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Items: 32

1.

Tissue Resident Alveolar Macrophages Do Not Rely on Glycolysis for LPS-induced Inflammation.

Woods PS, Kimmig LM, Meliton AY, Sun KA, Tian Y, O'Leary EM, Gökalp GA, Hamanaka RB, Mutlu GM.

Am J Respir Cell Mol Biol. 2019 Aug 30. doi: 10.1165/rcmb.2019-0244OC. [Epub ahead of print]

PMID:
31469581
2.

Glutamine Metabolism is Required for Collagen Protein Synthesis in Lung Fibroblasts.

Hamanaka RB, O'Leary EM, Witt LJ, Tian Y, Gökalp GA, Meliton AY, Dulin NO, Mutlu GM.

Am J Respir Cell Mol Biol. 2019 Apr 11. doi: 10.1165/rcmb.2019-0008OC. [Epub ahead of print]

PMID:
30973753
3.

Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis.

Soberanes S, Misharin AV, Jairaman A, Morales-Nebreda L, McQuattie-Pimentel AC, Cho T, Hamanaka RB, Meliton AY, Reyfman PA, Walter JM, Chen CI, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Antalek M, Abdala-Valencia H, Chiarella SE, Sun KA, Woods PS, Ghio AJ, Jain M, Perlman H, Ridge KM, Morimoto RI, Sznajder JI, Balch WE, Bhorade SM, Bharat A, Prakriya M, Chandel NS, Mutlu GM, Budinger GRS.

Cell Metab. 2019 Feb 5;29(2):503. doi: 10.1016/j.cmet.2018.12.001. No abstract available.

4.

Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis.

Soberanes S, Misharin AV, Jairaman A, Morales-Nebreda L, McQuattie-Pimentel AC, Cho T, Hamanaka RB, Meliton AY, Reyfman PA, Walter JM, Chen CI, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Antalek M, Abdala-Valencia H, Chiarella SE, Sun KA, Woods PS, Ghio AJ, Jain M, Perlman H, Ridge KM, Morimoto RI, Sznajder JI, Balch WE, Bhorade SM, Bharat A, Prakriya M, Chandel NS, Mutlu GM, Budinger GRS.

Cell Metab. 2019 Feb 5;29(2):335-347.e5. doi: 10.1016/j.cmet.2018.09.019. Epub 2018 Oct 11. Erratum in: Cell Metab. 2019 Feb 5;29(2):503.

PMID:
30318339
5.

Inhalational exposure to particulate matter air pollution alters the composition of the gut microbiome.

Mutlu EA, Comba IY, Cho T, Engen PA, Yazıcı C, Soberanes S, Hamanaka RB, Niğdelioğlu R, Meliton AY, Ghio AJ, Budinger GRS, Mutlu GM.

Environ Pollut. 2018 Sep;240:817-830. doi: 10.1016/j.envpol.2018.04.130. Epub 2018 May 18.

6.

Inhibition of Phosphoglycerate Dehydrogenase Attenuates Bleomycin-induced Pulmonary Fibrosis.

Hamanaka RB, Nigdelioglu R, Meliton AY, Tian Y, Witt LJ, O'Leary E, Sun KA, Woods PS, Wu D, Ansbro B, Ard S, Rohde JM, Dulin NO, Guzy RD, Mutlu GM.

Am J Respir Cell Mol Biol. 2018 May;58(5):585-593. doi: 10.1165/rcmb.2017-0186OC.

7.

HIF-1α is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium.

Wu D, Huang RT, Hamanaka RB, Krause M, Oh MJ, Kuo CH, Nigdelioglu R, Meliton AY, Witt L, Dai G, Civelek M, Prabhakar NR, Fang Y, Mutlu GM.

Elife. 2017 May 30;6. pii: e25217. doi: 10.7554/eLife.25217.

8.

Transforming Growth Factor (TGF)-β Promotes de Novo Serine Synthesis for Collagen Production.

Nigdelioglu R, Hamanaka RB, Meliton AY, O'Leary E, Witt LJ, Cho T, Sun K, Bonham C, Wu D, Woods PS, Husain AN, Wolfgeher D, Dulin NO, Chandel NS, Mutlu GM.

J Biol Chem. 2016 Dec 30;291(53):27239-27251. doi: 10.1074/jbc.M116.756247. Epub 2016 Nov 11.

