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Alpha-synuclein and the prion hypothesis in Parkinson's disease.

Melki R.

Rev Neurol (Paris). 2018 Sep 7. pii: S0035-3787(18)30734-3. doi: 10.1016/j.neurol.2018.08.002. [Epub ahead of print] Review.


Assessment of the efficacy of different procedures that remove and disassemble alpha-synuclein, tau and A-beta fibrils from laboratory material and surfaces.

Fenyi A, Coens A, Bellande T, Melki R, Bousset L.

Sci Rep. 2018 Jul 17;8(1):10788. doi: 10.1038/s41598-018-28856-2.


ɑ-Synuclein strains and seeding in Parkinson's disease, incidental Lewy body disease, dementia with Lewy bodies and multiple system atrophy: similarities and differences.

Peelaerts W, Bousset L, Baekelandt V, Melki R.

Cell Tissue Res. 2018 Jul;373(1):195-212. doi: 10.1007/s00441-018-2839-5. Epub 2018 Apr 27. Review.


Significant association between ERCC2 and MTHR polymorphisms and breast cancer susceptibility in Moroccan population: genotype and haplotype analysis in a case-control study.

Hardi H, Melki R, Boughaleb Z, El Harroudi T, Aissaoui S, Boukhatem N.

BMC Cancer. 2018 Mar 15;18(1):292. doi: 10.1186/s12885-018-4214-z.


Recommendations of the Global Multiple System Atrophy Research Roadmap Meeting.

Walsh RR, Krismer F, Galpern WR, Wenning GK, Low PA, Halliday G, Koroshetz WJ, Holton J, Quinn NP, Rascol O, Shaw LM, Eidelberg D, Bower P, Cummings JL, Abler V, Biedenharn J, Bitan G, Brooks DJ, Brundin P, Fernandez H, Fortier P, Freeman R, Gasser T, Hewitt A, Höglinger GU, Huentelman MJ, Jensen PH, Jeromin A, Kang UJ, Kaufmann H, Kellerman L, Khurana V, Klockgether T, Kim WS, Langer C, LeWitt P, Masliah E, Meissner W, Melki R, Ostrowitzki S, Piantadosi S, Poewe W, Robertson D, Roemer C, Schenk D, Schlossmacher M, Schmahmann JD, Seppi K, Shih L, Siderowf A, Stebbins GT, Stefanova N, Tsuji S, Sutton S, Zhang J.

Neurology. 2018 Jan 9;90(2):74-82. doi: 10.1212/WNL.0000000000004798. Epub 2017 Dec 13. Review.


Prying into the Prion Hypothesis for Parkinson's Disease.

Brundin P, Melki R.

J Neurosci. 2017 Oct 11;37(41):9808-9818. doi: 10.1523/JNEUROSCI.1788-16.2017. Review.


A prolonged chronological lifespan is an unexpected benefit of the [PSI+] prion in yeast.

Wang K, Melki R, Kabani M.

PLoS One. 2017 Sep 14;12(9):e0184905. doi: 10.1371/journal.pone.0184905. eCollection 2017.


α-Synuclein transfer between neurons and astrocytes indicates that astrocytes play a role in degradation rather than in spreading.

Loria F, Vargas JY, Bousset L, Syan S, Salles A, Melki R, Zurzolo C.

Acta Neuropathol. 2017 Nov;134(5):789-808. doi: 10.1007/s00401-017-1746-2. Epub 2017 Jul 19.


Physico-Pathologic Mechanisms Involved in Neurodegeneration: Misfolded Protein-Plasma Membrane Interactions.

Shrivastava AN, Aperia A, Melki R, Triller A.

Neuron. 2017 Jul 5;95(1):33-50. doi: 10.1016/j.neuron.2017.05.026. Review.


Endocytic vesicle rupture is a conserved mechanism of cellular invasion by amyloid proteins.

Flavin WP, Bousset L, Green ZC, Chu Y, Skarpathiotis S, Chaney MJ, Kordower JH, Melki R, Campbell EM.

Acta Neuropathol. 2017 Oct;134(4):629-653. doi: 10.1007/s00401-017-1722-x. Epub 2017 May 19.


How the shapes of seeds can influence pathology.

Melki R.

Neurobiol Dis. 2018 Jan;109(Pt B):201-208. doi: 10.1016/j.nbd.2017.03.011. Epub 2017 Mar 29.


