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Items: 48


ColoGuidePro: a prognostic 7-gene expression signature for stage III colorectal cancer patients.

Sveen A, Ågesen TH, Nesbakken A, Meling GI, Rognum TO, Liestøl K, Skotheim RI, Lothe RA.

Clin Cancer Res. 2012 Nov 1;18(21):6001-10. doi: 10.1158/1078-0432.CCR-11-3302. Epub 2012 Sep 18.


Identification of an epigenetic biomarker panel with high sensitivity and specificity for colorectal cancer and adenomas.

Lind GE, Danielsen SA, Ahlquist T, Merok MA, Andresen K, Skotheim RI, Hektoen M, Rognum TO, Meling GI, Hoff G, Bretthauer M, Thiis-Evensen E, Nesbakken A, Lothe RA.

Mol Cancer. 2011 Jul 21;10:85. doi: 10.1186/1476-4598-10-85.


DNA methylation analyses of the connexin gene family reveal silencing of GJC1 (Connexin45) by promoter hypermethylation in colorectal cancer.

Sirnes S, Honne H, Ahmed D, Danielsen SA, Rognum TO, Meling GI, Leithe E, Rivedal E, Lothe RA, Lind GE.

Epigenetics. 2011 May;6(5):602-9. Epub 2011 May 1.


Gene methylation profiles of normal mucosa, and benign and malignant colorectal tumors identify early onset markers.

Ahlquist T, Lind GE, Costa VL, Meling GI, Vatn M, Hoff GS, Rognum TO, Skotheim RI, Thiis-Evensen E, Lothe RA.

Mol Cancer. 2008 Dec 31;7:94. doi: 10.1186/1476-4598-7-94.


Novel mutations of the suppressor gene PTEN in colorectal carcinomas stratified by microsatellite instability- and TP53 mutation- status.

Danielsen SA, Lind GE, Bjørnslett M, Meling GI, Rognum TO, Heim S, Lothe RA.

Hum Mutat. 2008 Nov;29(11):E252-62. doi: 10.1002/humu.20860. Erratum in: Hum Mutat. 2009 Jun;30(6):1023.


Lack of association between skewing of X-chromosome inactivation in blood cells and colorectal cancer.

Knudsen GP, Riegert-Johnson DL, Meling GI, Boardman LA, Orstavik KH.

Int J Biol Markers. 2008 Apr-Jun;23(2):127-8. No abstract available.


RAS signaling in colorectal carcinomas through alteration of RAS, RAF, NF1, and/or RASSF1A.

Ahlquist T, Bottillo I, Danielsen SA, Meling GI, Rognum TO, Lind GE, Dallapiccola B, Lothe RA.

Neoplasia. 2008 Jul;10(7):680-6, 2 p following 686.


Hypermethylated MAL gene - a silent marker of early colon tumorigenesis.

Lind GE, Ahlquist T, Kolberg M, Berg M, Eknaes M, Alonso MA, Kallioniemi A, Meling GI, Skotheim RI, Rognum TO, Thiis-Evensen E, Lothe RA.

J Transl Med. 2008 Mar 17;6:13. doi: 10.1186/1479-5876-6-13.


Gene expression profiles of primary colorectal carcinomas, liver metastases, and carcinomatoses.

Kleivi K, Lind GE, Diep CB, Meling GI, Brandal LT, Nesland JM, Myklebost O, Rognum TO, Giercksky KE, Skotheim RI, Lothe RA.

Mol Cancer. 2007 Jan 3;6:2.


ADAMTS1, CRABP1, and NR3C1 identified as epigenetically deregulated genes in colorectal tumorigenesis.

Lind GE, Kleivi K, Meling GI, Teixeira MR, Thiis-Evensen E, Rognum TO, Lothe RA.

Cell Oncol. 2006;28(5-6):259-72.


Functional categories of TP53 mutation in colorectal cancer: results of an International Collaborative Study.

