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Items: 1 to 50 of 143

1.

Pulse-Chase Analysis for Studies of MHC Class II Biosynthesis, Maturation, and Peptide Loading.

Hou T, Rinderknecht C, Ghosh D, Hadjinicolaou AV, Busch R, Mellins ED.

Methods Mol Biol. 2019;1988:315-341. doi: 10.1007/978-1-4939-9450-2_23.

PMID:
31147950
2.

HLA associations in inflammatory arthritis: emerging mechanisms and clinical implications.

Busch R, Kollnberger S, Mellins ED.

Nat Rev Rheumatol. 2019 Jun;15(6):364-381. doi: 10.1038/s41584-019-0219-5. Review.

PMID:
31092910
3.

Tmem178 negatively regulates store-operated calcium entry in myeloid cells via association with STIM1.

Yang Z, Yan H, Dai W, Jing J, Yang Y, Mahajan S, Zhou Y, Li W, Macaubas C, Mellins ED, Shih CC, Fitzpatrick JAJ, Faccio R.

J Autoimmun. 2019 Jul;101:94-108. doi: 10.1016/j.jaut.2019.04.015. Epub 2019 Apr 22.

PMID:
31018906
4.

Epitope Selection for HLA-DQ2 Presentation: Implications for Celiac Disease and Viral Defense.

Hung SC, Hou T, Jiang W, Wang N, Qiao SW, Chow IT, Liu X, van der Burg SH, Koelle DM, Kwok WW, Sollid LM, Mellins ED.

J Immunol. 2019 May 1;202(9):2558-2569. doi: 10.4049/jimmunol.1801454. Epub 2019 Mar 29.

PMID:
30926644
5.

Plcγ2/Tmem178 dependent pathway in myeloid cells modulates the pathogenesis of cytokine storm syndrome.

Mahajan S, Decker CE, Yang Z, Veis D, Mellins ED, Faccio R.

J Autoimmun. 2019 Jun;100:62-74. doi: 10.1016/j.jaut.2019.02.005. Epub 2019 Mar 15.

PMID:
30879886
6.

US Adult Rheumatologists' Perspective on the Transition Process for Young Adults with Rheumatic Conditions.

Zisman D, Samad A, Ardoin SP, Chira P, White P, Lavi I, von Scheven E, Lawson EF, Hing M, Mellins ED.

Arthritis Care Res (Hoboken). 2019 Feb 11. doi: 10.1002/acr.23845. [Epub ahead of print]

PMID:
30740937
7.

Epithelial MHC Class II Expression and Its Role in Antigen Presentation in the Gastrointestinal and Respiratory Tracts.

Wosen JE, Mukhopadhyay D, Macaubas C, Mellins ED.

Front Immunol. 2018 Sep 25;9:2144. doi: 10.3389/fimmu.2018.02144. eCollection 2018. Review.

8.

Interleukin-1 in monocyte activation phenotypes in systemic juvenile idiopathic arthritis: Observations from a clinical trial of rilonacept, an interleukin-1 inhibitor.

Zhang Y, Gupta S, Ilstad-Minnihan A, Ayyangar S, Hay AD, Pascual V, Ilowite NT, Macaubas C, Mellins ED.

Clin Immunol. 2018 Sep;194:9-18. doi: 10.1016/j.clim.2018.06.005. Epub 2018 Jun 19.

PMID:
29928998
9.

Juvenile Psoriatic Arthritis: A Report from the GRAPPA 2017 Annual Meeting.

Zisman D, Stoll ML, Butbul Aviel Y, Mellins ED.

J Rheumatol Suppl. 2018 Jun;94:11-16. doi: 10.3899/jrheum.180131.

PMID:
29858347
10.

Detection of autoimmune antibodies in localized scleroderma by synthetic oligonucleotide antigens.

Samuelsen S, Jørgensen CD, Mellins ED, Torok KS, Astakhova K.

PLoS One. 2018 Apr 11;13(4):e0195381. doi: 10.1371/journal.pone.0195381. eCollection 2018.

11.

Autoantibody Profiling in Lupus Patients using Synthetic Nucleic Acids.

Klecka M, Thybo C, Macaubas C, Solov'yov I, Simard J, Balboni IM, Fox E, Voss A, Mellins ED, Astakhova K.

Sci Rep. 2018 Apr 3;8(1):5554. doi: 10.1038/s41598-018-23910-5.

12.

IL1RN Variation Influences Both Disease Susceptibility and Response to Recombinant Human Interleukin-1 Receptor Antagonist Therapy in Systemic Juvenile Idiopathic Arthritis.

