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Items: 1 to 50 of 273

1.

In vitro characterization and preclinical immunogenicity of Typhax, a typhoid fever protein capsular matrix vaccine candidate.

Griffin TJ 4th, Thanawastien A, Cartee RT, Mekalanos JJ, Killeen KP.

Hum Vaccin Immunother. 2019;15(6):1310-1316. doi: 10.1080/21645515.2019.1599674. Epub 2019 May 28.

PMID:
31021700
2.

Alarmone Ap4A is elevated by aminoglycoside antibiotics and enhances their bactericidal activity.

Ji X, Zou J, Peng H, Stolle AS, Xie R, Zhang H, Peng B, Mekalanos JJ, Zheng J.

Proc Natl Acad Sci U S A. 2019 May 7;116(19):9578-9585. doi: 10.1073/pnas.1822026116. Epub 2019 Apr 19.

3.

Bacterial cGAS-like enzymes synthesize diverse nucleotide signals.

Whiteley AT, Eaglesham JB, de Oliveira Mann CC, Morehouse BR, Lowey B, Nieminen EA, Danilchanka O, King DS, Lee ASY, Mekalanos JJ, Kranzusch PJ.

Nature. 2019 Mar;567(7747):194-199. doi: 10.1038/s41586-019-0953-5. Epub 2019 Feb 20.

PMID:
30787435
4.

Exopolysaccharide protects Vibrio cholerae from exogenous attacks by the type 6 secretion system.

Toska J, Ho BT, Mekalanos JJ.

Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):7997-8002. doi: 10.1073/pnas.1808469115. Epub 2018 Jul 18.

5.

Structure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune Surveillance.

Zhou W, Whiteley AT, de Oliveira Mann CC, Morehouse BR, Nowak RP, Fischer ES, Gray NS, Mekalanos JJ, Kranzusch PJ.

Cell. 2018 Jul 12;174(2):300-311.e11. doi: 10.1016/j.cell.2018.06.026.

6.

The Drosophila Immune Deficiency Pathway Modulates Enteroendocrine Function and Host Metabolism.

Kamareddine L, Robins WP, Berkey CD, Mekalanos JJ, Watnick PI.

Cell Metab. 2018 Sep 4;28(3):449-462.e5. doi: 10.1016/j.cmet.2018.05.026. Epub 2018 Jun 21.

PMID:
29937377
7.

A live vaccine rapidly protects against cholera in an infant rabbit model.

Hubbard TP, Billings G, Dörr T, Sit B, Warr AR, Kuehl CJ, Kim M, Delgado F, Mekalanos JJ, Lewnard JA, Waldor MK.

Sci Transl Med. 2018 Jun 13;10(445). pii: eaap8423. doi: 10.1126/scitranslmed.aap8423.

8.

Structure and mutagenic analysis of the lipid II flippase MurJ from Escherichia coli.

Zheng S, Sham LT, Rubino FA, Brock KP, Robins WP, Mekalanos JJ, Marks DS, Bernhardt TG, Kruse AC.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6709-6714. doi: 10.1073/pnas.1802192115. Epub 2018 Jun 11.

9.

Draft Genome Sequence of Bowmanella denitrificans JL63, a Bacterium Isolated from Whiteleg Shrimp (Litopenaeus vannamei) That Can Inhibit the Growth of Vibrio parahaemolyticus.

LaPorte JP, Spinard EJ, Gomez-Chiarri M, Rowley DC, Mekalanos JJ, Nelson DR.

Genome Announc. 2018 Apr 5;6(14). pii: e00215-18. doi: 10.1128/genomeA.00215-18.

10.

Tracking Vibrio cholerae Cell-Cell Interactions during Infection Reveals Bacterial Population Dynamics within Intestinal Microenvironments.

Fu Y, Ho BT, Mekalanos JJ.

Cell Host Microbe. 2018 Feb 14;23(2):274-281.e2. doi: 10.1016/j.chom.2017.12.006. Epub 2018 Feb 2.

11.

Antagonism toward the intestinal microbiota and its effect on Vibrio cholerae virulence.

Zhao W, Caro F, Robins W, Mekalanos JJ.

Science. 2018 Jan 12;359(6372):210-213. doi: 10.1126/science.aap8775.

PMID:
29326272
12.

