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Items: 1 to 50 of 588

1.

Stearoyl CoA Desaturase Regulates Ferroptosis in Ovarian Cancer Offering New Therapeutic Perspectives.

Carbone M, Melino G.

Cancer Res. 2019 Oct 15;79(20):5149-5150. doi: 10.1158/0008-5472.CAN-19-2453.

PMID:
31615810
2.

HECT-Type E3 Ubiquitin Ligases in Cancer.

Bernassola F, Chillemi G, Melino G.

Trends Biochem Sci. 2019 Oct 11. pii: S0968-0004(19)30180-X. doi: 10.1016/j.tibs.2019.08.004. [Epub ahead of print] Review.

PMID:
31610939
3.

ZNF281 is recruited on DNA breaks to facilitate DNA repair by non-homologous end joining.

Nicolai S, Mahen R, Raschellà G, Marini A, Pieraccioli M, Malewicz M, Venkitaraman AR, Melino G.

Oncogene. 2019 Sep 30. doi: 10.1038/s41388-019-1028-7. [Epub ahead of print]

PMID:
31570788
4.

Lipid metabolism offers anticancer treatment by regulating ferroptosis.

Carbone M, Melino G.

Cell Death Differ. 2019 Sep 23. doi: 10.1038/s41418-019-0418-2. [Epub ahead of print] No abstract available.

PMID:
31543514
5.

Emerging roles of HECT-type E3 ubiquitin ligases in autophagy regulation.

Melino G, Cecconi F, Pelicci PG, Mak TW, Bernassola F.

Mol Oncol. 2019 Oct;13(10):2033-2048. doi: 10.1002/1878-0261.12567. Epub 2019 Sep 5. Review.

6.

A novel oral micellar fenretinide formulation with enhanced bioavailability and antitumour activity against multiple tumours from cancer stem cells.

Orienti I, Salvati V, Sette G, Zucchetti M, Bongiorno-Borbone L, Peschiaroli A, Zolla L, Francescangeli F, Ferrari M, Matteo C, Bello E, Di Virgilio A, Falchi M, De Angelis ML, Baiocchi M, Melino G, De Maria R, Zeuner A, Eramo A.

J Exp Clin Cancer Res. 2019 Aug 22;38(1):373. doi: 10.1186/s13046-019-1383-9.

7.

HUWE1 controls MCL1 stability to unleash AMBRA1-induced mitophagy.

Strappazzon F, Di Rita A, Peschiaroli A, Leoncini PP, Locatelli F, Melino G, Cecconi F.

Cell Death Differ. 2019 Aug 21. doi: 10.1038/s41418-019-0404-8. [Epub ahead of print]

PMID:
31434979
8.

Skin immunity and its dysregulation in psoriasis.

Lanna C, Mancini M, Gaziano R, Cannizzaro MV, Galluzzo M, Talamonti M, Rovella V, Annicchiarico-Petruzzelli M, Melino G, Wang Y, Shi Y, Campione E, Bianchi L.

Cell Cycle. 2019 Oct;18(20):2581-2589. doi: 10.1080/15384101.2019.1653099. Epub 2019 Aug 15.

PMID:
31416396
9.

ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP.

Bufalieri F, Infante P, Bernardi F, Caimano M, Romania P, Moretti M, Lospinoso Severini L, Talbot J, Melaiu O, Tanori M, Di Magno L, Bellavia D, Capalbo C, Puget S, De Smaele E, Canettieri G, Guardavaccaro D, Busino L, Peschiaroli A, Pazzaglia S, Giannini G, Melino G, Locatelli F, Gulino A, Ayrault O, Fruci D, Di Marcotullio L.

Nat Commun. 2019 Jul 24;10(1):3304. doi: 10.1038/s41467-019-11093-0.

10.

A new bioavailable fenretinide formulation with antiproliferative, antimetabolic, and cytotoxic effects on solid tumors.

