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Items: 1 to 50 of 265

1.

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells.

Mariathasan S, Turley SJ, Nickles D, Castiglioni A, Yuen K, Wang Y, Kadel EE III, Koeppen H, Astarita JL, Cubas R, Jhunjhunwala S, Banchereau R, Yang Y, Guan Y, Chalouni C, Ziai J, Şenbabaoğlu Y, Santoro S, Sheinson D, Hung J, Giltnane JM, Pierce AA, Mesh K, Lianoglou S, Riegler J, Carano RAD, Eriksson P, Höglund M, Somarriba L, Halligan DL, van der Heijden MS, Loriot Y, Rosenberg JE, Fong L, Mellman I, Chen DS, Green M, Derleth C, Fine GD, Hegde PS, Bourgon R, Powles T.

Nature. 2018 Feb 22;554(7693):544-548. doi: 10.1038/nature25501. Epub 2018 Feb 14.

PMID:
29443960
2.

SUV420H2 is an epigenetic regulator of epithelial/mesenchymal states in pancreatic cancer.

Viotti M, Wilson C, McCleland M, Koeppen H, Haley B, Jhunjhunwala S, Klijn C, Modrusan Z, Arnott D, Classon M, Stephan JP, Mellman I.

J Cell Biol. 2018 Feb 5;217(2):763-777. doi: 10.1083/jcb.201705031. Epub 2017 Dec 11.

PMID:
29229751
3.

Visualization of early influenza A virus trafficking in human dendritic cells using STED microscopy.

Baharom F, Thomas OS, Lepzien R, Mellman I, Chalouni C, Smed-Sörensen A.

PLoS One. 2017 Jun 7;12(6):e0177920. doi: 10.1371/journal.pone.0177920. eCollection 2017.

4.

T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition.

Hui E, Cheung J, Zhu J, Su X, Taylor MJ, Wallweber HA, Sasmal DK, Huang J, Kim JM, Mellman I, Vale RD.

Science. 2017 Mar 31;355(6332):1428-1433. doi: 10.1126/science.aaf1292. Epub 2017 Mar 9.

5.

Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice.

Lau J, Cheung J, Navarro A, Lianoglou S, Haley B, Totpal K, Sanders L, Koeppen H, Caplazi P, McBride J, Chiu H, Hong R, Grogan J, Javinal V, Yauch R, Irving B, Belvin M, Mellman I, Kim JM, Schmidt M.

Nat Commun. 2017 Feb 21;8:14572. doi: 10.1038/ncomms14572.

6.

Transcriptional determinants of tolerogenic and immunogenic states during dendritic cell maturation.

Vander Lugt B, Riddell J, Khan AA, Hackney JA, Lesch J, DeVoss J, Weirauch MT, Singh H, Mellman I.

J Cell Biol. 2017 Mar 6;216(3):779-792. doi: 10.1083/jcb.201512012. Epub 2017 Jan 27.

7.

Elements of cancer immunity and the cancer-immune set point.

Chen DS, Mellman I.

Nature. 2017 Jan 18;541(7637):321-330. doi: 10.1038/nature21349. Review.

PMID:
28102259
8.

Natural killer cell granules converge to avoid collateral damage.

Ritter AT, Mellman I.

J Cell Biol. 2016 Dec 19;215(6):765-767. Epub 2016 Dec 8.

9.

Immunomodulatory antibodies for the treatment of lymphoma: Report on the CALYM Workshop.

Houot R, Gaulard P, Schreiber R, Mellman I, Lambotte O, Coulie PG, Fest T, Korman A, Levy R, Shipp M, Tarte K, Kohrt H, Marabelle A, Ansell S, Watier H, van Elsas A, Balakumaran A, Arce Vargas F, Quezada SA, Salles G, Olive D.

Oncoimmunology. 2016 May 19;5(7):e1186323. doi: 10.1080/2162402X.2016.1186323. eCollection 2016 Jul.

10.

High cell-surface density of HER2 deforms cell membranes.

Chung I, Reichelt M, Shao L, Akita RW, Koeppen H, Rangell L, Schaefer G, Mellman I, Sliwkowski MX.

Nat Commun. 2016 Sep 7;7:12742. doi: 10.1038/ncomms12742.

11.

Society for immunotherapy of cancer (SITC) statement on the proposed changes to the common rule.

Kaufman HL, Butterfield LH, Coulie PG, Demaria S, Ferris RL, Galon J, Khleif SN, Mellman I, Ohashi PS, Overwijk WW, Topalian SL, Marincola FM.

J Immunother Cancer. 2016 Jun 21;4:37. doi: 10.1186/s40425-016-0142-0. eCollection 2016.

12.

The Human Vaccines Project: A roadmap for cancer vaccine development.

