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Increased Immune Activation by Pathologic α-Synuclein in Parkinson's Disease.

Grozdanov V, Bousset L, Hoffmeister M, Bliederhaeuser C, Meier C, Madiona K, Pieri L, Kiechle M, McLean PJ, Kassubek J, Behrends C, Ludolph AC, Weishaupt JH, Melki R, Danzer KM.

Ann Neurol. 2019 Jul 25. doi: 10.1002/ana.25557. [Epub ahead of print]


α-synuclein oligomers and fibrils: a spectrum of species, a spectrum of toxicities.

Alam P, Bousset L, Melki R, Otzen DE.

J Neurochem. 2019 Jun 29. doi: 10.1111/jnc.14808. [Epub ahead of print] Review.


Growth phase-dependent changes in the size and infectivity of SDS-resistant Sup35p assemblies associated with the [PSI+ ] prion in yeast.

Wang K, Melki R, Kabani M.

Mol Microbiol. 2019 Jun 17. doi: 10.1111/mmi.14329. [Epub ahead of print]


The N terminus of the small heat shock protein HSPB7 drives its polyQ aggregation-suppressing activity.

Wu D, Vonk JJ, Salles F, Vonk D, Haslbeck M, Melki R, Bergink S, Kampinga HH.

J Biol Chem. 2019 Jun 21;294(25):9985-9994. doi: 10.1074/jbc.RA118.007117. Epub 2019 May 16.


Detection of alpha-synuclein aggregates in gastrointestinal biopsies by protein misfolding cyclic amplification.

Fenyi A, Leclair-Visonneau L, Clairembault T, Coron E, Neunlist M, Melki R, Derkinderen P, Bousset L.

Neurobiol Dis. 2019 Sep;129:38-43. doi: 10.1016/j.nbd.2019.05.002. Epub 2019 May 9.


Mesenchymal Stromal Cell-Based Therapy: New Perspectives and Challenges.

Najar M, Bouhtit F, Melki R, Afif H, Hamal A, Fahmi H, Merimi M, Lagneaux L.

J Clin Med. 2019 May 8;8(5). pii: E626. doi: 10.3390/jcm8050626.


Effect of tolytoxin on tunneling nanotube formation and function.

Dilsizoglu Senol A, Pepe A, Grudina C, Sassoon N, Reiko U, Bousset L, Melki R, Piel J, Gugger M, Zurzolo C.

Sci Rep. 2019 Apr 5;9(1):5741. doi: 10.1038/s41598-019-42161-6.


LRRK2 modifies α-syn pathology and spread in mouse models and human neurons.

Bieri G, Brahic M, Bousset L, Couthouis J, Kramer NJ, Ma R, Nakayama L, Monbureau M, Defensor E, Schüle B, Shamloo M, Melki R, Gitler AD.

Acta Neuropathol. 2019 Jun;137(6):961-980. doi: 10.1007/s00401-019-01995-0. Epub 2019 Mar 29.


Demonstration of prion-like properties of mutant huntingtin fibrils in both in vitro and in vivo paradigms.

Masnata M, Sciacca G, Maxan A, Bousset L, Denis HL, Lauruol F, David L, Saint-Pierre M, Kordower JH, Melki R, Alpaugh M, Cicchetti F.

Acta Neuropathol. 2019 Jun;137(6):981-1001. doi: 10.1007/s00401-019-01973-6. Epub 2019 Feb 20.


Peripheral Inflammation Regulates CNS Immune Surveillance Through the Recruitment of Inflammatory Monocytes Upon Systemic α-Synuclein Administration.

Peralta Ramos JM, Iribarren P, Bousset L, Melki R, Baekelandt V, Van der Perren A.

Front Immunol. 2019 Jan 29;10:80. doi: 10.3389/fimmu.2019.00080. eCollection 2019.


Propagation of α-Synuclein Strains within Human Reconstructed Neuronal Network.

Gribaudo S, Tixador P, Bousset L, Fenyi A, Lino P, Melki R, Peyrin JM, Perrier AL.

Stem Cell Reports. 2019 Feb 12;12(2):230-244. doi: 10.1016/j.stemcr.2018.12.007. Epub 2019 Jan 10.


Clustering of Tau fibrils impairs the synaptic composition of α3-Na+/K+-ATPase and AMPA receptors.

Shrivastava AN, Redeker V, Pieri L, Bousset L, Renner M, Madiona K, Mailhes-Hamon C, Coens A, Buée L, Hantraye P, Triller A, Melki R.

