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Items: 46


P311 Promotes Lung Fibrosis via Stimulation of TGF-β1, 2 and 3 Translation.

Duan FF, Barron G, Meliton A, Mutlu GM, Dulin NO, Schuger L.

Am J Respir Cell Mol Biol. 2018 Sep 19. doi: 10.1165/rcmb.2018-0028OC. [Epub ahead of print]


Inhalational exposure to particulate matter air pollution alters the composition of the gut microbiome.

Mutlu EA, Comba IY, Cho T, Engen PA, Yazıcı C, Soberanes S, Hamanaka RB, Niğdelioğlu R, Meliton AY, Ghio AJ, Budinger GRS, Mutlu GM.

Environ Pollut. 2018 Sep;240:817-830. doi: 10.1016/j.envpol.2018.04.130. Epub 2018 May 18.


Baicalein Rescues Delayed Cooling via Preservation of Akt Activation and Akt-Mediated Phospholamban Phosphorylation.

Shao Z, Chen SJ, Zhu X, Lee C, Huang HH, Meliton A, Li C, Hoek TLV, Li J.

Int J Mol Sci. 2018 Mar 24;19(4). pii: E973. doi: 10.3390/ijms19040973.


Inhibition of Phosphoglycerate Dehydrogenase Attenuates Bleomycin-induced Pulmonary Fibrosis.

Hamanaka RB, Nigdelioglu R, Meliton AY, Tian Y, Witt LJ, O'Leary E, Sun KA, Woods PS, Wu D, Ansbro B, Ard S, Rohde JM, Dulin NO, Guzy RD, Mutlu GM.

Am J Respir Cell Mol Biol. 2018 May;58(5):585-593. doi: 10.1165/rcmb.2017-0186OC.


HIF-1α is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium.

Wu D, Huang RT, Hamanaka RB, Krause M, Oh MJ, Kuo CH, Nigdelioglu R, Meliton AY, Witt L, Dai G, Civelek M, Prabhakar NR, Fang Y, Mutlu GM.

Elife. 2017 May 30;6. pii: e25217. doi: 10.7554/eLife.25217.


Regulation of lung endothelial permeability and inflammatory responses by prostaglandin A2: role of EP4 receptor.

Ohmura T, Tian Y, Sarich N, Ke Y, Meliton A, Shah AS, Andreasson K, Birukov KG, Birukova AA.

Mol Biol Cell. 2017 Jun 15;28(12):1622-1635. doi: 10.1091/mbc.E16-09-0639. Epub 2017 Apr 20.


Experimental Lung Injury Reduces Krüppel-like Factor 2 to Increase Endothelial Permeability via Regulation of RAPGEF3-Rac1 Signaling.

Huang RT, Wu D, Meliton A, Oh MJ, Krause M, Lloyd JA, Nigdelioglu R, Hamanaka RB, Jain MK, Birukova A, Kress JP, Birukov KG, Mutlu GM, Fang Y.

Am J Respir Crit Care Med. 2017 Mar 1;195(5):639-651. doi: 10.1164/rccm.201604-0668OC.


Transforming Growth Factor (TGF)-β Promotes de Novo Serine Synthesis for Collagen Production.

Nigdelioglu R, Hamanaka RB, Meliton AY, O'Leary E, Witt LJ, Cho T, Sun K, Bonham C, Wu D, Woods PS, Husain AN, Wolfgeher D, Dulin NO, Chandel NS, Mutlu GM.

J Biol Chem. 2016 Dec 30;291(53):27239-27251. doi: 10.1074/jbc.M116.756247. Epub 2016 Nov 11.


Chronic Activation of the Renin-Angiotensin System Induces Lung Fibrosis.

Wang J, Chen L, Chen B, Meliton A, Liu SQ, Shi Y, Liu T, Deb DK, Solway J, Li YC.

Sci Rep. 2015 Oct 23;5:15561. doi: 10.1038/srep15561.


Alterations of lung microbiota in a mouse model of LPS-induced lung injury.

Poroyko V, Meng F, Meliton A, Afonyushkin T, Ulanov A, Semenyuk E, Latif O, Tesic V, Birukova AA, Birukov KG.

Am J Physiol Lung Cell Mol Physiol. 2015 Jul 1;309(1):L76-83. doi: 10.1152/ajplung.00061.2014. Epub 2015 May 8.


