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Items: 1 to 50 of 125

1.

Diacylglycerol Kinase ζ Regulates Macrophage Responses in Juvenile Arthritis and Cytokine Storm Syndrome Mouse Models.

Mahajan S, Mellins ED, Faccio R.

J Immunol. 2019 Dec 4. pii: ji1900721. doi: 10.4049/jimmunol.1900721. [Epub ahead of print]

PMID:
31801815
2.

In vivo clonal expansion and phenotypes of hypocretin-specific CD4+ T cells in narcolepsy patients and controls.

Jiang W, Birtley JR, Hung SC, Wang W, Chiou SH, Macaubas C, Kornum B, Tian L, Huang H, Adler L, Weaver G, Lu L, Ilstad-Minnihan A, Somasundaram S, Ayyangar S, Davis MM, Stern LJ, Mellins ED.

Nat Commun. 2019 Nov 20;10(1):5247. doi: 10.1038/s41467-019-13234-x.

3.

Combined Assay for Detecting Autoantibodies to Nucleic Acids and Apolipoprotein H in Patients with Systemic Lupus Erythematosus.

Khatri S, Mellins ED, Torok KS, Bukhari SA, Astakhova K.

Methods Mol Biol. 2020;2063:57-71. doi: 10.1007/978-1-0716-0138-9_6.

PMID:
31667763
4.

Emergent high fatality lung disease in systemic juvenile arthritis.

Saper VE, Chen G, Deutsch GH, Guillerman RP, Birgmeier J, Jagadeesh K, Canna S, Schulert G, Deterding R, Xu J, Leung AN, Bouzoubaa L, Abulaban K, Baszis K, Behrens EM, Birmingham J, Casey A, Cidon M, Cron RQ, De A, De Benedetti F, Ferguson I, Fishman MP, Goodman SI, Graham TB, Grom AA, Haines K, Hazen M, Henderson LA, Ho A, Ibarra M, Inman CJ, Jerath R, Khawaja K, Kingsbury DJ, Klein-Gitelman M, Lai K, Lapidus S, Lin C, Lin J, Liptzin DR, Milojevic D, Mombourquette J, Onel K, Ozen S, Perez M, Phillippi K, Prahalad S, Radhakrishna S, Reinhardt A, Riskalla M, Rosenwasser N, Roth J, Schneider R, Schonenberg-Meinema D, Shenoi S, Smith JA, Sönmez HE, Stoll ML, Towe C, Vargas SO, Vehe RK, Young LR, Yang J, Desai T, Balise R, Lu Y, Tian L, Bejerano G, Davis MM, Khatri P, Mellins ED; Childhood Arthritis and Rheumatology Research Alliance Registry Investigators.

Ann Rheum Dis. 2019 Dec;78(12):1722-1731. doi: 10.1136/annrheumdis-2019-216040. Epub 2019 Sep 27.

PMID:
31562126
5.

Synergy between B cell receptor/antigen uptake and MHCII peptide editing relies on HLA-DO tuning.

Jiang W, Adler LN, Macmillan H, Mellins ED.

Sci Rep. 2019 Sep 25;9(1):13877. doi: 10.1038/s41598-019-50455-y.

6.

Citrullinated Peptide Epitope Targets Therapeutic Nanoparticles to Human Neutrophils.

Khatri S, Hansen J, Mendes AC, Chronakis IS, Hung SC, Mellins ED, Astakhova K.

Bioconjug Chem. 2019 Oct 16;30(10):2584-2593. doi: 10.1021/acs.bioconjchem.9b00518. Epub 2019 Sep 27.

PMID:
31524379
7.

Human Intestinal Enteroids Model MHC-II in the Gut Epithelium.

Wosen JE, Ilstad-Minnihan A, Co JY, Jiang W, Mukhopadhyay D, Fernandez-Becker NQ, Kuo CJ, Amieva MR, Mellins ED.

Front Immunol. 2019 Aug 20;10:1970. doi: 10.3389/fimmu.2019.01970. eCollection 2019.

8.

Systemic Juvenile Idiopathic Arthritis-Associated Lung Disease: Characterization and Risk Factors.

