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A Novel Phenotype Links HIV-1 Capsid Stability to cGAS-Mediated DNA Sensing.

Siddiqui MA, Saito A, Halambage UD, Ferhadian D, Fischer DK, Francis AC, Melikyan GB, Ambrose Z, Aiken C, Yamashita M.

J Virol. 2019 Jul 30;93(16). pii: e00706-19. doi: 10.1128/JVI.00706-19. Print 2019 Aug 15.


HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors.

Koneru PC, Francis AC, Deng N, Rebensburg SV, Hoyte AC, Lindenberger J, Adu-Ampratwum D, Larue RC, Wempe MF, Engelman AN, Lyumkis D, Fuchs JR, Levy RM, Melikyan GB, Kvaratskhelia M.

Elife. 2019 May 23;8. pii: e46344. doi: 10.7554/eLife.46344.


HIV-1 Fusion with CD4+ T cells Is Promoted by Proteins Involved in Endocytosis and Intracellular Membrane Trafficking.

Marin M, Kushnareva Y, Mason CS, Chanda SK, Melikyan GB.

Viruses. 2019 Jan 25;11(2). pii: E100. doi: 10.3390/v11020100.


Interferon-induced transmembrane protein 3 blocks fusion of sensitive but not resistant viruses by partitioning into virus-carrying endosomes.

Suddala KC, Lee CC, Meraner P, Marin M, Markosyan RM, Desai TM, Cohen FS, Brass AL, Melikyan GB.

PLoS Pathog. 2019 Jan 14;15(1):e1007532. doi: 10.1371/journal.ppat.1007532. eCollection 2019 Jan.


Exploring Modifications of an HIV-1 Capsid Inhibitor: Design, Synthesis, and Mechanism of Action.

Xu JP, Francis AC, Meuser ME, Mankowski M, Ptak RG, Rashad AA, Melikyan GB, Cocklin S.

J Drug Des Res. 2018;5(2). pii: 1070. Epub 2018 Aug 13.


Live-Cell Imaging of Early Steps of Single HIV-1 Infection.

Francis AC, Melikyan GB.

Viruses. 2018 May 19;10(5). pii: E275. doi: 10.3390/v10050275. Review.


Single HIV-1 Imaging Reveals Progression of Infection through CA-Dependent Steps of Docking at the Nuclear Pore, Uncoating, and Nuclear Transport.

Francis AC, Melikyan GB.

Cell Host Microbe. 2018 Apr 11;23(4):536-548.e6. doi: 10.1016/j.chom.2018.03.009.


An improved labeling strategy enables automated detection of single-virus fusion and assessment of HIV-1 protease activity in single virions.

Sood C, Francis AC, Desai TM, Melikyan GB.

J Biol Chem. 2017 Dec 8;292(49):20196-20207. doi: 10.1074/jbc.M117.818088. Epub 2017 Oct 18.


How entry inhibitors synergize to fight HIV.

Melikyan GB.

J Biol Chem. 2017 Oct 6;292(40):16511-16512. doi: 10.1074/jbc.H117.791731. Review.


Fusion Stage of HIV-1 Entry Depends on Virus-Induced Cell Surface Exposure of Phosphatidylserine.

Zaitseva E, Zaitsev E, Melikov K, Arakelyan A, Marin M, Villasmil R, Margolis LB, Melikyan GB, Chernomordik LV.

Cell Host Microbe. 2017 Jul 12;22(1):99-110.e7. doi: 10.1016/j.chom.2017.06.012.


pH regulation in early endosomes and interferon-inducible transmembrane proteins control avian retrovirus fusion.

Desai TM, Marin M, Mason C, Melikyan GB.

J Biol Chem. 2017 May 12;292(19):7817-7827. doi: 10.1074/jbc.M117.783878. Epub 2017 Mar 24.


Screening and Functional Profiling of Small-Molecule HIV-1 Entry and Fusion Inhibitors.

Giroud C, Du Y, Marin M, Min Q, Jui NT, Fu H, Melikyan GB.

Assay Drug Dev Technol. 2017 Feb/Mar;15(2):53-63. doi: 10.1089/adt.2017.777.


SERINC5 protein inhibits HIV-1 fusion pore formation by promoting functional inactivation of envelope glycoproteins.

Sood C, Marin M, Chande A, Pizzato M, Melikyan GB.

J Biol Chem. 2017 Apr 7;292(14):6014-6026. doi: 10.1074/jbc.M117.777714. Epub 2017 Feb 8.


Siglec-1 initiates formation of the virus-containing compartment and enhances macrophage-to-T cell transmission of HIV-1.

Hammonds JE, Beeman N, Ding L, Takushi S, Francis AC, Wang JJ, Melikyan GB, Spearman P.

PLoS Pathog. 2017 Jan 27;13(1):e1006181. doi: 10.1371/journal.ppat.1006181. eCollection 2017 Jan.


Correlated fluorescence microscopy and cryo-electron tomography of virus-infected or transfected mammalian cells.

Hampton CM, Strauss JD, Ke Z, Dillard RS, Hammonds JE, Alonas E, Desai TM, Marin M, Storms RE, Leon F, Melikyan GB, Santangelo PJ, Spearman PW, Wright ER.

