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Items: 1 to 50 of 317

1.

Alzheimer's disease: Key developments support promising perspectives for therapy.

Meldolesi J.

Pharmacol Res. 2019 Aug;146:104316. doi: 10.1016/j.phrs.2019.104316. Epub 2019 Jun 28. Review.

PMID:
31260730
2.

Extracellular vesicles, news about their role in immune cells: physiology, pathology and diseases.

Meldolesi J.

Clin Exp Immunol. 2019 Jun;196(3):318-327. doi: 10.1111/cei.13274. Epub 2019 Mar 11. Review.

PMID:
30756386
3.

News about non-secretory exocytosis: mechanisms, properties, and functions.

D'Alessandro R, Meldolesi J.

J Mol Cell Biol. 2019 Sep 19;11(9):736-746. doi: 10.1093/jmcb/mjy084.

4.

Exosomes and Ectosomes in Intercellular Communication.

Meldolesi J.

Curr Biol. 2018 Apr 23;28(8):R435-R444. doi: 10.1016/j.cub.2018.01.059. Review.

5.

Neurotrophin Trk Receptors: New Targets for Cancer Therapy.

Meldolesi J.

Rev Physiol Biochem Pharmacol. 2018;174:67-79. doi: 10.1007/112_2017_6. Review.

PMID:
28884193
6.

Neurotrophin receptors in the pathogenesis, diagnosis and therapy of neurodegenerative diseases.

Meldolesi J.

Pharmacol Res. 2017 Jul;121:129-137. doi: 10.1016/j.phrs.2017.04.024. Epub 2017 Apr 21. Review.

PMID:
28438600
7.

PRRT2: from Paroxysmal Disorders to Regulation of Synaptic Function.

Valtorta F, Benfenati F, Zara F, Meldolesi J.

Trends Neurosci. 2016 Oct;39(10):668-679. doi: 10.1016/j.tins.2016.08.005. Epub 2016 Sep 10. Review.

PMID:
27624551
8.

Binding and Fusion of Extracellular Vesicles to the Plasma Membrane of Their Cell Targets.

Prada I, Meldolesi J.

Int J Mol Sci. 2016 Aug 9;17(8). pii: E1296. doi: 10.3390/ijms17081296. Review.

9.

REST-Governed Gene Expression Profiling in a Neuronal Cell Model Reveals Novel Direct and Indirect Processes of Repression and Up-Regulation.

Garcia-Manteiga JM, Bonfiglio S, Folladori L, Malosio ML, Lazarevic D, Stupka E, Cittaro D, Meldolesi J.

Front Cell Neurosci. 2015 Nov 10;9:438. doi: 10.3389/fncel.2015.00438. eCollection 2015.

10.

Pharmacology of the cell/matrix form of adhesion.

Meldolesi J.

Pharmacol Res. 2016 May;107:430-436. doi: 10.1016/j.phrs.2015.10.019. Epub 2015 Oct 30. Review.

PMID:
26521758
11.

L1-CAM and N-CAM: From Adhesion Proteins to Pharmacological Targets.

Colombo F, Meldolesi J.

Trends Pharmacol Sci. 2015 Nov;36(11):769-781. doi: 10.1016/j.tips.2015.08.004. Epub 2015 Nov 2. Review.

PMID:
26478212
12.

The Transcription Repressor REST in Adult Neurons: Physiology, Pathology, and Diseases

Baldelli P, Meldolesi J.

eNeuro. 2015 Jul 10;2(4). pii: ENEURO.0010-15.2015. doi: 10.1523/ENEURO.0010-15.2015. eCollection 2015 Jul-Aug. Review.

13.

Epigenomics of Neural Cells: REST-Induced Down- and Upregulation of Gene Expression in a Two-Clone PC12 Cell Model.

Garcia-Manteiga JM, Bonfiglio S, Malosio ML, Lazarevic D, Stupka E, Cittaro D, Meldolesi J.

Biomed Res Int. 2015;2015:202914. doi: 10.1155/2015/202914. Epub 2015 Aug 27.

14.

Ectosomes and exosomes: shedding the confusion between extracellular vesicles.

Cocucci E, Meldolesi J.