Role of Krev Interaction Trapped-1 in Prostacyclin-Induced Protection against Lung Vascular Permeability Induced by Excessive Mechanical Forces and Thrombin Receptor Activating Peptide 6.

Meliton A, Meng F, Tian Y, Shah AA, Birukova AA, Birukov KG.

Am J Respir Cell Mol Biol. 2015 Dec;53(6):834-43. doi: 10.1165/rcmb.2014-0376OC.


Oxidized phospholipids protect against lung injury and endothelial barrier dysfunction caused by heat-inactivated Staphylococcus aureus.

Meliton AY, Meng F, Tian Y, Sarich N, Mutlu GM, Birukova AA, Birukov KG.

Am J Physiol Lung Cell Mol Physiol. 2015 Mar 15;308(6):L550-62. doi: 10.1152/ajplung.00248.2014. Epub 2015 Jan 9.


Prostacyclin post-treatment improves LPS-induced acute lung injury and endothelial barrier recovery via Rap1.

Birukova AA, Meng F, Tian Y, Meliton A, Sarich N, Quilliam LA, Birukov KG.

Biochim Biophys Acta. 2015 May;1852(5):778-91. doi: 10.1016/j.bbadis.2014.12.016. Epub 2014 Dec 26.


Asef mediates HGF protective effects against LPS-induced lung injury and endothelial barrier dysfunction.

Meng F, Meliton A, Moldobaeva N, Mutlu G, Kawasaki Y, Akiyama T, Birukova AA.

Am J Physiol Lung Cell Mol Physiol. 2015 Mar 1;308(5):L452-63. doi: 10.1152/ajplung.00170.2014. Epub 2014 Dec 24.


Attenuation of lipopolysaccharide-induced lung vascular stiffening by lipoxin reduces lung inflammation.

Meng F, Mambetsariev I, Tian Y, Beckham Y, Meliton A, Leff A, Gardel ML, Allen MJ, Birukov KG, Birukova AA.

Am J Respir Cell Mol Biol. 2015 Feb;52(2):152-61. doi: 10.1165/rcmb.2013-0468OC.


TAT-protein blockade during ischemia/reperfusion reveals critical role for p85 PI3K-PTEN interaction in cardiomyocyte injury.

Zhu X, Shao ZH, Li C, Li J, Zhong Q, Learoyd J, Meliton A, Meliton L, Leff AR, Vanden Hoek TL.

PLoS One. 2014 Apr 21;9(4):e95622. doi: 10.1371/journal.pone.0095622. eCollection 2014.


Mechanical induction of group V phospholipase A(2) causes lung inflammation and acute lung injury.

Meliton AY, Muñoz NM, Meliton LN, Birukova AA, Leff AR, Birukov KG.

Am J Physiol Lung Cell Mol Physiol. 2013 May 15;304(10):L689-700. doi: 10.1152/ajplung.00047.2013. Epub 2013 Mar 22.


Oxidative stress contributes to lung injury and barrier dysfunction via microtubule destabilization.

Kratzer E, Tian Y, Sarich N, Wu T, Meliton A, Leff A, Birukova AA.

Am J Respir Cell Mol Biol. 2012 Nov;47(5):688-97. doi: 10.1165/rcmb.2012-0161OC. Epub 2012 Jul 27.


Group V phospholipase A(2) increases pulmonary endothelial permeability through direct hydrolysis of the cell membrane.

Muñoz NM, Desai A, Meliton LN, Meliton AY, Zhou T, Leff AR, Dudek SM.

Pulm Circ. 2012 Apr-Jun;2(2):182-92. doi: 10.4103/2045-8932.97604.


Iloprost improves endothelial barrier function in lipopolysaccharide-induced lung injury.

Birukova AA, Wu T, Tian Y, Meliton A, Sarich N, Tian X, Leff A, Birukov KG.

Eur Respir J. 2013 Jan;41(1):165-76. doi: 10.1183/09031936.00148311. Epub 2012 Jul 12.


Stimulation of Rho signaling by pathologic mechanical stretch is a "second hit" to Rho-independent lung injury induced by IL-6.

Birukova AA, Tian Y, Meliton A, Leff A, Wu T, Birukov KG.