Arthur VL, Shuldiner E, Remmers EF, Hinks A, Grom AA, Foell D, Martini A, Gattorno M, Özen S, Prahalad S, Zeft AS, Bohnsack JF, Ilowite NT, Mellins ED, Russo R, Len C, Oliveira S, Yeung RSM, Rosenberg AM, Wedderburn LR, Anton J, Haas JP, Rösen-Wolff A, Minden K, Szymanski AM; INCHARGE Consortium, Thomson W, Kastner DL, Woo P, Ombrello MJ.

Arthritis Rheumatol. 2018 Aug;70(8):1319-1330. doi: 10.1002/art.40498. Epub 2018 Jun 28.

PMID:
29609200
13.

Brief Report: The Genetic Profile of Rheumatoid Factor-Positive Polyarticular Juvenile Idiopathic Arthritis Resembles That of Adult Rheumatoid Arthritis.

Hinks A, Marion MC, Cobb J, Comeau ME, Sudman M, Ainsworth HC, Bowes J; Juvenile Idiopathic Arthritis Consortium for Immunochip, Becker ML, Bohnsack JF, Haas JP, Lovell DJ, Mellins ED, Nelson JL, Nordal E, Punaro M, Reed AM, Rose CD, Rosenberg AM, Rygg M, Smith SL, Stevens AM, Videm V, Wallace CA, Wedderburn LR, Yarwood A, Yeung RSM, Langefeld CD, Thompson SD, Thomson W, Prahalad S.

Arthritis Rheumatol. 2018 Jun;70(6):957-962. doi: 10.1002/art.40443. Epub 2018 Apr 21.

14.

Adiposity in Juvenile Psoriatic Arthritis.

Samad A, Stoll ML, Lavi I, Hsu JJ, Strand V, Robinson TN, Mellins ED, Zisman D; CARRA Legacy Registry Investigators.

J Rheumatol. 2018 Mar;45(3):411-418. doi: 10.3899/jrheum.170598. Epub 2017 Dec 15.

PMID:
29247150
15.

The MHC class II antigen presentation pathway in human monocytes differs by subset and is regulated by cytokines.

Lee J, Tam H, Adler L, Ilstad-Minnihan A, Macaubas C, Mellins ED.

PLoS One. 2017 Aug 23;12(8):e0183594. doi: 10.1371/journal.pone.0183594. eCollection 2017.

16.

New frontiers in the treatment of systemic juvenile idiopathic arthritis.

Canny S, Mellins E.

F1000Res. 2017 Jun 22;6:971. doi: 10.12688/f1000research.11327.1. eCollection 2017. Review.

17.

The Other Function: Class II-Restricted Antigen Presentation by B Cells.

Adler LN, Jiang W, Bhamidipati K, Millican M, Macaubas C, Hung SC, Mellins ED.

Front Immunol. 2017 Mar 23;8:319. doi: 10.3389/fimmu.2017.00319. eCollection 2017. Review.

18.

Paediatric rheumatic diseases: Navigating the transition from paediatric to adult care.

Lawson EF, Mellins ED.

Nat Rev Rheumatol. 2017 Mar;13(3):138-139. doi: 10.1038/nrrheum.2017.16. Epub 2017 Feb 9. No abstract available.

PMID:
28202918
19.

The Juvenile Psoriatic Arthritis Cohort in the CARRA Registry: Clinical Characteristics, Classification, and Outcomes.

Zisman D, Gladman DD, Stoll ML, Strand V, Lavi I, Hsu JJ, Mellins ED; CARRA Legacy Registry Investigators.

J Rheumatol. 2017 Mar;44(3):342-351. doi: 10.3899/jrheum.160717. Epub 2017 Feb 1.

PMID:
28148698
20.

Genetic architecture distinguishes systemic juvenile idiopathic arthritis from other forms of juvenile idiopathic arthritis: clinical and therapeutic implications.