Trends Cell Biol. 2015 Jun;25(6):364-72. doi: 10.1016/j.tcb.2015.01.004. Epub 2015 Feb 12. Review.

PMID:
25683921
15.

Neurite outgrowth induced by NGF or L1CAM via activation of the TrkA receptor is sustained also by the exocytosis of enlargeosomes.

Colombo F, Racchetti G, Meldolesi J.

Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16943-8. doi: 10.1073/pnas.1406097111. Epub 2014 Nov 10.

16.

REST/NRSF-mediated intrinsic homeostasis protects neuronal networks from hyperexcitability.

Pozzi D, Lignani G, Ferrea E, Contestabile A, Paonessa F, D'Alessandro R, Lippiello P, Boido D, Fassio A, Meldolesi J, Valtorta F, Benfenati F, Baldelli P.

EMBO J. 2013 Nov 13;32(22):2994-3007. doi: 10.1038/emboj.2013.231. Epub 2013 Oct 22.

17.

NGF signaling in PC12 cells: the cooperation of p75(NTR) with TrkA is needed for the activation of both mTORC2 and the PI3K signalling cascade.

Negrini S, D'Alessandro R, Meldolesi J.

Biol Open. 2013 Jul 12;2(8):855-66. doi: 10.1242/bio.20135116. eCollection 2013 Aug 15.

18.

Expression and function of the dense-core vesicle membranes are governed by the transcription repressor REST.

D'Alessandro R, Meldolesi J.

FEBS Lett. 2013 Jun 27;587(13):1915-22. doi: 10.1016/j.febslet.2013.04.024. Epub 2013 May 4. Review.

19.

REST: an oncogene or a tumor suppressor?

Negrini S, Prada I, D'Alessandro R, Meldolesi J.

Trends Cell Biol. 2013 Jun;23(6):289-95. doi: 10.1016/j.tcb.2013.01.006. Epub 2013 Feb 14. Review.

PMID:
23414932
20.

Cell surface dynamics - how Rho GTPases orchestrate the interplay between the plasma membrane and the cortical cytoskeleton.

de Curtis I, Meldolesi J.

J Cell Sci. 2012 Oct 1;125(Pt 19):4435-44. doi: 10.1242/jcs.108266. Epub 2012 Oct 23. Review.

21.

L1CAM and its cell-surface mutants: new mechanisms and effects relevant to the physiology and pathology of neural cells.

Tagliavacca L, Colombo F, Racchetti G, Meldolesi J.

J Neurochem. 2013 Feb;124(3):397-409. doi: 10.1111/jnc.12015. Epub 2012 Dec 10.

22.

Dual REST-dependence of L1CAM: from gene expression to alternative splicing governed by Nova2 in neural cells.

Mikulak J, Negrini S, Klajn A, D'Alessandro R, Mavilio D, Meldolesi J.

J Neurochem. 2012 Mar;120(5):699-709. doi: 10.1111/j.1471-4159.2011.07626.x. Epub 2012 Jan 23.

23.

Ectosomes.

Cocucci E, Meldolesi J.

Curr Biol. 2011 Dec 6;21(23):R940-1. doi: 10.1016/j.cub.2011.10.011. Epub 2011 Dec 5. No abstract available. Erratum in: Curr Biol. 2012 Jul 24;22(14):1359. Cocucci, Emanulele [corrected to Cocucci, Emanuele].

24.

Astrocyte stellation, a process dependent on Rac1 is sustained by the regulated exocytosis of enlargeosomes.

Racchetti G, D'Alessandro R, Meldolesi J.

Glia. 2012 Mar;60(3):465-75. doi: 10.1002/glia.22280. Epub 2011 Dec 5.

25.

A signaling loop of REST, TSC2 and β-catenin governs proliferation and function of PC12 neural cells.

Tomasoni R, Negrini S, Fiordaliso S, Klajn A, Tkatch T, Mondino A, Meldolesi J, D'Alessandro R.

J Cell Sci. 2011 Sep 15;124(Pt 18):3174-86. doi: 10.1242/jcs.087551. Epub 2011 Aug 24.

26.

Translocation of signalling proteins to the plasma membrane revealed by a new bioluminescent procedure.