Schulert GS, Yasin S, Carey B, Chalk C, Do T, Schapiro AH, Husami A, Watts A, Brunner HI, Huggins J, Mellins ED, Morgan EM, Ting T, Trapnell BC, Wikenheiser-Brokamp KA, Towe C, Grom AA.

Arthritis Rheumatol. 2019 Nov;71(11):1943-1954. doi: 10.1002/art.41073. Epub 2019 Oct 1.

PMID:
31379071
9.

Severe autoinflammation in 4 patients with C-terminal variants in cell division control protein 42 homolog (CDC42) successfully treated with IL-1β inhibition.

Gernez Y, de Jesus AA, Alsaleem H, Macaubas C, Roy A, Lovell D, Jagadeesh KA, Alehashemi S, Erdman L, Grimley M, Talarico S, Bacchetta R, Lewis DB, Canna SW, Laxer RM, Mellins ED, Goldbach-Mansky R, Weinacht KG.

J Allergy Clin Immunol. 2019 Oct;144(4):1122-1125.e6. doi: 10.1016/j.jaci.2019.06.017. Epub 2019 Jul 2. No abstract available.

PMID:
31271789
10.

Pulse-Chase Analysis for Studies of MHC Class II Biosynthesis, Maturation, and Peptide Loading.

Hou T, Rinderknecht C, Ghosh D, Hadjinicolaou AV, Busch R, Mellins ED.

Methods Mol Biol. 2019;1988:315-341. doi: 10.1007/978-1-4939-9450-2_23.

PMID:
31147950
11.

HLA associations in inflammatory arthritis: emerging mechanisms and clinical implications.

Busch R, Kollnberger S, Mellins ED.

Nat Rev Rheumatol. 2019 Jun;15(6):364-381. doi: 10.1038/s41584-019-0219-5. Review.

PMID:
31092910
12.

Tmem178 negatively regulates store-operated calcium entry in myeloid cells via association with STIM1.

Yang Z, Yan H, Dai W, Jing J, Yang Y, Mahajan S, Zhou Y, Li W, Macaubas C, Mellins ED, Shih CC, Fitzpatrick JAJ, Faccio R.

J Autoimmun. 2019 Jul;101:94-108. doi: 10.1016/j.jaut.2019.04.015. Epub 2019 Apr 22.

PMID:
31018906
13.

Epitope Selection for HLA-DQ2 Presentation: Implications for Celiac Disease and Viral Defense.

Hung SC, Hou T, Jiang W, Wang N, Qiao SW, Chow IT, Liu X, van der Burg SH, Koelle DM, Kwok WW, Sollid LM, Mellins ED.

J Immunol. 2019 May 1;202(9):2558-2569. doi: 10.4049/jimmunol.1801454. Epub 2019 Mar 29.

PMID:
30926644
14.

Plcγ2/Tmem178 dependent pathway in myeloid cells modulates the pathogenesis of cytokine storm syndrome.

Mahajan S, Decker CE, Yang Z, Veis D, Mellins ED, Faccio R.

J Autoimmun. 2019 Jun;100:62-74. doi: 10.1016/j.jaut.2019.02.005. Epub 2019 Mar 15.

PMID:
30879886
15.

US Adult Rheumatologists' Perspective on the Transition Process for Young Adults with Rheumatic Conditions.

Zisman D, Samad A, Ardoin SP, Chira P, White P, Lavi I, von Scheven E, Lawson EF, Hing M, Mellins ED.

Arthritis Care Res (Hoboken). 2019 Feb 11. doi: 10.1002/acr.23845. [Epub ahead of print]

PMID:
30740937
16.

Epithelial MHC Class II Expression and Its Role in Antigen Presentation in the Gastrointestinal and Respiratory Tracts.

Wosen JE, Mukhopadhyay D, Macaubas C, Mellins ED.

Front Immunol. 2018 Sep 25;9:2144. doi: 10.3389/fimmu.2018.02144. eCollection 2018. Review.

17.

Interleukin-1 in monocyte activation phenotypes in systemic juvenile idiopathic arthritis: Observations from a clinical trial of rilonacept, an interleukin-1 inhibitor.

