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Items: 25


Modulating the antibody density changes the uptake and transport at the blood-brain barrier of both transferrin receptor-targeted gold nanoparticles and liposomal cargo.

Johnsen KB, Bak M, Melander F, Thomsen MS, Burkhart A, Kempen PJ, Andresen TL, Moos T.

J Control Release. 2019 Feb 10;295:237-249. doi: 10.1016/j.jconrel.2019.01.005. Epub 2019 Jan 10.


Theranostic Imaging May Vaccinate against the Therapeutic Benefit of Long Circulating PEGylated Liposomes and Change Cargo Pharmacokinetics.

Børresen B, Henriksen JR, Clergeaud G, Jørgensen JS, Melander F, Elema DR, Szebeni J, Engelholm SA, Kristensen AT, Kjær A, Andresen TL, Hansen AE.

ACS Nano. 2018 Nov 27;12(11):11386-11398. doi: 10.1021/acsnano.8b06266. Epub 2018 Oct 31.


Multifarious Biologic Loaded Liposomes that Stimulate the Mammalian Target of Rapamycin Signaling Pathway Show Retina Neuroprotection after Retina Damage.

Eriksen AZ, Eliasen R, Oswald J, Kempen PJ, Melander F, Andresen TL, Young M, Baranov P, Urquhart AJ.

ACS Nano. 2018 Aug 28;12(8):7497-7508. doi: 10.1021/acsnano.8b00596. Epub 2018 Jul 18.


Antibody affinity and valency impact brain uptake of transferrin receptor-targeted gold nanoparticles.

Johnsen KB, Bak M, Kempen PJ, Melander F, Burkhart A, Thomsen MS, Nielsen MS, Moos T, Andresen TL.

Theranostics. 2018 May 24;8(12):3416-3436. doi: 10.7150/thno.25228. eCollection 2018.


Endothelial Protein C-Targeting Liposomes Show Enhanced Uptake and Improved Therapeutic Efficacy in Human Retinal Endothelial Cells.

Arta A, Eriksen AZ, Melander F, Kempen P, Larsen M, Andresen TL, Urquhart AJ.

Invest Ophthalmol Vis Sci. 2018 Apr 1;59(5):2119-2132. doi: 10.1167/iovs.18-23800.


Targeting transferrin receptors at the blood-brain barrier improves the uptake of immunoliposomes and subsequent cargo transport into the brain parenchyma.

Johnsen KB, Burkhart A, Melander F, Kempen PJ, Vejlebo JB, Siupka P, Nielsen MS, Andresen TL, Moos T.

Sci Rep. 2017 Sep 4;7(1):10396. doi: 10.1038/s41598-017-11220-1.


Revisiting the use of sPLA2-sensitive liposomes in cancer therapy.

Pourhassan H, Clergeaud G, Hansen AE, Østrem RG, Fliedner FP, Melander F, Nielsen OL, O'Sullivan CK, Kjær A, Andresen TL.

J Control Release. 2017 Sep 10;261:163-173. doi: 10.1016/j.jconrel.2017.06.024. Epub 2017 Jun 27.


18F-FDG PET/CT-based early treatment response evaluation of nanoparticle-assisted photothermal cancer therapy.

Norregaard K, Jørgensen JT, Simón M, Melander F, Kristensen LK, Bendix PM, Andresen TL, Oddershede LB, Kjaer A.

PLoS One. 2017 May 24;12(5):e0177997. doi: 10.1371/journal.pone.0177997. eCollection 2017.


Multiplexed Dosing Assays by Digitally Definable Hydrogel Volumes.

Faralli A, Melander F, Larsen EK, Chernyy S, Andresen TL, Larsen NB.

Adv Healthc Mater. 2016 Jan 21;5(2):244-54. doi: 10.1002/adhm.201500542. Epub 2015 Nov 30.


Impedimetric toxicity assay in microfluidics using free and liposome-encapsulated anticancer drugs.

Caviglia C, Zór K, Montini L, Tilli V, Canepa S, Melander F, Muhammad HB, Carminati M, Ferrari G, Raiteri R, Heiskanen A, Andresen TL, Emnéus J.

