression is a relevant step in cervical carcinogenesis.

Mellone M, Rinaldi C, Massimi I, Petroni M, Veschi V, Talora C, Truffa S, Stabile H, Frati L, Screpanti I, Gulino A, Giannini G.

Neoplasia. 2008 Aug;10(8):773-81.

41.

High mobility group A1 is a molecular target for MYCN in human neuroblastoma.

Giannini G, Cerignoli F, Mellone M, Massimi I, Ambrosi C, Rinaldi C, Dominici C, Frati L, Screpanti I, Gulino A.

Cancer Res. 2005 Sep 15;65(18):8308-16.

42.

Molecular mechanism of HMGA1 deregulation in human neuroblastoma.

Giannini G, Cerignoli F, Mellone M, Massimi I, Ambrosi C, Rinaldi C, Gulino A.

Cancer Lett. 2005 Oct 18;228(1-2):97-104. Review.

PMID:
15923078
43.

HMGA molecules in neuroblastic tumors.

Cerignoli F, Ambrosi C, Mellone M, Assimi I, di Marcotullio L, Gulino A, Giannini G.

Ann N Y Acad Sci. 2004 Dec;1028:122-32. Review.

PMID:
15650238
44.

Effects of selenium and zinc supplementation on nutritional status in patients with cancer of digestive tract.

Federico A, Iodice P, Federico P, Del Rio A, Mellone MC, Catalano G, Federico P.

Eur J Clin Nutr. 2001 Apr;55(4):293-7.

45.

A prospective study of hypertension and the incidence of kidney stones in men.

Cappuccio FP, Siani A, Barba G, Mellone MC, Russo L, Farinaro E, Trevisan M, Mancini M, Strazzullo P.

J Hypertens. 1999 Jul;17(7):1017-22.

PMID:
10419076
46.

Salt intake, urinary sodium, and hypercalciuria.

Cirillo M, Ciacci C, Laurénzi M, Mellone M, Mazzacca G, De Santo NG.

Miner Electrolyte Metab. 1997;23(3-6):265-8.

PMID:
9387130
47.

Analysis of metal-regulated metallothionein and heat shock gene expression in HeLa-derived cadmium-resistant cells.

Cigliano S, Remondelli P, Minichiello L, Mellone MC, Martire G, Bonatti S, Leone A.

Exp Cell Res. 1996 Nov 1;228(2):173-80.

PMID:
8912708
48.

Hypocalciuria in overt and subclinical celiac disease.

Ciacci C, Cirillo M, Mellone M, Basile F, Mazzacca G, De Santo NG.

Am J Gastroenterol. 1995 Sep;90(9):1480-4.

PMID:
7661174
49.

Can overnight urine replace 24-hour urine collection to measure urinary calcium in epidemiologic studies?

Cirillo M, Mellone M, De Santo NG.

Miner Electrolyte Metab. 1993;19(6):385-8.

PMID:
8164621
50.

Transglutaminase changes in intestinal mucosa after experimental small bowel resection in the rat.

D'Argenio G, Ciacci C, Sorrentini I, Ventriglia R, Spagnuolo S, Mattera D, Mellone MC, Iovino P, Mazzacca G.

Clin Physiol Biochem. 1992;9(2):74-7.

PMID:
1363917

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