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Items: 1 to 50 of 109

1.

Interleukin-1 in monocyte activation phenotypes in systemic juvenile idiopathic arthritis: Observations from a clinical trial of rilonacept, an interleukin-1 inhibitor.

Zhang Y, Gupta S, Ilstad-Minnihan A, Ayyangar S, Hay AD, Pascual V, Ilowite NT, Macaubas C, Mellins ED.

Clin Immunol. 2018 Sep;194:9-18. doi: 10.1016/j.clim.2018.06.005. Epub 2018 Jun 19.

PMID:
29928998
2.

Juvenile Psoriatic Arthritis: A Report from the GRAPPA 2017 Annual Meeting.

Zisman D, Stoll ML, Butbul Aviel Y, Mellins ED.

J Rheumatol Suppl. 2018 Jun;94:11-16. doi: 10.3899/jrheum.180131.

PMID:
29858347
3.

Detection of autoimmune antibodies in localized scleroderma by synthetic oligonucleotide antigens.

Samuelsen S, Jørgensen CD, Mellins ED, Torok KS, Astakhova K.

PLoS One. 2018 Apr 11;13(4):e0195381. doi: 10.1371/journal.pone.0195381. eCollection 2018.

4.

Autoantibody Profiling in Lupus Patients using Synthetic Nucleic Acids.

Klecka M, Thybo C, Macaubas C, Solov'yov I, Simard J, Balboni IM, Fox E, Voss A, Mellins ED, Astakhova K.

Sci Rep. 2018 Apr 3;8(1):5554. doi: 10.1038/s41598-018-23910-5.

5.

IL1RN Variation Influences Both Disease Susceptibility and Response to Recombinant Human Interleukin-1 Receptor Antagonist Therapy in Systemic Juvenile Idiopathic Arthritis.

Arthur VL, Shuldiner E, Remmers EF, Hinks A, Grom AA, Foell D, Martini A, Gattorno M, Özen S, Prahalad S, Zeft AS, Bohnsack JF, Ilowite NT, Mellins ED, Russo R, Len C, Oliveira S, Yeung RSM, Rosenberg AM, Wedderburn LR, Anton J, Haas JP, Rösen-Wolff A, Minden K, Szymanski AM; INCHARGE Consortium, Thomson W, Kastner DL, Woo P, Ombrello MJ.

Arthritis Rheumatol. 2018 Aug;70(8):1319-1330. doi: 10.1002/art.40498. Epub 2018 Jun 28.

PMID:
29609200
6.

Brief Report: The Genetic Profile of Rheumatoid Factor-Positive Polyarticular Juvenile Idiopathic Arthritis Resembles That of Adult Rheumatoid Arthritis.

Hinks A, Marion MC, Cobb J, Comeau ME, Sudman M, Ainsworth HC, Bowes J; Juvenile Idiopathic Arthritis Consortium for Immunochip, Becker ML, Bohnsack JF, Haas JP, Lovell DJ, Mellins ED, Nelson JL, Nordal E, Punaro M, Reed AM, Rose CD, Rosenberg AM, Rygg M, Smith SL, Stevens AM, Videm V, Wallace CA, Wedderburn LR, Yarwood A, Yeung RSM, Langefeld CD, Thompson SD, Thomson W, Prahalad S.

Arthritis Rheumatol. 2018 Jun;70(6):957-962. doi: 10.1002/art.40443. Epub 2018 Apr 21.

7.

Adiposity in Juvenile Psoriatic Arthritis.

Samad A, Stoll ML, Lavi I, Hsu JJ, Strand V, Robinson TN, Mellins ED, Zisman D; CARRA Legacy Registry Investigators.

J Rheumatol. 2018 Mar;45(3):411-418. doi: 10.3899/jrheum.170598. Epub 2017 Dec 15.

PMID:
29247150
8.

The MHC class II antigen presentation pathway in human monocytes differs by subset and is regulated by cytokines.