Zhang Y, Gupta S, Ilstad-Minnihan A, Ayyangar S, Hay AD, Pascual V, Ilowite NT, Macaubas C, Mellins ED.

Clin Immunol. 2018 Sep;194:9-18. doi: 10.1016/j.clim.2018.06.005. Epub 2018 Jun 19.

18.

Juvenile Psoriatic Arthritis: A Report from the GRAPPA 2017 Annual Meeting.

Zisman D, Stoll ML, Butbul Aviel Y, Mellins ED.

J Rheumatol Suppl. 2018 Jun;94:11-16. doi: 10.3899/jrheum.180131.

PMID:
29858347
19.

Detection of autoimmune antibodies in localized scleroderma by synthetic oligonucleotide antigens.

Samuelsen S, Jørgensen CD, Mellins ED, Torok KS, Astakhova K.

PLoS One. 2018 Apr 11;13(4):e0195381. doi: 10.1371/journal.pone.0195381. eCollection 2018.

20.

Autoantibody Profiling in Lupus Patients using Synthetic Nucleic Acids.

Klecka M, Thybo C, Macaubas C, Solov'yov I, Simard J, Balboni IM, Fox E, Voss A, Mellins ED, Astakhova K.

Sci Rep. 2018 Apr 3;8(1):5554. doi: 10.1038/s41598-018-23910-5.

21.

IL1RN Variation Influences Both Disease Susceptibility and Response to Recombinant Human Interleukin-1 Receptor Antagonist Therapy in Systemic Juvenile Idiopathic Arthritis.

Arthur VL, Shuldiner E, Remmers EF, Hinks A, Grom AA, Foell D, Martini A, Gattorno M, Özen S, Prahalad S, Zeft AS, Bohnsack JF, Ilowite NT, Mellins ED, Russo R, Len C, Oliveira S, Yeung RSM, Rosenberg AM, Wedderburn LR, Anton J, Haas JP, Rösen-Wolff A, Minden K, Szymanski AM; INCHARGE Consortium, Thomson W, Kastner DL, Woo P, Ombrello MJ.

Arthritis Rheumatol. 2018 Aug;70(8):1319-1330. doi: 10.1002/art.40498. Epub 2018 Jun 28.

22.

Brief Report: The Genetic Profile of Rheumatoid Factor-Positive Polyarticular Juvenile Idiopathic Arthritis Resembles That of Adult Rheumatoid Arthritis.

Hinks A, Marion MC, Cobb J, Comeau ME, Sudman M, Ainsworth HC, Bowes J; Juvenile Idiopathic Arthritis Consortium for Immunochip, Becker ML, Bohnsack JF, Haas JP, Lovell DJ, Mellins ED, Nelson JL, Nordal E, Punaro M, Reed AM, Rose CD, Rosenberg AM, Rygg M, Smith SL, Stevens AM, Videm V, Wallace CA, Wedderburn LR, Yarwood A, Yeung RSM, Langefeld CD, Thompson SD, Thomson W, Prahalad S.

Arthritis Rheumatol. 2018 Jun;70(6):957-962. doi: 10.1002/art.40443. Epub 2018 Apr 21.

23.

Adiposity in Juvenile Psoriatic Arthritis.

Samad A, Stoll ML, Lavi I, Hsu JJ, Strand V, Robinson TN, Mellins ED, Zisman D; CARRA Legacy Registry Investigators.

J Rheumatol. 2018 Mar;45(3):411-418. doi: 10.3899/jrheum.170598. Epub 2017 Dec 15.

PMID:
29247150
24.

The MHC class II antigen presentation pathway in human monocytes differs by subset and is regulated by cytokines.

Lee J, Tam H, Adler L, Ilstad-Minnihan A, Macaubas C, Mellins ED.

PLoS One. 2017 Aug 23;12(8):e0183594. doi: 10.1371/journal.pone.0183594. eCollection 2017.

25.

The Other Function: Class II-Restricted Antigen Presentation by B Cells.

Adler LN, Jiang W, Bhamidipati K, Millican M, Macaubas C, Hung SC, Mellins ED.

