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The ubiquitin-like modifier FAT10 interferes with SUMO activation.

Aichem A, Sailer C, Ryu S, Catone N, Stankovic-Valentin N, Schmidtke G, Melchior F, Stengel F, Groettrup M.

Nat Commun. 2019 Oct 1;10(1):4452. doi: 10.1038/s41467-019-12430-z.


Intervention of Inflammatory Monocyte Activity Limits Dermal Fibrosis.

Haub J, Roehrig N, Uhrin P, Schabbauer G, Eulberg D, Melchior F, Shahneh F, Probst HC, Becker C, Steinbrink K, Raker VK.

J Invest Dermatol. 2019 Oct;139(10):2144-2153. doi: 10.1016/j.jid.2019.04.006. Epub 2019 Apr 27.


Hypoxia-induced Changes in SUMO Conjugation Affect Transcriptional Regulation Under Low Oxygen.

Chachami G, Stankovic-Valentin N, Karagiota A, Basagianni A, Plessmann U, Urlaub H, Melchior F, Simos G.

Mol Cell Proteomics. 2019 Jun;18(6):1197-1209. doi: 10.1074/mcp.RA119.001401. Epub 2019 Mar 29.


Retraction: Pyrophosphate modulates plant stress responses via SUMOylation.

Patir Nebioglu MG, Andrés Z, Krebs M, Fink F, Drzewicka K, Stankovic-Valentin N, Segami S, Schuck S, Büttner M, Hell R, Maeshima M, Melchior F, Schumacher K.

Elife. 2019 Mar 26;8. pii: e46993. doi: 10.7554/eLife.46993.


Pyrophosphate modulates plant stress responses via SUMOylation.

Patir-Nebioglu MG, Andrés Z, Krebs M, Fink F, Drzewicka K, Stankovic-Valentin N, Segami S, Schuck S, Büttner M, Hell R, Maeshima M, Melchior F, Schumacher K.

Elife. 2019 Feb 20;8. pii: e44213. doi: 10.7554/eLife.44213. Retraction in: Elife. 2019 Mar 26;8:.


Production of Extracellular Adenosine by CD73+ Dendritic Cells Is Crucial for Induction of Tolerance in Contact Hypersensitivity Reactions.

Silva-Vilches C, Ring S, Schrader J, Clausen BE, Probst HC, Melchior F, Schild H, Enk A, Mahnke K.

J Invest Dermatol. 2019 Mar;139(3):541-551. doi: 10.1016/j.jid.2018.10.016. Epub 2018 Oct 28.


Dermal CD207-Negative Migratory Dendritic Cells Are Fully Competent to Prime Protective, Skin Homing Cytotoxic T-Lymphocyte Responses.

Hain T, Melchior F, Kamenjarin N, Muth S, Weslati H, Clausen BE, Mahnke K, Silva-Vilches C, Schütze K, Sohl J, Radsak MP, Bündgen G, Bopp T, Danckwardt S, Schild H, Probst HC.

J Invest Dermatol. 2019 Feb;139(2):422-429. doi: 10.1016/j.jid.2018.08.022. Epub 2018 Oct 6.


Control of SUMO and Ubiquitin by ROS: Signaling and disease implications.

Stankovic-Valentin N, Melchior F.

Mol Aspects Med. 2018 Oct;63:3-17. doi: 10.1016/j.mam.2018.07.002. Epub 2018 Aug 4. Review.


IRAK2 directs stimulus-dependent nuclear export of inflammatory mRNAs.

Zhou H, Bulek K, Li X, Herjan T, Yu M, Qian W, Wang H, Zhou G, Chen X, Yang H, Hong L, Zhao J, Qin L, Fukuda K, Flotho A, Gao J, Dongre A, Carman JA, Kang Z, Su B, Kern TS, Smith JD, Hamilton TA, Melchior F, Fox PL, Li X.

Elife. 2017 Oct 9;6. pii: e29630. doi: 10.7554/eLife.29630.


Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases.

Lauinger L, Li J, Shostak A, Cemel IA, Ha N, Zhang Y, Merkl PE, Obermeyer S, Stankovic-Valentin N, Schafmeier T, Wever WJ, Bowers AA, Carter KP, Palmer AE, Tschochner H, Melchior F, Deshaies RJ, Brunner M, Diernfellner A.