Orienti I, Francescangeli F, De Angelis ML, Fecchi K, Bongiorno-Borbone L, Signore M, Peschiaroli A, Boe A, Bruselles A, Costantino A, Eramo A, Salvati V, Sette G, Contavalli P, Zolla L, Oki T, Kitamura T, Spada M, Giuliani A, Baiocchi M, La Torre F, Melino G, Tartaglia M, De Maria R, Zeuner A.

Cell Death Dis. 2019 Jul 23;10(7):529. doi: 10.1038/s41419-019-1775-y.

11.

Developmental programming of adult haematopoiesis system.

Balistreri CR, Garagnani P, Madonna R, Vaiserman A, Melino G.

Ageing Res Rev. 2019 Sep;54:100918. doi: 10.1016/j.arr.2019.100918. Epub 2019 Jun 19. Review.

PMID:
31226498
12.

Correction: Negative Regulation of the Hippo Pathway by E3 Ubiquitin Ligase ITCH Is Sufficient to Promote Tumorigenicity.

Salah Z, Melino G, Aqeilan RI.

Cancer Res. 2019 Jun 1;79(11):3007. doi: 10.1158/0008-5472.CAN-19-1086. No abstract available.

PMID:
31160310
13.

Luteolin-7-O-β-d-Glucoside Inhibits Cellular Energy Production Interacting with HEK2 in Keratinocytes.

Palombo R, Caporali S, Falconi M, Iacovelli F, Morozzo Della Rocca B, Lo Surdo A, Campione E, Candi E, Melino G, Bernardini S, Terrinoni A.

Int J Mol Sci. 2019 May 31;20(11). pii: E2689. doi: 10.3390/ijms20112689.

14.

p63 at the Crossroads between Stemness and Metastasis in Breast Cancer.

Gatti V, Bongiorno-Borbone L, Fierro C, Annicchiarico-Petruzzelli M, Melino G, Peschiaroli A.

Int J Mol Sci. 2019 May 31;20(11). pii: E2683. doi: 10.3390/ijms20112683. Review.

15.

Smyd2 conformational changes in response to p53 binding: role of the C-terminal domain.

Chandramouli B, Melino G, Chillemi G.

Mol Oncol. 2019 Jun;13(6):1450-1461. doi: 10.1002/1878-0261.12502. Epub 2019 May 21.

16.

Single cell transcriptomic analysis of human mesenchymal stem cells reveals limited heterogeneity.

Huang Y, Li Q, Zhang K, Hu M, Wang Y, Du L, Lin L, Li S, Sorokin L, Melino G, Shi Y, Wang Y.

Cell Death Dis. 2019 May 8;10(5):368. doi: 10.1038/s41419-019-1583-4.

17.

ΔNp63 in squamous cell carcinoma: defining the oncogenic routes affecting epigenetic landscape and tumour microenvironment.

Gatti V, Fierro C, Annicchiarico-Petruzzelli M, Melino G, Peschiaroli A.

Mol Oncol. 2019 May;13(5):981-1001. doi: 10.1002/1878-0261.12473. Epub 2019 Mar 22. Review.

18.

ΔNp63 promotes IGF1 signalling through IRS1 in squamous cell carcinoma.

Frezza V, Fierro C, Gatti E, Peschiaroli A, Lena AM, Petruzzelli MA, Candi E, Anemona L, Mauriello A, Pelicci PG, Melino G, Bernassola F.

Aging (Albany NY). 2018 Dec 28;10(12):4224-4240. doi: 10.18632/aging.101725.

19.

Cell death pathologies: targeting death pathways and the immune system for cancer therapy.

Pentimalli F, Grelli S, Di Daniele N, Melino G, Amelio I.

Genes Immun. 2019 Sep;20(7):539-554. doi: 10.1038/s41435-018-0052-x. Epub 2018 Dec 19. Review.

20.

TAp73 regulates ATP7A: possible implications for ageing-related diseases.