Nat Protoc. 2017 Jan;12(1):150-167. doi: 10.1038/nprot.2016.168. Epub 2016 Dec 15.


Time-Resolved Imaging of Single HIV-1 Uncoating In Vitro and in Living Cells.

Francis AC, Marin M, Shi J, Aiken C, Melikyan GB.

PLoS Pathog. 2016 Jun 20;12(6):e1005709. doi: 10.1371/journal.ppat.1005709. eCollection 2016 Jun.


Click labeling of unnatural sugars metabolically incorporated into viral envelope glycoproteins enables visualization of single particle fusion.

Oum YH, Desai TM, Marin M, Melikyan GB.

J Virol Methods. 2016 Jul;233:62-71. doi: 10.1016/j.jviromet.2016.02.016. Epub 2016 Mar 29.


Visualization of Content Release from Cell Surface-Attached Single HIV-1 Particles Carrying an Extra-Viral Fluorescent pH-Sensor.

Sood C, Marin M, Mason CS, Melikyan GB.

PLoS One. 2016 Feb 10;11(2):e0148944. doi: 10.1371/journal.pone.0148944. eCollection 2016.


Induction of Cell-Cell Fusion by Ebola Virus Glycoprotein: Low pH Is Not a Trigger.

Markosyan RM, Miao C, Zheng YM, Melikyan GB, Liu SL, Cohen FS.

PLoS Pathog. 2016 Jan 5;12(1):e1005373. doi: 10.1371/journal.ppat.1005373. eCollection 2016 Jan.


Fluorescent protein-tagged Vpr dissociates from HIV-1 core after viral fusion and rapidly enters the cell nucleus.

Desai TM, Marin M, Sood C, Shi J, Nawaz F, Aiken C, Melikyan GB.

Retrovirology. 2015 Oct 29;12:88. doi: 10.1186/s12977-015-0215-z.


P2X1 Receptor Antagonists Inhibit HIV-1 Fusion by Blocking Virus-Coreceptor Interactions.

Giroud C, Marin M, Hammonds J, Spearman P, Melikyan GB.

J Virol. 2015 Sep;89(18):9368-82. doi: 10.1128/JVI.01178-15. Epub 2015 Jul 1.


High-Throughput HIV-Cell Fusion Assay for Discovery of Virus Entry Inhibitors.

Marin M, Du Y, Giroud C, Kim JH, Qui M, Fu H, Melikyan GB.

Assay Drug Dev Technol. 2015 Apr;13(3):155-66. doi: 10.1089/adt.2015.639. Epub 2015 Apr 14.


Can HIV-1 entry sites be deduced by comparing bulk endocytosis to functional readouts for viral fusion?

Marin M, Melikyan GB.

J Virol. 2015 Mar;89(5):2985. doi: 10.1128/JVI.03352-14. No abstract available.


Distinct requirements for HIV-cell fusion and HIV-mediated cell-cell fusion.

Kondo N, Marin M, Kim JH, Desai TM, Melikyan GB.

J Biol Chem. 2015 Mar 6;290(10):6558-73. doi: 10.1074/jbc.M114.623181. Epub 2015 Jan 14.


Pinpointing retrovirus entry sites in cells expressing alternatively spliced receptor isoforms by single virus imaging.

Padilla-Parra S, Marin M, Kondo N, Melikyan GB.

Retrovirology. 2014 Jun 16;11:47. doi: 10.1186/1742-4690-11-47.


IFITM3 restricts influenza A virus entry by blocking the formation of fusion pores following virus-endosome hemifusion.

Desai TM, Marin M, Chin CR, Savidis G, Brass AL, Melikyan GB.

PLoS Pathog. 2014 Apr 3;10(4):e1004048. doi: 10.1371/journal.ppat.1004048. eCollection 2014 Apr.


HIV entry: a game of hide-and-fuse?

Melikyan GB.

Curr Opin Virol. 2014 Feb;4:1-7. doi: 10.1016/j.coviro.2013.09.004. Epub 2013 Nov 1. Review.


Fusion of mature HIV-1 particles leads to complete release of a gag-GFP-based content marker and raises the intraviral pH.

Padilla-Parra S, Marin M, Gahlaut N, Suter R, Kondo N, Melikyan GB.

PLoS One. 2013 Aug 9;8(8):e71002. doi: 10.1371/journal.pone.0071002. eCollection 2013.


Sub-inhibitory concentrations of human α-defensin potentiate neutralizing antibodies against HIV-1 gp41 pre-hairpin intermediates in the presence of serum.

Demirkhanyan L, Marin M, Lu W, Melikyan GB.

PLoS Pathog. 2013;9(6):e1003431. doi: 10.1371/journal.ppat.1003431. Epub 2013 Jun 13.


Anionic lipids are required for vesicular stomatitis virus G protein-mediated single particle fusion with supported lipid bilayers.

Matos PM, Marin M, Ahn B, Lam W, Santos NC, Melikyan GB.

J Biol Chem. 2013 May 3;288(18):12416-25. doi: 10.1074/jbc.M113.462028. Epub 2013 Mar 14.