EMBO J. 2019 Feb 1;38(3). pii: e99871. doi: 10.15252/embj.201899871. Epub 2019 Jan 10.


Cell biology and dynamics of Neuronal Na+/K+-ATPase in health and diseases.

Shrivastava AN, Triller A, Melki R.

Neuropharmacology. 2018 Dec 11. pii: S0028-3908(18)30907-9. doi: 10.1016/j.neuropharm.2018.12.008. [Epub ahead of print] Review.


CONFINE-MAS: a magic-angle spinning NMR probe that confines the sample in case of a rotor explosion.

Wiegand T, Hunkeler A, Däpp A, Verasdonck J, Cadalbert R, Bousset L, Melki R, Böckmann A, Meier BH.

J Biomol NMR. 2018 Dec;72(3-4):171-177. doi: 10.1007/s10858-018-0218-x. Epub 2018 Dec 10.


Empowering the immune fate of bone marrow mesenchymal stromal cells: gene and protein changes.

Najar M, Ouhaddi Y, Bouhtit F, Melki R, Afif H, Boukhatem N, Merimi M, Fahmi H.

Inflamm Res. 2019 Feb;68(2):167-176. doi: 10.1007/s00011-018-1198-8. Epub 2018 Nov 14.


2D polarization imaging as a low-cost fluorescence method to detect α-synuclein aggregation ex vivo in models of Parkinson's disease.

Camacho R, Täuber D, Hansen C, Shi J, Bousset L, Melki R, Li JY, Scheblykin IG.

Commun Biol. 2018 Oct 2;1:157. doi: 10.1038/s42003-018-0156-x. eCollection 2018.


Alpha-synuclein and the prion hypothesis in Parkinson's disease.

Melki R.

Rev Neurol (Paris). 2018 Nov;174(9):644-652. doi: 10.1016/j.neurol.2018.08.002. Epub 2018 Sep 7. Review.


Assessment of the efficacy of different procedures that remove and disassemble alpha-synuclein, tau and A-beta fibrils from laboratory material and surfaces.

Fenyi A, Coens A, Bellande T, Melki R, Bousset L.

Sci Rep. 2018 Jul 17;8(1):10788. doi: 10.1038/s41598-018-28856-2.


ɑ-Synuclein strains and seeding in Parkinson's disease, incidental Lewy body disease, dementia with Lewy bodies and multiple system atrophy: similarities and differences.

Peelaerts W, Bousset L, Baekelandt V, Melki R.

Cell Tissue Res. 2018 Jul;373(1):195-212. doi: 10.1007/s00441-018-2839-5. Epub 2018 Apr 27. Review.


Significant association between ERCC2 and MTHR polymorphisms and breast cancer susceptibility in Moroccan population: genotype and haplotype analysis in a case-control study.

Hardi H, Melki R, Boughaleb Z, El Harroudi T, Aissaoui S, Boukhatem N.

BMC Cancer. 2018 Mar 15;18(1):292. doi: 10.1186/s12885-018-4214-z.


Recommendations of the Global Multiple System Atrophy Research Roadmap Meeting.

Walsh RR, Krismer F, Galpern WR, Wenning GK, Low PA, Halliday G, Koroshetz WJ, Holton J, Quinn NP, Rascol O, Shaw LM, Eidelberg D, Bower P, Cummings JL, Abler V, Biedenharn J, Bitan G, Brooks DJ, Brundin P, Fernandez H, Fortier P, Freeman R, Gasser T, Hewitt A, Höglinger GU, Huentelman MJ, Jensen PH, Jeromin A, Kang UJ, Kaufmann H, Kellerman L, Khurana V, Klockgether T, Kim WS, Langer C, LeWitt P, Masliah E, Meissner W, Melki R, Ostrowitzki S, Piantadosi S, Poewe W, Robertson D, Roemer C, Schenk D, Schlossmacher M, Schmahmann JD, Seppi K, Shih L, Siderowf A, Stebbins GT, Stefanova N, Tsuji S, Sutton S, Zhang J.

Neurology. 2018 Jan 9;90(2):74-82. doi: 10.1212/WNL.0000000000004798. Epub 2017 Dec 13.


Prying into the Prion Hypothesis for Parkinson's Disease.

Brundin P, Melki R.

J Neurosci. 2017 Oct 11;37(41):9808-9818. doi: 10.1523/JNEUROSCI.1788-16.2017. Review.


A prolonged chronological lifespan is an unexpected benefit of the [PSI+] prion in yeast.

Wang K, Melki R, Kabani M.

