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Structure and Mechanism of a Cyclic Trinucleotide-Activated Bacterial Endonuclease Mediating Bacteriophage Immunity.

Lau RK, Ye Q, Birkholz EA, Berg KR, Patel L, Mathews IT, Watrous JD, Ego K, Whiteley AT, Lowey B, Mekalanos JJ, Kranzusch PJ, Jain M, Pogliano J, Corbett KD.

Mol Cell. 2020 Jan 6. pii: S1097-2765(19)30923-2. doi: 10.1016/j.molcel.2019.12.010. [Epub ahead of print]


Microbiota-targeted maternal antibodies protect neonates from enteric infection.

Zheng W, Zhao W, Wu M, Song X, Caro F, Sun X, Gazzaniga F, Stefanetti G, Oh S, Mekalanos JJ, Kasper DL.

Nature. 2020 Jan 8. doi: 10.1038/s41586-019-1898-4. [Epub ahead of print]


A phase 1 randomized safety, reactogenicity, and immunogenicity study of Typhax: A novel protein capsular matrix vaccine candidate for the prevention of typhoid fever.

Cartee RT, Thanawastien A, Griffin Iv TJ, Mekalanos JJ, Bart S, Killeen KP.

PLoS Negl Trop Dis. 2020 Jan 6;14(1):e0007912. doi: 10.1371/journal.pntd.0007912. eCollection 2020 Jan.


An onboard checking mechanism ensures effector delivery of the type VI secretion system in Vibrio cholerae.

Liang X, Kamal F, Pei TT, Xu P, Mekalanos JJ, Dong TG.

Proc Natl Acad Sci U S A. 2019 Nov 12;116(46):23292-23298. doi: 10.1073/pnas.1914202116. Epub 2019 Oct 28.


Long-term Persistence of an Extensively Drug Resistant Subclade of Globally Distributed Pseudomonas aeruginosa Clonal Complex 446 in an Academic Medical Center.

Pincus NB, Bachta KER, Ozer EA, Allen JP, Pura ON, Qi C, Rhodes NJ, Marty FM, Pandit A, Mekalanos JJ, Oliver A, Hauser AR.

Clin Infect Dis. 2019 Oct 4. pii: ciz973. doi: 10.1093/cid/ciz973. [Epub ahead of print]


Analysis of lipoprotein transport depletion in Vibrio cholerae using CRISPRi.

Caro F, Place NM, Mekalanos JJ.

Proc Natl Acad Sci U S A. 2019 Aug 20;116(34):17013-17022. doi: 10.1073/pnas.1906158116. Epub 2019 Aug 1. Erratum in: Proc Natl Acad Sci U S A. 2019 Sep 17;116(38):19210.


Cholera toxin promotes pathogen acquisition of host-derived nutrients.

Rivera-Chávez F, Mekalanos JJ.

Nature. 2019 Aug;572(7768):244-248. doi: 10.1038/s41586-019-1453-3. Epub 2019 Jul 31.


Draft Genome Sequence of Pseudomonas aeruginosa Strain BWH047, a Sequence Type 235 Multidrug-Resistant Clinical Isolate Expressing High Levels of Colistin Resistance.

Bachta KER, Ozer EA, Pandit A, Marty FM, Mekalanos JJ, Hauser AR.

Microbiol Resour Announc. 2019 Jul 18;8(29). pii: e00623-19. doi: 10.1128/MRA.00623-19.


In vitro characterization and preclinical immunogenicity of Typhax, a typhoid fever protein capsular matrix vaccine candidate.

Griffin TJ 4th, Thanawastien A, Cartee RT, Mekalanos JJ, Killeen KP.

Hum Vaccin Immunother. 2019;15(6):1310-1316. doi: 10.1080/21645515.2019.1599674. Epub 2019 May 28.


Alarmone Ap4A is elevated by aminoglycoside antibiotics and enhances their bactericidal activity.

Ji X, Zou J, Peng H, Stolle AS, Xie R, Zhang H, Peng B, Mekalanos JJ, Zheng J.

Proc Natl Acad Sci U S A. 2019 May 7;116(19):9578-9585. doi: 10.1073/pnas.1822026116. Epub 2019 Apr 19.


Bacterial cGAS-like enzymes synthesize diverse nucleotide signals.

Whiteley AT, Eaglesham JB, de Oliveira Mann CC, Morehouse BR, Lowey B, Nieminen EA, Danilchanka O, King DS, Lee ASY, Mekalanos JJ, Kranzusch PJ.