Quantitative imaging of endosome acidification and single retrovirus fusion with distinct pools of early endosomes.

Padilla-Parra S, Matos PM, Kondo N, Marin M, Santos NC, Melikyan GB.

Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17627-32. doi: 10.1073/pnas.1211714109. Epub 2012 Oct 9.


Intercellular adhesion molecule 1 promotes HIV-1 attachment but not fusion to target cells.

Kondo N, Melikyan GB.

PLoS One. 2012;7(9):e44827. doi: 10.1371/journal.pone.0044827. Epub 2012 Sep 6.


Multifaceted mechanisms of HIV-1 entry inhibition by human α-defensin.

Demirkhanyan LH, Marin M, Padilla-Parra S, Zhan C, Miyauchi K, Jean-Baptiste M, Novitskiy G, Lu W, Melikyan GB.

J Biol Chem. 2012 Aug 17;287(34):28821-38. doi: 10.1074/jbc.M112.375949. Epub 2012 Jun 25.


Synchronized retrovirus fusion in cells expressing alternative receptor isoforms releases the viral core into distinct sub-cellular compartments.

Padilla-Parra S, Marin M, Kondo N, Melikyan GB.

PLoS Pathog. 2012;8(5):e1002694. doi: 10.1371/journal.ppat.1002694. Epub 2012 May 10.


Inhibition of HIV-1 endocytosis allows lipid mixing at the plasma membrane, but not complete fusion.

de la Vega M, Marin M, Kondo N, Miyauchi K, Kim Y, Epand RF, Epand RM, Melikyan GB.

Retrovirology. 2011 Dec 6;8:99. doi: 10.1186/1742-4690-8-99.


Membrane fusion mediated by human immunodeficiency virus envelope glycoprotein.

Melikyan GB.

Curr Top Membr. 2011;68:81-106. doi: 10.1016/B978-0-12-385891-7.00004-0. Review. No abstract available.


Hepatitis C virus is primed by CD81 protein for low pH-dependent fusion.

Sharma NR, Mateu G, Dreux M, Grakoui A, Cosset FL, Melikyan GB.

J Biol Chem. 2011 Sep 2;286(35):30361-76. doi: 10.1074/jbc.M111.263350. Epub 2011 Jul 7.


Imaging single retrovirus entry through alternative receptor isoforms and intermediates of virus-endosome fusion.

Jha NK, Latinovic O, Martin E, Novitskiy G, Marin M, Miyauchi K, Naughton J, Young JA, Melikyan GB.

PLoS Pathog. 2011 Jan 20;7(1):e1001260. doi: 10.1371/journal.ppat.1001260.


Visualization of retrovirus uptake and delivery into acidic endosomes.

Miyauchi K, Marin M, Melikyan GB.

Biochem J. 2011 Mar 15;434(3):559-69. doi: 10.1042/BJ20101588.


Driving a wedge between viral lipids blocks infection.

Melikyan GB.

Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17069-70. doi: 10.1073/pnas.1012748107. Epub 2010 Sep 27. No abstract available.


Early steps of HIV-1 fusion define the sensitivity to inhibitory peptides that block 6-helix bundle formation.

Miyauchi K, Kozlov MM, Melikyan GB.

PLoS Pathog. 2009 Sep;5(9):e1000585. doi: 10.1371/journal.ppat.1000585. Epub 2009 Sep 18.


HIV enters cells via endocytosis and dynamin-dependent fusion with endosomes.

Miyauchi K, Kim Y, Latinovic O, Morozov V, Melikyan GB.

Cell. 2009 May 1;137(3):433-44. doi: 10.1016/j.cell.2009.02.046.


Common principles and intermediates of viral protein-mediated fusion: the HIV-1 paradigm.

Melikyan GB.

Retrovirology. 2008 Dec 10;5:111. doi: 10.1186/1742-4690-5-111. Review.


Rapamycin reduces CCR5 density levels on CD4 T cells, and this effect results in potentiation of enfuvirtide (T-20) against R5 strains of human immunodeficiency virus type 1 in vitro.

Heredia A, Gilliam B, Latinovic O, Le N, Bamba D, Devico A, Melikyan GB, Gallo RC, Redfield RR.

Antimicrob Agents Chemother. 2007 Jul;51(7):2489-96. Epub 2007 May 7.


Time-resolved imaging of HIV-1 Env-mediated lipid and content mixing between a single virion and cell membrane.

Markosyan RM, Cohen FS, Melikyan GB.

Mol Biol Cell. 2005 Dec;16(12):5502-13. Epub 2005 Sep 29.


Ternary complex formation of human immunodeficiency virus type 1 Env, CD4, and chemokine receptor captured as an intermediate of membrane fusion.

Mkrtchyan SR, Markosyan RM, Eadon MT, Moore JP, Melikyan GB, Cohen FS.

J Virol. 2005 Sep;79(17):11161-9.


Imaging individual retroviral fusion events: from hemifusion to pore formation and growth.

Melikyan GB, Barnard RJ, Abrahamyan LG, Mothes W, Young JA.

Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8728-33. Epub 2005 Jun 3.


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