Front Immunol. 2017 Mar 23;8:319. doi: 10.3389/fimmu.2017.00319. eCollection 2017. Review.

26.

Paediatric rheumatic diseases: Navigating the transition from paediatric to adult care.

Lawson EF, Mellins ED.

Nat Rev Rheumatol. 2017 Mar;13(3):138-139. doi: 10.1038/nrrheum.2017.16. Epub 2017 Feb 9. No abstract available.

PMID:
28202918
27.

The Juvenile Psoriatic Arthritis Cohort in the CARRA Registry: Clinical Characteristics, Classification, and Outcomes.

Zisman D, Gladman DD, Stoll ML, Strand V, Lavi I, Hsu JJ, Mellins ED; CARRA Legacy Registry Investigators.

J Rheumatol. 2017 Mar;44(3):342-351. doi: 10.3899/jrheum.160717. Epub 2017 Feb 1.

PMID:
28148698
28.

Genetic architecture distinguishes systemic juvenile idiopathic arthritis from other forms of juvenile idiopathic arthritis: clinical and therapeutic implications.

Ombrello MJ, Arthur VL, Remmers EF, Hinks A, Tachmazidou I, Grom AA, Foell D, Martini A, Gattorno M, Özen S, Prahalad S, Zeft AS, Bohnsack JF, Ilowite NT, Mellins ED, Russo R, Len C, Hilario MO, Oliveira S, Yeung RS, Rosenberg AM, Wedderburn LR, Anton J, Haas JP, Rosen-Wolff A, Minden K, Tenbrock K, Demirkaya E, Cobb J, Baskin E, Signa S, Shuldiner E, Duerr RH, Achkar JP, Kamboh MI, Kaufman KM, Kottyan LC, Pinto D, Scherer SW, Alarcón-Riquelme ME, Docampo E, Estivill X, Gül A; British Society of Pediatric and Adolescent Rheumatology (BSPAR) Study Group, Inception Cohort of Newly Diagnosed Patients with Juvenile Idiopathic Arthritis (ICON-JIA) Study Group, Childhood Arthritis Prospective Study (CAPS) Group, Randomized Placebo Phase Study of Rilonacept in sJIA (RAPPORT) Investigators, Sparks-Childhood Arthritis Response to Medication Study (CHARMS) Group, Biologically Based Outcome Predictors in JIA (BBOP) Group, Langefeld CD, Thompson S, Zeggini E, Kastner DL, Woo P, Thomson W.

Ann Rheum Dis. 2017 May;76(5):906-913. doi: 10.1136/annrheumdis-2016-210324. Epub 2016 Dec 7.

29.

The Systemic Juvenile Idiopathic Arthritis Cohort of the Childhood Arthritis and Rheumatology Research Alliance Registry: 2010-2013.

Janow G, Schanberg LE, Setoguchi S, Hasselblad V, Mellins ED, Schneider R, Kimura Y; CARRA Legacy Registry Investigators.

J Rheumatol. 2016 Sep;43(9):1755-62. doi: 10.3899/jrheum.150997. Epub 2016 Jun 15. Erratum in: J Rheumatol. 2016 Aug;43(8):1618.

PMID:
27307527
30.

Novel Phospholipid-Protein Conjugates Allow Improved Detection of Antibodies in Patients with Autoimmune Diseases.

Samuelsen SV, Maity A, Nybo M, Macaubas C, Lønstrup L, Balboni IM, Mellins ED, Astakhova K.

PLoS One. 2016 Jun 3;11(6):e0156125. doi: 10.1371/journal.pone.0156125. eCollection 2016.

31.

Altered signaling in systemic juvenile idiopathic arthritis monocytes.

Macaubas C, Wong E, Zhang Y, Nguyen KD, Lee J, Milojevic D, Shenoi S, Stevens AM, Ilowite N, Saper V, Lee T, Mellins ED.

Clin Immunol. 2016 Feb;163:66-74. doi: 10.1016/j.clim.2015.12.011. Epub 2015 Dec 31.

32.

Tmem178 acts in a novel negative feedback loop targeting NFATc1 to regulate bone mass.