Nature. 2019 Mar;567(7747):194-199. doi: 10.1038/s41586-019-0953-5. Epub 2019 Feb 20.


Farewell Stan Stanley Falkow: 1934-2018.

Cabello FC, Cohen SN, Curtiss R 3rd, Dougan G, van Embden J, Finlay BB, Heffron F, Helinski D, Hull R, Hull S, Isberg R, Kopecko DJ, Levy S, Mekalanos J, Ortiz JM, Rappuoli R, Roberts MC, So M, Timmis KN.

Environ Microbiol. 2018 Jul;20(7):2322-2333. doi: 10.1111/1462-2920.14308. Epub 2018 Aug 26. No abstract available.


Exopolysaccharide protects Vibrio cholerae from exogenous attacks by the type 6 secretion system.

Toska J, Ho BT, Mekalanos JJ.

Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):7997-8002. doi: 10.1073/pnas.1808469115. Epub 2018 Jul 18.


Structure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune Surveillance.

Zhou W, Whiteley AT, de Oliveira Mann CC, Morehouse BR, Nowak RP, Fischer ES, Gray NS, Mekalanos JJ, Kranzusch PJ.

Cell. 2018 Jul 12;174(2):300-311.e11. doi: 10.1016/j.cell.2018.06.026.


The Drosophila Immune Deficiency Pathway Modulates Enteroendocrine Function and Host Metabolism.

Kamareddine L, Robins WP, Berkey CD, Mekalanos JJ, Watnick PI.

Cell Metab. 2018 Sep 4;28(3):449-462.e5. doi: 10.1016/j.cmet.2018.05.026. Epub 2018 Jun 21.


A live vaccine rapidly protects against cholera in an infant rabbit model.

Hubbard TP, Billings G, Dörr T, Sit B, Warr AR, Kuehl CJ, Kim M, Delgado F, Mekalanos JJ, Lewnard JA, Waldor MK.

Sci Transl Med. 2018 Jun 13;10(445). pii: eaap8423. doi: 10.1126/scitranslmed.aap8423.


Structure and mutagenic analysis of the lipid II flippase MurJ from Escherichia coli.

Zheng S, Sham LT, Rubino FA, Brock KP, Robins WP, Mekalanos JJ, Marks DS, Bernhardt TG, Kruse AC.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6709-6714. doi: 10.1073/pnas.1802192115. Epub 2018 Jun 11.


Draft Genome Sequence of Bowmanella denitrificans JL63, a Bacterium Isolated from Whiteleg Shrimp (Litopenaeus vannamei) That Can Inhibit the Growth of Vibrio parahaemolyticus.

LaPorte JP, Spinard EJ, Gomez-Chiarri M, Rowley DC, Mekalanos JJ, Nelson DR.

Genome Announc. 2018 Apr 5;6(14). pii: e00215-18. doi: 10.1128/genomeA.00215-18.


Tracking Vibrio cholerae Cell-Cell Interactions during Infection Reveals Bacterial Population Dynamics within Intestinal Microenvironments.

Fu Y, Ho BT, Mekalanos JJ.

Cell Host Microbe. 2018 Feb 14;23(2):274-281.e2. doi: 10.1016/j.chom.2017.12.006. Epub 2018 Feb 2.


Antagonism toward the intestinal microbiota and its effect on Vibrio cholerae virulence.

Zhao W, Caro F, Robins W, Mekalanos JJ.

Science. 2018 Jan 12;359(6372):210-213. doi: 10.1126/science.aap8775.


Vibrio cholerae type 6 secretion system effector trafficking in target bacterial cells.

Ho BT, Fu Y, Dong TG, Mekalanos JJ.

Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):9427-9432. doi: 10.1073/pnas.1711219114. Epub 2017 Aug 14.


Isolation of Bdellovibrio and like organisms and potential to reduce acute hepatopancreatic necrosis disease caused by Vibrio parahaemolyticus.

Kongrueng J, Mitraparp-Arthorn P, Bangpanwimon K, Robins W, Vuddhakul V, Mekalanos J.

Dis Aquat Organ. 2017 May 11;124(3):223-232. doi: 10.3354/dao03120.


Quorum Regulated Resistance of Vibrio cholerae against Environmental Bacteriophages.

Hoque MM, Naser IB, Bari SM, Zhu J, Mekalanos JJ, Faruque SM.