Nat Chem Biol. 2017 Jul;13(7):709-714. doi: 10.1038/nchembio.2370. Epub 2017 May 1.


Reconstitution of the Recombinant RanBP2 SUMO E3 Ligase Complex.

Ritterhoff T, Das H, Hao Y, Sakin V, Flotho A, Werner A, Melchior F.

Methods Mol Biol. 2016;1475:41-54. doi: 10.1007/978-1-4939-6358-4_3.


Redox regulation of SUMO enzymes is required for ATM activity and survival in oxidative stress.

Stankovic-Valentin N, Drzewicka K, König C, Schiebel E, Melchior F.

EMBO J. 2016 Jun 15;35(12):1312-29. doi: 10.15252/embj.201593404. Epub 2016 May 12.


The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes.

Ritterhoff T, Das H, Hofhaus G, Schröder RR, Flotho A, Melchior F.

Nat Commun. 2016 May 10;7:11482. doi: 10.1038/ncomms11482.


Sumoylation of the GTPase Ran by the RanBP2 SUMO E3 Ligase Complex.

Sakin V, Richter SM, Hsiao HH, Urlaub H, Melchior F.

J Biol Chem. 2015 Sep 25;290(39):23589-602. doi: 10.1074/jbc.M115.660118. Epub 2015 Aug 6.


A stable chemical SUMO1-Ubc9 conjugate specifically binds as a thioester mimic to the RanBP2-E3 ligase complex.

Sommer S, Ritterhoff T, Melchior F, Mootz HD.

Chembiochem. 2015 May 26;16(8):1183-9. doi: 10.1002/cbic.201500011. Epub 2015 Apr 27.


SUMOylation-dependent LRH-1/PROX1 interaction promotes atherosclerosis by decreasing hepatic reverse cholesterol transport.

Stein S, Oosterveer MH, Mataki C, Xu P, Lemos V, Havinga R, Dittner C, Ryu D, Menzies KJ, Wang X, Perino A, Houten SM, Melchior F, Schoonjans K.

Cell Metab. 2014 Oct 7;20(4):603-13. doi: 10.1016/j.cmet.2014.07.023. Epub 2014 Aug 28.


The Ran GTPase-activating protein (RanGAP1) is critically involved in smooth muscle cell differentiation, proliferation and migration following vascular injury: implications for neointima formation and restenosis.

Vorpahl M, Schönhofer-Merl S, Michaelis C, Flotho A, Melchior F, Wessely R.

PLoS One. 2014 Jul 2;9(7):e101519. doi: 10.1371/journal.pone.0101519. eCollection 2014.


Identification and analysis of endogenous SUMO1 and SUMO2/3 targets in mammalian cells and tissues using monoclonal antibodies.

Barysch SV, Dittner C, Flotho A, Becker J, Melchior F.

Nat Protoc. 2014 Apr;9(4):896-909. doi: 10.1038/nprot.2014.053. Epub 2014 Mar 20.


A role for the Cajal-body-associated SUMO isopeptidase USPL1 in snRNA transcription mediated by RNA polymerase II.

Hutten S, Chachami G, Winter U, Melchior F, Lamond AI.

J Cell Sci. 2014 Mar 1;127(Pt 5):1065-78. doi: 10.1242/jcs.141788. Epub 2014 Jan 10.


Sumoylation: a regulatory protein modification in health and disease.

Flotho A, Melchior F.

Annu Rev Biochem. 2013;82:357-85. doi: 10.1146/annurev-biochem-061909-093311. Review.


Detecting endogenous SUMO targets in mammalian cells and tissues.

Becker J, Barysch SV, Karaca S, Dittner C, Hsiao HH, Berriel Diaz M, Herzig S, Urlaub H, Melchior F.

Nat Struct Mol Biol. 2013 Apr;20(4):525-31. doi: 10.1038/nsmb.2526. Epub 2013 Mar 17.


Exploring the association between genetic variation in the SUMO isopeptidase gene USPL1 and breast cancer through integration of data from the population-based GENICA study and external genetic databases.

Bermejo JL, Kabisch M, Dünnebier T, Schnaidt S, Melchior F, Fischer HP, Harth V, Rabstein S, Pesch B, Brüning T, Justenhoven C, Brauch H, Baisch C, Ko YD, Hamann U.