Ombrello MJ, Arthur VL, Remmers EF, Hinks A, Tachmazidou I, Grom AA, Foell D, Martini A, Gattorno M, Özen S, Prahalad S, Zeft AS, Bohnsack JF, Ilowite NT, Mellins ED, Russo R, Len C, Hilario MO, Oliveira S, Yeung RS, Rosenberg AM, Wedderburn LR, Anton J, Haas JP, Rosen-Wolff A, Minden K, Tenbrock K, Demirkaya E, Cobb J, Baskin E, Signa S, Shuldiner E, Duerr RH, Achkar JP, Kamboh MI, Kaufman KM, Kottyan LC, Pinto D, Scherer SW, Alarcón-Riquelme ME, Docampo E, Estivill X, Gül A; British Society of Pediatric and Adolescent Rheumatology (BSPAR) Study Group, Inception Cohort of Newly Diagnosed Patients with Juvenile Idiopathic Arthritis (ICON-JIA) Study Group, Childhood Arthritis Prospective Study (CAPS) Group, Randomized Placebo Phase Study of Rilonacept in sJIA (RAPPORT) Investigators, Sparks-Childhood Arthritis Response to Medication Study (CHARMS) Group, Biologically Based Outcome Predictors in JIA (BBOP) Group, Langefeld CD, Thompson S, Zeggini E, Kastner DL, Woo P, Thomson W.

Ann Rheum Dis. 2017 May;76(5):906-913. doi: 10.1136/annrheumdis-2016-210324. Epub 2016 Dec 7.

21.

Synthetic oligonucleotide antigens modified with locked nucleic acids detect disease specific antibodies.

Samuelsen SV, Solov'yov IA, Balboni IM, Mellins E, Nielsen CT, Heegaard NH, Astakhova K.

Sci Rep. 2016 Oct 24;6:35827. doi: 10.1038/srep35827.

22.

Enhancing translational research in paediatric rheumatology through standardization.

Yeung RS, Albani S, Feldman BM, Mellins E, Prakken B, Wedderburn LR.

Nat Rev Rheumatol. 2016 Nov;12(11):684-690. doi: 10.1038/nrrheum.2016.156. Epub 2016 Sep 22. Review.

PMID:
27652504
23.

The Systemic Juvenile Idiopathic Arthritis Cohort of the Childhood Arthritis and Rheumatology Research Alliance Registry: 2010-2013.

Janow G, Schanberg LE, Setoguchi S, Hasselblad V, Mellins ED, Schneider R, Kimura Y; CARRA Legacy Registry Investigators.

J Rheumatol. 2016 Sep;43(9):1755-62. doi: 10.3899/jrheum.150997. Epub 2016 Jun 15. Erratum in: J Rheumatol. 2016 Aug;43(8):1618.

PMID:
27307527
24.

Novel Phospholipid-Protein Conjugates Allow Improved Detection of Antibodies in Patients with Autoimmune Diseases.

Samuelsen SV, Maity A, Nybo M, Macaubas C, Lønstrup L, Balboni IM, Mellins ED, Astakhova K.

PLoS One. 2016 Jun 3;11(6):e0156125. doi: 10.1371/journal.pone.0156125. eCollection 2016.

25.

Altered signaling in systemic juvenile idiopathic arthritis monocytes.

Macaubas C, Wong E, Zhang Y, Nguyen KD, Lee J, Milojevic D, Shenoi S, Stevens AM, Ilowite N, Saper V, Lee T, Mellins ED.

Clin Immunol. 2016 Feb;163:66-74. doi: 10.1016/j.clim.2015.12.011. Epub 2015 Dec 31.

26.

Tmem178 acts in a novel negative feedback loop targeting NFATc1 to regulate bone mass.

Decker CE, Yang Z, Rimer R, Park-Min KH, Macaubas C, Mellins ED, Novack DV, Faccio R.

Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):15654-9. doi: 10.1073/pnas.1511285112. Epub 2015 Dec 7.

27.

pH-susceptibility of HLA-DO tunes DO/DM ratios to regulate HLA-DM catalytic activity.

Jiang W, Strohman MJ, Somasundaram S, Ayyangar S, Hou T, Wang N, Mellins ED.

Sci Rep. 2015 Nov 27;5:17333. doi: 10.1038/srep17333.

28.

HLA-DRB1*11 and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis.

Ombrello MJ, Remmers EF, Tachmazidou I, Grom A, Foell D, Haas JP, Martini A, Gattorno M, Özen S, Prahalad S, Zeft AS, Bohnsack JF, Mellins ED, Ilowite NT, Russo R, Len C, Hilario MO, Oliveira S, Yeung RS, Rosenberg A, Wedderburn LR, Anton J, Schwarz T, Hinks A, Bilginer Y, Park J, Cobb J, Satorius CL, Han B, Baskin E, Signa S, Duerr RH, Achkar JP, Kamboh MI, Kaufman KM, Kottyan LC, Pinto D, Scherer SW, Alarcón-Riquelme ME, Docampo E, Estivill X, Gül A; British Society of Pediatric and Adolescent Rheumatology (BSPAR) Study Group; Childhood Arthritis Prospective Study (CAPS) Group; Randomized Placebo Phase Study of Rilonacept in sJIA (RAPPORT) Investigators; Sparks-Childhood Arthritis Response to Medication Study (CHARMS) Group; Biologically Based Outcome Predictors in JIA (BBOP) Group, de Bakker PI, Raychaudhuri S, Langefeld CD, Thompson S, Zeggini E, Thomson W, Kastner DL, Woo P; International Childhood Arthritis Genetics (INCHARGE) Consortium.

Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):15970-5. doi: 10.1073/pnas.1520779112. Epub 2015 Nov 23.

29.

Viral Vectors Take On HIV Infection.

Mellins ED, Kay MA.

N Engl J Med. 2015 Aug 20;373(8):770-2. doi: 10.1056/NEJMcibr1504232. No abstract available.

PMID:
26287853
30.

Comparison of biomarkers for systemic juvenile idiopathic arthritis.

Shenoi S, Ou JN, Ni C, Macaubas C, Gersuk VH, Wallace CA, Mellins ED, Stevens AM.

Pediatr Res. 2015 Nov;78(5):554-9. doi: 10.1038/pr.2015.144. Epub 2015 Aug 12.

PMID:
26267155
31.

Synthesis of Phospholipid-Protein Conjugates as New Antigens for Autoimmune Antibodies.

Maity A, Macaubas C, Mellins E, Astakhova K.

Molecules. 2015 Jun 3;20(6):10253-63. doi: 10.3390/molecules200610253.

32.

Immunological Basis for Rapid Progression of Diabetes in Older NOD Mouse Recipients Post BM-HSC Transplantation.

Wang N, Rajasekaran N, Hou T, Macaubas C, Mellins ED.

PLoS One. 2015 May 28;10(5):e0128494. doi: 10.1371/journal.pone.0128494. eCollection 2015.

33.

Optimized purification strategies for the elimination of non-specific products in the isolation of GAD65-specific monoclonal autoantibodies.

Jiang W, Macmillan H, Madec AM, Mellins ED.

Version 2. F1000Res. 2015 May 29 [revised 2016 Jan 1];4:135. doi: 10.12688/f1000research.6467.2. eCollection 2015.

34.

Reduced locomotor activity correlates with increased severity of arthritis in a mouse model of antibody-induced arthritis.

Rajasekaran N, Tran R, Pascual C, Xie X, Mellins ED.

Open J Rheumatol Autoimmune Dis. 2014 Feb 1;4(1):62-68.

35.

Alternative pathways of osteoclastogenesis in inflammatory arthritis.

Adamopoulos IE, Mellins ED.

Nat Rev Rheumatol. 2015 Mar;11(3):189-94. doi: 10.1038/nrrheum.2014.198. Epub 2014 Nov 25. Review.

36.

Assembly and architecture of the EBV B cell entry triggering complex.

Sathiyamoorthy K, Jiang J, Hu YX, Rowe CL, Möhl BS, Chen J, Jiang W, Mellins ED, Longnecker R, Zhou ZH, Jardetzky TS.

PLoS Pathog. 2014 Aug 21;10(8):e1004309. doi: 10.1371/journal.ppat.1004309. eCollection 2014 Aug.

37.

The MHC class II cofactor HLA-DM interacts with Ig in B cells.

Macmillan H, Strohman MJ, Ayyangar S, Jiang W, Rajasekaran N, Spura A, Hessell AJ, Madec AM, Mellins ED.

J Immunol. 2014 Sep 15;193(6):2641-2650. doi: 10.4049/jimmunol.1400075. Epub 2014 Aug 6.

38.

Retraction of the research article: "CD4⁺ T cell autoimmunity to hypocretin/orexin and cross-reactivity to a 2009 H1N1 influenza A epitope in narcolepsy".

De la Herrán-Arita AK, Kornum BR, Mahlios J, Jiang W, Lin L, Hou T, Macaubas C, Einen M, Plazzi G, Crowe C, Newell EW, Davis MM, Mellins ED, Mignot E.

Sci Transl Med. 2014 Jul 30;6(247):247rt1. doi: 10.1126/scitranslmed.3009995. No abstract available.

PMID:
25080479
39.

Susceptibility to HLA-DM protein is determined by a dynamic conformation of major histocompatibility complex class II molecule bound with peptide.

Yin L, Trenh P, Guce A, Wieczorek M, Lange S, Sticht J, Jiang W, Bylsma M, Mellins ED, Freund C, Stern LJ.

J Biol Chem. 2014 Aug 22;289(34):23449-64. doi: 10.1074/jbc.M114.585539. Epub 2014 Jul 7.