Sci Rep. 2016 Nov 28;6:37956. doi: 10.1038/srep37956.


SEDS proteins are a widespread family of bacterial cell wall polymerases.

Meeske AJ, Riley EP, Robins WP, Uehara T, Mekalanos JJ, Kahne D, Walker S, Kruse AC, Bernhardt TG, Rudner DZ.

Nature. 2016 Sep 29;537(7622):634-638. doi: 10.1038/nature19331. Epub 2016 Aug 15.


Type VI secretion system sheaths as nanoparticles for antigen display.

Del Tordello E, Danilchanka O, McCluskey AJ, Mekalanos JJ.

Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3042-7. doi: 10.1073/pnas.1524290113. Epub 2016 Feb 29.


Emergence of Antimicrobial-Resistant Escherichia coli of Animal Origin Spreading in Humans.

Skurnik D, Clermont O, Guillard T, Launay A, Danilchanka O, Pons S, Diancourt L, Lebreton F, Kadlec K, Roux D, Jiang D, Dion S, Aschard H, Denamur M, Cywes-Bentley C, Schwarz S, Tenaillon O, Andremont A, Picard B, Mekalanos J, Brisse S, Denamur E.

Mol Biol Evol. 2016 Apr;33(4):898-914. doi: 10.1093/molbev/msv280. Epub 2015 Nov 26.


Fitness cost of antibiotic susceptibility during bacterial infection.

Roux D, Danilchanka O, Guillard T, Cattoir V, Aschard H, Fu Y, Angoulvant F, Messika J, Ricard JD, Mekalanos JJ, Lory S, Pier GB, Skurnik D.

Sci Transl Med. 2015 Jul 22;7(297):297ra114. doi: 10.1126/scitranslmed.aab1621.


Secretome analysis of Vibrio cholerae type VI secretion system reveals a new effector-immunity pair.

Altindis E, Dong T, Catalano C, Mekalanos J.

mBio. 2015 Mar 10;6(2):e00075. doi: 10.1128/mBio.00075-15.


Conjugate-like immunogens produced as protein capsular matrix vaccines.

Thanawastien A, Cartee RT, Griffin TJ 4th, Killeen KP, Mekalanos JJ.

Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):E1143-51. doi: 10.1073/pnas.1425005112. Epub 2015 Feb 19.


Generation of reactive oxygen species by lethal attacks from competing microbes.

Dong TG, Dong S, Catalano C, Moore R, Liang X, Mekalanos JJ.

Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):2181-6. doi: 10.1073/pnas.1425007112. Epub 2015 Feb 2.


The acetate switch of an intestinal pathogen disrupts host insulin signaling and lipid metabolism.

Hang S, Purdy AE, Robins WP, Wang Z, Mandal M, Chang S, Mekalanos JJ, Watnick PI.

Cell Host Microbe. 2014 Nov 12;16(5):592-604. doi: 10.1016/j.chom.2014.10.006. Epub 2014 Nov 12.


Vibrio cholerae T3SS effector VopE modulates mitochondrial dynamics and innate immune signaling by targeting Miro GTPases.

Suzuki M, Danilchanka O, Mekalanos JJ.

Cell Host Microbe. 2014 Nov 12;16(5):581-91. doi: 10.1016/j.chom.2014.09.015. Epub 2014 Oct 23.


RS1 satellite phage promotes diversity of toxigenic Vibrio cholerae by driving CTX prophage loss and elimination of lysogenic immunity.

Kamruzzaman M, Robins WP, Bari SM, Nahar S, Mekalanos JJ, Faruque SM.

Infect Immun. 2014 Sep;82(9):3636-43. doi: 10.1128/IAI.01699-14. Epub 2014 Jun 16.


The highly conserved bacterial RNase YbeY is essential in Vibrio cholerae, playing a critical role in virulence, stress regulation, and RNA processing.

Vercruysse M, Köhrer C, Davies BW, Arnold MF, Mekalanos JJ, RajBhandary UL, Walker GC.

PLoS Pathog. 2014 Jun 5;10(6):e1004175. doi: 10.1371/journal.ppat.1004175. eCollection 2014 Jun.


Infant Rabbit Colonization Competition Assays.

Fu Y, Mekalanos JJ.

Bio Protoc. 2014 Jun 5;4(11). pii: e1147. doi: 10.21769/BioProtoc.1147.