Lee J, Tam H, Adler L, Ilstad-Minnihan A, Macaubas C, Mellins ED.

PLoS One. 2017 Aug 23;12(8):e0183594. doi: 10.1371/journal.pone.0183594. eCollection 2017.

9.

The Other Function: Class II-Restricted Antigen Presentation by B Cells.

Adler LN, Jiang W, Bhamidipati K, Millican M, Macaubas C, Hung SC, Mellins ED.

Front Immunol. 2017 Mar 23;8:319. doi: 10.3389/fimmu.2017.00319. eCollection 2017. Review.

10.

Paediatric rheumatic diseases: Navigating the transition from paediatric to adult care.

Lawson EF, Mellins ED.

Nat Rev Rheumatol. 2017 Mar;13(3):138-139. doi: 10.1038/nrrheum.2017.16. Epub 2017 Feb 9. No abstract available.

PMID:
28202918
11.

The Juvenile Psoriatic Arthritis Cohort in the CARRA Registry: Clinical Characteristics, Classification, and Outcomes.

Zisman D, Gladman DD, Stoll ML, Strand V, Lavi I, Hsu JJ, Mellins ED; CARRA Legacy Registry Investigators.

J Rheumatol. 2017 Mar;44(3):342-351. doi: 10.3899/jrheum.160717. Epub 2017 Feb 1.

PMID:
28148698
12.

Genetic architecture distinguishes systemic juvenile idiopathic arthritis from other forms of juvenile idiopathic arthritis: clinical and therapeutic implications.

Ombrello MJ, Arthur VL, Remmers EF, Hinks A, Tachmazidou I, Grom AA, Foell D, Martini A, Gattorno M, Özen S, Prahalad S, Zeft AS, Bohnsack JF, Ilowite NT, Mellins ED, Russo R, Len C, Hilario MO, Oliveira S, Yeung RS, Rosenberg AM, Wedderburn LR, Anton J, Haas JP, Rosen-Wolff A, Minden K, Tenbrock K, Demirkaya E, Cobb J, Baskin E, Signa S, Shuldiner E, Duerr RH, Achkar JP, Kamboh MI, Kaufman KM, Kottyan LC, Pinto D, Scherer SW, Alarcón-Riquelme ME, Docampo E, Estivill X, Gül A; British Society of Pediatric and Adolescent Rheumatology (BSPAR) Study Group, Inception Cohort of Newly Diagnosed Patients with Juvenile Idiopathic Arthritis (ICON-JIA) Study Group, Childhood Arthritis Prospective Study (CAPS) Group, Randomized Placebo Phase Study of Rilonacept in sJIA (RAPPORT) Investigators, Sparks-Childhood Arthritis Response to Medication Study (CHARMS) Group, Biologically Based Outcome Predictors in JIA (BBOP) Group, Langefeld CD, Thompson S, Zeggini E, Kastner DL, Woo P, Thomson W.

Ann Rheum Dis. 2017 May;76(5):906-913. doi: 10.1136/annrheumdis-2016-210324. Epub 2016 Dec 7.

13.

The Systemic Juvenile Idiopathic Arthritis Cohort of the Childhood Arthritis and Rheumatology Research Alliance Registry: 2010-2013.

Janow G, Schanberg LE, Setoguchi S, Hasselblad V, Mellins ED, Schneider R, Kimura Y; CARRA Legacy Registry Investigators.

J Rheumatol. 2016 Sep;43(9):1755-62. doi: 10.3899/jrheum.150997. Epub 2016 Jun 15. Erratum in: J Rheumatol. 2016 Aug;43(8):1618.

PMID:
27307527
14.

Novel Phospholipid-Protein Conjugates Allow Improved Detection of Antibodies in Patients with Autoimmune Diseases.

Samuelsen SV, Maity A, Nybo M, Macaubas C, Lønstrup L, Balboni IM, Mellins ED, Astakhova K.

