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Items: 1 to 50 of 110

1.

Characteristics of patients with confirmed epilepsy and psychogenic nonepileptic seizures in Qatar.

Wilkins SS, Mesraoua B, Palomo GA, Al Hail H, Salam A, Melikyan G, Azar N, Haddad N, Uthman B, Siddiqi M, Elsheikh L, Ali M, Alrabi A, Shuaib A, Deleu D, Asadi-Pooya AA.

Epilepsy Behav. 2018 Jul 3. pii: S1525-5050(18)30225-7. doi: 10.1016/j.yebeh.2018.06.014. [Epub ahead of print]

PMID:
29980425
2.

Live-Cell Imaging of Early Steps of Single HIV-1 Infection.

Francis AC, Melikyan GB.

Viruses. 2018 May 19;10(5). pii: E275. doi: 10.3390/v10050275. Review.

3.

Oral disease-modifying therapies for multiple sclerosis in the Middle Eastern and North African (MENA) region: an overview.

Deleu D, Mesraoua B, Canibaño B, Melikyan G, Al Hail H, El-Sheikh L, Ali M, Al Hussein H, Ibrahim F, Hanssens Y.

Curr Med Res Opin. 2018 Jun 18:1-12. doi: 10.1080/03007995.2018.1476334. [Epub ahead of print]

PMID:
29764226
4.

Single HIV-1 Imaging Reveals Progression of Infection through CA-Dependent Steps of Docking at the Nuclear Pore, Uncoating, and Nuclear Transport.

Francis AC, Melikyan GB.

Cell Host Microbe. 2018 Apr 11;23(4):536-548.e6. doi: 10.1016/j.chom.2018.03.009.

PMID:
29649444
5.

Clinical presentation, epidemiology, neurophysiological findings, treatment and outcome of nonconvulsive status epilepticus: a 3-year prospective, hospital-based study.

Mesraoua B, Deleu D, Al Hail H, Ibrahim F, Melikyan G, Al Hussein H, Singh R, Uthman B, Streletz L, Kaplan PW, Wieser HG.

J Drug Assess. 2017 Nov 10;6(1):18-32. doi: 10.1080/21556660.2017.1396992. eCollection 2017.

6.

Phenoxypropanolamine derivatives as selective inhibitors of the 20S proteasome β1 and β5 subunits.

Hovhannisyan AA, Pham TH, Bouvier D, Tan X, Touhar S, Mkryan GG, Dallakyan AM, El Amri C, Melikyan GS, Reboud-Ravaux M, Bouvier-Durand M.

Bioorg Med Chem Lett. 2017 Dec 1;27(23):5172-5178. doi: 10.1016/j.bmcl.2017.10.055. Epub 2017 Oct 23.

PMID:
29113763
7.

An improved labeling strategy enables automated detection of single-virus fusion and assessment of HIV-1 protease activity in single virions.

Sood C, Francis AC, Desai TM, Melikyan GB.

J Biol Chem. 2017 Dec 8;292(49):20196-20207. doi: 10.1074/jbc.M117.818088. Epub 2017 Oct 18.

PMID:
29046351
8.

How entry inhibitors synergize to fight HIV.

Melikyan GB.

J Biol Chem. 2017 Oct 6;292(40):16511-16512. doi: 10.1074/jbc.H117.791731. Review.

9.

Fusion Stage of HIV-1 Entry Depends on Virus-Induced Cell Surface Exposure of Phosphatidylserine.

Zaitseva E, Zaitsev E, Melikov K, Arakelyan A, Marin M, Villasmil R, Margolis LB, Melikyan GB, Chernomordik LV.

Cell Host Microbe. 2017 Jul 12;22(1):99-110.e7. doi: 10.1016/j.chom.2017.06.012.

10.

pH regulation in early endosomes and interferon-inducible transmembrane proteins control avian retrovirus fusion.

Desai TM, Marin M, Mason C, Melikyan GB.

J Biol Chem. 2017 May 12;292(19):7817-7827. doi: 10.1074/jbc.M117.783878. Epub 2017 Mar 24.

11.

