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Items: 1 to 50 of 62

1.

Zika Virus Non-Structural Protein NS5 Inhibits the RIG-I Pathway and Interferon Lambda 1 Promoter Activation by Targeting IKK Epsilon.

Lundberg R, Melén K, Westenius V, Jiang M, Österlund P, Khan H, Vapalahti O, Julkunen I, Kakkola L.

Viruses. 2019 Nov 4;11(11). pii: E1024. doi: 10.3390/v11111024.

2.

Asian and African lineage Zika viruses show differential replication and innate immune responses in human dendritic cells and macrophages.

Österlund P, Jiang M, Westenius V, Kuivanen S, Järvi R, Kakkola L, Lundberg R, Melén K, Korva M, Avšič-Županc T, Vapalahti O, Julkunen I.

Sci Rep. 2019 Oct 31;9(1):15710. doi: 10.1038/s41598-019-52307-1.

3.

Ebolavirus protein VP24 interferes with innate immune responses by inhibiting interferon-λ1 gene expression.

He F, Melén K, Maljanen S, Lundberg R, Jiang M, Österlund P, Kakkola L, Julkunen I.

Virology. 2017 Sep;509:23-34. doi: 10.1016/j.virol.2017.06.002. Epub 2017 Jun 5.

4.

Production, purification and immunogenicity of recombinant Ebola virus proteins - A comparison of Freund's adjuvant and adjuvant system 03.

Melén K, Kakkola L, He F, Airenne K, Vapalahti O, Karlberg H, Mirazimi A, Julkunen I.

J Virol Methods. 2017 Apr;242:35-45. doi: 10.1016/j.jviromet.2016.12.014. Epub 2016 Dec 24.

PMID:
28025125
5.

Middle East respiratory syndrome coronavirus shows poor replication but significant induction of antiviral responses in human monocyte-derived macrophages and dendritic cells.

Tynell J, Westenius V, Rönkkö E, Munster VJ, Melén K, Österlund P, Julkunen I.

J Gen Virol. 2016 Feb;97(2):344-355. doi: 10.1099/jgv.0.000351. Epub 2015 Nov 24.

6.

Blood MxA protein as a marker for respiratory virus infections in young children.

Toivonen L, Schuez-Havupalo L, Rulli M, Ilonen J, Pelkonen J, Melen K, Julkunen I, Peltola V, Waris M.

J Clin Virol. 2015 Jan;62:8-13. doi: 10.1016/j.jcv.2014.11.018. Epub 2014 Nov 18.

PMID:
25542463
7.

Mutations within the conserved NS1 nuclear export signal lead to inhibition of influenza A virus replication.

Tynell J, Melén K, Julkunen I.

Virol J. 2014 Jul 14;11:128. doi: 10.1186/1743-422X-11-128.

8.

No serological evidence of influenza A H1N1pdm09 virus infection as a contributing factor in childhood narcolepsy after Pandemrix vaccination campaign in Finland.

Melén K, Partinen M, Tynell J, Sillanpää M, Himanen SL, Saarenpää-Heikkilä O, Hublin C, Olsen P, Ilonen J, Nohynek H, Syrjänen R, Kilpi T, Vuorela A, Kirjavainen T, Vaarala O, Julkunen I.

PLoS One. 2013 Aug 8;8(8):e68402. doi: 10.1371/journal.pone.0068402. eCollection 2013.

9.

Hepatitis C virus NS2 protease inhibits host cell antiviral response by inhibiting IKKε and TBK1 functions.

Kaukinen P, Sillanpää M, Nousiainen L, Melén K, Julkunen I.

J Med Virol. 2013 Jan;85(1):71-82. doi: 10.1002/jmv.23442. Epub 2012 Oct 23.

PMID:
23096996
10.

Influenza A H3N2 subtype virus NS1 protein targets into the nucleus and binds primarily via its C-terminal NLS2/NoLS to nucleolin and fibrillarin.