Lopriore P, Capitanio N, Panatta E, Di Daniele N, Gambacurta A, Melino G, Amelio I.

Aging (Albany NY). 2018 Dec 8;10(12):3745-3760. doi: 10.18632/aging.101669.

21.

Sustained protein synthesis and reduced eEF2K levels in TAp73-\- mice brain: a possible compensatory mechanism.

Rotblat B, Agostini M, Niklison-Chirou MV, Amelio I, Willis AE, Melino G.

Cell Cycle. 2018;17(23):2637-2643. doi: 10.1080/15384101.2018.1553341. Epub 2018 Dec 4.

PMID:
30507330
22.

Myoblasts rely on TAp63 to control basal mitochondria respiration.

Ciuffoli V, Lena AM, Gambacurta A, Melino G, Candi E.

Aging (Albany NY). 2018 Nov 28;10(11):3558-3573. doi: 10.18632/aging.101668.

23.

Orphan receptor NR4A3 is a novel target of p53 that contributes to apoptosis.

Fedorova O, Petukhov A, Daks A, Shuvalov O, Leonova T, Vasileva E, Aksenov N, Melino G, Barlev NA.

Oncogene. 2019 Mar;38(12):2108-2122. doi: 10.1038/s41388-018-0566-8. Epub 2018 Nov 19.

PMID:
30455429
24.

ZNF185 is a p53 target gene following DNA damage.

Smirnov A, Cappello A, Lena AM, Anemona L, Mauriello A, Di Daniele N, Annicchiarico-Petruzzelli M, Melino G, Candi E.

Aging (Albany NY). 2018 Nov 16;10(11):3308-3326. doi: 10.18632/aging.101639.

25.

p53 mutants cooperate with HIF-1 in transcriptional regulation of extracellular matrix components to promote tumor progression.

Amelio I, Mancini M, Petrova V, Cairns RA, Vikhreva P, Nicolai S, Marini A, Antonov AA, Le Quesne J, Baena Acevedo JD, Dudek K, Sozzi G, Pastorino U, Knight RA, Mak TW, Melino G.

Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):E10869-E10878. doi: 10.1073/pnas.1808314115. Epub 2018 Oct 31.

26.

Erratum: Actin-binding protein alpha-actinin 4 (ACTN4) is a transcriptional co-activator of RelA/p65 sub-unit of NF-kB.

Aksenova V, Turoverova L, Khotin M, Magnusson KE, Tulchinsky E, Melino G, Pinaev GP, Barlev N, Tentler D.

Oncotarget. 2018 Sep 28;9(76):34450. doi: 10.18632/oncotarget.26206. eCollection 2018 Sep 28.

27.

Cell death in cancer in the era of precision medicine.

Raschellà G, Melino G, Gambacurta A.

Genes Immun. 2019 Sep;20(7):529-538. doi: 10.1038/s41435-018-0048-6. Epub 2018 Oct 19. Review.

PMID:
30341419
28.

ZNF185 is a p63 target gene critical for epidermal differentiation and squamous cell carcinoma development.

Smirnov A, Lena AM, Cappello A, Panatta E, Anemona L, Bischetti S, Annicchiarico-Petruzzelli M, Mauriello A, Melino G, Candi E.

Oncogene. 2019 Mar;38(10):1625-1638. doi: 10.1038/s41388-018-0509-4. Epub 2018 Oct 18.

29.

Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine.

Carbone M, Amelio I, Affar EB, Brugarolas J, Cannon-Albright LA, Cantley LC, Cavenee WK, Chen Z, Croce CM, Andrea A, Gandara D, Giorgi C, Jia W, Lan Q, Mak TW, Manley JL, Mikoshiba K, Onuchic JN, Pass HI, Pinton P, Prives C, Rothman N, Sebti SM, Turkson J, Wu X, Yang H, Yu H, Melino G.

Cell Death Differ. 2018 Nov;25(11):1885-1904. doi: 10.1038/s41418-018-0213-5. Epub 2018 Oct 15. Review.

