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Understanding and predicting the longitudinal course of dementia.

Melis RJF, Haaksma ML, Muniz-Terrera G.

Curr Opin Psychiatry. 2019 Jan 7. doi: 10.1097/YCO.0000000000000482. [Epub ahead of print]


The clinical course and interrelations of dementia related symptoms - CORRIGENDUM.

Haaksma ML, Leoutsakos JS, Bremer JAE, Aalten P, Ramakers IHGB, Verhey FRJ, Olde Rikkert MGM, Melis RJF.

Int Psychogeriatr. 2018 Dec 6:1. doi: 10.1017/S1041610218001771. [Epub ahead of print] No abstract available.


Frailty, multimorbidity and functional status as predictors for health outcomes of acute psychiatric hospitalisation in older adults.

Benraad CEM, Disselhorst L, Laurenssen NCW, Hilderink PH, Melis RJF, Spijker J, Olde Rikkert MGM.

Aging Ment Health. 2018 Nov 18:1-10. doi: 10.1080/13607863.2018.1515888. [Epub ahead of print]


Quantifying resilience of humans and other animals.

Scheffer M, Bolhuis JE, Borsboom D, Buchman TG, Gijzel SMW, Goulson D, Kammenga JE, Kemp B, van de Leemput IA, Levin S, Martin CM, Melis RJF, van Nes EH, Romero LM, Olde Rikkert MGM.

Proc Natl Acad Sci U S A. 2018 Nov 20;115(47):11883-11890. doi: 10.1073/pnas.1810630115. Epub 2018 Oct 29.


Development of a Patient-Reported Outcome Measure for Geriatric Care: The Older Persons and Informal Caregivers Survey Short Form.

Santoso AMM, Lutomski JE, Hofman CS, Metzelthin SF, Blom JW, van der Wees PJ, Olde Rikkert MGM, Melis RJF; TOPICS-MDS Consortium.

Value Health. 2018 Oct;21(10):1198-1204. doi: 10.1016/j.jval.2018.02.011. Epub 2018 Apr 11.


The Impact of Frailty and Comorbidity on Institutionalization and Mortality in Persons With Dementia: A Prospective Cohort Study.

Haaksma ML, Rizzuto D, Ramakers IHGB, Garcia-Ptacek S, Marengoni A, van der Flier WM, Verhey FRJ, Olde Rikkert MGM, Melis RJF.

J Am Med Dir Assoc. 2018 Aug 23. pii: S1525-8610(18)30358-X. doi: 10.1016/j.jamda.2018.06.020. [Epub ahead of print]


Ethnic differences in frailty: a cross-sectional study of pooled data from community-dwelling older persons in the Netherlands.

Franse CB, van Grieken A, Qin L, Melis RJF, Rietjens JAC, Raat H.

BMJ Open. 2018 Aug 8;8(8):e022241. doi: 10.1136/bmjopen-2018-022241.


Dynamical indicators of resilience in postural balance time series are related to successful aging in high-functioning older adults.

Gijzel SMW, van de Leemput IA, Scheffer M, van Bon GEA, Weerdesteyn V, Eijsvogels TMH, Hopman MTE, Olde Rikkert MGM, Melis RJF.

J Gerontol A Biol Sci Med Sci. 2018 Jul 25. doi: 10.1093/gerona/gly170. [Epub ahead of print]


Longitudinal multiple case study on effectiveness of network-based dementia care towards more integration, quality of care, and collaboration in primary care.

Richters A, Nieuwboer MS, Olde Rikkert MGM, Melis RJF, Perry M, van der Marck MA.

PLoS One. 2018 Jun 27;13(6):e0198811. doi: 10.1371/journal.pone.0198811. eCollection 2018.


Cognitive and functional progression in Alzheimer disease: A prediction model of latent classes.

Haaksma ML, Calderón-Larrañaga A, Olde Rikkert MGM, Melis RJF, Leoutsakos JS.

Int J Geriatr Psychiatry. 2018 Aug;33(8):1057-1064. doi: 10.1002/gps.4893. Epub 2018 May 15.


