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Items: 20


Genetic Incorporation of Unnatural Amino Acids into Proteins of Interest in Streptomyces venezuelae ATCC 15439.

He J, Melançon CE 3rd.

Methods Mol Biol. 2018;1728:155-168. doi: 10.1007/978-1-4939-7574-7_10.


Complete Genome Sequence of Streptomyces venezuelae ATCC 15439, Producer of the Methymycin/Pikromycin Family of Macrolide Antibiotics, Using PacBio Technology.

He J, Sundararajan A, Devitt NP, Schilkey FD, Ramaraj T, Melançon CE 3rd.

Genome Announc. 2016 May 5;4(3). pii: e00337-16. doi: 10.1128/genomeA.00337-16.


Development of an Unnatural Amino Acid Incorporation System in the Actinobacterial Natural Product Producer Streptomyces venezuelae ATCC 15439.

He J, Van Treeck B, Nguyen HB, Melançon CE 3rd.

ACS Synth Biol. 2016 Feb 19;5(2):125-32. doi: 10.1021/acssynbio.5b00209. Epub 2015 Nov 18.


Detection and Quantification of Ribosome Inhibition by Aminoglycoside Antibiotics in Living Bacteria Using an Orthogonal Ribosome-Controlled Fluorescent Reporter.

Huang S, Zhu X, Melançon CE 3rd.

ACS Chem Biol. 2016 Jan 15;11(1):31-7. doi: 10.1021/acschembio.5b00779. Epub 2015 Nov 4.


Correction: Expanding our Understanding of Sequence-Function Relationships of Type II Polyketide Biosynthetic Gene Clusters: Bioinformatics-Guided Identification of Frankiamicin A from Frankia sp. EAN1pec.

Ogasawara Y, Yackley BJ, Greenberg JA, Rogelj S, Melançon CE 3rd.

PLoS One. 2015 Jun 1;10(6):e0129408. doi: 10.1371/journal.pone.0129408. eCollection 2015. No abstract available.


High-Quality Draft Genome Sequence of Actinobacterium Kibdelosporangium sp. MJ126-NF4, Producer of Type II Polyketide Azicemicins, Using Illumina and PacBio Technologies.

Ogasawara Y, Torrez-Martinez N, Aragon AD, Yackley BJ, Weber JA, Sundararajan A, Ramaraj T, Edwards JS, Melançon CE 3rd.

Genome Announc. 2015 Apr 2;3(2). pii: e00114-15. doi: 10.1128/genomeA.00114-15.


Expanding our understanding of sequence-function relationships of type II polyketide biosynthetic gene clusters: bioinformatics-guided identification of Frankiamicin A from Frankia sp. EAN1pec.

Ogasawara Y, Yackley BJ, Greenberg JA, Rogelj S, Melançon CE 3rd.

PLoS One. 2015 Apr 2;10(4):e0121505. doi: 10.1371/journal.pone.0121505. eCollection 2015. Erratum in: PLoS One. 2015;10(6):e0129408.


Biochemistry: Elusive source of sulfur unravelled.

Melançon CE 3rd.

Nature. 2015 Feb 5;518(7537):45-6. doi: 10.1038/nature14197. Epub 2015 Jan 14. No abstract available.


Emerging trends in the discovery of natural product antibacterials.

Bologa CG, Ursu O, Oprea TI, Melançon CE 3rd, Tegos GP.

Curr Opin Pharmacol. 2013 Oct;13(5):678-87. doi: 10.1016/j.coph.2013.07.002. Epub 2013 Jul 24. Review.


Evolution of amber suppressor tRNAs for efficient bacterial production of proteins containing nonnatural amino acids.

Guo J, Melançon CE 3rd, Lee HS, Groff D, Schultz PG.

Angew Chem Int Ed Engl. 2009;48(48):9148-51. doi: 10.1002/anie.200904035. No abstract available.


One plasmid selection system for the rapid evolution of aminoacyl-tRNA synthetases.

Melançon CE 3rd, Schultz PG.

Bioorg Med Chem Lett. 2009 Jul 15;19(14):3845-7. doi: 10.1016/j.bmcl.2009.04.007. Epub 2009 Apr 9.


Natural-product sugar biosynthesis and enzymatic glycodiversification.

Thibodeaux CJ, Melançon CE 3rd, Liu HW.

Angew Chem Int Ed Engl. 2008;47(51):9814-59. doi: 10.1002/anie.200801204. Review.


In vitro characterization of the enzymes involved in TDP-D-forosamine biosynthesis in the spinosyn pathway of Saccharopolyspora spinosa.

Hong L, Zhao Z, Melançon CE 3rd, Zhang H, Liu HW.

J Am Chem Soc. 2008 Apr 9;130(14):4954-67. doi: 10.1021/ja0771383. Epub 2008 Mar 18.


Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.

Zhang H, White-Phillip JA, Melançon CE 3rd, Kwon HJ, Yu WL, Liu HW.

J Am Chem Soc. 2007 Nov 28;129(47):14670-83. Epub 2007 Nov 7.


Unusual sugar biosynthesis and natural product glycodiversification.

Thibodeaux CJ, Melançon CE, Liu HW.

Nature. 2007 Apr 26;446(7139):1008-16. Review.


Engineered biosynthesis of macrolide derivatives bearing the non-natural deoxysugars 4-epi-D-mycaminose and 3-n-monomethylamino-3-deoxy-D-fucose.

Melançon CE 3rd, Liu HW.

J Am Chem Soc. 2007 Apr 25;129(16):4896-7. Epub 2007 Mar 28. No abstract available.


Glyco-stripping and glyco-swapping.

Melançon CE 3rd, Thibodeaux CJ, Liu HW.

ACS Chem Biol. 2006 Sep 19;1(8):499-504.


TDP-mycaminose biosynthetic pathway revised and conversion of desosamine pathway to mycaminose pathway with one gene.

Melançon CE 3rd, Yu WL, Liu HW.

J Am Chem Soc. 2005 Sep 7;127(35):12240-1.


Characterization of tylM3/tylM2 and mydC/mycB pairs required for efficient glycosyltransfer in macrolide antibiotic biosynthesis.

Melançon CE 3rd, Takahashi H, Liu HW.

J Am Chem Soc. 2004 Dec 29;126(51):16726-7.


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