Am J Physiol Lung Cell Mol Physiol. 2012 May 1;302(9):L965-75. doi: 10.1152/ajplung.00292.2011. Epub 2012 Feb 17.


Inhibition of Pyk2 blocks lung inflammation and injury in a mouse model of acute lung injury.

Duan Y, Learoyd J, Meliton AY, Leff AR, Zhu X.

Respir Res. 2012 Jan 18;13:4. doi: 10.1186/1465-9921-13-4.


Group V phospholipase A2 mediates barrier disruption of human pulmonary endothelial cells caused by LPS in vitro.

Dudek SM, Muñoz NM, Desai A, Osan CM, Meliton AY, Leff AR.

Am J Respir Cell Mol Biol. 2011 Mar;44(3):361-8. doi: 10.1165/rcmb.2009-0446OC. Epub 2010 May 6.


Cytosolic group IVa phospholipase A2 mediates IL-8/CXCL8-induced transmigration of human polymorphonuclear leukocytes in vitro.

Meliton AY, Muñoz NM, Meliton LN, Binder DC, Osan CM, Zhu X, Dudek SM, Leff AR.

J Inflamm (Lond). 2010 Mar 18;7:14. doi: 10.1186/1476-9255-7-14.


Leukotriene D4 activates {beta}2-integrin adhesion in human polymorphonuclear leukocytes.

Meliton AY, Muñoz NM, Osan CM, Meliton LN, Leff AR.

Eur Respir J. 2010 Feb;35(2):402-9. doi: 10.1183/09031936.00009309. Epub 2009 Aug 13.


Inhibition of Pyk2 blocks airway inflammation and hyperresponsiveness in a mouse model of asthma.

Duan Y, Learoyd J, Meliton AY, Clay BS, Leff AR, Zhu X.

Am J Respir Cell Mol Biol. 2010 Apr;42(4):491-7. doi: 10.1165/rcmb.2008-0469OC. Epub 2009 Jun 11.


Secretory group V phospholipase A2 regulates acute lung injury and neutrophilic inflammation caused by LPS in mice.

Muñoz NM, Meliton AY, Meliton LN, Dudek SM, Leff AR.

Am J Physiol Lung Cell Mol Physiol. 2009 Jun;296(6):L879-87. doi: 10.1152/ajplung.90580.2008. Epub 2009 Mar 13.


Pulmonary mastocytosis and enhanced lung inflammation in mice heterozygous null for the Foxf1 gene.

Kalin TV, Meliton L, Meliton AY, Zhu X, Whitsett JA, Kalinichenko VV.

Am J Respir Cell Mol Biol. 2008 Oct;39(4):390-9. doi: 10.1165/rcmb.2008-0044OC. Epub 2008 Apr 17.


Blockade of avidity and focal clustering of beta 2-integrin by cysteinyl leukotriene antagonism attenuates eosinophil adhesion.

Meliton AY, Munoz NM, Leff AR.

J Allergy Clin Immunol. 2007 Dec;120(6):1316-23. Epub 2007 Sep 29.


Deletion of secretory group V phospholipase A2 attenuates cell migration and airway hyperresponsiveness in immunosensitized mice.

Muñoz NM, Meliton AY, Arm JP, Bonventre JV, Cho W, Leff AR.

J Immunol. 2007 Oct 1;179(7):4800-7.


Phosphodiesterase 4 inhibition of beta2-integrin adhesion caused by leukotriene B4 and TNF-alpha in human neutrophils.

Meliton AY, Muñoz NM, Lambertino A, Boetticher E, Learoyd J, Zhu X, Leff AR.

Eur Respir J. 2006 Nov;28(5):920-8. Epub 2006 Jun 28.


Transcellular secretion of group V phospholipase A2 from epithelium induces beta 2-integrin-mediated adhesion and synthesis of leukotriene C4 in eosinophils.

Muñoz NM, Meliton AY, Lambertino A, Boetticher E, Learoyd J, Sultan F, Zhu X, Cho W, Leff AR.

J Immunol. 2006 Jul 1;177(1):574-82.


Regulation of interleukin-5-induced beta2-integrin adhesion of human eosinophils by phosphoinositide 3-kinase.