Vibrio cholerae type 6 secretion system effector trafficking in target bacterial cells.

Ho BT, Fu Y, Dong TG, Mekalanos JJ.

Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):9427-9432. doi: 10.1073/pnas.1711219114. Epub 2017 Aug 14.

13.

Quorum Regulated Resistance of Vibrio cholerae against Environmental Bacteriophages.

Hoque MM, Naser IB, Bari SM, Zhu J, Mekalanos JJ, Faruque SM.

Sci Rep. 2016 Nov 28;6:37956. doi: 10.1038/srep37956.

14.

SEDS proteins are a widespread family of bacterial cell wall polymerases.

Meeske AJ, Riley EP, Robins WP, Uehara T, Mekalanos JJ, Kahne D, Walker S, Kruse AC, Bernhardt TG, Rudner DZ.

Nature. 2016 Sep 29;537(7622):634-638. doi: 10.1038/nature19331. Epub 2016 Aug 15.

15.

Type VI secretion system sheaths as nanoparticles for antigen display.

Del Tordello E, Danilchanka O, McCluskey AJ, Mekalanos JJ.

Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3042-7. doi: 10.1073/pnas.1524290113. Epub 2016 Feb 29.

16.

Fitness cost of antibiotic susceptibility during bacterial infection.

Roux D, Danilchanka O, Guillard T, Cattoir V, Aschard H, Fu Y, Angoulvant F, Messika J, Ricard JD, Mekalanos JJ, Lory S, Pier GB, Skurnik D.

Sci Transl Med. 2015 Jul 22;7(297):297ra114. doi: 10.1126/scitranslmed.aab1621.

PMID:
26203082
17.

Conjugate-like immunogens produced as protein capsular matrix vaccines.

Thanawastien A, Cartee RT, Griffin TJ 4th, Killeen KP, Mekalanos JJ.

Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):E1143-51. doi: 10.1073/pnas.1425005112. Epub 2015 Feb 19.

18.

Generation of reactive oxygen species by lethal attacks from competing microbes.

Dong TG, Dong S, Catalano C, Moore R, Liang X, Mekalanos JJ.

Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):2181-6. doi: 10.1073/pnas.1425007112. Epub 2015 Feb 2.

19.

The acetate switch of an intestinal pathogen disrupts host insulin signaling and lipid metabolism.

Hang S, Purdy AE, Robins WP, Wang Z, Mandal M, Chang S, Mekalanos JJ, Watnick PI.

Cell Host Microbe. 2014 Nov 12;16(5):592-604. doi: 10.1016/j.chom.2014.10.006. Epub 2014 Nov 12.

20.

Vibrio cholerae T3SS effector VopE modulates mitochondrial dynamics and innate immune signaling by targeting Miro GTPases.

Suzuki M, Danilchanka O, Mekalanos JJ.

Cell Host Microbe. 2014 Nov 12;16(5):581-91. doi: 10.1016/j.chom.2014.09.015. Epub 2014 Oct 23.

21.

RS1 satellite phage promotes diversity of toxigenic Vibrio cholerae by driving CTX prophage loss and elimination of lysogenic immunity.

Kamruzzaman M, Robins WP, Bari SM, Nahar S, Mekalanos JJ, Faruque SM.

Infect Immun. 2014 Sep;82(9):3636-43. doi: 10.1128/IAI.01699-14. Epub 2014 Jun 16.

22.

The highly conserved bacterial RNase YbeY is essential in Vibrio cholerae, playing a critical role in virulence, stress regulation, and RNA processing.

Vercruysse M, Köhrer C, Davies BW, Arnold MF, Mekalanos JJ, RajBhandary UL, Walker GC.

PLoS Pathog. 2014 Jun 5;10(6):e1004175. doi: 10.1371/journal.ppat.1004175. eCollection 2014 Jun.

23.

Infant Rabbit Colonization Competition Assays.

Fu Y, Mekalanos JJ.

Bio Protoc. 2014 Jun 5;4(11). pii: e1147. doi: 10.21769/BioProtoc.1147.

24.

Proteomic analysis of Vibrio cholerae outer membrane vesicles.

Altindis E, Fu Y, Mekalanos JJ.

Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):E1548-56. doi: 10.1073/pnas.1403683111. Epub 2014 Mar 31.

25.