Iacopetta B, Russo A, Bazan V, Dardanoni G, Gebbia N, Soussi T, Kerr D, Elsaleh H, Soong R, Kandioler D, Janschek E, Kappel S, Lung M, Leung CS, Ko JM, Yuen S, Ho J, Leung SY, Crapez E, Duffour J, Ychou M, Leahy DT, O'Donoghue DP, Agnese V, Cascio S, Di Fede G, Chieco-Bianchi L, Bertorelle R, Belluco C, Giaretti W, Castagnola P, Ricevuto E, Ficorella C, Bosari S, Arizzi CD, Miyaki M, Onda M, Kampman E, Diergaarde B, Royds J, Lothe RA, Diep CB, Meling GI, Ostrowski J, Trzeciak L, Guzinska-Ustymowicz K, Zalewski B, Capellá GM, Moreno V, Peinado MA, Lönnroth C, Lundholm K, Sun XF, Jansson A, Bouzourene H, Hsieh LL, Tang R, Smith DR, Allen-Mersh TG, Khan ZA, Shorthouse AJ, Silverman ML, Kato S, Ishioka C; TP53-CRC Collaborative Group.

Ann Oncol. 2006 May;17(5):842-7. Epub 2006 Mar 8.


Genetic and epigenetic changes of components affecting the WNT pathway in colorectal carcinomas stratified by microsatellite instability.

Thorstensen L, Lind GE, Løvig T, Diep CB, Meling GI, Rognum TO, Lothe RA.

Neoplasia. 2005 Feb;7(2):99-108.


Mitochondrial microsatellite instability in colorectal carcinomas--frequency and association with nuclear microsatellite instability.

Guleng G, Løvig T, Meling GI, Andersen SN, Rognum TO.

Cancer Lett. 2005 Feb 28;219(1):97-103.


A CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell lines.

Lind GE, Thorstensen L, Løvig T, Meling GI, Hamelin R, Rognum TO, Esteller M, Lothe RA.

Mol Cancer. 2004 Oct 11;3:28.


Immunofluorometric assay for the metastasis-related protein S100A4: release of S100A4 from normal blood cells prohibits the use of S100A4 as a tumor marker in plasma and serum.

Flatmark K, Maelandsmo GM, Mikalsen SO, Nustad K, Varaas T, Rasmussen H, Meling GI, Fodstad Ø, Paus E.

Tumour Biol. 2004 Jan-Apr;25(1-2):31-40.


Telomere instability detected in sporadic colon cancers, some showing mutations in a mismatch repair gene.

Pickett HA, Baird DM, Hoff-Olsen P, Meling GI, Rognum TO, Shaw J, West KP, Royle NJ.

Oncogene. 2004 Apr 22;23(19):3434-43.


Genetic tumor markers with prognostic impact in Dukes' stages B and C colorectal cancer patients.

Diep CB, Thorstensen L, Meling GI, Skovlund E, Rognum TO, Lothe RA.

J Clin Oncol. 2003 Mar 1;21(5):820-9.


The TP53 codon 72 polymorphism may affect the function of TP53 mutations in breast carcinomas but not in colorectal carcinomas.

Langerød A, Bukholm IR, Bregård A, Lønning PE, Andersen TI, Rognum TO, Meling GI, Lothe RA, Børresen-Dale AL.

Cancer Epidemiol Biomarkers Prev. 2002 Dec;11(12):1684-8.


APC and CTNNB1 mutations in a large series of sporadic colorectal carcinomas stratified by the microsatellite instability status.

Løvig T, Meling GI, Diep CB, Thorstensen L, Norheim Andersen S, Lothe RA, Rognum TO.

Scand J Gastroenterol. 2002 Oct;37(10):1184-93.


Strong HLA-DR expression in microsatellite stable carcinomas of the large bowel is associated with good prognosis.

Løvig T, Andersen SN, Thorstensen L, Diep CB, Meling GI, Lothe RA, Rognum TO.

Br J Cancer. 2002 Sep 23;87(7):756-62.


WNT1 inducible signaling pathway protein 3, WISP-3, a novel target gene in colorectal carcinomas with microsatellite instability.

Thorstensen L, Diep CB, Meling GI, Aagesen TH, Ahrens CH, Rognum TO, Lothe RA.