Romero P, Banchereau J, Bhardwaj N, Cockett M, Disis ML, Dranoff G, Gilboa E, Hammond SA, Hershberg R, Korman AJ, Kvistborg P, Melief C, Mellman I, Palucka AK, Redchenko I, Robins H, Sallusto F, Schenkelberg T, Schoenberger S, Sosman J, Türeci Ö, Van den Eynde B, Koff W, Coukos G.

Sci Transl Med. 2016 Apr 13;8(334):334ps9. doi: 10.1126/scitranslmed.aaf0685. Review.

PMID:
27075624
13.

De-Risking Immunotherapy: Report of a Consensus Workshop of the Cancer Immunotherapy Consortium of the Cancer Research Institute.

Mellman I, Hubbard-Lucey VM, Tontonoz MJ, Kalos MD, Chen DS, Allison JP, Drake CG, Levitsky H, Lonberg N, van der Burg SH, Fearon DT, Wherry EJ, Lowy I, Vonderheide RH, Hwu P.

Cancer Immunol Res. 2016 Apr;4(4):279-88. doi: 10.1158/2326-6066.CIR-16-0045. Review.

14.

Voices of biotech.

Amit I, Baker D, Barker R, Berger B, Bertozzi C, Bhatia S, Biffi A, Demichelis F, Doudna J, Dowdy SF, Endy D, Helmstaedter M, Junca H, June C, Kamb S, Khvorova A, Kim DH, Kim JS, Krishnan Y, Lakadamyali M, Lappalainen T, Lewin S, Liao J, Loman N, Lundberg E, Lynd L, Martin C, Mellman I, Miyawaki A, Mummery C, Nelson K, Paz J, Peralta-Yahya P, Picotti P, Polyak K, Prather K, Qin J, Quake S, Regev A, Rogers JA, Shetty R, Sommer M, Stevens M, Stolovitzky G, Takahashi M, Tang F, Teichmann S, Torres-Padilla ME, Tripathi L, Vemula P, Verdine G, Vollmer F, Wang J, Ying JY, Zhang F, Zhang T.

Nat Biotechnol. 2016 Mar;34(3):270-5. doi: 10.1038/nbt.3502. No abstract available.

PMID:
26963549
15.

MAP Kinase Inhibition Promotes T Cell and Anti-tumor Activity in Combination with PD-L1 Checkpoint Blockade.

Ebert PJR, Cheung J, Yang Y, McNamara E, Hong R, Moskalenko M, Gould SE, Maecker H, Irving BA, Kim JM, Belvin M, Mellman I.

Immunity. 2016 Mar 15;44(3):609-621. doi: 10.1016/j.immuni.2016.01.024. Epub 2016 Mar 2.

16.

Is all cancer therapy immunotherapy?

Belvin M, Mellman I.

Sci Transl Med. 2015 Nov 25;7(315):315fs48. doi: 10.1126/scitranslmed.aad7661.

PMID:
26606965
17.

Dendritic cells require NIK for CD40-dependent cross-priming of CD8+ T cells.

Katakam AK, Brightbill H, Franci C, Kung C, Nunez V, Jones C 3rd, Peng I, Jeet S, Wu LC, Mellman I, Delamarre L, Austin CD.

Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):14664-9. doi: 10.1073/pnas.1520627112. Epub 2015 Nov 11.

18.

Immunotherapy: The path to win the war on cancer?

Topalian SL, Wolchok JD, Chan TA, Mellman I, Palucka K, Banchereau J, Rosenberg SA, Dane Wittrup K.

Cell. 2015 Apr 9;161(2):185-6. No abstract available.

19.

Cancer immunotherapy. Neo approaches to cancer vaccines.

Delamarre L, Mellman I, Yadav M.

Science. 2015 May 15;348(6236):760-1. doi: 10.1126/science.aab3465. No abstract available.

PMID:
25977539
20.

Protection of human myeloid dendritic cell subsets against influenza A virus infection is differentially regulated upon TLR stimulation.

Baharom F, Thomas S, Bieder A, Hellmér M, Volz J, Sandgren KJ, McInerney GM, Karlsson Hedestam GB, Mellman I, Smed-Sörensen A.

J Immunol. 2015 May 1;194(9):4422-30. doi: 10.4049/jimmunol.1402671. Epub 2015 Mar 23.

21.

β-Catenin in dendritic cells exerts opposite functions in cross-priming and maintenance of CD8+ T cells through regulation of IL-10.

Fu C, Liang X, Cui W, Ober-Blöbaum JL, Vazzana J, Shrikant PA, Lee KP, Clausen BE, Mellman I, Jiang A.

Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2823-8. doi: 10.1073/pnas.1414167112. Epub 2015 Feb 17.

22.