Decker CE, Yang Z, Rimer R, Park-Min KH, Macaubas C, Mellins ED, Novack DV, Faccio R.

Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):15654-9. doi: 10.1073/pnas.1511285112. Epub 2015 Dec 7.

33.

pH-susceptibility of HLA-DO tunes DO/DM ratios to regulate HLA-DM catalytic activity.

Jiang W, Strohman MJ, Somasundaram S, Ayyangar S, Hou T, Wang N, Mellins ED.

Sci Rep. 2015 Nov 27;5:17333. doi: 10.1038/srep17333.

34.

HLA-DRB1*11 and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis.

Ombrello MJ, Remmers EF, Tachmazidou I, Grom A, Foell D, Haas JP, Martini A, Gattorno M, Özen S, Prahalad S, Zeft AS, Bohnsack JF, Mellins ED, Ilowite NT, Russo R, Len C, Hilario MO, Oliveira S, Yeung RS, Rosenberg A, Wedderburn LR, Anton J, Schwarz T, Hinks A, Bilginer Y, Park J, Cobb J, Satorius CL, Han B, Baskin E, Signa S, Duerr RH, Achkar JP, Kamboh MI, Kaufman KM, Kottyan LC, Pinto D, Scherer SW, Alarcón-Riquelme ME, Docampo E, Estivill X, Gül A; British Society of Pediatric and Adolescent Rheumatology (BSPAR) Study Group; Childhood Arthritis Prospective Study (CAPS) Group; Randomized Placebo Phase Study of Rilonacept in sJIA (RAPPORT) Investigators; Sparks-Childhood Arthritis Response to Medication Study (CHARMS) Group; Biologically Based Outcome Predictors in JIA (BBOP) Group, de Bakker PI, Raychaudhuri S, Langefeld CD, Thompson S, Zeggini E, Thomson W, Kastner DL, Woo P; International Childhood Arthritis Genetics (INCHARGE) Consortium.

Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):15970-5. doi: 10.1073/pnas.1520779112. Epub 2015 Nov 23.

35.

Viral Vectors Take On HIV Infection.

Mellins ED, Kay MA.

N Engl J Med. 2015 Aug 20;373(8):770-2. doi: 10.1056/NEJMcibr1504232. No abstract available.

PMID:
26287853
36.

Comparison of biomarkers for systemic juvenile idiopathic arthritis.

Shenoi S, Ou JN, Ni C, Macaubas C, Gersuk VH, Wallace CA, Mellins ED, Stevens AM.

Pediatr Res. 2015 Nov;78(5):554-9. doi: 10.1038/pr.2015.144. Epub 2015 Aug 12.

PMID:
26267155
37.

Immunological Basis for Rapid Progression of Diabetes in Older NOD Mouse Recipients Post BM-HSC Transplantation.

Wang N, Rajasekaran N, Hou T, Macaubas C, Mellins ED.

PLoS One. 2015 May 28;10(5):e0128494. doi: 10.1371/journal.pone.0128494. eCollection 2015.

38.

Optimized purification strategies for the elimination of non-specific products in the isolation of GAD65-specific monoclonal autoantibodies.

Jiang W, Macmillan H, Madec AM, Mellins ED.

Version 2. F1000Res. 2015 May 29 [revised 2016 Jan 1];4:135. doi: 10.12688/f1000research.6467.2. eCollection 2015.

39.

Reduced locomotor activity correlates with increased severity of arthritis in a mouse model of antibody-induced arthritis.

Rajasekaran N, Tran R, Pascual C, Xie X, Mellins ED.

Open J Rheumatol Autoimmune Dis. 2014 Feb 1;4(1):62-68.

40.

Alternative pathways of osteoclastogenesis in inflammatory arthritis.

Adamopoulos IE, Mellins ED.

Nat Rev Rheumatol. 2015 Mar;11(3):189-94. doi: 10.1038/nrrheum.2014.198. Epub 2014 Nov 25. Review.

41.

Assembly and architecture of the EBV B cell entry triggering complex.

Sathiyamoorthy K, Jiang J, Hu YX, Rowe CL, Möhl BS, Chen J, Jiang W, Mellins ED, Longnecker R, Zhou ZH, Jardetzky TS.