PLoS One. 2017 Sep 14;12(9):e0184905. doi: 10.1371/journal.pone.0184905. eCollection 2017.


α-Synuclein transfer between neurons and astrocytes indicates that astrocytes play a role in degradation rather than in spreading.

Loria F, Vargas JY, Bousset L, Syan S, Salles A, Melki R, Zurzolo C.

Acta Neuropathol. 2017 Nov;134(5):789-808. doi: 10.1007/s00401-017-1746-2. Epub 2017 Jul 19.


Physico-Pathologic Mechanisms Involved in Neurodegeneration: Misfolded Protein-Plasma Membrane Interactions.

Shrivastava AN, Aperia A, Melki R, Triller A.

Neuron. 2017 Jul 5;95(1):33-50. doi: 10.1016/j.neuron.2017.05.026. Review.


Endocytic vesicle rupture is a conserved mechanism of cellular invasion by amyloid proteins.

Flavin WP, Bousset L, Green ZC, Chu Y, Skarpathiotis S, Chaney MJ, Kordower JH, Melki R, Campbell EM.

Acta Neuropathol. 2017 Oct;134(4):629-653. doi: 10.1007/s00401-017-1722-x. Epub 2017 May 19.


How the shapes of seeds can influence pathology.

Melki R.

Neurobiol Dis. 2018 Jan;109(Pt B):201-208. doi: 10.1016/j.nbd.2017.03.011. Epub 2017 Mar 29.


Nanomechanical properties of distinct fibrillar polymorphs of the protein α-synuclein.

Makky A, Bousset L, Polesel-Maris J, Melki R.

Sci Rep. 2016 Nov 30;6:37970. doi: 10.1038/srep37970.


KLK6 proteolysis is implicated in the turnover and uptake of extracellular alpha-synuclein species.

Pampalakis G, Sykioti VS, Ximerakis M, Stefanakou-Kalakou I, Melki R, Vekrellis K, Sotiropoulou G.

Oncotarget. 2017 Feb 28;8(9):14502-14515. doi: 10.18632/oncotarget.13264.


Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies.

Tardivel M, Bégard S, Bousset L, Dujardin S, Coens A, Melki R, Buée L, Colin M.

Acta Neuropathol Commun. 2016 Nov 4;4(1):117.


Tunneling nanotubes spread fibrillar α-synuclein by intercellular trafficking of lysosomes.

Abounit S, Bousset L, Loria F, Zhu S, de Chaumont F, Pieri L, Olivo-Marin JC, Melki R, Zurzolo C.

EMBO J. 2016 Oct 4;35(19):2120-2138. Epub 2016 Aug 22.


The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model.

Kakkar V, Månsson C, de Mattos EP, Bergink S, van der Zwaag M, van Waarde MAWH, Kloosterhuis NJ, Melki R, van Cruchten RTP, Al-Karadaghi S, Arosio P, Dobson CM, Knowles TPJ, Bates GP, van Deursen JM, Linse S, van de Sluis B, Emanuelsson C, Kampinga HH.

Mol Cell. 2016 Apr 21;62(2):272-283. doi: 10.1016/j.molcel.2016.03.017. Epub 2016 Apr 14.


Structural and functional properties of prefibrillar α-synuclein oligomers.

Pieri L, Madiona K, Melki R.

Sci Rep. 2016 Apr 14;6:24526. doi: 10.1038/srep24526.


Data in support of the identification of neuronal and astrocyte proteins interacting with extracellularly applied oligomeric and fibrillar α-synuclein assemblies by mass spectrometry.

Shrivastava AN, Redeker V, Fritz N, Pieri L, Almeida LG, Spolidoro M, Liebmann T, Bousset L, Renner M, Léna C, Aperia A, Melki R, Triller A.

Data Brief. 2016 Feb 12;7:221-8. doi: 10.1016/j.dib.2016.02.018. eCollection 2016 Jun.


Axonal transport and secretion of fibrillar forms of α-synuclein, Aβ42 peptide and HTTExon 1.

Brahic M, Bousset L, Bieri G, Melki R, Gitler AD.

Acta Neuropathol. 2016 Apr;131(4):539-48. doi: 10.1007/s00401-016-1538-0. Epub 2016 Jan 28.


α-Synuclein and huntingtin exon 1 amyloid fibrils bind laterally to the cellular membrane.

Monsellier E, Bousset L, Melki R.

Sci Rep. 2016 Jan 13;6:19180. doi: 10.1038/srep19180.