Melén K, Tynell J, Fagerlund R, Roussel P, Hernandez-Verdun D, Julkunen I.

Virol J. 2012 Aug 21;9:167. doi: 10.1186/1743-422X-9-167.

11.

Incoming influenza A virus evades early host recognition, while influenza B virus induces interferon expression directly upon entry.

Österlund P, Strengell M, Sarin LP, Poranen MM, Fagerlund R, Melén K, Julkunen I.

J Virol. 2012 Oct;86(20):11183-93. Epub 2012 Aug 1.

12.

Preoperative hair removal to reduce surgical site infection.

Tanner J, Norrie P, Melen K.

Cochrane Database Syst Rev. 2011 Nov 9;(11):CD004122. doi: 10.1002/14651858.CD004122.pub4. Review.

PMID:
22071812
13.

Hepatitis C virus core, NS3, NS4B and NS5A are the major immunogenic proteins in humoral immunity in chronic HCV infection.

Sillanpää M, Melén K, Porkka P, Fagerlund R, Nevalainen K, Lappalainen M, Julkunen I.

Virol J. 2009 Jun 23;6:84. doi: 10.1186/1743-422X-6-84.

14.

Analysis of influenza B Virus NS1 protein trafficking reveals a novel interaction with nuclear speckle domains.

Schneider J, Dauber B, Melén K, Julkunen I, Wolff T.

J Virol. 2009 Jan;83(2):701-11. doi: 10.1128/JVI.01858-08. Epub 2008 Nov 5.

15.

NF-kappaB p52, RelB and c-Rel are transported into the nucleus via a subset of importin alpha molecules.

Fagerlund R, Melén K, Cao X, Julkunen I.

Cell Signal. 2008 Aug;20(8):1442-51. doi: 10.1016/j.cellsig.2008.03.012. Epub 2008 Apr 1.

PMID:
18462924
16.

Hepatitis C virus proteins interfere with the activation of chemokine gene promoters and downregulate chemokine gene expression.

Sillanpää M, Kaukinen P, Melén K, Julkunen I.

J Gen Virol. 2008 Feb;89(Pt 2):432-43. doi: 10.1099/vir.0.83316-0.

PMID:
18198374
17.

Avian and 1918 Spanish influenza a virus NS1 proteins bind to Crk/CrkL Src homology 3 domains to activate host cell signaling.

Heikkinen LS, Kazlauskas A, Melén K, Wagner R, Ziegler T, Julkunen I, Saksela K.

J Biol Chem. 2008 Feb 29;283(9):5719-27. doi: 10.1074/jbc.M707195200. Epub 2007 Dec 28.

18.

Nuclear and nucleolar targeting of influenza A virus NS1 protein: striking differences between different virus subtypes.

Melén K, Kinnunen L, Fagerlund R, Ikonen N, Twu KY, Krug RM, Julkunen I.

J Virol. 2007 Jun;81(11):5995-6006. Epub 2007 Mar 21.

19.

Hepatitis C virus NS2 and NS3/4A proteins are potent inhibitors of host cell cytokine/chemokine gene expression.

Kaukinen P, Sillanpää M, Kotenko S, Lin R, Hiscott J, Melén K, Julkunen I.

Virol J. 2006 Sep 1;3:66.

20.

A global topology map of the Saccharomyces cerevisiae membrane proteome.

Kim H, Melén K, Osterberg M, von Heijne G.

Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11142-7. Epub 2006 Jul 17.

21.

Phenotypic effects of membrane protein overexpression in Saccharomyces cerevisiae.

Osterberg M, Kim H, Warringer J, Melén K, Blomberg A, von Heijne G.

Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11148-53. Epub 2006 Jul 17.

22.
23.

Serum antibodies to putative proteinase maturation protein A in children with acute otitis media.

Vainio A, Fagerlund R, Melén K, Lehtinen MJ, Julkunen I, Virolainen A.