Screening and Functional Profiling of Small-Molecule HIV-1 Entry and Fusion Inhibitors.

Giroud C, Du Y, Marin M, Min Q, Jui NT, Fu H, Melikyan GB.

Assay Drug Dev Technol. 2017 Feb/Mar;15(2):53-63. doi: 10.1089/adt.2017.777.

12.

Prestroke CHA2DS2-VASc Score and Severity of Acute Stroke in Patients with Atrial Fibrillation: Findings from RAF Study.

Acciarresi M, Paciaroni M, Agnelli G, Falocci N, Caso V, Becattini C, Marcheselli S, Rueckert C, Pezzini A, Morotti A, Costa P, Padovani A, Csiba L, Szabó L, Sohn SI, Tassinari T, Abdul-Rahim AH, Michel P, Cordier M, Vanacker P, Remillard S, Alberti A, Venti M, D'Amore C, Scoditti U, Denti L, Orlandi G, Chiti A, Gialdini G, Bovi P, Carletti M, Rigatelli A, Putaala J, Tatlisumak T, Masotti L, Lorenzini G, Tassi R, Guideri F, Martini G, Tsivgoulis G, Vadikolias K, Liantinioti C, Corea F, Del Sette M, Ageno W, De Lodovici ML, Bono G, Baldi A, D'Anna S, Sacco S, Carolei A, Tiseo C, Imberti D, Zabzuni D, Doronin B, Volodina V, Consoli D, Galati F, Pieroni A, Toni D, Monaco S, Baronello MM, Barlinn K, Pallesen LP, Kepplinger J, Bodechtel U, Gerber J, Deleu D, Melikyan G, Ibrahim F, Akhtar N, Mosconi MG, Lees KR.

J Stroke Cerebrovasc Dis. 2017 Jun;26(6):1363-1368. doi: 10.1016/j.jstrokecerebrovasdis.2017.02.011. Epub 2017 Feb 22.

PMID:
28236595
13.

Prediction of Early Recurrent Thromboembolic Event and Major Bleeding in Patients With Acute Stroke and Atrial Fibrillation by a Risk Stratification Schema: The ALESSA Score Study.

Paciaroni M, Agnelli G, Caso V, Tsivgoulis G, Furie KL, Tadi P, Becattini C, Falocci N, Zedde M, Abdul-Rahim AH, Lees KR, Alberti A, Venti M, Acciarresi M, D'Amore C, Mosconi MG, Cimini LA, Procopio A, Bovi P, Carletti M, Rigatelli A, Cappellari M, Putaala J, Tomppo L, Tatlisumak T, Bandini F, Marcheselli S, Pezzini A, Poli L, Padovani A, Masotti L, Vannucchi V, Sohn SI, Lorenzini G, Tassi R, Guideri F, Acampa M, Martini G, Ntaios G, Karagkiozi E, Athanasakis G, Makaritsis K, Vadikolias K, Liantinioti C, Chondrogianni M, Mumoli N, Consoli D, Galati F, Sacco S, Carolei A, Tiseo C, Corea F, Ageno W, Bellesini M, Colombo G, Silvestrelli G, Ciccone A, Scoditti U, Denti L, Mancuso M, Maccarrone M, Orlandi G, Giannini N, Gialdini G, Tassinari T, De Lodovici ML, Bono G, Rueckert C, Baldi A, D'Anna S, Toni D, Letteri F, Giuntini M, Lotti EM, Flomin Y, Pieroni A, Kargiotis O, Karapanayiotides T, Monaco S, Baronello MM, Csiba L, Szabó L, Chiti A, Giorli E, Del Sette M, Imberti D, Zabzuni D, Doronin B, Volodina V, Michel P, Vanacker P, Barlinn K, Pallesen LP, Kepplinger J, Bodechtel U, Gerber J, Deleu D, Melikyan G, Ibrahim F, Akhtar N, Gourbali V, Yaghi S.

Stroke. 2017 Mar;48(3):726-732. doi: 10.1161/STROKEAHA.116.015770. Epub 2017 Feb 9.

14.

SERINC5 protein inhibits HIV-1 fusion pore formation by promoting functional inactivation of envelope glycoproteins.