Int J Cancer. 2013 Jul 15;133(2):362-72. doi: 10.1002/ijc.28040. Epub 2013 Feb 25.


SCFFbxw5 mediates transient degradation of actin remodeller Eps8 to allow proper mitotic progression.

Werner A, Disanza A, Reifenberger N, Habeck G, Becker J, Calabrese M, Urlaub H, Lorenz H, Schulman B, Scita G, Melchior F.

Nat Cell Biol. 2013 Feb;15(2):179-88. doi: 10.1038/ncb2661. Epub 2013 Jan 13.


In vivo localization and identification of SUMOylated proteins in the brain of His6-HA-SUMO1 knock-in mice.

Tirard M, Hsiao HH, Nikolov M, Urlaub H, Melchior F, Brose N.

Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):21122-7. doi: 10.1073/pnas.1215366110. Epub 2012 Dec 3.


A novel SUMO1-specific interacting motif in dipeptidyl peptidase 9 (DPP9) that is important for enzymatic regulation.

Pilla E, Möller U, Sauer G, Mattiroli F, Melchior F, Geiss-Friedlander R.

J Biol Chem. 2012 Dec 28;287(53):44320-9. doi: 10.1074/jbc.M112.397224. Epub 2012 Nov 14.


Ubiquitin-specific protease-like 1 (USPL1) is a SUMO isopeptidase with essential, non-catalytic functions.

Schulz S, Chachami G, Kozaczkiewicz L, Winter U, Stankovic-Valentin N, Haas P, Hofmann K, Urlaub H, Ovaa H, Wittbrodt J, Meulmeester E, Melchior F.

EMBO Rep. 2012 Oct;13(10):930-8. doi: 10.1038/embor.2012.125. Epub 2012 Aug 10.


SUMO unloads the Kap114 cab.

Werner A, Melchior F.

EMBO J. 2012 May 30;31(11):2439-40. doi: 10.1038/emboj.2012.103. Epub 2012 May 4.


Dynamically regulated sumoylation of HDAC2 controls p53 deacetylation and restricts apoptosis following genotoxic stress.

Brandl A, Wagner T, Uhlig KM, Knauer SK, Stauber RH, Melchior F, Schneider G, Heinzel T, Krämer OH.

J Mol Cell Biol. 2012 Oct;4(5):284-93. doi: 10.1093/jmcb/mjs013. Epub 2012 Apr 5.


The RanBP2/RanGAP1*SUMO1/Ubc9 complex is a multisubunit SUMO E3 ligase.

Werner A, Flotho A, Melchior F.

Mol Cell. 2012 May 11;46(3):287-98. doi: 10.1016/j.molcel.2012.02.017. Epub 2012 Mar 29.


Recombinant reconstitution of sumoylation reactions in vitro.

Flotho A, Werner A, Winter T, Frank AS, Ehret H, Melchior F.

Methods Mol Biol. 2012;832:93-110. doi: 10.1007/978-1-61779-474-2_5.


Sumoylation inhibits alpha-synuclein aggregation and toxicity.

Krumova P, Meulmeester E, Garrido M, Tirard M, Hsiao HH, Bossis G, Urlaub H, Zweckstetter M, Kügler S, Melchior F, Bähr M, Weishaupt JH.

J Cell Biol. 2011 Jul 11;194(1):49-60. doi: 10.1083/jcb.201010117.


Importin α/β mediates nuclear import of individual SUMO E1 subunits and of the holo-enzyme.

Moutty MC, Sakin V, Melchior F.

Mol Biol Cell. 2011 Mar 1;22(5):652-60. doi: 10.1091/mbc.E10-05-0461. Epub 2011 Jan 5.


Bicaudal D2, dynein, and kinesin-1 associate with nuclear pore complexes and regulate centrosome and nuclear positioning during mitotic entry.

Splinter D, Tanenbaum ME, Lindqvist A, Jaarsma D, Flotho A, Yu KL, Grigoriev I, Engelsma D, Haasdijk ED, Keijzer N, Demmers J, Fornerod M, Melchior F, Hoogenraad CC, Medema RH, Akhmanova A.

PLoS Biol. 2010 Apr 6;8(4):e1000350. doi: 10.1371/journal.pbio.1000350.


Frauke Melchior: How SUMO wrestles other proteins. Interview by Caitlin Sedwick.

Melchior F.

