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MR Imaging Biomarkers in Amyotrophic Lateral Sclerosis.

Melhem ER.

Acad Radiol. 2017 Oct;24(10):1185-1186. doi: 10.1016/j.acra.2017.07.004. Epub 2017 Aug 16. No abstract available.


Metabolic imaging of energy metabolism in traumatic brain injury using hyperpolarized [1-13C]pyruvate.

DeVience SJ, Lu X, Proctor J, Rangghran P, Melhem ER, Gullapalli R, Fiskum GM, Mayer D.

Sci Rep. 2017 May 15;7(1):1907. doi: 10.1038/s41598-017-01736-x.


Synthetic MRI for Clinical Neuroimaging: Results of the Magnetic Resonance Image Compilation (MAGiC) Prospective, Multicenter, Multireader Trial.

Tanenbaum LN, Tsiouris AJ, Johnson AN, Naidich TP, DeLano MC, Melhem ER, Quarterman P, Parameswaran SX, Shankaranarayanan A, Goyen M, Field AS.

AJNR Am J Neuroradiol. 2017 Jun;38(6):1103-1110. doi: 10.3174/ajnr.A5227. Epub 2017 Apr 27.


Brain morphometric analysis predicts decline of intelligence quotient in children with sickle cell disease: A preliminary study.

Chen R, Krejza J, Arkuszewski M, Zimmerman RA, Herskovits EH, Melhem ER.

Adv Med Sci. 2017 Mar;62(1):151-157. doi: 10.1016/j.advms.2016.09.002. Epub 2017 Mar 6.


Assignment Confidence in Localization of the Hand Motor Cortex: Comparison of Structural Imaging With Functional MRI.

Sahin N, Mohan S, Maralani PJ, Duddukuri S, O'Rourke DM, Melhem ER, Wolf RL.

AJR Am J Roentgenol. 2016 Dec;207(6):1263-1270. Epub 2016 Sep 13.


Gender-based analysis of cortical thickness and structural connectivity in Parkinson's disease.

Yadav SK, Kathiresan N, Mohan S, Vasileiou G, Singh A, Kaura D, Melhem ER, Gupta RK, Wang E, Marincola FM, Borthakur A, Haris M.

J Neurol. 2016 Nov;263(11):2308-2318. Epub 2016 Aug 20.


Intracranial Applications of MR Imaging-Guided Focused Ultrasound.

Khanna N, Gandhi D, Steven A, Frenkel V, Melhem ER.

AJNR Am J Neuroradiol. 2017 Mar;38(3):426-431. doi: 10.3174/ajnr.A4902. Epub 2016 Aug 18. Review.


Metabolic, endocrine, and other genetic disorders.

Dahmoush HM, Melhem ER, Vossough A.

Handb Clin Neurol. 2016;136:1221-59. doi: 10.1016/B978-0-444-53486-6.00063-6. Review.


Limbic pathway lesions in patients with multiple sclerosis.

Sahin N, Selouan R, Markowitz CE, Melhem ER, Bilello M.

Acta Radiol. 2016 Mar;57(3):341-7. doi: 10.1177/0284185115578689. Epub 2015 Apr 6.


T1rho MRI and CSF biomarkers in diagnosis of Alzheimer's disease.

Haris M, Yadav SK, Rizwan A, Singh A, Cai K, Kaura D, Wang E, Davatzikos C, Trojanowski JQ, Melhem ER, Marincola FM, Borthakur A.

Neuroimage Clin. 2015 Feb 26;7:598-604. doi: 10.1016/j.nicl.2015.02.016. eCollection 2015.


Association of dynamic susceptibility contrast enhanced MR Perfusion parameters with prognosis in elderly patients with glioblastomas.

Jabehdar Maralani P, Melhem ER, Wang S, Herskovits EH, Voluck MR, Kim SJ, Learned KO, O'Rourke DM, Mohan S.

Eur Radiol. 2015 Sep;25(9):2738-44. doi: 10.1007/s00330-015-3640-4. Epub 2015 Feb 14.


A prospective longitudinal brain morphometry study of children with sickle cell disease.

Chen R, Arkuszewski M, Krejza J, Zimmerman RA, Herskovits EH, Melhem ER.

AJNR Am J Neuroradiol. 2015 Feb;36(2):403-10. doi: 10.3174/ajnr.A4101. Epub 2014 Sep 18.


Linear associations between clinically assessed upper motor neuron disease and diffusion tensor imaging metrics in amyotrophic lateral sclerosis.

Woo JH, Wang S, Melhem ER, Gee JC, Cucchiara A, McCluskey L, Elman L.