PLoS One. 2016 Jun 3;11(6):e0156125. doi: 10.1371/journal.pone.0156125. eCollection 2016.

15.

Altered signaling in systemic juvenile idiopathic arthritis monocytes.

Macaubas C, Wong E, Zhang Y, Nguyen KD, Lee J, Milojevic D, Shenoi S, Stevens AM, Ilowite N, Saper V, Lee T, Mellins ED.

Clin Immunol. 2016 Feb;163:66-74. doi: 10.1016/j.clim.2015.12.011. Epub 2015 Dec 31.

16.

Tmem178 acts in a novel negative feedback loop targeting NFATc1 to regulate bone mass.

Decker CE, Yang Z, Rimer R, Park-Min KH, Macaubas C, Mellins ED, Novack DV, Faccio R.

Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):15654-9. doi: 10.1073/pnas.1511285112. Epub 2015 Dec 7.

17.

pH-susceptibility of HLA-DO tunes DO/DM ratios to regulate HLA-DM catalytic activity.

Jiang W, Strohman MJ, Somasundaram S, Ayyangar S, Hou T, Wang N, Mellins ED.

Sci Rep. 2015 Nov 27;5:17333. doi: 10.1038/srep17333.

18.

HLA-DRB1*11 and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis.

Ombrello MJ, Remmers EF, Tachmazidou I, Grom A, Foell D, Haas JP, Martini A, Gattorno M, Özen S, Prahalad S, Zeft AS, Bohnsack JF, Mellins ED, Ilowite NT, Russo R, Len C, Hilario MO, Oliveira S, Yeung RS, Rosenberg A, Wedderburn LR, Anton J, Schwarz T, Hinks A, Bilginer Y, Park J, Cobb J, Satorius CL, Han B, Baskin E, Signa S, Duerr RH, Achkar JP, Kamboh MI, Kaufman KM, Kottyan LC, Pinto D, Scherer SW, Alarcón-Riquelme ME, Docampo E, Estivill X, Gül A; British Society of Pediatric and Adolescent Rheumatology (BSPAR) Study Group; Childhood Arthritis Prospective Study (CAPS) Group; Randomized Placebo Phase Study of Rilonacept in sJIA (RAPPORT) Investigators; Sparks-Childhood Arthritis Response to Medication Study (CHARMS) Group; Biologically Based Outcome Predictors in JIA (BBOP) Group, de Bakker PI, Raychaudhuri S, Langefeld CD, Thompson S, Zeggini E, Thomson W, Kastner DL, Woo P; International Childhood Arthritis Genetics (INCHARGE) Consortium.

Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):15970-5. doi: 10.1073/pnas.1520779112. Epub 2015 Nov 23.

19.

Viral Vectors Take On HIV Infection.

Mellins ED, Kay MA.

N Engl J Med. 2015 Aug 20;373(8):770-2. doi: 10.1056/NEJMcibr1504232. No abstract available.

PMID:
26287853
20.

Comparison of biomarkers for systemic juvenile idiopathic arthritis.

Shenoi S, Ou JN, Ni C, Macaubas C, Gersuk VH, Wallace CA, Mellins ED, Stevens AM.

Pediatr Res. 2015 Nov;78(5):554-9. doi: 10.1038/pr.2015.144. Epub 2015 Aug 12.

PMID:
26267155
21.

Immunological Basis for Rapid Progression of Diabetes in Older NOD Mouse Recipients Post BM-HSC Transplantation.

Wang N, Rajasekaran N, Hou T, Macaubas C, Mellins ED.

PLoS One. 2015 May 28;10(5):e0128494. doi: 10.1371/journal.pone.0128494. eCollection 2015.

22.

Optimized purification strategies for the elimination of non-specific products in the isolation of GAD65-specific monoclonal autoantibodies.

Jiang W, Macmillan H, Madec AM, Mellins ED.

Version 2. F1000Res. 2015 May 29 [revised 2016 Jan 1];4:135. doi: 10.12688/f1000research.6467.2. eCollection 2015.