Nanomechanical properties of distinct fibrillar polymorphs of the protein α-synuclein.

Makky A, Bousset L, Polesel-Maris J, Melki R.

Sci Rep. 2016 Nov 30;6:37970. doi: 10.1038/srep37970.


KLK6 proteolysis is implicated in the turnover and uptake of extracellular alpha-synuclein species.

Pampalakis G, Sykioti VS, Ximerakis M, Stefanakou-Kalakou I, Melki R, Vekrellis K, Sotiropoulou G.

Oncotarget. 2017 Feb 28;8(9):14502-14515. doi: 10.18632/oncotarget.13264.


Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies.

Tardivel M, Bégard S, Bousset L, Dujardin S, Coens A, Melki R, Buée L, Colin M.

Acta Neuropathol Commun. 2016 Nov 4;4(1):117.


Tunneling nanotubes spread fibrillar α-synuclein by intercellular trafficking of lysosomes.

Abounit S, Bousset L, Loria F, Zhu S, de Chaumont F, Pieri L, Olivo-Marin JC, Melki R, Zurzolo C.

EMBO J. 2016 Oct 4;35(19):2120-2138. Epub 2016 Aug 22.


The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model.

Kakkar V, Månsson C, de Mattos EP, Bergink S, van der Zwaag M, van Waarde MAWH, Kloosterhuis NJ, Melki R, van Cruchten RTP, Al-Karadaghi S, Arosio P, Dobson CM, Knowles TPJ, Bates GP, van Deursen JM, Linse S, van de Sluis B, Emanuelsson C, Kampinga HH.

Mol Cell. 2016 Apr 21;62(2):272-283. doi: 10.1016/j.molcel.2016.03.017. Epub 2016 Apr 14.


Structural and functional properties of prefibrillar α-synuclein oligomers.

Pieri L, Madiona K, Melki R.

Sci Rep. 2016 Apr 14;6:24526. doi: 10.1038/srep24526.


Data in support of the identification of neuronal and astrocyte proteins interacting with extracellularly applied oligomeric and fibrillar α-synuclein assemblies by mass spectrometry.

Shrivastava AN, Redeker V, Fritz N, Pieri L, Almeida LG, Spolidoro M, Liebmann T, Bousset L, Renner M, Léna C, Aperia A, Melki R, Triller A.

Data Brief. 2016 Feb 12;7:221-8. doi: 10.1016/j.dib.2016.02.018. eCollection 2016 Jun.


Axonal transport and secretion of fibrillar forms of α-synuclein, Aβ42 peptide and HTTExon 1.

Brahic M, Bousset L, Bieri G, Melki R, Gitler AD.

Acta Neuropathol. 2016 Apr;131(4):539-48. doi: 10.1007/s00401-016-1538-0. Epub 2016 Jan 28.


α-Synuclein and huntingtin exon 1 amyloid fibrils bind laterally to the cellular membrane.

Monsellier E, Bousset L, Melki R.

Sci Rep. 2016 Jan 13;6:19180. doi: 10.1038/srep19180.


An Efficient Procedure for Removal and Inactivation of Alpha-Synuclein Assemblies from Laboratory Materials.

Bousset L, Brundin P, Böckmann A, Meier B, Melki R.

J Parkinsons Dis. 2016;6(1):143-51. doi: 10.3233/JPD-150691.


More than just trash bins? Potential roles for extracellular vesicles in the vertical and horizontal transmission of yeast prions.

Kabani M, Melki R.

Curr Genet. 2016 May;62(2):265-70. doi: 10.1007/s00294-015-0534-6. Epub 2015 Nov 9. Review.


Cellular response of human neuroblastoma cells to α-synuclein fibrils, the main constituent of Lewy bodies.

Pieri L, Chafey P, Le Gall M, Clary G, Melki R, Redeker V.

Biochim Biophys Acta. 2016 Jan;1860(1 Pt A):8-19. doi: 10.1016/j.bbagen.2015.10.007. Epub 2015 Oct 22.


α-synuclein assemblies sequester neuronal α3-Na+/K+-ATPase and impair Na+ gradient.

Shrivastava AN, Redeker V, Fritz N, Pieri L, Almeida LG, Spolidoro M, Liebmann T, Bousset L, Renner M, Léna C, Aperia A, Melki R, Triller A.

EMBO J. 2015 Oct 1;34(19):2408-23. doi: 10.15252/embj.201591397. Epub 2015 Aug 31.