Polarity protein Par3 controls B-cell receptor dynamics and antigen extraction at the immune synapse.

Reversat A, Yuseff MI, Lankar D, Malbec O, Obino D, Maurin M, Penmatcha NV, Amoroso A, Sengmanivong L, Gundersen GG, Mellman I, Darchen F, Desnos C, Pierobon P, Lennon-Duménil AM.

Mol Biol Cell. 2015 Apr 1;26(7):1273-85. doi: 10.1091/mbc.E14-09-1373. Epub 2015 Jan 28.

23.

Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing.

Yadav M, Jhunjhunwala S, Phung QT, Lupardus P, Tanguay J, Bumbaca S, Franci C, Cheung TK, Fritsche J, Weinschenk T, Modrusan Z, Mellman I, Lill JR, Delamarre L.

Nature. 2014 Nov 27;515(7528):572-6. doi: 10.1038/nature14001.

PMID:
25428506
24.

Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients.

Herbst RS, Soria JC, Kowanetz M, Fine GD, Hamid O, Gordon MS, Sosman JA, McDermott DF, Powderly JD, Gettinger SN, Kohrt HE, Horn L, Lawrence DP, Rost S, Leabman M, Xiao Y, Mokatrin A, Koeppen H, Hegde PS, Mellman I, Chen DS, Hodi FS.

Nature. 2014 Nov 27;515(7528):563-7. doi: 10.1038/nature14011.

25.

Single-molecule optical methods analyzing receptor tyrosine kinase activation in living cells.

Chung I, Mellman I.

Methods Mol Biol. 2015;1233:35-44. doi: 10.1007/978-1-4939-1789-1_4.

PMID:
25319887
26.

Dendritic cells: master regulators of the immune response.

Mellman I.

Cancer Immunol Res. 2013 Sep;1(3):145-9. doi: 10.1158/2326-6066.CIR-13-0102. Review.

27.

Endosomes are specialized platforms for bacterial sensing and NOD2 signalling.

Nakamura N, Lill JR, Phung Q, Jiang Z, Bakalarski C, de Mazière A, Klumperman J, Schlatter M, Delamarre L, Mellman I.

Nature. 2014 May 8;509(7499):240-4. doi: 10.1038/nature13133. Epub 2014 Mar 30.

PMID:
24695226
28.

Transcriptional programming of dendritic cells for enhanced MHC class II antigen presentation.

Vander Lugt B, Khan AA, Hackney JA, Agrawal S, Lesch J, Zhou M, Lee WP, Park S, Xu M, DeVoss J, Spooner CJ, Chalouni C, Delamarre L, Mellman I, Singh H.

Nat Immunol. 2014 Feb;15(2):161-7. doi: 10.1038/ni.2795. Epub 2013 Dec 22.

PMID:
24362890
29.

Endocytosis and cancer.

Mellman I, Yarden Y.

Cold Spring Harb Perspect Biol. 2013 Dec 1;5(12):a016949. doi: 10.1101/cshperspect.a016949. Review.

30.

A Nobel Prize for membrane traffic: vesicles find their journey's end.

Mellman I, Emr SD.

J Cell Biol. 2013 Nov 25;203(4):559-61. doi: 10.1083/jcb.201310134. Epub 2013 Nov 8.

31.

Antibody therapeutics in cancer.

Sliwkowski MX, Mellman I.

Science. 2013 Sep 13;341(6151):1192-8. doi: 10.1126/science.1241145. Review.

PMID:
24031011
32.

β-catenin mediates tumor-induced immunosuppression by inhibiting cross-priming of CD8⁺ T cells.

Liang X, Fu C, Cui W, Ober-Blöbaum JL, Zahner SP, Shrikant PA, Clausen BE, Flavell RA, Mellman I, Jiang A.

J Leukoc Biol. 2014 Jan;95(1):179-90. doi: 10.1189/jlb.0613330. Epub 2013 Sep 10.

PMID:
24023259
33.

Oncology meets immunology: the cancer-immunity cycle.

Chen DS, Mellman I.

Immunity. 2013 Jul 25;39(1):1-10. doi: 10.1016/j.immuni.2013.07.012. Review.

34.

MARCH1-mediated MHCII ubiquitination promotes dendritic cell selection of natural regulatory T cells.

Oh J, Wu N, Baravalle G, Cohn B, Ma J, Lo B, Mellman I, Ishido S, Anderson M, Shin JS.

J Exp Med. 2013 Jun 3;210(6):1069-77. doi: 10.1084/jem.20122695. Epub 2013 May 27.

35.

Antigen delivery to early endosomes eliminates the superiority of human blood BDCA3+ dendritic cells at cross presentation.