23.

Reduced locomotor activity correlates with increased severity of arthritis in a mouse model of antibody-induced arthritis.

Rajasekaran N, Tran R, Pascual C, Xie X, Mellins ED.

Open J Rheumatol Autoimmune Dis. 2014 Feb 1;4(1):62-68.

24.

Alternative pathways of osteoclastogenesis in inflammatory arthritis.

Adamopoulos IE, Mellins ED.

Nat Rev Rheumatol. 2015 Mar;11(3):189-94. doi: 10.1038/nrrheum.2014.198. Epub 2014 Nov 25. Review.

25.

Assembly and architecture of the EBV B cell entry triggering complex.

Sathiyamoorthy K, Jiang J, Hu YX, Rowe CL, Möhl BS, Chen J, Jiang W, Mellins ED, Longnecker R, Zhou ZH, Jardetzky TS.

PLoS Pathog. 2014 Aug 21;10(8):e1004309. doi: 10.1371/journal.ppat.1004309. eCollection 2014 Aug.

26.

The MHC class II cofactor HLA-DM interacts with Ig in B cells.

Macmillan H, Strohman MJ, Ayyangar S, Jiang W, Rajasekaran N, Spura A, Hessell AJ, Madec AM, Mellins ED.

J Immunol. 2014 Sep 15;193(6):2641-2650. doi: 10.4049/jimmunol.1400075. Epub 2014 Aug 6.

27.

Retraction of the research article: "CD4⁺ T cell autoimmunity to hypocretin/orexin and cross-reactivity to a 2009 H1N1 influenza A epitope in narcolepsy".

De la Herrán-Arita AK, Kornum BR, Mahlios J, Jiang W, Lin L, Hou T, Macaubas C, Einen M, Plazzi G, Crowe C, Newell EW, Davis MM, Mellins ED, Mignot E.

Sci Transl Med. 2014 Jul 30;6(247):247rt1. doi: 10.1126/scitranslmed.3009995. No abstract available.

PMID:
25080479
28.

Susceptibility to HLA-DM protein is determined by a dynamic conformation of major histocompatibility complex class II molecule bound with peptide.

Yin L, Trenh P, Guce A, Wieczorek M, Lange S, Sticht J, Jiang W, Bylsma M, Mellins ED, Freund C, Stern LJ.

J Biol Chem. 2014 Aug 22;289(34):23449-64. doi: 10.1074/jbc.M114.585539. Epub 2014 Jul 7.

29.

Serum amyloid A induces mitogenic signals in regulatory T cells via monocyte activation.

Nguyen KD, Macaubas C, Truong P, Wang N, Hou T, Yoon T, Mellins ED.

Mol Immunol. 2014 Jun;59(2):172-9. doi: 10.1016/j.molimm.2014.02.011. Epub 2014 Mar 13.

30.

HLA-DM and HLA-DO, key regulators of MHC-II processing and presentation.

Mellins ED, Stern LJ.

Curr Opin Immunol. 2014 Feb;26:115-22. doi: 10.1016/j.coi.2013.11.005. Epub 2013 Dec 8. Review.

31.

The IL-23/IL-17 axis in psoriatic arthritis.

Suzuki E, Mellins ED, Gershwin ME, Nestle FO, Adamopoulos IE.

Autoimmun Rev. 2014 Apr-May;13(4-5):496-502. doi: 10.1016/j.autrev.2014.01.050. Epub 2014 Jan 11. Review.

32.

CD4+ T cell autoimmunity to hypocretin/orexin and cross-reactivity to a 2009 H1N1 influenza A epitope in narcolepsy.

De la Herrán-Arita AK, Kornum BR, Mahlios J, Jiang W, Lin L, Hou T, Macaubas C, Einen M, Plazzi G, Crowe C, Newell EW, Davis MM, Mellins ED, Mignot E.