40.

Serum amyloid A induces mitogenic signals in regulatory T cells via monocyte activation.

Nguyen KD, Macaubas C, Truong P, Wang N, Hou T, Yoon T, Mellins ED.

Mol Immunol. 2014 Jun;59(2):172-9. doi: 10.1016/j.molimm.2014.02.011. Epub 2014 Mar 13.

41.

HLA-DM and HLA-DO, key regulators of MHC-II processing and presentation.

Mellins ED, Stern LJ.

Curr Opin Immunol. 2014 Feb;26:115-22. doi: 10.1016/j.coi.2013.11.005. Epub 2013 Dec 8. Review.

42.

The IL-23/IL-17 axis in psoriatic arthritis.

Suzuki E, Mellins ED, Gershwin ME, Nestle FO, Adamopoulos IE.

Autoimmun Rev. 2014 Apr-May;13(4-5):496-502. doi: 10.1016/j.autrev.2014.01.050. Epub 2014 Jan 11. Review.

43.

CD4+ T cell autoimmunity to hypocretin/orexin and cross-reactivity to a 2009 H1N1 influenza A epitope in narcolepsy.

De la Herrán-Arita AK, Kornum BR, Mahlios J, Jiang W, Lin L, Hou T, Macaubas C, Einen M, Plazzi G, Crowe C, Newell EW, Davis MM, Mellins ED, Mignot E.

Sci Transl Med. 2013 Dec 18;5(216):216ra176. doi: 10.1126/scitranslmed.3007762. Retraction in: De la Herrán-Arita AK, Kornum BR, Mahlios J, Jiang W, Lin L, Hou T, Macaubas C, Einen M, Plazzi G, Crowe C, Newell EW, Davis MM, Mellins ED, Mignot E. Sci Transl Med. 2014 Jul 30;6(247):247rt1.

PMID:
24353159
44.

Transgene expression in various organs post BM-HSC transplantation.

Wang N, Rajasekaran N, Hou T, Mellins ED.

Stem Cell Res. 2014 Jan;12(1):209-21. doi: 10.1016/j.scr.2013.10.010. Epub 2013 Nov 2.

45.

Comparison of transduction efficiency among various lentiviruses containing GFP reporter in bone marrow hematopoietic stem cell transplantation.

Wang N, Rajasekaran N, Hou T, Lisowski L, Mellins ED.

Exp Hematol. 2013 Nov;41(11):934-43. doi: 10.1016/j.exphem.2013.07.002. Epub 2013 Aug 14.

46.

B6.g7 mice reconstituted with BDC2·5 non-obese diabetic (BDC2·5NOD) stem cells do not develop autoimmune diabetes.

Rajasekaran N, Wang N, Hang Y, Macaubas C, Rinderknecht C, Beilhack GF, Shizuru JA, Mellins ED.

Clin Exp Immunol. 2013 Oct;174(1):27-37. doi: 10.1111/cei.12163.

47.

Susceptibility to childhood-onset rheumatoid arthritis: investigation of a weighted genetic risk score that integrates cumulative effects of variants at five genetic loci.

Prahalad S, Conneely KN, Jiang Y, Sudman M, Wallace CA, Brown MR, Ponder LA, Rohani-Pichavant M, Zwick ME, Cutler DJ, Angeles-Han ST, Vogler LB, Kennedy C, Rouster-Stevens K, Wise CA, Punaro M, Reed AM, Mellins ED, Bohnsack JF, Glass DN, Thompson SD.

Arthritis Rheum. 2013 Jun;65(6):1663-7. doi: 10.1002/art.37913.

48.

Pulse-chase analysis for studies of MHC class II biosynthesis, maturation, and peptide loading.

Hou T, Rinderknecht CH, Hadjinicolaou AV, Busch R, Mellins E.

Methods Mol Biol. 2013;960:411-432. doi: 10.1007/978-1-62703-218-6_31.

49.

A new era in the treatment of systemic juvenile idiopathic arthritis.

Sandborg C, Mellins ED.

N Engl J Med. 2012 Dec 20;367(25):2439-40. doi: 10.1056/NEJMe1212640. No abstract available.

PMID:
23252530
50.

Host-derived CD4+ T cells attenuate stem cell-mediated transfer of autoimmune arthritis in lethally irradiated C57BL/6.g7 mice.

Rajasekaran N, Wang N, Truong P, Rinderknecht C, Macaubas C, Beilhack GF, Shizuru JA, Mellins ED.

Arthritis Rheum. 2013 Mar;65(3):681-92. doi: 10.1002/art.37800.

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