PLoS One. 2014 Aug 21;9(8):e105753. doi: 10.1371/journal.pone.0105753. eCollection 2014.


Characteristics of spondylotic myelopathy on 3D driven-equilibrium fast spin echo and 2D fast spin echo magnetic resonance imaging: a retrospective cross-sectional study.

Abdulhadi MA, Perno JR, Melhem ER, Nucifora PG.

PLoS One. 2014 Jul 15;9(7):e100964. doi: 10.1371/journal.pone.0100964. eCollection 2014.


Sickle cell anemia: intracranial stenosis and silent cerebral infarcts in children with low risk of stroke.

Arkuszewski M, Krejza J, Chen R, Ichord R, Kwiatkowski JL, Bilello M, Zimmerman R, Ohene-Frempong K, Melhem ER.

Adv Med Sci. 2014 Mar;59(1):108-13. doi: 10.1016/j.advms.2013.09.001. Epub 2014 Mar 27.


Extraventricular neurocytoma and ganglioneurocytoma: advanced MR imaging, histopathological, and chromosomal findings.

Nabavizadeh SA, Chawla S, Baccon J, Zhang PJ, Poptani H, Melhem ER, Vossough A.

J Neuroimaging. 2014 Nov-Dec;24(6):613-616. doi: 10.1111/jon.12081. Epub 2014 Feb 19.


Perineural spread of malignant mesothelioma with spinal intramedullary involvement.

Tanwar M, Simone CB 2nd, Newman S, Cengel K, Yu GH, Melhem ER, Mohan S.

Clin Neurol Neurosurg. 2014 May;120:116-9. doi: 10.1016/j.clineuro.2014.03.005. Epub 2014 Mar 13. No abstract available.


Diagnostic utility of diffusion tensor imaging in differentiating glioblastomas from brain metastases.

Wang S, Kim SJ, Poptani H, Woo JH, Mohan S, Jin R, Voluck MR, O'Rourke DM, Wolf RL, Melhem ER, Kim S.

AJNR Am J Neuroradiol. 2014 May;35(5):928-34. doi: 10.3174/ajnr.A3871. Epub 2014 Feb 6.


Diffusion kurtosis imaging: an emerging technique for evaluating the microstructural environment of the brain.

Steven AJ, Zhuo J, Melhem ER.

AJR Am J Roentgenol. 2014 Jan;202(1):W26-33. doi: 10.2214/AJR.13.11365. Review.


Brain ischemia in patients with intracranial hemorrhage: pathophysiological reasoning for aggressive diagnostic management.

Naranjo D, Arkuszewski M, Rudzinski W, Melhem ER, Krejza J.

Neuroradiol J. 2013 Dec;26(6):610-28. Epub 2013 Dec 18. Review.


Advanced MR imaging techniques in the evaluation of nonenhancing gliomas: perfusion-weighted imaging compared with proton magnetic resonance spectroscopy and tumor grade.

Sahin N, Melhem ER, Wang S, Krejza J, Poptani H, Chawla S, Verma G.

Neuroradiol J. 2013 Oct;26(5):531-41. Epub 2013 Nov 7.


Vertebral and Basilar Arteries: Transcranial Color-Coded Duplex Ultrasonography versus Conventional TCD in Detection of Narrowings.

Arkuszewski M, Swiat M, Hurst RW, Weigele JB, Al-Okaili RN, Kasner SE, Melhem ER, Krejza J.

Neuroradiol J. 2012 Nov;25(5):509-14. Epub 2012 Nov 9.


Sickle cell disease in children: accuracy of imaging transcranial Doppler ultrasonography in detection of intracranial arterial stenosis.

Arkuszewski M, Krejza J, Chen R, Kwiatkowski JL, Ichord R, Zimmerman R, Ohene-Frempong K, Melhem ER.

Neuroradiol J. 2012 Sep;25(4):402-10. Epub 2012 Sep 6.


Prevalence of intracranial stenosis and silent cerebral infarcts in children with sickle cell anemia and low risk of stroke.

Arkuszewski M, Krejza J, Chen R, Ichord R, Kwiatkowski JL, Bilello M, Zimmerman R, Ohene-Frempong K, Melhem ER.

Int J Stroke. 2013 Oct;8(7):E50-1. doi: 10.1111/ijs.12115. No abstract available.


Cerebrovascular reactivity across the menstrual cycle in young healthy women.

Krejza J, Rudzinski W, Arkuszewski M, Onuoha O, Melhem ER.

Neuroradiol J. 2013 Aug;26(4):413-9. Epub 2013 Aug 27.