Sood C, Marin M, Chande A, Pizzato M, Melikyan GB.

J Biol Chem. 2017 Apr 7;292(14):6014-6026. doi: 10.1074/jbc.M117.777714. Epub 2017 Feb 8.

15.

Siglec-1 initiates formation of the virus-containing compartment and enhances macrophage-to-T cell transmission of HIV-1.

Hammonds JE, Beeman N, Ding L, Takushi S, Francis AC, Wang JJ, Melikyan GB, Spearman P.

PLoS Pathog. 2017 Jan 27;13(1):e1006181. doi: 10.1371/journal.ppat.1006181. eCollection 2017 Jan.

16.

Correlated fluorescence microscopy and cryo-electron tomography of virus-infected or transfected mammalian cells.

Hampton CM, Strauss JD, Ke Z, Dillard RS, Hammonds JE, Alonas E, Desai TM, Marin M, Storms RE, Leon F, Melikyan GB, Santangelo PJ, Spearman PW, Wright ER.

Nat Protoc. 2017 Jan;12(1):150-167. doi: 10.1038/nprot.2016.168. Epub 2016 Dec 15.

17.

Optimization and stratification of multiple sclerosis treatment in fast developing economic countries: a perspective from Qatar.

Deleu D, Mesraoua B, El Khider H, Canibano B, Melikyan G, Al Hail H, Mhjob N, Bhagat A, Ibrahim F, Hanssens Y.

Curr Med Res Opin. 2017 Mar;33(3):439-458. doi: 10.1080/03007995.2016.1261818. Epub 2016 Dec 31. Review.

PMID:
27892723
18.

Epilepsy in Qatar: Causes, treatment, and outcome.

Haddad N, Melikyan G, Al Hail H, Al Jurdi A, Aqeel F, Elzafarany A, Abuhadra N, Laswi M, Alsamman Y, Uthman B, Deleu D, Mesraoua B, Alarcon G, Azar N, Streletz L, Mahfoud Z.

Epilepsy Behav. 2016 Oct;63:98-102. doi: 10.1016/j.yebeh.2016.07.043. Epub 2016 Aug 30.

19.

Time-Resolved Imaging of Single HIV-1 Uncoating In Vitro and in Living Cells.

Francis AC, Marin M, Shi J, Aiken C, Melikyan GB.

PLoS Pathog. 2016 Jun 20;12(6):e1005709. doi: 10.1371/journal.ppat.1005709. eCollection 2016 Jun.

20.

Click labeling of unnatural sugars metabolically incorporated into viral envelope glycoproteins enables visualization of single particle fusion.

Oum YH, Desai TM, Marin M, Melikyan GB.

J Virol Methods. 2016 Jul;233:62-71. doi: 10.1016/j.jviromet.2016.02.016. Epub 2016 Mar 29.

21.

Visualization of Content Release from Cell Surface-Attached Single HIV-1 Particles Carrying an Extra-Viral Fluorescent pH-Sensor.

Sood C, Marin M, Mason CS, Melikyan GB.

PLoS One. 2016 Feb 10;11(2):e0148944. doi: 10.1371/journal.pone.0148944. eCollection 2016.

22.

Cortex-sparing infarction in triple cervical artery dissection following chiropractic neck manipulation.

Melikyan G, Kamran S, Akhtar N, Deleu D, Miyares FR.

Qatar Med J. 2016 Jan 14;2015(2):16. doi: 10.5339/qmj.2015.16. eCollection 2015.

23.

Induction of Cell-Cell Fusion by Ebola Virus Glycoprotein: Low pH Is Not a Trigger.

Markosyan RM, Miao C, Zheng YM, Melikyan GB, Liu SL, Cohen FS.

PLoS Pathog. 2016 Jan 5;12(1):e1005373. doi: 10.1371/journal.ppat.1005373. eCollection 2016 Jan.

24.

Prognostic value of trans-thoracic echocardiography in patients with acute stroke and atrial fibrillation: findings from the RAF study.