Gastroenterology. 2001 Dec;121(6):1275-80.


Gender difference for mismatch repair deficiency in human colorectal cancer.

Duval A, Iacopetta B, Thorstensen L, Meling GI, Lothe RA, Thuille B, Suraweera N, Thomas G, Hamelin R.

Gastroenterology. 2001 Oct;121(4):1026-7. No abstract available.


Kirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' study.

Andreyev HJ, Norman AR, Cunningham D, Oates J, Dix BR, Iacopetta BJ, Young J, Walsh T, Ward R, Hawkins N, Beranek M, Jandik P, Benamouzig R, Jullian E, Laurent-Puig P, Olschwang S, Muller O, Hoffmann I, Rabes HM, Zietz C, Troungos C, Valavanis C, Yuen ST, Ho JW, Croke CT, O'Donoghue DP, Giaretti W, Rapallo A, Russo A, Bazan V, Tanaka M, Omura K, Azuma T, Ohkusa T, Fujimori T, Ono Y, Pauly M, Faber C, Glaesener R, de Goeij AF, Arends JW, Andersen SN, Lövig T, Breivik J, Gaudernack G, Clausen OP, De Angelis PD, Meling GI, Rognum TO, Smith R, Goh HS, Font A, Rosell R, Sun XF, Zhang H, Benhattar J, Losi L, Lee JQ, Wang ST, Clarke PA, Bell S, Quirke P, Bubb VJ, Piris J, Cruickshank NR, Morton D, Fox JC, Al-Mulla F, Lees N, Hall CN, Snary D, Wilkinson K, Dillon D, Costa J, Pricolo VE, Finkelstein SD, Thebo JS, Senagore AJ, Halter SA, Wadler S, Malik S, Krtolica K, Urosevic N.

Br J Cancer. 2001 Sep 1;85(5):692-6.


Association of p53 accumulation with TP53 mutations, loss of heterozygosity at 17p13, and DNA ploidy status in 273 colorectal carcinomas.

Clausen OP, Lothe RA, Børresen-Dale AL, De Angelis P, Chen Y, Rognum TO, Meling GI.

Diagn Mol Pathol. 1998 Aug;7(4):215-23.


The APC gene I1307K variant is rare in Norwegian patients with familial and sporadic colorectal or breast cancer.

Lothe RA, Hektoen M, Johnsen H, Meling GI, Andersen TI, Rognum TO, Lindblom A, Børresen-Dale AL.

Cancer Res. 1998 Jul 15;58(14):2923-4.


TP53 and long-term prognosis in colorectal cancer: mutations in the L3 zinc-binding domain predict poor survival.

Børresen-Dale AL, Lothe RA, Meling GI, Hainaut P, Rognum TO, Skovlund E.

Clin Cancer Res. 1998 Jan;4(1):203-10.


Different genetic pathways to proximal and distal colorectal cancer influenced by sex-related factors.

Breivik J, Lothe RA, Meling GI, Rognum TO, Børresen-Dale AL, Gaudernack G.

Int J Cancer. 1997 Dec 19;74(6):664-9.


K-ras mutations and prognosis in large-bowel carcinomas.

Andersen SN, Løvig T, Breivik J, Lund E, Gaudernack G, Meling GI, Rognum TO.

Scand J Gastroenterol. 1997 Jan;32(1):62-9.


K-ras mutations and HLA-DR expression in large bowel adenomas.

Norheim Andersen S, Breivik J, Løvig T, Meling GI, Gaudernack G, Clausen OP, Schjölberg A, Fausa O, Langmark F, Lund E, Rognum TO.

Br J Cancer. 1996 Jul;74(1):99-108.


Secretory component mRNA and protein expression in colorectal adenomas and carcinomas.

Krajci P, Meling GI, Andersen SN, Hofstad B, Vatn MH, Rognum TO, Brandtzaeg P.

Br J Cancer. 1996 Jun;73(12):1503-10.


[Extrapulmonary tuberculosis. An important differential diagnosis in immigrants with suspected malignancy].

Jensenius M, Bergmann A, Rø J, Meling GI, Nyhus S, Sauer T, Scheel B.