Sano M, Leff AR, Myou S, Boetticher E, Meliton AY, Learoyd J, Lambertino AT, Munoz NM, Zhu X.

Am J Respir Cell Mol Biol. 2005 Jul;33(1):65-70. Epub 2005 Mar 31.


Glucocorticoid-induced surface expression of annexin 1 blocks beta2-integrin adhesion of human eosinophils to intercellular adhesion molecule 1 surrogate protein.

Liu J, Zhu X, Myo S, Lambertino AT, Xu C, Boetticher E, Muñoz NM, Sano M, Cordoba M, Learoyd J, Meliton A, Johnson M, Leff AR.

J Allergy Clin Immunol. 2005 Mar;115(3):493-500.


Beta2-integrin adhesion caused by eotaxin but not IL-5 is blocked by PDE-4 inhibition and beta2-adrenoceptor activation in human eosinophils.

Liu J, Muñoz NM, Meliton AY, Zhu X, Lambertino AT, Xu C, Myo S, Myou S, Boetticher E, Johnson M, Leff AR.

Pulm Pharmacol Ther. 2004;17(2):73-9.


Additive blockade of beta 2-integrin adhesion of eosinophils by salmeterol and fluticasone propionate.

Myo S, Zhu X, Myou S, Meliton AY, Liu J, Boetticher E, Lambertino AT, Xu C, Muñoz NM, Leff AR.

Eur Respir J. 2004 Apr;23(4):511-7.


Blockade of inflammation and airway hyperresponsiveness in immune-sensitized mice by dominant-negative phosphoinositide 3-kinase-TAT.

Myou S, Leff AR, Myo S, Boetticher E, Tong J, Meliton AY, Liu J, Munoz NM, Zhu X.

J Exp Med. 2003 Nov 17;198(10):1573-82.


Activation of group IV cytosolic phospholipase A2 in human eosinophils by phosphoinositide 3-kinase through a mitogen-activated protein kinase-independent pathway.

Myou S, Leff AR, Myo S, Boetticher E, Meliton AY, Lambertino AT, Liu J, Xu C, Munoz NM, Zhu X.

J Immunol. 2003 Oct 15;171(8):4399-405.


Blockade of airway inflammation and hyperresponsiveness by HIV-TAT-dominant negative Ras.

Myou S, Zhu X, Myo S, Boetticher E, Meliton AY, Liu J, Munoz NM, Leff AR.

J Immunol. 2003 Oct 15;171(8):4379-84.


Blockade of LTC4 synthesis caused by additive inhibition of gIV-PLA2 phosphorylation: Effect of salmeterol and PDE4 inhibition in human eosinophils.

Meliton AY, Muñoz NM, Liu J, Lambertino AT, Boetticher E, Myo S, Myou S, Zhu X, Johnson M, Leff AR.

J Allergy Clin Immunol. 2003 Aug;112(2):404-10.


Human group V phospholipase A2 induces group IVA phospholipase A2-independent cysteinyl leukotriene synthesis in human eosinophils.

Muñoz NM, Kim YJ, Meliton AY, Kim KP, Han SK, Boetticher E, O'Leary E, Myou S, Zhu X, Bonventre JV, Leff AR, Cho W.

J Biol Chem. 2003 Oct 3;278(40):38813-20. Epub 2003 Jun 9.


IL-5-induced integrin adhesion of human eosinophils caused by ERK1/2-mediated activation of cPLA2.

Zhu X, Jacobs B, Boetticher E, Myou S, Meliton A, Sano H, Lambertino AT, Muñoz NM, Leff AR.

J Leukoc Biol. 2002 Nov;72(5):1046-53.


Regulation of adhesion of AML14.3D10 cells by surface clustering of beta2-integrin caused by ERK-independent activation of cPLA2.

Myou S, Zhu X, Boetticher E, Qin Y, Myo S, Meliton A, Lambertino A, Munoz NM, Hamann KJ, Leff AR.

Immunology. 2002 Sep;107(1):77-85.


Quantitation of secretory group V phospholipase A(2) in human tissues by sandwich enzyme-linked immunosorbent assay.

Muñoz NM, Boetticher E, Sperling AI, Kim KP, Meliton AY, Zhu X, Lambertino A, Cho W, Leff AR.

J Immunol Methods. 2002 Apr 1;262(1-2):41-51.


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