Giorgi C, Romagnoli A, Agnoletto C, Bergamelli L, Sorrentino G, Brini M, Pozzan T, Meldolesi J, Pinton P, Rizzuto R.

BMC Cell Biol. 2011 Jun 9;12:27. doi: 10.1186/1471-2121-12-27.

27.

REST/NRSF governs the expression of dense-core vesicle gliosecretion in astrocytes.

Prada I, Marchaland J, Podini P, Magrassi L, D'Alessandro R, Bezzi P, Meldolesi J.

J Cell Biol. 2011 May 2;193(3):537-49. doi: 10.1083/jcb.201010126.

28.

Outgrowth of neurites is a dual process.

D'Alessandro R, Racchetti G, Meldolesi J.

Commun Integr Biol. 2010 Nov;3(6):576-8. doi: 10.4161/cib.3.6.13093. Epub 2010 Nov 1.

29.

In PC12 cells, expression of neurosecretion and neurite outgrowth are governed by the transcription repressor REST/NRSF.

D'Alessandro R, Meldolesi J.

Cell Mol Neurobiol. 2010 Nov;30(8):1295-302. doi: 10.1007/s10571-010-9602-0. Epub 2010 Nov 3. Review.

PMID:
21046448
30.

A new form of neurite outgrowth sustained by the exocytosis of enlargeosomes expressed under the control of REST.

Schulte C, Racchetti G, D'Alessandro R, Meldolesi J.

Traffic. 2010 Oct;11(10):1304-14. doi: 10.1111/j.1600-0854.2010.01095.x.

31.

Neurite outgrowth: this process, first discovered by Santiago Ramon y Cajal, is sustained by the exocytosis of two distinct types of vesicles.

Meldolesi J.

Brain Res Rev. 2011 Jan 7;66(1-2):246-55. doi: 10.1016/j.brainresrev.2010.06.004. Epub 2010 Jun 19.

PMID:
20600308
32.

The regulation of synaptic function by alpha-synuclein.

Bellani S, Sousa VL, Ronzitti G, Valtorta F, Meldolesi J, Chieregatti E.

Commun Integr Biol. 2010 Mar;3(2):106-9.

33.

Differential repression by the transcription factor REST/NRSF of the various Ca2+ signalling mechanisms in pheochromocytoma PC12 cells.

Ariano P, Zamburlin P, D'Alessandro R, Meldolesi J, Lovisolo D.

Cell Calcium. 2010 Apr;47(4):360-8. doi: 10.1016/j.ceca.2010.01.007. Epub 2010 Feb 19.

PMID:
20171735
34.

Rapid neurite outgrowth in neurosecretory cells and neurons is sustained by the exocytosis of a cytoplasmic organelle, the enlargeosome.

Racchetti G, Lorusso A, Schulte C, Gavello D, Carabelli V, D'Alessandro R, Meldolesi J.

J Cell Sci. 2010 Jan 15;123(Pt 2):165-70. doi: 10.1242/jcs.059634. Epub 2009 Dec 21.

35.

{alpha}-synuclein and its A30P mutant affect actin cytoskeletal structure and dynamics.

Sousa VL, Bellani S, Giannandrea M, Yousuf M, Valtorta F, Meldolesi J, Chieregatti E.

Mol Biol Cell. 2009 Aug;20(16):3725-39. doi: 10.1091/mbc.E08-03-0302. Epub 2009 Jun 24.

36.

The surface-exposed chaperone, Hsp60, is an agonist of the microglial TREM2 receptor.

Stefano L, Racchetti G, Bianco F, Passini N, Gupta RS, Panina Bordignon P, Meldolesi J.

J Neurochem. 2009 Jul;110(1):284-94. doi: 10.1111/j.1471-4159.2009.06130.x. Epub 2009 Apr 29.

37.

The rest repression of the neurosecretory phenotype is negatively modulated by BHC80, a protein of the BRAF/HDAC complex.

Klajn A, Ferrai C, Stucchi L, Prada I, Podini P, Baba T, Rocchi M, Meldolesi J, D'Alessandro R.

J Neurosci. 2009 May 13;29(19):6296-307. doi: 10.1523/JNEUROSCI.5943-08.2009.