PLoS Pathog. 2014 Aug 21;10(8):e1004309. doi: 10.1371/journal.ppat.1004309. eCollection 2014 Aug.

42.

The MHC class II cofactor HLA-DM interacts with Ig in B cells.

Macmillan H, Strohman MJ, Ayyangar S, Jiang W, Rajasekaran N, Spura A, Hessell AJ, Madec AM, Mellins ED.

J Immunol. 2014 Sep 15;193(6):2641-2650. doi: 10.4049/jimmunol.1400075. Epub 2014 Aug 6.

43.

Retraction of the research article: "CD4⁺ T cell autoimmunity to hypocretin/orexin and cross-reactivity to a 2009 H1N1 influenza A epitope in narcolepsy".

De la Herrán-Arita AK, Kornum BR, Mahlios J, Jiang W, Lin L, Hou T, Macaubas C, Einen M, Plazzi G, Crowe C, Newell EW, Davis MM, Mellins ED, Mignot E.

Sci Transl Med. 2014 Jul 30;6(247):247rt1. doi: 10.1126/scitranslmed.3009995. No abstract available.

PMID:
25080479
44.

Susceptibility to HLA-DM protein is determined by a dynamic conformation of major histocompatibility complex class II molecule bound with peptide.

Yin L, Trenh P, Guce A, Wieczorek M, Lange S, Sticht J, Jiang W, Bylsma M, Mellins ED, Freund C, Stern LJ.

J Biol Chem. 2014 Aug 22;289(34):23449-64. doi: 10.1074/jbc.M114.585539. Epub 2014 Jul 7.

45.

Serum amyloid A induces mitogenic signals in regulatory T cells via monocyte activation.

Nguyen KD, Macaubas C, Truong P, Wang N, Hou T, Yoon T, Mellins ED.

Mol Immunol. 2014 Jun;59(2):172-9. doi: 10.1016/j.molimm.2014.02.011. Epub 2014 Mar 13.

46.

HLA-DM and HLA-DO, key regulators of MHC-II processing and presentation.

Mellins ED, Stern LJ.

Curr Opin Immunol. 2014 Feb;26:115-22. doi: 10.1016/j.coi.2013.11.005. Epub 2013 Dec 8. Review.

47.

The IL-23/IL-17 axis in psoriatic arthritis.

Suzuki E, Mellins ED, Gershwin ME, Nestle FO, Adamopoulos IE.

Autoimmun Rev. 2014 Apr-May;13(4-5):496-502. doi: 10.1016/j.autrev.2014.01.050. Epub 2014 Jan 11. Review.

48.

CD4+ T cell autoimmunity to hypocretin/orexin and cross-reactivity to a 2009 H1N1 influenza A epitope in narcolepsy.

De la Herrán-Arita AK, Kornum BR, Mahlios J, Jiang W, Lin L, Hou T, Macaubas C, Einen M, Plazzi G, Crowe C, Newell EW, Davis MM, Mellins ED, Mignot E.

Sci Transl Med. 2013 Dec 18;5(216):216ra176. doi: 10.1126/scitranslmed.3007762. Retraction in: De la Herrán-Arita AK, Kornum BR, Mahlios J, Jiang W, Lin L, Hou T, Macaubas C, Einen M, Plazzi G, Crowe C, Newell EW, Davis MM, Mellins ED, Mignot E. Sci Transl Med. 2014 Jul 30;6(247):247rt1.

PMID:
24353159
49.

Transgene expression in various organs post BM-HSC transplantation.

Wang N, Rajasekaran N, Hou T, Mellins ED.

Stem Cell Res. 2014 Jan;12(1):209-21. doi: 10.1016/j.scr.2013.10.010. Epub 2013 Nov 2.

50.

Comparison of transduction efficiency among various lentiviruses containing GFP reporter in bone marrow hematopoietic stem cell transplantation.

Wang N, Rajasekaran N, Hou T, Lisowski L, Mellins ED.

Exp Hematol. 2013 Nov;41(11):934-43. doi: 10.1016/j.exphem.2013.07.002. Epub 2013 Aug 14.

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