Tidsskr Nor Laegeforen. 1995 Nov 10;115(27):3365-8. Norwegian.


Somatic mutations in the hMSH2 gene in microsatellite unstable colorectal carcinomas.

Børresen AL, Lothe RA, Meling GI, Lystad S, Morrison P, Lipford J, Kane MF, Rognum TO, Kolodner RD.

Hum Mol Genet. 1995 Nov;4(11):2065-72.


Deletion of 1p loci and microsatellite instability in colorectal polyps.

Lothe RA, Andersen SN, Hofstad B, Meling GI, Peltomäki P, Heim S, Brøgger A, Vatn M, Rognum TO, Børresen AL.

Genes Chromosomes Cancer. 1995 Nov;14(3):182-8.


A K-ras 13Gly-->Asp mutation is recognized by HLA-DQ7 restricted T cells in a patient with colorectal cancer. Modifying effect of DQ7 on established cancers harbouring this mutation?

Fossum B, Breivik J, Meling GI, Gedde-Dahl T 3rd, Hansen T, Knutsen I, Rognum TO, Thorsby E, Gaudernack G.

Int J Cancer. 1994 Aug 15;58(4):506-11.


K-ras mutation in colorectal cancer: relations to patient age, sex and tumour location.

Breivik J, Meling GI, Spurkland A, Rognum TO, Gaudernack G.

Br J Cancer. 1994 Feb;69(2):367-71.


Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history.

Lothe RA, Peltomäki P, Meling GI, Aaltonen LA, Nyström-Lahti M, Pylkkänen L, Heimdal K, Andersen TI, Møller P, Rognum TO, et al.

Cancer Res. 1993 Dec 15;53(24):5849-52.


Strong HLA-DR expression in large bowel carcinomas is associated with good prognosis.

Andersen SN, Rognum TO, Lund E, Meling GI, Hauge S.

Br J Cancer. 1993 Jul;68(1):80-5.


The TP53 tumour suppressor gene in colorectal carcinomas. II. Relation to DNA ploidy pattern and clinicopathological variables.

Meling GI, Lothe RA, Børresen AL, Graue C, Hauge S, Clausen OP, Rognum TO.

Br J Cancer. 1993 Jan;67(1):93-8.


The TP53 tumour suppressor gene in colorectal carcinomas. I. Genetic alterations on chromosome 17.

Meling GI, Lothe RA, Børresen AL, Graue C, Hauge S, Clausen OP, Rognum TO.

Br J Cancer. 1993 Jan;67(1):88-92.


Serum carcinoembryonic antigen in relation to survival, DNA ploidy pattern, and recurrent disease in 406 colorectal carcinoma patients.

Meling GI, Rognum TO, Clausen OP, Børmer O, Lunde OC, Schlichting E, Grüner OP, Hognestad J, Trondsen E, Havig O, et al.

Scand J Gastroenterol. 1992 Dec;27(12):1061-8.


Circulating secretory component in relation to early diagnosis and treatment of liver metastasis from colorectal carcinomas.

Kvale D, Norstein J, Meling GI, Børmer OP, Brandtzaeg P, Langmark F, Rognum TO.

J Clin Pathol. 1992 Jul;45(7):568-71.


Near diploid large bowel carcinomas have better five-year survival than aneuploid ones.

Rognum TO, Lund E, Meling GI, Langmark F.

Cancer. 1991 Sep 1;68(5):1077-81.


Genetic alterations within the retinoblastoma locus in colorectal carcinomas. Relation to DNA ploidy pattern studied by flow cytometric analysis.

Meling GI, Lothe RA, Børresen AL, Hauge S, Graue C, Clausen OP, Rognum TO.

Br J Cancer. 1991 Sep;64(3):475-80.


Association between DNA ploidy pattern and cellular atypia in colorectal carcinomas. A new clinical application of DNA flow cytometric study?

Meling GI, Rognum TO, Clausen OP, Chen Y, Lunde OC, Schlichting E, Wiig JN, Hognestad J, Bakka A, Havig O, et al.

Cancer. 1991 Mar 15;67(6):1642-9.


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