Vibrio parahaemolyticus and its specific bacteriophages as an indicator in cockles (Anadara granosa) for the risk of V. parahaemolyticus infection in Southern Thailand.

Yingkajorn M, Sermwitayawong N, Palittapongarnpimp P, Nishibuchi M, Robins WP, Mekalanos JJ, Vuddhakul V.

Microb Ecol. 2014 May;67(4):849-56. doi: 10.1007/s00248-014-0382-9. Epub 2014 Feb 28.

PMID:
24682339
26.

Genomic science in understanding cholera outbreaks and evolution of Vibrio cholerae as a human pathogen.

Robins WP, Mekalanos JJ.

Curr Top Microbiol Immunol. 2014;379:211-29. doi: 10.1007/82_2014_366. Review.

27.

A view to a kill: the bacterial type VI secretion system.

Ho BT, Dong TG, Mekalanos JJ.

Cell Host Microbe. 2014 Jan 15;15(1):9-21. doi: 10.1016/j.chom.2013.11.008. Epub 2013 Dec 11. Review.

28.

Tn-Seq analysis of Vibrio cholerae intestinal colonization reveals a role for T6SS-mediated antibacterial activity in the host.

Fu Y, Waldor MK, Mekalanos JJ.

Cell Host Microbe. 2013 Dec 11;14(6):652-63. doi: 10.1016/j.chom.2013.11.001.

29.

Enhanced in vivo fitness of carbapenem-resistant oprD mutants of Pseudomonas aeruginosa revealed through high-throughput sequencing.

Skurnik D, Roux D, Cattoir V, Danilchanka O, Lu X, Yoder-Himes DR, Han K, Guillard T, Jiang D, Gaultier C, Guerin F, Aschard H, Leclercq R, Mekalanos JJ, Lory S, Pier GB.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20747-52. doi: 10.1073/pnas.1221552110. Epub 2013 Nov 18.

30.

Type 6 secretion system-mediated immunity to type 4 secretion system-mediated gene transfer.

Ho BT, Basler M, Mekalanos JJ.

Science. 2013 Oct 11;342(6155):250-3. doi: 10.1126/science.1243745.

31.

Vaccine economics: what price human life?

Mekalanos JJ.

Sci Transl Med. 2013 Sep 25;5(204):204ed16. doi: 10.1126/scitranslmed.3007588. No abstract available.

32.

Cyclic dinucleotides and the innate immune response.

Danilchanka O, Mekalanos JJ.

Cell. 2013 Aug 29;154(5):962-970. doi: 10.1016/j.cell.2013.08.014. Review.

33.

PAAR-repeat proteins sharpen and diversify the type VI secretion system spike.

Shneider MM, Buth SA, Ho BT, Basler M, Mekalanos JJ, Leiman PG.

Nature. 2013 Aug 15;500(7462):350-353. doi: 10.1038/nature12453. Epub 2013 Aug 7.

34.

Quorum-sensing autoinducers resuscitate dormant Vibrio cholerae in environmental water samples.

Bari SM, Roky MK, Mohiuddin M, Kamruzzaman M, Mekalanos JJ, Faruque SM.

Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9926-31. doi: 10.1073/pnas.1307697110. Epub 2013 May 28.

35.

Tit-for-tat: type VI secretion system counterattack during bacterial cell-cell interactions.

Basler M, Ho BT, Mekalanos JJ.

Cell. 2013 Feb 14;152(4):884-94. doi: 10.1016/j.cell.2013.01.042.

36.

Coupling mutagenesis and parallel deep sequencing to probe essential residues in a genome or gene.

Robins WP, Faruque SM, Mekalanos JJ.

Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):E848-57. doi: 10.1073/pnas.1222538110. Epub 2013 Feb 11.

37.

Identification of T6SS-dependent effector and immunity proteins by Tn-seq in Vibrio cholerae.

Dong TG, Ho BT, Yoder-Himes DR, Mekalanos JJ.

Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2623-8. doi: 10.1073/pnas.1222783110. Epub 2013 Jan 29.

38.

Phage-bacterial interactions in the evolution of toxigenic Vibrio cholerae.

Faruque SM, Mekalanos JJ.

Virulence. 2012 Nov 15;3(7):556-65. doi: 10.4161/viru.22351. Epub 2012 Oct 17. Review.

39.

Non-O1 Vibrio cholerae unlinked to cholera in Haiti.