38.

Expression of dense-core vesicles and of their exocytosis are governed by the repressive transcription factor NRSF/REST.

D'Alessandro R, Klajn A, Meldolesi J.

Ann N Y Acad Sci. 2009 Jan;1152:194-200. doi: 10.1111/j.1749-6632.2008.03988.x. Review.

PMID:
19161390
39.

Shedding microvesicles: artefacts no more.

Cocucci E, Racchetti G, Meldolesi J.

Trends Cell Biol. 2009 Feb;19(2):43-51. doi: 10.1016/j.tcb.2008.11.003. Epub 2009 Jan 12. Review.

PMID:
19144520
40.

The regulated exocytosis of enlargeosomes is mediated by a SNARE machinery that includes VAMP4.

Cocucci E, Racchetti G, Rupnik M, Meldolesi J.

J Cell Sci. 2008 Sep 15;121(Pt 18):2983-91. doi: 10.1242/jcs.032029. Epub 2008 Aug 19.

41.

Inhibition of adipogenesis: a new job for the ER Ca2+ pool.

Meldolesi J.

J Cell Biol. 2008 Jul 14;182(1):11-3. doi: 10.1083/jcb.200805110. Epub 2008 Jul 7.

42.

Beta cell chromogranin B is partially segregated in distinct granules and can be released separately from insulin in response to stimulation.

Giordano T, Brigatti C, Podini P, Bonifacio E, Meldolesi J, Malosio ML.

Diabetologia. 2008 Jun;51(6):997-1007. doi: 10.1007/s00125-008-0980-5. Epub 2008 Apr 24.

PMID:
18437352
43.

Expression of the neurosecretory process in PC12 cells is governed by REST.

D'Alessandro R, Klajn A, Stucchi L, Podini P, Malosio ML, Meldolesi J.

J Neurochem. 2008 May;105(4):1369-83. doi: 10.1111/j.1471-4159.2008.05259.x. Epub 2008 Feb 19.

44.

The Ca2+-dependent exocytosis of enlargeosomes is greatly reinforced by genistein via a non-tyrosine kinase-dependent mechanism.

Prada I, Cocucci E, Racchetti G, Meldolesi J.

FEBS Lett. 2007 Oct 16;581(25):4932-6. Epub 2007 Sep 21.

45.

BACE1 expression and activity: relevance in Alzheimer's disease.

Zacchetti D, Chieregatti E, Bettegazzi B, Mihailovich M, Sousa VL, Grohovaz F, Meldolesi J.

Neurodegener Dis. 2007;4(2-3):117-26. Review.

PMID:
17596706
46.

Enlargeosome traffic: exocytosis triggered by various signals is followed by endocytosis, membrane shedding or both.

Cocucci E, Racchetti G, Podini P, Meldolesi J.

Traffic. 2007 Jun;8(6):742-57. Epub 2007 May 4.

47.

Annexin2 coating the surface of enlargeosomes is needed for their regulated exocytosis.

Lorusso A, Covino C, Priori G, Bachi A, Meldolesi J, Chieregatti E.

EMBO J. 2006 Nov 29;25(23):5443-56. Epub 2006 Nov 2.

48.

Macropinocytosis: regulated coordination of endocytic and exocytic membrane traffic events.

Falcone S, Cocucci E, Podini P, Kirchhausen T, Clementi E, Meldolesi J.

J Cell Sci. 2006 Nov 15;119(Pt 22):4758-69. Epub 2006 Oct 31.

49.

Triggering receptor expressed in myeloid cells 2 (TREM2) trafficking in microglial cells: continuous shuttling to and from the plasma membrane regulated by cell stimulation.

Prada I, Ongania GN, Buonsanti C, Panina-Bordignon P, Meldolesi J.

Neuroscience. 2006 Jul 21;140(4):1139-48. Epub 2006 May 3.

PMID:
16675145
50.

Non-secretory exocytoses in the brain.

Cocucci E, Lorusso A, Ongania GN, Klajn A, Meldolesi J.

J Physiol Paris. 2006 Mar-May;99(2-3):140-5. Epub 2006 Jan 19. Review.

PMID:
16426824

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