Paciaroni M, Agnelli G, Falocci N, Caso V, Becattini C, Marcheselli S, Rueckert C, Pezzini A, Poli L, Padovani A, Csiba L, Szabó L, Sohn SI, Tassinari T, Abdul-Rahim AH, Michel P, Cordier M, Vanacker P, Remillard S, Alberti A, Venti M, Acciarresi M, D'Amore C, Mosconi MG, Scoditti U, Denti L, Orlandi G, Chiti A, Gialdini G, Bovi P, Carletti M, Rigatelli A, Putaala J, Tatlisumak T, Masotti L, Lorenzini G, Tassi R, Guideri F, Martini G, Tsivgoulis G, Vadikolias K, Liantinioti C, Corea F, Del Sette M, Ageno W, De Lodovici ML, Bono G, Baldi A, D'Anna S, Sacco S, Carolei A, Tiseo C, Imberti D, Zabzuni D, Doronin B, Volodina V, Consoli D, Galati F, Pieroni A, Toni D, Monaco S, Baronello MM, Barlinn K, Pallesen LP, Kepplinger J, Bodechtel U, Gerber J, Deleu D, Melikyan G, Ibrahim F, Akhtar N, Lees KR.

J Neurol. 2016 Feb;263(2):231-237. doi: 10.1007/s00415-015-7957-3. Epub 2015 Nov 14.

PMID:
26566907
25.

Fluorescent protein-tagged Vpr dissociates from HIV-1 core after viral fusion and rapidly enters the cell nucleus.

Desai TM, Marin M, Sood C, Shi J, Nawaz F, Aiken C, Melikyan GB.

Retrovirology. 2015 Oct 29;12:88. doi: 10.1186/s12977-015-0215-z.

26.

P2X1 Receptor Antagonists Inhibit HIV-1 Fusion by Blocking Virus-Coreceptor Interactions.

Giroud C, Marin M, Hammonds J, Spearman P, Melikyan GB.

J Virol. 2015 Sep;89(18):9368-82. doi: 10.1128/JVI.01178-15. Epub 2015 Jul 1.

27.

Early Recurrence and Cerebral Bleeding in Patients With Acute Ischemic Stroke and Atrial Fibrillation: Effect of Anticoagulation and Its Timing: The RAF Study.

Paciaroni M, Agnelli G, Falocci N, Caso V, Becattini C, Marcheselli S, Rueckert C, Pezzini A, Poli L, Padovani A, Csiba L, Szabó L, Sohn SI, Tassinari T, Abdul-Rahim AH, Michel P, Cordier M, Vanacker P, Remillard S, Alberti A, Venti M, Scoditti U, Denti L, Orlandi G, Chiti A, Gialdini G, Bovi P, Carletti M, Rigatelli A, Putaala J, Tatlisumak T, Masotti L, Lorenzini G, Tassi R, Guideri F, Martini G, Tsivgoulis G, Vadikolias K, Liantinioti C, Corea F, Del Sette M, Ageno W, De Lodovici ML, Bono G, Baldi A, D'Anna S, Sacco S, Carolei A, Tiseo C, Acciarresi M, D'Amore C, Imberti D, Zabzuni D, Doronin B, Volodina V, Consoli D, Galati F, Pieroni A, Toni D, Monaco S, Baronello MM, Barlinn K, Pallesen LP, Kepplinger J, Bodechtel U, Gerber J, Deleu D, Melikyan G, Ibrahim F, Akhtar N, Mosconi MG, Bubba V, Silvestri I, Lees KR.

Stroke. 2015 Aug;46(8):2175-82. doi: 10.1161/STROKEAHA.115.008891. Epub 2015 Jun 30.

28.

High-Throughput HIV-Cell Fusion Assay for Discovery of Virus Entry Inhibitors.

Marin M, Du Y, Giroud C, Kim JH, Qui M, Fu H, Melikyan GB.

Assay Drug Dev Technol. 2015 Apr;13(3):155-66. doi: 10.1089/adt.2015.639. Epub 2015 Apr 14.

29.

Propargyl radical chemistry: renaissance instigated by metal coordination.

Melikyan GG.