Proteomic analysis of Vibrio cholerae outer membrane vesicles.

Altindis E, Fu Y, Mekalanos JJ.

Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):E1548-56. doi: 10.1073/pnas.1403683111. Epub 2014 Mar 31.


Vibrio parahaemolyticus and its specific bacteriophages as an indicator in cockles (Anadara granosa) for the risk of V. parahaemolyticus infection in Southern Thailand.

Yingkajorn M, Sermwitayawong N, Palittapongarnpimp P, Nishibuchi M, Robins WP, Mekalanos JJ, Vuddhakul V.

Microb Ecol. 2014 May;67(4):849-56. doi: 10.1007/s00248-014-0382-9. Epub 2014 Feb 28.


Genomic science in understanding cholera outbreaks and evolution of Vibrio cholerae as a human pathogen.

Robins WP, Mekalanos JJ.

Curr Top Microbiol Immunol. 2014;379:211-29. doi: 10.1007/82_2014_366. Review.


A view to a kill: the bacterial type VI secretion system.

Ho BT, Dong TG, Mekalanos JJ.

Cell Host Microbe. 2014 Jan 15;15(1):9-21. doi: 10.1016/j.chom.2013.11.008. Epub 2013 Dec 11. Review.


Tn-Seq analysis of Vibrio cholerae intestinal colonization reveals a role for T6SS-mediated antibacterial activity in the host.

Fu Y, Waldor MK, Mekalanos JJ.

Cell Host Microbe. 2013 Dec 11;14(6):652-63. doi: 10.1016/j.chom.2013.11.001.


Enhanced in vivo fitness of carbapenem-resistant oprD mutants of Pseudomonas aeruginosa revealed through high-throughput sequencing.

Skurnik D, Roux D, Cattoir V, Danilchanka O, Lu X, Yoder-Himes DR, Han K, Guillard T, Jiang D, Gaultier C, Guerin F, Aschard H, Leclercq R, Mekalanos JJ, Lory S, Pier GB.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20747-52. doi: 10.1073/pnas.1221552110. Epub 2013 Nov 18.


Type 6 secretion system-mediated immunity to type 4 secretion system-mediated gene transfer.

Ho BT, Basler M, Mekalanos JJ.

Science. 2013 Oct 11;342(6155):250-3. doi: 10.1126/science.1243745.


Vaccine economics: what price human life?

Mekalanos JJ.

Sci Transl Med. 2013 Sep 25;5(204):204ed16. doi: 10.1126/scitranslmed.3007588. No abstract available.


Cyclic dinucleotides and the innate immune response.

Danilchanka O, Mekalanos JJ.

Cell. 2013 Aug 29;154(5):962-970. doi: 10.1016/j.cell.2013.08.014. Review.


PAAR-repeat proteins sharpen and diversify the type VI secretion system spike.

Shneider MM, Buth SA, Ho BT, Basler M, Mekalanos JJ, Leiman PG.

Nature. 2013 Aug 15;500(7462):350-353. doi: 10.1038/nature12453. Epub 2013 Aug 7.


Quorum-sensing autoinducers resuscitate dormant Vibrio cholerae in environmental water samples.

Bari SM, Roky MK, Mohiuddin M, Kamruzzaman M, Mekalanos JJ, Faruque SM.

Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9926-31. doi: 10.1073/pnas.1307697110. Epub 2013 May 28.


Tit-for-tat: type VI secretion system counterattack during bacterial cell-cell interactions.

Basler M, Ho BT, Mekalanos JJ.

Cell. 2013 Feb 14;152(4):884-94. doi: 10.1016/j.cell.2013.01.042.


Coupling mutagenesis and parallel deep sequencing to probe essential residues in a genome or gene.

Robins WP, Faruque SM, Mekalanos JJ.

Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):E848-57. doi: 10.1073/pnas.1222538110. Epub 2013 Feb 11.


Identification of T6SS-dependent effector and immunity proteins by Tn-seq in Vibrio cholerae.

Dong TG, Ho BT, Yoder-Himes DR, Mekalanos JJ.

Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2623-8. doi: 10.1073/pnas.1222783110. Epub 2013 Jan 29.


Phage-bacterial interactions in the evolution of toxigenic Vibrio cholerae.

Faruque SM, Mekalanos JJ.

Virulence. 2012 Nov 15;3(7):556-65. doi: 10.4161/viru.22351. Epub 2012 Oct 17. Review.

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