PMID:
30323273
30.

HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα.

Di Rita A, Peschiaroli A, D Acunzo P, Strobbe D, Hu Z, Gruber J, Nygaard M, Lambrughi M, Melino G, Papaleo E, Dengjel J, El Alaoui S, Campanella M, Dötsch V, Rogov VV, Strappazzon F, Cecconi F.

Nat Commun. 2018 Sep 14;9(1):3755. doi: 10.1038/s41467-018-05722-3.

31.

The biological basis and clinical symptoms of CAR-T therapy-associated toxicites.

Titov A, Petukhov A, Staliarova A, Motorin D, Bulatov E, Shuvalov O, Soond SM, Piacentini M, Melino G, Zaritskey A, Barlev NA.

Cell Death Dis. 2018 Sep 4;9(9):897. doi: 10.1038/s41419-018-0918-x.

32.

ΔNp63 regulates the expression of hyaluronic acid-related genes in breast cancer cells.

Gatti V, Fierro C, Compagnone M, Giangrazi F, Markert EK, Bongiorno-Borbone L, Melino G, Peschiaroli A.

Oncogenesis. 2018 Aug 24;7(8):65. doi: 10.1038/s41389-018-0073-3.

33.

Novel isatin-derived molecules activate p53 via interference with Mdm2 to promote apoptosis.

Fedorova O, Daks A, Petrova V, Petukhov A, Lezina L, Shuvalov O, Davidovich P, Kriger D, Lomert E, Tentler D, Kartsev V, Uyanik B, Tribulovich V, Demidov O, Melino G, Barlev NA.

Cell Cycle. 2018;17(15):1917-1930. doi: 10.1080/15384101.2018.1506664. Epub 2018 Sep 5.

34.

Similar Domains for Different Regulations of p53 Family.

Amelio I, Melino G.

Structure. 2018 Aug 7;26(8):1047-1049. doi: 10.1016/j.str.2018.07.003.

35.

ZNF281 inhibits neuronal differentiation and is a prognostic marker for neuroblastoma.

Pieraccioli M, Nicolai S, Pitolli C, Agostini M, Antonov A, Malewicz M, Knight RA, Raschellà G, Melino G.

Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):7356-7361. doi: 10.1073/pnas.1801435115. Epub 2018 Jun 25.

36.

TAp73 contributes to the oxidative stress response by regulating protein synthesis.

Marini A, Rotblat B, Sbarrato T, Niklison-Chirou MV, Knight JRP, Dudek K, Jones C, Bushell M, Knight RA, Amelio I, Willis AE, Melino G.

Proc Natl Acad Sci U S A. 2018 Jun 12;115(24):6219-6224. doi: 10.1073/pnas.1718531115. Epub 2018 May 29.

37.

p73 Alternative Splicing: Exploring a Biological Role for the C-Terminal Isoforms.

Vikhreva P, Melino G, Amelio I.

J Mol Biol. 2018 Jun 22;430(13):1829-1838. doi: 10.1016/j.jmb.2018.04.034. Epub 2018 May 4. Review.

38.

Pir2/Rnf144b is a potential endometrial cancer biomarker that promotes cell proliferation.

Zhou Q, Eldakhakhny S, Conforti F, Crosbie EJ, Melino G, Sayan BS.

Cell Death Dis. 2018 May 1;9(5):504. doi: 10.1038/s41419-018-0521-1.

39.

Cold crystalloid versus warm blood cardioplegia in patients undergoing aortic valve replacement.

Nardi P, Vacirca SR, Russo M, Colella DF, Bassano C, Scafuri A, Pellegrino A, Melino G, Ruvolo G.

J Thorac Dis. 2018 Mar;10(3):1490-1499. doi: 10.21037/jtd.2018.03.67.

40.

Order must spring from chaos in Italian research.

Melino G.

Nature. 2018 Apr;556(7702):436. doi: 10.1038/d41586-018-04896-6. No abstract available.