Further exploration of the conformational space of α-synuclein fibrils: solid-state NMR assignment of a high-pH polymorph.

Verasdonck J, Bousset L, Gath J, Melki R, Böckmann A, Meier BH.

Biomol NMR Assign. 2016 Apr;10(1):5-12. doi: 10.1007/s12104-015-9628-9. Epub 2015 Aug 30.


Sup35p in Its Soluble and Prion States Is Packaged inside Extracellular Vesicles.

Kabani M, Melki R.

MBio. 2015 Aug 18;6(4). pii: e01017-15. doi: 10.1128/mBio.01017-15.


The 26S Proteasome Degrades the Soluble but Not the Fibrillar Form of the Yeast Prion Ure2p In Vitro.

Wang K, Redeker V, Madiona K, Melki R, Kabani M.

PLoS One. 2015 Jun 26;10(6):e0131789. doi: 10.1371/journal.pone.0131789. eCollection 2015.


Binding, internalization and fate of Huntingtin Exon1 fibrillar assemblies in mitotic and nonmitotic neuroblastoma cells.

Ruiz-Arlandis G, Pieri L, Bousset L, Melki R.

Neuropathol Appl Neurobiol. 2016 Feb;42(2):137-52. doi: 10.1111/nan.12258. Epub 2015 Jul 20.


α-Synuclein strains cause distinct synucleinopathies after local and systemic administration.

Peelaerts W, Bousset L, Van der Perren A, Moskalyuk A, Pulizzi R, Giugliano M, Van den Haute C, Melki R, Baekelandt V.

Nature. 2015 Jun 18;522(7556):340-4. doi: 10.1038/nature14547. Epub 2015 Jun 10.


Methyl-branched lipids promote the membrane adsorption of α-synuclein by enhancing shallow lipid-packing defects.

Garten M, Prévost C, Cadart C, Gautier R, Bousset L, Melki R, Bassereau P, Vanni S.

Phys Chem Chem Phys. 2015 Jun 28;17(24):15589-97. doi: 10.1039/c5cp00244c. Epub 2015 Mar 31.


A novel bio-orthogonal cross-linker for improved protein/protein interaction analysis.

Nury C, Redeker V, Dautrey S, Romieu A, van der Rest G, Renard PY, Melki R, Chamot-Rooke J.

Anal Chem. 2015 Feb 3;87(3):1853-60. doi: 10.1021/ac503892c. Epub 2015 Jan 12.


Molecular interaction between the chaperone Hsc70 and the N-terminal flank of huntingtin exon 1 modulates aggregation.

Monsellier E, Redeker V, Ruiz-Arlandis G, Bousset L, Melki R.

J Biol Chem. 2015 Jan 30;290(5):2560-76. doi: 10.1074/jbc.M114.603332. Epub 2014 Dec 10.


Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats.

Holmqvist S, Chutna O, Bousset L, Aldrin-Kirk P, Li W, Björklund T, Wang ZY, Roybon L, Melki R, Li JY.

Acta Neuropathol. 2014 Dec;128(6):805-20. doi: 10.1007/s00401-014-1343-6. Epub 2014 Oct 9.


Ectosomes: a new mechanism for non-exosomal secretion of tau protein.

Dujardin S, Bégard S, Caillierez R, Lachaud C, Delattre L, Carrier S, Loyens A, Galas MC, Bousset L, Melki R, Aurégan G, Hantraye P, Brouillet E, Buée L, Colin M.

PLoS One. 2014 Jun 27;9(6):e100760. doi: 10.1371/journal.pone.0100760. eCollection 2014.


Dynamical properties of α-synuclein in soluble and fibrillar forms by Quasi Elastic Neutron Scattering.

Bousset L, Brewee C, Melki R, Migliardo F.

Biochim Biophys Acta. 2014 Jul;1844(7):1307-16. doi: 10.1016/j.bbapap.2014.04.010. Epub 2014 Apr 21.


Protein aggregation and prionopathies.

Renner M, Melki R.

Pathol Biol (Paris). 2014 Jun;62(3):162-8. doi: 10.1016/j.patbio.2014.01.003. Epub 2014 Mar 31. Review.


Alpha-synuclein spreading in M83 mice brain revealed by detection of pathological α-synuclein by enhanced ELISA.