Diagnostic accuracy of diffusion tensor imaging in amyotrophic lateral sclerosis: a systematic review and individual patient data meta-analysis.

Foerster BR, Dwamena BA, Petrou M, Carlos RC, Callaghan BC, Churchill CL, Mohamed MA, Bartels C, Benatar M, Bonzano L, Ciccarelli O, Cosottini M, Ellis CM, Ehrenreich H, Filippini N, Ito M, Kalra S, Melhem ER, Pyra T, Roccatagliata L, Senda J, Sobue G, Turner MR, Feldman EL, Pomper MG.

Acad Radiol. 2013 Sep;20(9):1099-106. doi: 10.1016/j.acra.2013.03.017. Review.


Sickle cell anemia: reference values of cerebral blood flow determined by continuous arterial spin labeling MRI.

Arkuszewski M, Krejza J, Chen R, Melhem ER.

Neuroradiol J. 2013 Apr;26(2):191-200. Epub 2013 May 10.


A Bayesian diagnostic system to differentiate glioblastomas from solitary brain metastases.

Chen R, Wang S, Poptani H, Melhem ER, Herskovits EH.

Neuroradiol J. 2013 Apr;26(2):175-83. Epub 2013 May 10.


Multiple sclerosis: identification of temporal changes in brain lesions with computer-assisted detection software.

Bilello M, Arkuszewski M, Nucifora P, Nasrallah I, Melhem ER, Cirillo L, Krejza J.

Neuroradiol J. 2013 Apr;26(2):143-50. Epub 2013 May 10.


Incidental findings in youths volunteering for brain MRI research.

Gur RE, Kaltman D, Melhem ER, Ruparel K, Prabhakaran K, Riley M, Yodh E, Hakonarson H, Satterthwaite T, Gur RC.

AJNR Am J Neuroradiol. 2013 Oct;34(10):2021-5. doi: 10.3174/ajnr.A3525. Epub 2013 Jun 27.


Vascular distribution of glioblastoma multiforme at diagnosis.

Yohay K, Wolf DS, Aronson LJ, Duus M, Melhem ER, Cohen KJ.

Interv Neuroradiol. 2013 Mar;19(1):127-31. Epub 2013 Mar 4.


Differentiation between oligodendroglioma genotypes using dynamic susceptibility contrast perfusion-weighted imaging and proton MR spectroscopy.

Chawla S, Krejza J, Vossough A, Zhang Y, Kapoor GS, Wang S, O'Rourke DM, Melhem ER, Poptani H.

AJNR Am J Neuroradiol. 2013 Aug;34(8):1542-9. doi: 10.3174/ajnr.A3384. Epub 2013 Jan 31.


Whole-brain analysis of amyotrophic lateral sclerosis by using echo-planar spectroscopic imaging.

Verma G, Woo JH, Chawla S, Wang S, Sheriff S, Elman LB, McCluskey LF, Grossman M, Melhem ER, Maudsley AA, Poptani H.

Radiology. 2013 Jun;267(3):851-7. doi: 10.1148/radiol.13121148. Epub 2013 Jan 29.


Imaging of glutamate neurotransmitter alterations in Alzheimer's disease.

Haris M, Nath K, Cai K, Singh A, Crescenzi R, Kogan F, Verma G, Reddy S, Hariharan H, Melhem ER, Reddy R.

NMR Biomed. 2013 Apr;26(4):386-91. doi: 10.1002/nbm.2875. Epub 2012 Oct 9.


GLISTR: glioma image segmentation and registration.

Gooya A, Pohl KM, Bilello M, Cirillo L, Biros G, Melhem ER, Davatzikos C.

IEEE Trans Med Imaging. 2012 Oct;31(10):1941-54. doi: 10.1109/TMI.2012.2210558. Epub 2012 Aug 13.


Association of pulsatility index in the middle cerebral artery with intelligence quotient in children with sickle cell disease.

Krejza J, Arkuszewski M, Radcliffe J, Flynn TB, Chen R, Kwiatkowski JL, Ichord R, Zimmerman R, Bilello M, Ohene-Frempong K, Melhem ER.

Neuroradiol J. 2012 Jul;25(3):351-9. Epub 2012 Jun 26.


Use of magnetic perfusion-weighted imaging to determine epidermal growth factor receptor variant III expression in glioblastoma.

Tykocinski ES, Grant RA, Kapoor GS, Krejza J, Bohman LE, Gocke TA, Chawla S, Halpern CH, Lopinto J, Melhem ER, O'Rourke DM.