PMID:
29695852
41.

Role of the keratin 1 and keratin 10 tails in the pathogenesis of ichthyosis hystrix of Curth Macklin.

Terrinoni A, Didona B, Caporali S, Chillemi G, Lo Surdo A, Paradisi M, Annichiarico-Petruzzelli M, Candi E, Bernardini S, Melino G.

PLoS One. 2018 Apr 24;13(4):e0195792. doi: 10.1371/journal.pone.0195792. eCollection 2018.

42.

Kruppel-like factor 4 regulates keratinocyte senescence.

Panatta E, Lena AM, Mancini M, Affinati M, Smirnov A, Annicchiarico-Petruzzelli M, Piro MC, Campione E, Bianchi L, Mazzanti C, Melino G, Candi E.

Biochem Biophys Res Commun. 2018 May 5;499(2):389-395. doi: 10.1016/j.bbrc.2018.03.172. Epub 2018 Mar 26.

PMID:
29580988
43.

Non-alcoholic fatty liver disease severity is modulated by transglutaminase type 2.

Piacentini M, Baiocchini A, Del Nonno F, Melino G, Barlev NA, Rossin F, D'Eletto M, Falasca L.

Cell Death Dis. 2018 Feb 15;9(3):257. doi: 10.1038/s41419-018-0292-8.

44.

Metabolic profiling of visceral adipose tissue from obese subjects with or without metabolic syndrome.

Candi E, Tesauro M, Cardillo C, Lena AM, Schinzari F, Rodia G, Sica G, Gentileschi P, Rovella V, Annicchiarico-Petruzzelli M, Di Daniele N, Melino G.

Biochem J. 2018 Mar 15;475(5):1019-1035. doi: 10.1042/BCJ20170604.

PMID:
29437994
45.

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G.

Cell Death Differ. 2018 Mar;25(3):486-541. doi: 10.1038/s41418-017-0012-4. Epub 2018 Jan 23. Review.

46.

The hypoxic tumour microenvironment.

Petrova V, Annicchiarico-Petruzzelli M, Melino G, Amelio I.

Oncogenesis. 2018 Jan 24;7(1):10. doi: 10.1038/s41389-017-0011-9. Review.

47.

Integrin-β4 is a novel transcriptional target of TAp73.

Xie N, Vikhreva P, Annicchiarico-Petruzzelli M, Amelio I, Barlev N, Knight RA, Melino G.

Cell Cycle. 2018;17(5):589-594. doi: 10.1080/15384101.2017.1403684. Epub 2018 Feb 8.

48.

Tissue regeneration: The crosstalk between mesenchymal stem cells and immune response.

Qi K, Li N, Zhang Z, Melino G.

Cell Immunol. 2018 Apr;326:86-93. doi: 10.1016/j.cellimm.2017.11.010. Epub 2017 Dec 2. Review.

PMID:
29221689
49.

The E3 ubiquitin ligase WWP1 sustains the growth of acute myeloid leukaemia.

Sanarico AG, Ronchini C, Croce A, Memmi EM, Cammarata UA, De Antoni A, Lavorgna S, Divona M, Giacò L, Melloni GEM, Brendolan A, Simonetti G, Martinelli G, Mancuso P, Bertolini F, Coco FL, Melino G, Pelicci PG, Bernassola F.

Leukemia. 2018 Apr;32(4):911-919. doi: 10.1038/leu.2017.342. Epub 2017 Dec 6.

50.

ΔNp63-mediated regulation of hyaluronic acid metabolism and signaling supports HNSCC tumorigenesis.

Compagnone M, Gatti V, Presutti D, Ruberti G, Fierro C, Markert EK, Vousden KH, Zhou H, Mauriello A, Anemone L, Bongiorno-Borbone L, Melino G, Peschiaroli A.

Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):13254-13259. doi: 10.1073/pnas.1711777114. Epub 2017 Nov 21.

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