Correction: Examining the construct and known-group validity of a composite endpoint for The Older Persons and Informal Caregivers Survey Minimum Data Set (TOPICS-MDS); A large-scale data sharing initiative.

Hofman CS, Lutomski JE, Boter H, Buurman BM, de Craen AJM, Donders R, Olde Rikkert MGM, Makai P, Melis RJF; TOPICS-MDS research consortium.

PLoS One. 2018 Apr 23;13(4):e0196316. doi: 10.1371/journal.pone.0196316. eCollection 2018.


Archaeology and ichnology at Gombore II-2, Melka Kunture, Ethiopia: everyday life of a mixed-age hominin group 700,000 years ago.

Altamura F, Bennett MR, D'Août K, Gaudzinski-Windheuser S, Melis RT, Reynolds SC, Mussi M.

Sci Rep. 2018 Feb 12;8(1):2815. doi: 10.1038/s41598-018-21158-7.


Unravelling complex primary-care programs to maintain independent living in older people: a systematic overview.

Smit LC, Schuurmans MJ, Blom JW, Fabbricotti IN, Jansen APD, Kempen GIJM, Koopmans R, Looman WM, Melis RJF, Metzelthin SF, Moll van Charante EP, Muntinga ME, Ruikes FGH, Spoorenberg SLW, Suijker JJ, Wynia K, Gussekloo J, De Wit NJ, Bleijenberg N.

J Clin Epidemiol. 2018 Apr;96:110-119. doi: 10.1016/j.jclinepi.2017.12.013. Epub 2017 Dec 28.


Frailty and quality of life among older people with and without a cancer diagnosis: Findings from TOPICS-MDS.

Geessink N, Schoon Y, van Goor H, Olde Rikkert M, Melis R; TOPICS-MDS consortium.

PLoS One. 2017 Dec 15;12(12):e0189648. doi: 10.1371/journal.pone.0189648. eCollection 2017.


Genetic inheritance of pulp colour and selected traits of cassava (Manihot esculenta Crantz) at early generation selection.

Nduwumuremyi A, Melis R, Shanahan P, Theodore A.

J Sci Food Agric. 2018 Jun;98(8):3190-3197. doi: 10.1002/jsfa.8825. Epub 2018 Jan 16.


On evidence-based medicine.

van der Marck MA, Melis RJF, Rikkert MGMO.

Lancet. 2017 Nov 18;390(10109):2244-2245. doi: 10.1016/S0140-6736(17)32851-9. No abstract available.


Socioeconomic inequalities in frailty and frailty components among community-dwelling older citizens.

Franse CB, van Grieken A, Qin L, Melis RJF, Rietjens JAC, Raat H.

PLoS One. 2017 Nov 9;12(11):e0187946. doi: 10.1371/journal.pone.0187946. eCollection 2017.


[Patient reported outcome measures in geriatric care: first experiences].

Hems M, Harkes M, Moret-Hartman M, Melis RJF, Schoon Y.

Tijdschr Gerontol Geriatr. 2017 Dec;48(6):287-296. doi: 10.1007/s12439-017-0237-1. Dutch.


Holocene sea ice variability driven by wind and polynya efficiency in the Ross Sea.

Mezgec K, Stenni B, Crosta X, Masson-Delmotte V, Baroni C, Braida M, Ciardini V, Colizza E, Melis R, Salvatore MC, Severi M, Scarchilli C, Traversi R, Udisti R, Frezzotti M.

Nat Commun. 2017 Nov 6;8(1):1334. doi: 10.1038/s41467-017-01455-x.


[Dementia: growing disaster or declining epidemic?]

Haaksma ML, Claassen JAHR, Olde Rikkert MGM, Melis RJF.

Ned Tijdschr Geneeskd. 2017;161:D2016. Review. Dutch.


Responsiveness of the full-length and short form of The Older Persons and Informal Caregivers Survey.

Lutomski JE, Santoso AMM, Hofman CS, Olde Rikkert MGM, Melis RJF.