Acc Chem Res. 2015 Apr 21;48(4):1065-79. doi: 10.1021/ar500365v. Epub 2015 Mar 6.

PMID:
25746443
30.

Can HIV-1 entry sites be deduced by comparing bulk endocytosis to functional readouts for viral fusion?

Marin M, Melikyan GB.

J Virol. 2015 Mar;89(5):2985. doi: 10.1128/JVI.03352-14. No abstract available.

31.

Distinct requirements for HIV-cell fusion and HIV-mediated cell-cell fusion.

Kondo N, Marin M, Kim JH, Desai TM, Melikyan GB.

J Biol Chem. 2015 Mar 6;290(10):6558-73. doi: 10.1074/jbc.M114.623181. Epub 2015 Jan 14.

32.

Pinpointing retrovirus entry sites in cells expressing alternatively spliced receptor isoforms by single virus imaging.

Padilla-Parra S, Marin M, Kondo N, Melikyan GB.

Retrovirology. 2014 Jun 16;11:47. doi: 10.1186/1742-4690-11-47.

33.

IFITM3 restricts influenza A virus entry by blocking the formation of fusion pores following virus-endosome hemifusion.

Desai TM, Marin M, Chin CR, Savidis G, Brass AL, Melikyan GB.

PLoS Pathog. 2014 Apr 3;10(4):e1004048. doi: 10.1371/journal.ppat.1004048. eCollection 2014 Apr.

34.

New C(4)- and C(1)-derivatives of furo[3,4-c]pyridine-3-ones and related compounds: evidence for site-specific inhibition of the constitutive proteasome and its immunoisoform.

Hovhannisyan A, Pham TH, Bouvier D, Piroyan A, Dufau L, Qin L, Cheng Y, Melikyan G, Reboud-Ravaux M, Bouvier-Durand M.

Bioorg Med Chem Lett. 2014 Mar 15;24(6):1571-80. doi: 10.1016/j.bmcl.2014.01.072. Epub 2014 Feb 3.

PMID:
24534487
35.

HIV entry: a game of hide-and-fuse?

Melikyan GB.

Curr Opin Virol. 2014 Feb;4:1-7. doi: 10.1016/j.coviro.2013.09.004. Epub 2013 Nov 1. Review.

36.

Case of paraspinal collection due to Burkholderia pseudomallei.

Melikyan G, Badawi M, Akhtar N, Elsetouhy AH.

BMJ Case Rep. 2013 Oct 16;2013. pii: bcr2013201447. doi: 10.1136/bcr-2013-201447. No abstract available.

37.

Impact of reducing agent, temperature, and substrate topology on diastereoselectivity of the intermolecular coupling reactions, or how "free" are cobalt-complexed propargyl radicals?

Melikyan GG, Carlson L, Sahakyan N, Floruti A, Garrison M.

Dalton Trans. 2013 Oct 1;42(41):14801-12. doi: 10.1039/c3dt51502h.

PMID:
23986295
38.

Fusion of mature HIV-1 particles leads to complete release of a gag-GFP-based content marker and raises the intraviral pH.

Padilla-Parra S, Marin M, Gahlaut N, Suter R, Kondo N, Melikyan GB.

PLoS One. 2013 Aug 9;8(8):e71002. doi: 10.1371/journal.pone.0071002. eCollection 2013.

39.

Sub-inhibitory concentrations of human α-defensin potentiate neutralizing antibodies against HIV-1 gp41 pre-hairpin intermediates in the presence of serum.

Demirkhanyan L, Marin M, Lu W, Melikyan GB.

PLoS Pathog. 2013;9(6):e1003431. doi: 10.1371/journal.ppat.1003431. Epub 2013 Jun 13.

40.

C1 and N5 derivatives of cerpegin: synthesis of a new series based on structure-activity relationships to optimize their inhibitory effect on 20S proteasome.

Hovhannisyan A, Pham TH, Bouvier D, Qin L, Melikyan G, Reboud-Ravaux M, Bouvier-Durand M.

Bioorg Med Chem Lett. 2013 May 1;23(9):2696-703. doi: 10.1016/j.bmcl.2013.02.079. Epub 2013 Feb 27.