An Efficient Procedure for Removal and Inactivation of Alpha-Synuclein Assemblies from Laboratory Materials.

Bousset L, Brundin P, Böckmann A, Meier B, Melki R.

J Parkinsons Dis. 2016;6(1):143-51. doi: 10.3233/JPD-150691.


More than just trash bins? Potential roles for extracellular vesicles in the vertical and horizontal transmission of yeast prions.

Kabani M, Melki R.

Curr Genet. 2016 May;62(2):265-70. doi: 10.1007/s00294-015-0534-6. Epub 2015 Nov 9. Review.


Cellular response of human neuroblastoma cells to α-synuclein fibrils, the main constituent of Lewy bodies.

Pieri L, Chafey P, Le Gall M, Clary G, Melki R, Redeker V.

Biochim Biophys Acta. 2016 Jan;1860(1 Pt A):8-19. doi: 10.1016/j.bbagen.2015.10.007. Epub 2015 Oct 22.


α-synuclein assemblies sequester neuronal α3-Na+/K+-ATPase and impair Na+ gradient.

Shrivastava AN, Redeker V, Fritz N, Pieri L, Almeida LG, Spolidoro M, Liebmann T, Bousset L, Renner M, Léna C, Aperia A, Melki R, Triller A.

EMBO J. 2015 Oct 1;34(19):2408-23. doi: 10.15252/embj.201591397. Epub 2015 Aug 31.


Further exploration of the conformational space of α-synuclein fibrils: solid-state NMR assignment of a high-pH polymorph.

Verasdonck J, Bousset L, Gath J, Melki R, Böckmann A, Meier BH.

Biomol NMR Assign. 2016 Apr;10(1):5-12. doi: 10.1007/s12104-015-9628-9. Epub 2015 Aug 30.


Sup35p in Its Soluble and Prion States Is Packaged inside Extracellular Vesicles.

Kabani M, Melki R.

MBio. 2015 Aug 18;6(4). pii: e01017-15. doi: 10.1128/mBio.01017-15.


The 26S Proteasome Degrades the Soluble but Not the Fibrillar Form of the Yeast Prion Ure2p In Vitro.

Wang K, Redeker V, Madiona K, Melki R, Kabani M.

PLoS One. 2015 Jun 26;10(6):e0131789. doi: 10.1371/journal.pone.0131789. eCollection 2015.


Binding, internalization and fate of Huntingtin Exon1 fibrillar assemblies in mitotic and nonmitotic neuroblastoma cells.

Ruiz-Arlandis G, Pieri L, Bousset L, Melki R.

Neuropathol Appl Neurobiol. 2016 Feb;42(2):137-52. doi: 10.1111/nan.12258. Epub 2015 Jul 20.


α-Synuclein strains cause distinct synucleinopathies after local and systemic administration.

Peelaerts W, Bousset L, Van der Perren A, Moskalyuk A, Pulizzi R, Giugliano M, Van den Haute C, Melki R, Baekelandt V.

Nature. 2015 Jun 18;522(7556):340-4. doi: 10.1038/nature14547. Epub 2015 Jun 10.


Methyl-branched lipids promote the membrane adsorption of α-synuclein by enhancing shallow lipid-packing defects.

Garten M, Prévost C, Cadart C, Gautier R, Bousset L, Melki R, Bassereau P, Vanni S.

Phys Chem Chem Phys. 2015 Jun 28;17(24):15589-97. doi: 10.1039/c5cp00244c. Epub 2015 Mar 31.


A novel bio-orthogonal cross-linker for improved protein/protein interaction analysis.

Nury C, Redeker V, Dautrey S, Romieu A, van der Rest G, Renard PY, Melki R, Chamot-Rooke J.

Anal Chem. 2015 Feb 3;87(3):1853-60. doi: 10.1021/ac503892c. Epub 2015 Jan 12.


Molecular interaction between the chaperone Hsc70 and the N-terminal flank of huntingtin exon 1 modulates aggregation.

Monsellier E, Redeker V, Ruiz-Arlandis G, Bousset L, Melki R.

J Biol Chem. 2015 Jan 30;290(5):2560-76. doi: 10.1074/jbc.M114.603332. Epub 2014 Dec 10.


Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats.

Holmqvist S, Chutna O, Bousset L, Aldrin-Kirk P, Li W, Björklund T, Wang ZY, Roybon L, Melki R, Li JY.

Acta Neuropathol. 2014 Dec;128(6):805-20. doi: 10.1007/s00401-014-1343-6. Epub 2014 Oct 9.


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