Anal Chem. 2015 Feb 17;87(4):2204-12. doi: 10.1021/ac503621d. Epub 2015 Feb 4.


Synthesis of tocopheryl succinate phospholipid conjugates and monitoring of phospholipase A₂ activity.

Pedersen PJ, Viart HM, Melander F, Andresen TL, Madsen R, Clausen MH.

Bioorg Med Chem. 2012 Jul 1;20(13):3972-8. doi: 10.1016/j.bmc.2012.05.024. Epub 2012 May 17.


Mechanistic study of the sPLA2-mediated hydrolysis of a thio-ester pro anticancer ether lipid.

Linderoth L, Fristrup P, Hansen M, Melander F, Madsen R, Andresen TL, Peters GH.

J Am Chem Soc. 2009 Sep 2;131(34):12193-200. doi: 10.1021/ja901412j.


Synthesis and biophysical characterization of chlorambucil anticancer ether lipid prodrugs.

Pedersen PJ, Christensen MS, Ruysschaert T, Linderoth L, Andresen TL, Melander F, Mouritsen OG, Madsen R, Clausen MH.

J Med Chem. 2009 May 28;52(10):3408-15. doi: 10.1021/jm900091h.


Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin.

Melander F, Bekker-Jensen S, Falck J, Bartek J, Mailand N, Lukas J.

J Cell Biol. 2008 Apr 21;181(2):213-26. doi: 10.1083/jcb.200708210. Epub 2008 Apr 14.


RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins.

Mailand N, Bekker-Jensen S, Faustrup H, Melander F, Bartek J, Lukas C, Lukas J.

Cell. 2007 Nov 30;131(5):887-900. Epub 2007 Nov 20.


Regulation of the Rab5 GTPase-activating protein RN-tre by the dual specificity phosphatase Cdc14A in human cells.

Lanzetti L, Margaria V, Melander F, Virgili L, Lee MH, Bartek J, Jensen S.

J Biol Chem. 2007 May 18;282(20):15258-70. Epub 2007 Mar 19.


Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks.

Bekker-Jensen S, Lukas C, Kitagawa R, Melander F, Kastan MB, Bartek J, Lukas J.

J Cell Biol. 2006 Apr 24;173(2):195-206. Epub 2006 Apr 17.


Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1.

Bekker-Jensen S, Lukas C, Melander F, Bartek J, Lukas J.

J Cell Biol. 2005 Jul 18;170(2):201-11. Epub 2005 Jul 11.


Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention.

Lukas C, Melander F, Stucki M, Falck J, Bekker-Jensen S, Goldberg M, Lerenthal Y, Jackson SP, Bartek J, Lukas J.

EMBO J. 2004 Jul 7;23(13):2674-83. Epub 2004 Jun 17.


Engagement of beta2 integrins recruits 14-3-3 proteins to c-Cbl in human neutrophils.

Melander F, Andersson T, Dib K.

Biochem Biophys Res Commun. 2004 May 14;317(4):1000-5.


p38-MAPK signals survival by phosphorylation of caspase-8 and caspase-3 in human neutrophils.

Alvarado-Kristensson M, Melander F, Leandersson K, Rönnstrand L, Wernstedt C, Andersson T.

J Exp Med. 2004 Feb 16;199(4):449-58.


Down-regulation of Rac activity during beta 2 integrin-mediated adhesion of human neutrophils.

Dib K, Melander F, Axelsson L, Dagher MC, Aspenström P, Andersson T.

J Biol Chem. 2003 Jun 27;278(26):24181-8. Epub 2003 Apr 3.


Role of p190RhoGAP in beta 2 integrin regulation of RhoA in human neutrophils.

Dib K, Melander F, Andersson T.

J Immunol. 2001 May 15;166(10):6311-22.


Clustering of beta(2)-integrins on human neutrophils activates dual signaling pathways to PtdIns 3-kinase.

Axelsson L, Hellberg C, Melander F, Smith D, Zheng L, Andersson T.

Exp Cell Res. 2000 Apr 10;256(1):257-63.


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