J Am Med Dir Assoc. 2017 Sep 1;18(9):804-805. doi: 10.1016/j.jamda.2017.06.026. No abstract available.


Reply to: Function but not Multimorbidity at the Cornerstone of Geriatric Medicine.

Rizzuto D, Melis RJF, Marengoni A.

J Am Geriatr Soc. 2017 Oct;65(10):2334-2335. doi: 10.1111/jgs.15028. Epub 2017 Aug 22. No abstract available.


Quasi-experimental study designs: making a case for non-experimental designs in the spectrum.

Richters A, Melis RJF.

J Clin Epidemiol. 2017 Nov;91:146. doi: 10.1016/j.jclinepi.2017.07.012. Epub 2017 Aug 9. No abstract available.


Breaking the mirror: l-Amino acid deaminase, a novel stereoselective biocatalyst.

Molla G, Melis R, Pollegioni L.

Biotechnol Adv. 2017 Nov 1;35(6):657-668. doi: 10.1016/j.biotechadv.2017.07.011. Epub 2017 Aug 3. Review.


Evaluation of DementiaNet, a network-based primary care innovation for community-dwelling patients with dementia: protocol for a longitudinal mixed methods multiple case study.

Richters A, Nieuwboer MS, Perry M, Olde Rikkert MGM, Melis RJF, van der Marck MA.

BMJ Open. 2017 Aug 4;7(8):e016433. doi: 10.1136/bmjopen-2017-016433.


The role of fatty acids and triglycerides in the gonads of Paracentrotus lividus from Sardinia: Growth, reproduction and cold acclimatization.

Sanna R, Siliani S, Melis R, Loi B, Baroli M, Roggio T, Uzzau S, Anedda R.

Mar Environ Res. 2017 Sep;130:113-121. doi: 10.1016/j.marenvres.2017.07.003. Epub 2017 Jul 8.


Dynamical Resilience Indicators in Time Series of Self-Rated Health Correspond to Frailty Levels in Older Adults.

Gijzel SMW, van de Leemput IA, Scheffer M, Roppolo M, Olde Rikkert MGM, Melis RJF.

J Gerontol A Biol Sci Med Sci. 2017 Jul 1;72(7):991-996. doi: 10.1093/gerona/glx065.


Comorbidity and progression of late onset Alzheimer's disease: A systematic review.

Haaksma ML, Vilela LR, Marengoni A, Calderón-Larrañaga A, Leoutsakos JS, Olde Rikkert MGM, Melis RJF.

PLoS One. 2017 May 4;12(5):e0177044. doi: 10.1371/journal.pone.0177044. eCollection 2017. Review.


Perseverance time of informal caregivers for people with dementia: construct validity, responsiveness and predictive validity.

Richters A, Melis RJ, van Exel NJ, Olde Rikkert MG, van der Marck MA.

Alzheimers Res Ther. 2017 Apr 4;9(1):26. doi: 10.1186/s13195-017-0251-0.


Effect of Chronic Diseases and Multimorbidity on Survival and Functioning in Elderly Adults.

Rizzuto D, Melis RJF, Angleman S, Qiu C, Marengoni A.

J Am Geriatr Soc. 2017 May;65(5):1056-1060. doi: 10.1111/jgs.14868. Epub 2017 Mar 17.


Examining the construct and known-group validity of a composite endpoint for The Older Persons and Informal Caregivers Survey Minimum Data Set (TOPICS-MDS); A large-scale data sharing initiative.

Hofman CS, Lutomski JE, Boter H, Buurman BM, de Craen AJ, Donders R, Olde Rikkert MG, Makai P, Melis RJ; TOPICS-MDS research consortium.

PLoS One. 2017 Mar 15;12(3):e0173081. doi: 10.1371/journal.pone.0173081. eCollection 2017. Erratum in: PLoS One. 2018 Apr 23;13(4):e0196316.


The clinical course and interrelations of dementia related symptoms.

Haaksma ML, Leoutsakos JS, Bremer JAE, Aalten P, Ramakers IHGB, Verhey FRJ, Olde Rikkert MGM, Melis RJF.