Neuro Oncol. 2012 May;14(5):613-23. doi: 10.1093/neuonc/nos073. Epub 2012 Apr 4.


Automated diffusion tensor tractography: implementation and comparison to user-driven tractography.

Nucifora PG, Wu X, Melhem ER, Gur RE, Gur RC, Verma R.

Acad Radiol. 2012 May;19(5):622-9. doi: 10.1016/j.acra.2012.01.002. Epub 2012 Feb 18.


Survival analysis of patients with high-grade gliomas based on data mining of imaging variables.

Zacharaki EI, Morita N, Bhatt P, O'Rourke DM, Melhem ER, Davatzikos C.

AJNR Am J Neuroradiol. 2012 Jun;33(6):1065-71. doi: 10.3174/ajnr.A2939. Epub 2012 Feb 9.


Diffusion tensor imaging of the corticospinal tract in patients with brain neoplasms.

Morita N, Wang S, Kadakia P, Chawla S, Poptani H, Melhem ER.

Magn Reson Med Sci. 2011;10(4):239-43.


A validation study of multicenter diffusion tensor imaging: reliability of fractional anisotropy and diffusivity values.

Fox RJ, Sakaie K, Lee JC, Debbins JP, Liu Y, Arnold DL, Melhem ER, Smith CH, Philips MD, Lowe M, Fisher E.

AJNR Am J Neuroradiol. 2012 Apr;33(4):695-700. doi: 10.3174/ajnr.A2844. Epub 2011 Dec 15.


Determination of grade and subtype of meningiomas by using histogram analysis of diffusion-tensor imaging metrics.

Wang S, Kim S, Zhang Y, Wang L, Lee EB, Syre P, Poptani H, Melhem ER, Lee JY.

Radiology. 2012 Feb;262(2):584-92. doi: 10.1148/radiol.11110576. Epub 2011 Nov 14.


Sickle cell disease: reference values and interhemispheric differences of nonimaging transcranial Doppler blood flow parameters.

Arkuszewski M, Krejza J, Chen R, Kwiatkowski JL, Ichord R, Zimmerman R, Ohene-Frempong K, Desiderio L, Melhem ER.

AJNR Am J Neuroradiol. 2011 Sep;32(8):1444-50. doi: 10.3174/ajnr.A2529. Epub 2011 Jun 23.


Diffusion MR imaging: basic principles.

Yang E, Nucifora PG, Melhem ER.

Neuroimaging Clin N Am. 2011 Feb;21(1):1-25, vii. doi: 10.1016/j.nic.2011.02.001. Review.


Differentiation between glioblastomas, solitary brain metastases, and primary cerebral lymphomas using diffusion tensor and dynamic susceptibility contrast-enhanced MR imaging.

Wang S, Kim S, Chawla S, Wolf RL, Knipp DE, Vossough A, O'Rourke DM, Judy KD, Poptani H, Melhem ER.

AJNR Am J Neuroradiol. 2011 Mar;32(3):507-14. doi: 10.3174/ajnr.A2333. Epub 2011 Feb 17.


Neuroimaging in amyotrophic lateral sclerosis.

Wang S, Melhem ER, Poptani H, Woo JH.

Neurotherapeutics. 2011 Jan;8(1):63-71. doi: 10.1007/s13311-010-0011-3. Review.


Clinical Application of MR Spectroscopy and Imaging of Brain Tumor.

Morita N, Harada M, Otsuka H, Melhem ER, Nishitani H.

Magn Reson Med Sci. 2010;9(4):167-75. Review.


Neuroimaging in assessment of risk of stroke in children with sickle cell disease.

Arkuszewski M, Melhem ER, Krejza J.

Adv Med Sci. 2010;55(2):115-29. doi: 10.2478/v10039-010-0045-0. Review.


Sickle cell disease and transcranial Doppler imaging: inter-hemispheric differences in blood flow Doppler parameters.

Krejza J, Chen R, Romanowicz G, Kwiatkowski JL, Ichord R, Arkuszewski M, Zimmerman R, Ohene-Frempong K, Desiderio L, Melhem ER.

Stroke. 2011 Jan;42(1):81-6. doi: 10.1161/STROKEAHA.110.591818. Epub 2010 Nov 18.


Proton magnetic resonance spectroscopy in differentiating glioblastomas from primary cerebral lymphomas and brain metastases.

Chawla S, Zhang Y, Wang S, Chaudhary S, Chou C, O'Rourke DM, Vossough A, Melhem ER, Poptani H.

J Comput Assist Tomogr. 2010 Nov-Dec;34(6):836-41. doi: 10.1097/RCT.0b013e3181ec554e.


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