Cohn L, Chatterjee B, Esselborn F, Smed-Sörensen A, Nakamura N, Chalouni C, Lee BC, Vandlen R, Keler T, Lauer P, Brockstedt D, Mellman I, Delamarre L.

J Exp Med. 2013 May 6;210(5):1049-63. doi: 10.1084/jem.20121251. Epub 2013 Apr 8.

36.

Lkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and -independent pathways.

Lo B, Strasser G, Sagolla M, Austin CD, Junttila M, Mellman I.

J Cell Biol. 2012 Dec 24;199(7):1117-30. doi: 10.1083/jcb.201208080.

37.

Internalization and endosomal degradation of receptor-bound antigens regulate the efficiency of cross presentation by human dendritic cells.

Chatterjee B, Smed-Sörensen A, Cohn L, Chalouni C, Vandlen R, Lee BC, Widger J, Keler T, Delamarre L, Mellman I.

Blood. 2012 Sep 6;120(10):2011-20. doi: 10.1182/blood-2012-01-402370. Epub 2012 Jul 12.

38.

Profile of Ira Mellman. Interview by Prashant Nair.

Mellman I.

Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):8790-2. doi: 10.1073/pnas.1207791109. Epub 2012 May 29. No abstract available.

39.

MHC class II distribution in dendritic cells and B cells is determined by ubiquitin chain length.

Ma JK, Platt MY, Eastham-Anderson J, Shin JS, Mellman I.

Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):8820-7. doi: 10.1073/pnas.1202977109. Epub 2012 May 7.

40.

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity.

Maurer T, Garrenton LS, Oh A, Pitts K, Anderson DJ, Skelton NJ, Fauber BP, Pan B, Malek S, Stokoe D, Ludlam MJ, Bowman KK, Wu J, Giannetti AM, Starovasnik MA, Mellman I, Jackson PK, Rudolph J, Wang W, Fang G.

Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5299-304. doi: 10.1073/pnas.1116510109. Epub 2012 Mar 19.

41.

Influenza A virus infection of human primary dendritic cells impairs their ability to cross-present antigen to CD8 T cells.

Smed-Sörensen A, Chalouni C, Chatterjee B, Cohn L, Blattmann P, Nakamura N, Delamarre L, Mellman I.

PLoS Pathog. 2012;8(3):e1002572. doi: 10.1371/journal.ppat.1002572. Epub 2012 Mar 8.

42.

Remembering Ralph Steinman.

Banchereau J, Cohn F, Inaba K, Muller B, Mellman I, Nathan C, Nussenzweig M, O'Garra A, Seder B, Schuler G, Sher A.

J Exp Med. 2011 Nov 21;208(12):2343-7. No abstract available.

43.

Cancer immunotherapy comes of age.

Mellman I, Coukos G, Dranoff G.

Nature. 2011 Dec 21;480(7378):480-9. doi: 10.1038/nature10673. Review.

44.

Retrospective. Ralph M. Steinman (1943-2011).

Mellman I, Nussenzweig M.

Science. 2011 Oct 28;334(6055):466. doi: 10.1126/science.1215136. No abstract available.

PMID:
22034425
45.

Ralph Steinman (1943-2011).

Nussenzweig MC, Mellman I.

Nature. 2011 Oct 26;478(7370):460. doi: 10.1038/478460a. No abstract available.

PMID:
22031432
46.

A hierarchy of signals regulates entry of membrane proteins into the ciliary membrane domain in epithelial cells.

Francis SS, Sfakianos J, Lo B, Mellman I.

J Cell Biol. 2011 Apr 4;193(1):219-33. doi: 10.1083/jcb.201009001. Epub 2011 Mar 28.

47.

AMP-activated protein kinase (AMPK) activation and glycogen synthase kinase-3β (GSK-3β) inhibition induce Ca2+-independent deposition of tight junction components at the plasma membrane.

Zhang L, Jouret F, Rinehart J, Sfakianos J, Mellman I, Lifton RP, Young LH, Caplan MJ.

J Biol Chem. 2011 May 13;286(19):16879-90. doi: 10.1074/jbc.M110.186932. Epub 2011 Mar 7.

48.

Harnessing dendritic cells for immunotherapy.

Delamarre L, Mellman I.

Semin Immunol. 2011 Feb;23(1):2-11. doi: 10.1016/j.smim.2011.02.001. Epub 2011 Mar 5. Review.

PMID:
21377379
49.

Cell biology redux.

Mellman I.

Mol Biol Cell. 2010 Nov 15;21(22):3809-10. doi: 10.1091/mbc.E10-04-0346. No abstract available.

50.

Designing vaccines based on biology of human dendritic cell subsets.

Palucka K, Banchereau J, Mellman I.

Immunity. 2010 Oct 29;33(4):464-78. doi: 10.1016/j.immuni.2010.10.007. Review.

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