Mekalanos JJ, Robins W, Ussery DW, Davis BM, Schadt E, Waldor MK.

Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):E3206; author reply E3207. doi: 10.1073/pnas.1212443109. Epub 2012 Oct 3. No abstract available.

40.

Phase variable O antigen biosynthetic genes control expression of the major protective antigen and bacteriophage receptor in Vibrio cholerae O1.

Seed KD, Faruque SM, Mekalanos JJ, Calderwood SB, Qadri F, Camilli A.

PLoS Pathog. 2012 Sep;8(9):e1002917. doi: 10.1371/journal.ppat.1002917. Epub 2012 Sep 13.

41.

MetR-regulated Vibrio cholerae metabolism is required for virulence.

Bogard RW, Davies BW, Mekalanos JJ.

MBio. 2012 Sep 25;3(5). pii: e00236-12. doi: 10.1128/mBio.00236-12. Print 2012.

42.

Type 6 secretion dynamics within and between bacterial cells.

Basler M, Mekalanos JJ.

Science. 2012 Aug 17;337(6096):815. doi: 10.1126/science.1222901. Epub 2012 Jul 5.

43.

A hybrid approach for the automated finishing of bacterial genomes.

Bashir A, Klammer A, Robins WP, Chin CS, Webster D, Paxinos E, Hsu D, Ashby M, Wang S, Peluso P, Sebra R, Sorenson J, Bullard J, Yen J, Valdovino M, Mollova E, Luong K, Lin S, LaMay B, Joshi A, Rowe L, Frace M, Tarr CL, Turnsek M, Davis BM, Kasarskis A, Mekalanos JJ, Waldor MK, Schadt EE.

Nat Biotechnol. 2012 Jul 1;30(7):701-707. doi: 10.1038/nbt.2288.

44.

Characterization of the RpoN regulon reveals differential regulation of T6SS and new flagellar operons in Vibrio cholerae O37 strain V52.

Dong TG, Mekalanos JJ.

Nucleic Acids Res. 2012 Sep;40(16):7766-75. doi: 10.1093/nar/gks567. Epub 2012 Jun 20.

45.

Coordinated regulation of accessory genetic elements produces cyclic di-nucleotides for V. cholerae virulence.

Davies BW, Bogard RW, Young TS, Mekalanos JJ.

Cell. 2012 Apr 13;149(2):358-70. doi: 10.1016/j.cell.2012.01.053.

46.

Sigma E regulators control hemolytic activity and virulence in a shrimp pathogenic Vibrio harveyi.

Rattanama P, Thompson JR, Kongkerd N, Srinitiwarawong K, Vuddhakul V, Mekalanos JJ.

PLoS One. 2012;7(2):e32523. doi: 10.1371/journal.pone.0032523. Epub 2012 Feb 23. Erratum in: PLoS One. 2012;7(5): doi/10.1371/annotation/de7188a8-1565-41fa-bc0c-418ea1bf8f44.

47.

Type VI secretion requires a dynamic contractile phage tail-like structure.

Basler M, Pilhofer M, Henderson GP, Jensen GJ, Mekalanos JJ.

Nature. 2012 Feb 26;483(7388):182-6. doi: 10.1038/nature10846.

48.

Genetic analysis of anti-amoebae and anti-bacterial activities of the type VI secretion system in Vibrio cholerae.

Zheng J, Ho B, Mekalanos JJ.

PLoS One. 2011;6(8):e23876. doi: 10.1371/journal.pone.0023876. Epub 2011 Aug 31.

49.

Comparisons of Two Proteomic Analyses of Non-Mucoid and Mucoid Pseudomonas aeruginosa Clinical Isolates from a Cystic Fibrosis Patient.

Rao J, Damron FH, Basler M, Digiandomenico A, Sherman NE, Fox JW, Mekalanos JJ, Goldberg JB.

Front Microbiol. 2011 Aug 1;2:162. doi: 10.3389/fmicb.2011.00162. eCollection 2011.

50.

RNA-Seq-based monitoring of infection-linked changes in Vibrio cholerae gene expression.

Mandlik A, Livny J, Robins WP, Ritchie JM, Mekalanos JJ, Waldor MK.

Cell Host Microbe. 2011 Aug 18;10(2):165-74. doi: 10.1016/j.chom.2011.07.007.

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