J Cell Biol. 2009 Nov 30;187(5):586-7. doi: 10.1083/jcb.1875pi. No abstract available.


"ChopNSpice," a mass spectrometric approach that allows identification of endogenous small ubiquitin-like modifier-conjugated peptides.

Hsiao HH, Meulmeester E, Frank BT, Melchior F, Urlaub H.

Mol Cell Proteomics. 2009 Dec;8(12):2664-75. doi: 10.1074/mcp.M900087-MCP200. Epub 2009 Aug 31.


The cytoplasmic peptidase DPP9 is rate-limiting for degradation of proline-containing peptides.

Geiss-Friedlander R, Parmentier N, Möller U, Urlaub H, Van den Eynde BJ, Melchior F.

J Biol Chem. 2009 Oct 2;284(40):27211-9. doi: 10.1074/jbc.M109.041871. Epub 2009 Aug 10.


An in vitro FRET-based assay for the analysis of SUMO conjugation and isopeptidase cleavage.

Stankovic-Valentin N, Kozaczkiewicz L, Curth K, Melchior F.

Methods Mol Biol. 2009;497:241-51. doi: 10.1007/978-1-59745-566-4_16. Review.


Performing in vitro sumoylation reactions using recombinant enzymes.

Werner A, Moutty MC, Möller U, Melchior F.

Methods Mol Biol. 2009;497:187-99. doi: 10.1007/978-1-59745-566-4_12. Review.


Mechanism and consequences for paralog-specific sumoylation of ubiquitin-specific protease 25.

Meulmeester E, Kunze M, Hsiao HH, Urlaub H, Melchior F.

Mol Cell. 2008 Jun 6;30(5):610-9. doi: 10.1016/j.molcel.2008.03.021.


Cell biology: SUMO.

Meulmeester E, Melchior F.

Nature. 2008 Apr 10;452(7188):709-11. doi: 10.1038/452709a. No abstract available.


The Nup358-RanGAP complex is required for efficient importin alpha/beta-dependent nuclear import.

Hutten S, Flotho A, Melchior F, Kehlenbach RH.

Mol Biol Cell. 2008 May;19(5):2300-10. doi: 10.1091/mbc.E07-12-1279. Epub 2008 Feb 27.


Concepts in sumoylation: a decade on.

Geiss-Friedlander R, Melchior F.

Nat Rev Mol Cell Biol. 2007 Dec;8(12):947-56. Review.


Sumoylation and proteasomal activity determine the transactivation properties of the mineralocorticoid receptor.

Tirard M, Almeida OF, Hutzler P, Melchior F, Michaelidis TM.

Mol Cell Endocrinol. 2007 Mar 30;268(1-2):20-9. Epub 2007 Jan 25.


SUMO: regulating the regulator.

Bossis G, Melchior F.

Cell Div. 2006 Jun 29;1:13.


Regulation of SUMOylation by reversible oxidation of SUMO conjugating enzymes.

Bossis G, Melchior F.

Mol Cell. 2006 Feb 3;21(3):349-57.


SUMOylation of the corepressor N-CoR modulates its capacity to repress transcription.

Tiefenbach J, Novac N, Ducasse M, Eck M, Melchior F, Heinzel T.

Mol Biol Cell. 2006 Apr;17(4):1643-51. Epub 2006 Jan 18.


Edna Mabel Auger (1876-1932).

Melchior F.

Alta RN. 2005 Nov;61(10):13-4.


A fluorescence resonance energy transfer-based assay to study SUMO modification in solution.

Bossis G, Chmielarska K, Gärtner U, Pichler A, Stieger E, Melchior F.

Methods Enzymol. 2005;398:20-32.


Quantitative SUMO-1 modification of a vaccinia virus protein is required for its specific localization and prevents its self-association.

Palacios S, Perez LH, Welsch S, Schleich S, Chmielarska K, Melchior F, Locker JK.

Mol Biol Cell. 2005 Jun;16(6):2822-35. Epub 2005 Mar 30.


SUMO modification of the ubiquitin-conjugating enzyme E2-25K.

Pichler A, Knipscheer P, Oberhofer E, van Dijk WJ, Körner R, Olsen JV, Jentsch S, Melchior F, Sixma TK.

Nat Struct Mol Biol. 2005 Mar;12(3):264-9. Epub 2005 Feb 20.


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