9.

Oxidized phospholipids protect against lung injury and endothelial barrier dysfunction caused by heat-inactivated Staphylococcus aureus.

Meliton AY, Meng F, Tian Y, Sarich N, Mutlu GM, Birukova AA, Birukov KG.

Am J Physiol Lung Cell Mol Physiol. 2015 Mar 15;308(6):L550-62. doi: 10.1152/ajplung.00248.2014. Epub 2015 Jan 9.

10.

Mechanical induction of group V phospholipase A(2) causes lung inflammation and acute lung injury.

Meliton AY, Muñoz NM, Meliton LN, Birukova AA, Leff AR, Birukov KG.

Am J Physiol Lung Cell Mol Physiol. 2013 May 15;304(10):L689-700. doi: 10.1152/ajplung.00047.2013. Epub 2013 Mar 22.

11.

Group V phospholipase A(2) increases pulmonary endothelial permeability through direct hydrolysis of the cell membrane.

Muñoz NM, Desai A, Meliton LN, Meliton AY, Zhou T, Leff AR, Dudek SM.

Pulm Circ. 2012 Apr-Jun;2(2):182-92. doi: 10.4103/2045-8932.97604.

12.

Inhibition of Pyk2 blocks lung inflammation and injury in a mouse model of acute lung injury.

Duan Y, Learoyd J, Meliton AY, Leff AR, Zhu X.

Respir Res. 2012 Jan 18;13:4. doi: 10.1186/1465-9921-13-4.

13.

Group V phospholipase A2 mediates barrier disruption of human pulmonary endothelial cells caused by LPS in vitro.

Dudek SM, Muñoz NM, Desai A, Osan CM, Meliton AY, Leff AR.

Am J Respir Cell Mol Biol. 2011 Mar;44(3):361-8. doi: 10.1165/rcmb.2009-0446OC. Epub 2010 May 6.

14.

Cytosolic group IVa phospholipase A2 mediates IL-8/CXCL8-induced transmigration of human polymorphonuclear leukocytes in vitro.

Meliton AY, Muñoz NM, Meliton LN, Binder DC, Osan CM, Zhu X, Dudek SM, Leff AR.

J Inflamm (Lond). 2010 Mar 18;7:14. doi: 10.1186/1476-9255-7-14.

15.

Leukotriene D4 activates {beta}2-integrin adhesion in human polymorphonuclear leukocytes.

Meliton AY, Muñoz NM, Osan CM, Meliton LN, Leff AR.

Eur Respir J. 2010 Feb;35(2):402-9. doi: 10.1183/09031936.00009309. Epub 2009 Aug 13.

16.

Inhibition of Pyk2 blocks airway inflammation and hyperresponsiveness in a mouse model of asthma.

Duan Y, Learoyd J, Meliton AY, Clay BS, Leff AR, Zhu X.

Am J Respir Cell Mol Biol. 2010 Apr;42(4):491-7. doi: 10.1165/rcmb.2008-0469OC. Epub 2009 Jun 11.

17.

Secretory group V phospholipase A2 regulates acute lung injury and neutrophilic inflammation caused by LPS in mice.

Muñoz NM, Meliton AY, Meliton LN, Dudek SM, Leff AR.

Am J Physiol Lung Cell Mol Physiol. 2009 Jun;296(6):L879-87. doi: 10.1152/ajplung.90580.2008. Epub 2009 Mar 13.

18.

Pulmonary mastocytosis and enhanced lung inflammation in mice heterozygous null for the Foxf1 gene.

Kalin TV, Meliton L, Meliton AY, Zhu X, Whitsett JA, Kalinichenko VV.

Am J Respir Cell Mol Biol. 2008 Oct;39(4):390-9. doi: 10.1165/rcmb.2008-0044OC. Epub 2008 Apr 17.

19.
20.

Blockade of avidity and focal clustering of beta 2-integrin by cysteinyl leukotriene antagonism attenuates eosinophil adhesion.

Meliton AY, Munoz NM, Leff AR.

J Allergy Clin Immunol. 2007 Dec;120(6):1316-23. Epub 2007 Sep 29.

PMID:
17904626
21.

Deletion of secretory group V phospholipase A2 attenuates cell migration and airway hyperresponsiveness in immunosensitized mice.

Muñoz NM, Meliton AY, Arm JP, Bonventre JV, Cho W, Leff AR.