Sci Transl Med. 2013 Dec 18;5(216):216ra176. doi: 10.1126/scitranslmed.3007762. Retraction in: De la Herrán-Arita AK, Kornum BR, Mahlios J, Jiang W, Lin L, Hou T, Macaubas C, Einen M, Plazzi G, Crowe C, Newell EW, Davis MM, Mellins ED, Mignot E. Sci Transl Med. 2014 Jul 30;6(247):247rt1.

PMID:
24353159
33.

Transgene expression in various organs post BM-HSC transplantation.

Wang N, Rajasekaran N, Hou T, Mellins ED.

Stem Cell Res. 2014 Jan;12(1):209-21. doi: 10.1016/j.scr.2013.10.010. Epub 2013 Nov 2.

34.

Comparison of transduction efficiency among various lentiviruses containing GFP reporter in bone marrow hematopoietic stem cell transplantation.

Wang N, Rajasekaran N, Hou T, Lisowski L, Mellins ED.

Exp Hematol. 2013 Nov;41(11):934-43. doi: 10.1016/j.exphem.2013.07.002. Epub 2013 Aug 14.

35.

B6.g7 mice reconstituted with BDC2·5 non-obese diabetic (BDC2·5NOD) stem cells do not develop autoimmune diabetes.

Rajasekaran N, Wang N, Hang Y, Macaubas C, Rinderknecht C, Beilhack GF, Shizuru JA, Mellins ED.

Clin Exp Immunol. 2013 Oct;174(1):27-37. doi: 10.1111/cei.12163.

36.

Susceptibility to childhood-onset rheumatoid arthritis: investigation of a weighted genetic risk score that integrates cumulative effects of variants at five genetic loci.

Prahalad S, Conneely KN, Jiang Y, Sudman M, Wallace CA, Brown MR, Ponder LA, Rohani-Pichavant M, Zwick ME, Cutler DJ, Angeles-Han ST, Vogler LB, Kennedy C, Rouster-Stevens K, Wise CA, Punaro M, Reed AM, Mellins ED, Bohnsack JF, Glass DN, Thompson SD.

Arthritis Rheum. 2013 Jun;65(6):1663-7. doi: 10.1002/art.37913.

37.

A new era in the treatment of systemic juvenile idiopathic arthritis.

Sandborg C, Mellins ED.

N Engl J Med. 2012 Dec 20;367(25):2439-40. doi: 10.1056/NEJMe1212640. No abstract available.

PMID:
23252530
38.

Host-derived CD4+ T cells attenuate stem cell-mediated transfer of autoimmune arthritis in lethally irradiated C57BL/6.g7 mice.

Rajasekaran N, Wang N, Truong P, Rinderknecht C, Macaubas C, Beilhack GF, Shizuru JA, Mellins ED.

Arthritis Rheum. 2013 Mar;65(3):681-92. doi: 10.1002/art.37800.

39.

HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism.

Guce AI, Mortimer SE, Yoon T, Painter CA, Jiang W, Mellins ED, Stern LJ.

Nat Struct Mol Biol. 2013 Jan;20(1):90-8. doi: 10.1038/nsmb.2460. Epub 2012 Dec 9.

40.

Correlation analyses of clinical and molecular findings identify candidate biological pathways in systemic juvenile idiopathic arthritis.

Ling XB, Macaubas C, Alexander HC, Wen Q, Chen E, Peng S, Sun Y, Deshpande C, Pan KH, Lin R, Lih CJ, Chang SY, Lee T, Sandborg C, Begovich AB, Cohen SN, Mellins ED.

BMC Med. 2012 Oct 23;10:125. doi: 10.1186/1741-7015-10-125.

41.

Self-antigen recognition by follicular lymphoma B-cell receptors.

Sachen KL, Strohman MJ, Singletary J, Alizadeh AA, Kattah NH, Lossos C, Mellins ED, Levy S, Levy R.