Int Psychogeriatr. 2018 Jun;30(6):859-866. doi: 10.1017/S1041610217000321. Epub 2017 Mar 13.


Measurement properties of the EQ-5D across four major geriatric conditions: Findings from TOPICS-MDS.

Lutomski JE, Krabbe PF, Bleijenberg N, Blom J, Kempen GI, MacNeil-Vroomen J, Muntinga ME, Steyerburg E, Olde-Rikkert MG, Melis RJ; TOPICS Consortium.

Health Qual Life Outcomes. 2017 Mar 3;15(1):45. doi: 10.1186/s12955-017-0616-x.


Gait Speed and Grip Strength Reflect Cognitive Impairment and Are Modestly Related to Incident Cognitive Decline in Memory Clinic Patients With Subjective Cognitive Decline and Mild Cognitive Impairment: Findings From the 4C Study.

Hooghiemstra AM, Ramakers IHGB, Sistermans N, Pijnenburg YAL, Aalten P, Hamel REG, Melis RJF, Verhey FRJ, Olde Rikkert MGM, Scheltens P, van der Flier WM; 4C Study Group.

J Gerontol A Biol Sci Med Sci. 2017 Jun 1;72(6):846-854. doi: 10.1093/gerona/glx003.


Moving beyond multimorbidity as a simple count of diseases.

Melis RJ, Gijzel SM, Olde Rikkert MG.

J Eval Clin Pract. 2017 Feb;23(1):216-218. doi: 10.1111/jep.12693. Epub 2017 Jan 4. No abstract available.


Assessing and Measuring Chronic Multimorbidity in the Older Population: A Proposal for Its Operationalization.

Calderón-Larrañaga A, Vetrano DL, Onder G, Gimeno-Feliu LA, Coscollar-Santaliestra C, Carfí A, Pisciotta MS, Angleman S, Melis RJF, Santoni G, Mangialasche F, Rizzuto D, Welmer AK, Bernabei R, Prados-Torres A, Marengoni A, Fratiglioni L.

J Gerontol A Biol Sci Med Sci. 2017 Oct 1;72(10):1417-1423. doi: 10.1093/gerona/glw233.


A profile of The Clinical Course of Cognition and Comorbidity in Mild Cognitive Impairment and Dementia Study (The 4C study): two complementary longitudinal, clinical cohorts in the Netherlands.

Liao W, Hamel RE, Olde Rikkert MG, Oosterveld SM, Aalten P, Verhey FR, Scheltens P, Sistermans N, Pijnenburg YA, van der Flier WM, Ramakers IH, Melis RJ.

BMC Neurol. 2016 Nov 25;16(1):242.


Criterion Validity of a Frailty Index Derived from the Easycare Instrument.

Geessink NH, Schoon Y, Olde Rikkert MG, Melis RJ.

J Am Geriatr Soc. 2017 Jan;65(1):222-224. doi: 10.1111/jgs.14546. Epub 2016 Nov 23. No abstract available.


Molecular details on gilthead sea bream (Sparus aurata) sensitivity to low water temperatures from 1H NMR metabolomics.

Melis R, Sanna R, Braca A, Bonaglini E, Cappuccinelli R, Slawski H, Roggio T, Uzzau S, Anedda R.

Comp Biochem Physiol A Mol Integr Physiol. 2017 Feb;204:129-136. doi: 10.1016/j.cbpa.2016.11.010. Epub 2016 Nov 19.


Examining Consistency Between Self-Assessed and Peer-Rated Quality of Life in Older Persons.

Hofman CS, Lutomski JE, Olde Rikkert MG, Melis RJ, Donders AR.

J Am Geriatr Soc. 2016 Oct;64(10):e104-e105. doi: 10.1111/jgs.14358. Epub 2016 Oct 6. No abstract available.


Strategies to Improve Medication Adherence in Older Persons: Consensus Statement from the Senior Italia Federanziani Advisory Board.

Marengoni A, Monaco A, Costa E, Cherubini A, Prados-Torres A, Muth C, Melis RJ, Pasina L, van der Cammen TJ, Palmer K, Pecorelli S, Onder G.