Vaccine. 2006 Mar 10;24(11):1792-9. Epub 2005 Oct 25.

PMID:
16288938
24.

TNF-alpha and IFN-alpha enhance influenza-A-virus-induced chemokine gene expression in human A549 lung epithelial cells.

Veckman V, Osterlund P, Fagerlund R, Melén K, Matikainen S, Julkunen I.

Virology. 2006 Feb 5;345(1):96-104. Epub 2005 Oct 25.

25.

Severe acute respiratory syndrome coronavirus fails to activate cytokine-mediated innate immune responses in cultured human monocyte-derived dendritic cells.

Ziegler T, Matikainen S, Rönkkö E, Osterlund P, Sillanpää M, Sirén J, Fagerlund R, Immonen M, Melén K, Julkunen I.

J Virol. 2005 Nov;79(21):13800-5.

26.

Experimentally constrained topology models for 51,208 bacterial inner membrane proteins.

Granseth E, Daley DO, Rapp M, Melén K, von Heijne G.

J Mol Biol. 2005 Sep 23;352(3):489-94.

PMID:
16120447
27.

A nine-transmembrane domain topology for presenilin 1.

Laudon H, Hansson EM, Melén K, Bergman A, Farmery MR, Winblad B, Lendahl U, von Heijne G, Näslund J.

J Biol Chem. 2005 Oct 21;280(42):35352-60. Epub 2005 Jul 25.

28.

Global topology analysis of the Escherichia coli inner membrane proteome.

Daley DO, Rapp M, Granseth E, Melén K, Drew D, von Heijne G.

Science. 2005 May 27;308(5726):1321-3.

29.

NF-{kappa}B is transported into the nucleus by importin {alpha}3 and importin {alpha}4.

Fagerlund R, Kinnunen L, Köhler M, Julkunen I, Melén K.

J Biol Chem. 2005 Apr 22;280(16):15942-51. Epub 2005 Jan 27.

30.

Expression of hepatitis C virus core protein inhibits interferon-induced nuclear import of STATs.

Melén K, Fagerlund R, Nyqvist M, Keskinen P, Julkunen I.

J Med Virol. 2004 Aug;73(4):536-47.

PMID:
15221897
31.

Experimentally based topology models for E. coli inner membrane proteins.

Rapp M, Drew D, Daley DO, Nilsson J, Carvalho T, Melén K, De Gier JW, Von Heijne G.

Protein Sci. 2004 Apr;13(4):937-45.

32.

Importin alpha nuclear localization signal binding sites for STAT1, STAT2, and influenza A virus nucleoprotein.

Melen K, Fagerlund R, Franke J, Kohler M, Kinnunen L, Julkunen I.

J Biol Chem. 2003 Jul 25;278(30):28193-200. Epub 2003 May 9.

33.

Reliability measures for membrane protein topology prediction algorithms.

Melén K, Krogh A, von Heijne G.

J Mol Biol. 2003 Mar 28;327(3):735-44.

PMID:
12634065
34.

Protein levels of genes encoded on chromosome 21 in fetal Down syndrome brain: challenging the gene dosage effect hypothesis (Part I).

Cheon MS, Kim SH, Yaspo ML, Blasi F, Aoki Y, Melen K, Lubec G.

Amino Acids. 2003;24(1-2):111-7.

PMID:
12624742
35.

Topology models for 37 Saccharomyces cerevisiae membrane proteins based on C-terminal reporter fusions and predictions.

Kim H, Melén K, von Heijne G.

J Biol Chem. 2003 Mar 21;278(12):10208-13. Epub 2003 Jan 10.

36.

Effect of profound acid suppression in functional dyspepsia: a double-blind, randomized, placebo-controlled trial.

Bolling-Sternevald E, Lauritsen K, Aalykke C, Havelund T, Knudsen T, Unge P, Ekström P, Jaup B, Norrby A, Stubberöd A, Melén K, Carlsson R, Jerndal P, Junghard O, Glise H.