Bétemps D, Verchère J, Brot S, Morignat E, Bousset L, Gaillard D, Lakhdar L, Melki R, Baron T.

Acta Neuropathol Commun. 2014 Mar 13;2:29. doi: 10.1186/2051-5960-2-29.


Overexpression of the calpain-specific inhibitor calpastatin reduces human alpha-Synuclein processing, aggregation and synaptic impairment in [A30P]αSyn transgenic mice.

Diepenbroek M, Casadei N, Esmer H, Saido TC, Takano J, Kahle PJ, Nixon RA, Rao MV, Melki R, Pieri L, Helling S, Marcus K, Krueger R, Masliah E, Riess O, Nuber S.

Hum Mol Genet. 2014 Aug 1;23(15):3975-89. doi: 10.1093/hmg/ddu112. Epub 2014 Mar 11.


Unlike twins: an NMR comparison of two α-synuclein polymorphs featuring different toxicity.

Gath J, Bousset L, Habenstein B, Melki R, Böckmann A, Meier BH.

PLoS One. 2014 Mar 5;9(3):e90659. doi: 10.1371/journal.pone.0090659. eCollection 2014.


A role for the proteasome in the turnover of Sup35p and in [PSI(+) ] prion propagation.

Kabani M, Redeker V, Melki R.

Mol Microbiol. 2014 May;92(3):507-28. doi: 10.1111/mmi.12572. Epub 2014 Mar 17.


Alpha-synuclein transfers from neurons to oligodendrocytes.

Reyes JF, Rey NL, Bousset L, Melki R, Brundin P, Angot E.

Glia. 2014 Mar;62(3):387-98. doi: 10.1002/glia.22611. Epub 2013 Dec 31.


The conformation of the prion domain of Sup35p in isolation and in the full-length protein.

Luckgei N, Schütz AK, Bousset L, Habenstein B, Sourigues Y, Gardiennet C, Meier BH, Melki R, Böckmann A.

Angew Chem Int Ed Engl. 2013 Nov 25;52(48):12741-4. doi: 10.1002/anie.201304699. Epub 2013 Oct 9. No abstract available.


Yet another polymorph of α-synuclein: solid-state sequential assignments.

Gath J, Bousset L, Habenstein B, Melki R, Meier BH, Böckmann A.

Biomol NMR Assign. 2014 Oct;8(2):395-404. doi: 10.1007/s12104-013-9526-y. Epub 2013 Oct 10.


Structural and functional characterization of two alpha-synuclein strains.

Bousset L, Pieri L, Ruiz-Arlandis G, Gath J, Jensen PH, Habenstein B, Madiona K, Olieric V, Böckmann A, Meier BH, Melki R.

Nat Commun. 2013;4:2575. doi: 10.1038/ncomms3575.


Solid-state NMR sequential assignments of the amyloid core of full-length Sup35p.

Schütz AK, Habenstein B, Luckgei N, Bousset L, Sourigues Y, Nielsen AB, Melki R, Böckmann A, Meier BH.

Biomol NMR Assign. 2014 Oct;8(2):349-56. doi: 10.1007/s12104-013-9515-1. Epub 2013 Aug 14.


Solid-state NMR sequential assignments of the amyloid core of Sup35pNM.

Luckgei N, Schütz AK, Habenstein B, Bousset L, Sourigues Y, Melki R, Meier BH, Böckmann A.

Biomol NMR Assign. 2014 Oct;8(2):365-70. doi: 10.1007/s12104-013-9518-y. Epub 2013 Aug 10.


Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice.

Rey NL, Petit GH, Bousset L, Melki R, Brundin P.

Acta Neuropathol. 2013 Oct;126(4):555-73. doi: 10.1007/s00401-013-1160-3. Epub 2013 Aug 8.


β-amyloid and ATP-induced diffusional trapping of astrocyte and neuronal metabotropic glutamate type-5 receptors.

Shrivastava AN, Kowalewski JM, Renner M, Bousset L, Koulakoff A, Melki R, Giaume C, Triller A.

Glia. 2013 Oct;61(10):1673-86. doi: 10.1002/glia.22548. Epub 2013 Aug 6.


Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation.

Jakobsson ME, Moen A, Bousset L, Egge-Jacobsen W, Kernstock S, Melki R, Falnes PØ.

J Biol Chem. 2013 Sep 27;288(39):27752-63. doi: 10.1074/jbc.M113.483248. Epub 2013 Aug 6.

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