Blood. 2012 Nov 15;120(20):4182-90. doi: 10.1182/blood-2012-05-427534. Epub 2012 Sep 28.

42.

On the perils of poor editing: regulation of peptide loading by HLA-DQ and H2-A molecules associated with celiac disease and type 1 diabetes.

Busch R, De Riva A, Hadjinicolaou AV, Jiang W, Hou T, Mellins ED.

Expert Rev Mol Med. 2012 Jul 6;14:e15. doi: 10.1017/erm.2012.9. Review.

43.

Mapping the HLA-DO/HLA-DM complex by FRET and mutagenesis.

Yoon T, Macmillan H, Mortimer SE, Jiang W, Rinderknecht CH, Stern LJ, Mellins ED.

Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11276-81. doi: 10.1073/pnas.1113966109. Epub 2012 Jun 25.

44.

Alternative activation in systemic juvenile idiopathic arthritis monocytes.

Macaubas C, Nguyen KD, Peck A, Buckingham J, Deshpande C, Wong E, Alexander HC, Chang SY, Begovich A, Sun Y, Park JL, Pan KH, Lin R, Lih CJ, Augustine EM, Phillips C, Hadjinicolaou AV, Lee T, Mellins ED.

Clin Immunol. 2012 Mar;142(3):362-72. doi: 10.1016/j.clim.2011.12.008. Epub 2011 Dec 28.

45.

Hierarchy of risk of childhood-onset rheumatoid arthritis conferred by HLA-DRB1 alleles encoding the shared epitope.

Prahalad S, Thompson SD, Conneely KN, Jiang Y, Leong T, Prozonic J, Brown MR, Ponder LA, Angeles-Han ST, Vogler LB, Kennedy C, Wallace CA, Wise CA, Punaro M, Reed A, Park JL, Mellins ED, Zeft AS, Bohnsack JF, Glass DN.

Arthritis Rheum. 2012 Mar;64(3):925-30. doi: 10.1002/art.33376.

46.

An insertion mutant in DQA1*0501 restores susceptibility to HLA-DM: implications for disease associations.

Hou T, Macmillan H, Chen Z, Keech CL, Jin X, Sidney J, Strohman M, Yoon T, Mellins ED.

J Immunol. 2011 Sep 1;187(5):2442-52. doi: 10.4049/jimmunol.1100255. Epub 2011 Jul 20.

47.

Pathogenesis of systemic juvenile idiopathic arthritis: some answers, more questions.

Mellins ED, Macaubas C, Grom AA.

Nat Rev Rheumatol. 2011 Jun 7;7(7):416-26. doi: 10.1038/nrrheum.2011.68. Review.

48.

Human cytomegalovirus decreases constitutive transcription of MHC class II genes in mature Langerhans cells by reducing CIITA transcript levels.

Lee AW, Wang N, Hornell TM, Harding JJ, Deshpande C, Hertel L, Lacaille V, Pashine A, Macaubas C, Mocarski ES, Mellins ED.

Mol Immunol. 2011 May;48(9-10):1160-7. doi: 10.1016/j.molimm.2011.02.010. Epub 2011 Mar 31.

49.

Chaperone activity of α B-crystallin is responsible for its incorrect assignment as an autoantigen in multiple sclerosis.

Rothbard JB, Zhao X, Sharpe O, Strohman MJ, Kurnellas M, Mellins ED, Robinson WH, Steinman L.

J Immunol. 2011 Apr 1;186(7):4263-8. doi: 10.4049/jimmunol.1003934. Epub 2011 Feb 25.

50.

Serum amyloid A overrides Treg anergy via monocyte-dependent and Treg-intrinsic, SOCS3-associated pathways.

Nguyen KD, Macaubas C, Nadeau KC, Truong P, Yoon T, Lee T, Park JL, Mellins ED.

Blood. 2011 Apr 7;117(14):3793-8. doi: 10.1182/blood-2010-11-318832. Epub 2011 Feb 16.

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