Drugs Aging. 2016 Sep;33(9):629-37. doi: 10.1007/s40266-016-0387-9.


The International Dementia Alliance Instrument for Feasible and Valid Staging of Individuals with Dementia by Informal Caregivers.

Richters A, Melis RJ, Olde Rikkert MG, van der Marck MA.

J Am Geriatr Soc. 2016 Aug;64(8):1674-8. doi: 10.1111/jgs.14205. Epub 2016 Jun 15.


Perseverance Time of Informal Caregivers for Institutionalized Elderly: Construct Validity and Test-Retest Reliability of a Single-Question Instrument.

Richters A, Olde Rikkert MG, van Exel NJ, Melis RJ, van der Marck MA.

J Am Med Dir Assoc. 2016 Aug 1;17(8):761-2. doi: 10.1016/j.jamda.2016.05.001. Epub 2016 Jun 11. No abstract available.


Multigene and Drug Interaction Approach for Tamoxifen Metabolite Patterns Reveals Possible Involvement of CYP2C9, CYP2C19, and ABCB1.

Powers JL, Buys SS, Fletcher D, Melis R, Johnson-Davis KL, Lyon E, Malmberg EM, McMillin GA.

J Clin Pharmacol. 2016 Dec;56(12):1570-1581. doi: 10.1002/jcph.771. Epub 2016 Jun 21.


Sister chromatid exchange test in river buffalo lymphocytes treated in vitro with furocoumarin extracts.

Iannuzzi A, Perucatti A, Genualdo V, Pauciullo A, Melis R, Porqueddu C, Marchetti M, Usai M, Iannuzzi L.

Mutagenesis. 2016 Sep;31(5):547-51. doi: 10.1093/mutage/gew022. Epub 2016 May 14.


Multimorbidity: Epidemiology and Models of Care.

Marengoni A, Melis RJ, Prados Torres A, Onder G.

Biomed Res Int. 2016;2016:7029027. doi: 10.1155/2016/7029027. Epub 2016 Mar 27. No abstract available.


Defeating Alzheimer's disease and other dementias: a priority for European science and society.

Winblad B, Amouyel P, Andrieu S, Ballard C, Brayne C, Brodaty H, Cedazo-Minguez A, Dubois B, Edvardsson D, Feldman H, Fratiglioni L, Frisoni GB, Gauthier S, Georges J, Graff C, Iqbal K, Jessen F, Johansson G, Jönsson L, Kivipelto M, Knapp M, Mangialasche F, Melis R, Nordberg A, Rikkert MO, Qiu C, Sakmar TP, Scheltens P, Schneider LS, Sperling R, Tjernberg LO, Waldemar G, Wimo A, Zetterberg H.

Lancet Neurol. 2016 Apr;15(5):455-532. doi: 10.1016/S1474-4422(16)00062-4. Review. No abstract available.


Coexisting chronic conditions in the older population: Variation by health indicators.

Marengoni A, Angleman S, Meinow B, Santoni G, Mangialasche F, Rizzuto D, Fastbom J, Melis R, Parker M, Johnell K, Fratiglioni L.

Eur J Intern Med. 2016 Jun;31:29-34. doi: 10.1016/j.ejim.2016.02.014. Epub 2016 Mar 2.


Comparison of different microbial laccases as tools for industrial uses.

Tonin F, Melis R, Cordes A, Sanchez-Amat A, Pollegioni L, Rosini E.

N Biotechnol. 2016 May 25;33(3):387-98. doi: 10.1016/j.nbt.2016.01.007. Epub 2016 Feb 1.


Prevalence of Comorbidity in Patients With Young-Onset Alzheimer Disease Compared With Late-Onset: A Comparative Cohort Study.

Gerritsen AA, Bakker C, Verhey FR, de Vugt ME, Melis RJ, Koopmans RT; 4C study team.

J Am Med Dir Assoc. 2016 Apr 1;17(4):318-23. doi: 10.1016/j.jamda.2015.11.011. Epub 2016 Jan 5.


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