Scand J Gastroenterol. 2002 Dec;37(12):1395-402.

PMID:
12523588
37.

Expression of HCV structural proteins impairs IFN-mediated antiviral response.

Keskinen P, Melén K, Julkunen I.

Virology. 2002 Aug 1;299(2):164-71.

38.

Arginine/lysine-rich nuclear localization signals mediate interactions between dimeric STATs and importin alpha 5.

Fagerlund R, Mélen K, Kinnunen L, Julkunen I.

J Biol Chem. 2002 Aug 16;277(33):30072-8. Epub 2002 Jun 4.

39.

Dual versus triple therapy in eradication of Helicobacter pylori.

Ohlin B, Cederberg A, Kjellin T, Kullman E, Melén K, von Holstein CS, Thoring M.

Hepatogastroenterology. 2002 Jan-Feb;49(43):172-5.

PMID:
11941946
40.

Molecular pathogenesis of influenza A virus infection and virus-induced regulation of cytokine gene expression.

Julkunen I, Sareneva T, Pirhonen J, Ronni T, Melén K, Matikainen S.

Cytokine Growth Factor Rev. 2001 Jun-Sep;12(2-3):171-80. Review.

PMID:
11325600
41.

Inflammatory responses in influenza A virus infection.

Julkunen I, Melén K, Nyqvist M, Pirhonen J, Sareneva T, Matikainen S.

Vaccine. 2000 Dec 8;19 Suppl 1:S32-7. Review.

PMID:
11163460
42.

Arginine/lysine-rich structural element is involved in interferon-induced nuclear import of STATs.

Melen K, Kinnunen L, Julkunen I.

J Biol Chem. 2001 May 11;276(19):16447-55. Epub 2001 Jan 9.

43.

Interferon-induced gene expression and signaling in human hepatoma cell lines.

Melén K, Keskinen P, Lehtonen A, Julkunen I.

J Hepatol. 2000 Nov;33(5):764-72.

PMID:
11097485
44.

Impaired antiviral response in human hepatoma cells.

Keskinen P, Nyqvist M, Sareneva T, Pirhonen J, Melén K, Julkunen I.

Virology. 1999 Oct 25;263(2):364-75.

45.

Efficacy of PCR and other diagnostic methods for the detection of respiratory adenoviral infections.

Räty R, Kleemola M, Melén K, Stenvik M, Julkunen I.

J Med Virol. 1999 Sep;59(1):66-72.

PMID:
10440810
46.

Kinetics of cytokine and NFAT gene expression in human interleukin-2-dependent T lymphoblasts stimulated via T-cell receptor.

Sareneva T, Matikainen S, Vanhatalo J, Melén K, Pelkonen J, Julkunen I.

Immunology. 1998 Mar;93(3):350-7.

47.

Nuclear cotransport mechanism of cytoplasmic human MxB protein.

Melén K, Julkunen I.

J Biol Chem. 1997 Dec 19;272(51):32353-9.

48.

Retinoic acid induces signal transducer and activator of transcription (STAT) 1, STAT2, and p48 expression in myeloid leukemia cells and enhances their responsiveness to interferons.

Matikainen S, Ronni T, Lehtonen A, Sareneva T, Melén K, Nordling S, Levy DE, Julkunen I.

Cell Growth Differ. 1997 Jun;8(6):687-98.

49.

Regulation of IFN-alpha/beta, MxA, 2',5'-oligoadenylate synthetase, and HLA gene expression in influenza A-infected human lung epithelial cells.

Ronni T, Matikainen S, Sareneva T, Melén K, Pirhonen J, Keskinen P, Julkunen I.

J Immunol. 1997 Mar 1;158(5):2363-74.

PMID:
9036986
50.

Inhibition of puumala and tula hantaviruses in Vero cells by MxA protein.

Kanerva M, Melén K, Vaheri A, Julkunen I.

Virology. 1996 Oct 1;224(1):55-62.

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