PMID:
23541650
41.

Anionic lipids are required for vesicular stomatitis virus G protein-mediated single particle fusion with supported lipid bilayers.

Matos PM, Marin M, Ahn B, Lam W, Santos NC, Melikyan GB.

J Biol Chem. 2013 May 3;288(18):12416-25. doi: 10.1074/jbc.M113.462028. Epub 2013 Mar 14.

42.

Newly diagnosed multiple sclerosis in state of Qatar.

Akhtar N, Elsetouhy A, Deleu D, Kamran S, AlHail H, Elalamy O, Mesraoua B, Sokrab T, Kamil H, Melikyan G, D'souza A, Osman Y, Imam Y.

Clin Neurol Neurosurg. 2013 Aug;115(8):1333-7. doi: 10.1016/j.clineuro.2012.12.035. Epub 2013 Feb 5.

PMID:
23395161
43.

Transverse Myelitis Associated with Anti-Ro (SSA) Autoantibodies: A Record of Two Cases.

Melikyan G, Abdelrahman MH, D'Suoza A, Akhtar N, Elzouki AN, Hammoudeh M.

Case Rep Rheumatol. 2012;2012:515768. doi: 10.1155/2012/515768. Epub 2012 Nov 13.

44.

Quantitative imaging of endosome acidification and single retrovirus fusion with distinct pools of early endosomes.

Padilla-Parra S, Matos PM, Kondo N, Marin M, Santos NC, Melikyan GB.

Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17627-32. doi: 10.1073/pnas.1211714109. Epub 2012 Oct 9.

45.

Neurocysticercosis presenting as a vertical one-and-a-half syndrome with associated contralesional horizontal gaze paresis.

Mesraoua B, Deleu D, D'souza A, Imam YZ, Melikyan G.

J Neurol Sci. 2012 Dec 15;323(1-2):250-3. doi: 10.1016/j.jns.2012.08.022. Epub 2012 Sep 13.

PMID:
22982000
46.

Intercellular adhesion molecule 1 promotes HIV-1 attachment but not fusion to target cells.

Kondo N, Melikyan GB.

PLoS One. 2012;7(9):e44827. doi: 10.1371/journal.pone.0044827. Epub 2012 Sep 6.

47.

Prevalence, demographics and clinical characteristics of multiple sclerosis in Qatar.

Deleu D, Mir D, Al Tabouki A, Mesraoua R, Mesraoua B, Akhtar N, Al Hail H, D'souza A, Melikyan G, Imam YZ, Osman Y, Elalamy O, Sokrab T, Kamran S, Ruiz Miyares F, Ibrahim F.

Mult Scler. 2013 May;19(6):816-9. doi: 10.1177/1352458512459291. Epub 2012 Sep 11.

PMID:
22968545
48.

Multifaceted mechanisms of HIV-1 entry inhibition by human α-defensin.

Demirkhanyan LH, Marin M, Padilla-Parra S, Zhan C, Miyauchi K, Jean-Baptiste M, Novitskiy G, Lu W, Melikyan GB.

J Biol Chem. 2012 Aug 17;287(34):28821-38. doi: 10.1074/jbc.M112.375949. Epub 2012 Jun 25.

49.

Synchronized retrovirus fusion in cells expressing alternative receptor isoforms releases the viral core into distinct sub-cellular compartments.

Padilla-Parra S, Marin M, Kondo N, Melikyan GB.

PLoS Pathog. 2012;8(5):e1002694. doi: 10.1371/journal.ppat.1002694. Epub 2012 May 10.

50.

A new series of N5 derivatives of the 1,1,5-trimethyl furo[3,4-c]pyridine-3,4-dione (cerpegin) selectively inhibits the post-acid activity of mammalian 20S proteasomes.

Pham TH, Hovhannisyan A, Bouvier D, Tian L, Reboud-Ravaux M, Melikyan G, Bouvier-Durand M.

Bioorg Med Chem Lett. 2012 Jun 1;22(11):3822-7. doi: 10.1016/j.bmcl.2012.03.105. Epub 2012 Apr 13.

PMID:
22560566

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