J Immunol. 2007 Oct 1;179(7):4800-7.

22.

Phosphodiesterase 4 inhibition of beta2-integrin adhesion caused by leukotriene B4 and TNF-alpha in human neutrophils.

Meliton AY, Muñoz NM, Lambertino A, Boetticher E, Learoyd J, Zhu X, Leff AR.

Eur Respir J. 2006 Nov;28(5):920-8. Epub 2006 Jun 28.

23.

Transcellular secretion of group V phospholipase A2 from epithelium induces beta 2-integrin-mediated adhesion and synthesis of leukotriene C4 in eosinophils.

Muñoz NM, Meliton AY, Lambertino A, Boetticher E, Learoyd J, Sultan F, Zhu X, Cho W, Leff AR.

J Immunol. 2006 Jul 1;177(1):574-82.

24.

Regulation of interleukin-5-induced beta2-integrin adhesion of human eosinophils by phosphoinositide 3-kinase.

Sano M, Leff AR, Myou S, Boetticher E, Meliton AY, Learoyd J, Lambertino AT, Munoz NM, Zhu X.

Am J Respir Cell Mol Biol. 2005 Jul;33(1):65-70. Epub 2005 Mar 31.

25.

Beta2-integrin adhesion caused by eotaxin but not IL-5 is blocked by PDE-4 inhibition and beta2-adrenoceptor activation in human eosinophils.

Liu J, Muñoz NM, Meliton AY, Zhu X, Lambertino AT, Xu C, Myo S, Myou S, Boetticher E, Johnson M, Leff AR.

Pulm Pharmacol Ther. 2004;17(2):73-9.

PMID:
15123228
26.

Additive blockade of beta 2-integrin adhesion of eosinophils by salmeterol and fluticasone propionate.

Myo S, Zhu X, Myou S, Meliton AY, Liu J, Boetticher E, Lambertino AT, Xu C, Muñoz NM, Leff AR.

Eur Respir J. 2004 Apr;23(4):511-7.

27.

Blockade of inflammation and airway hyperresponsiveness in immune-sensitized mice by dominant-negative phosphoinositide 3-kinase-TAT.

Myou S, Leff AR, Myo S, Boetticher E, Tong J, Meliton AY, Liu J, Munoz NM, Zhu X.

J Exp Med. 2003 Nov 17;198(10):1573-82.

28.

Activation of group IV cytosolic phospholipase A2 in human eosinophils by phosphoinositide 3-kinase through a mitogen-activated protein kinase-independent pathway.

Myou S, Leff AR, Myo S, Boetticher E, Meliton AY, Lambertino AT, Liu J, Xu C, Munoz NM, Zhu X.

J Immunol. 2003 Oct 15;171(8):4399-405.

29.

Blockade of airway inflammation and hyperresponsiveness by HIV-TAT-dominant negative Ras.

Myou S, Zhu X, Myo S, Boetticher E, Meliton AY, Liu J, Munoz NM, Leff AR.

J Immunol. 2003 Oct 15;171(8):4379-84.

30.

Blockade of LTC4 synthesis caused by additive inhibition of gIV-PLA2 phosphorylation: Effect of salmeterol and PDE4 inhibition in human eosinophils.

Meliton AY, Muñoz NM, Liu J, Lambertino AT, Boetticher E, Myo S, Myou S, Zhu X, Johnson M, Leff AR.

J Allergy Clin Immunol. 2003 Aug;112(2):404-10.

PMID:
12897749
31.

Human group V phospholipase A2 induces group IVA phospholipase A2-independent cysteinyl leukotriene synthesis in human eosinophils.

Muñoz NM, Kim YJ, Meliton AY, Kim KP, Han SK, Boetticher E, O'Leary E, Myou S, Zhu X, Bonventre JV, Leff AR, Cho W.

J Biol Chem. 2003 Oct 3;278(40):38813-20. Epub 2003 Jun 9.

32.

Quantitation of secretory group V phospholipase A(2) in human tissues by sandwich enzyme-linked immunosorbent assay.

Muñoz NM, Boetticher E, Sperling AI, Kim KP, Meliton AY, Zhu X, Lambertino A, Cho W, Leff AR.

J Immunol Methods. 2002 Apr 1;262(1-2):41-51.

PMID:
11983218

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