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Items: 1 to 50 of 466

1.

KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance.

Hinohara K, Wu HJ, Sébastien Vigneau, McDonald TO, Igarashi KJ, Yamamoto KN, Madsen T, Fassl A, Egri SB, Papanastasiou M, Ding L, Peluffo G, Cohen O, Kales SC, Lal-Nag M, Rai G, Maloney DJ, Jadhav A, Simeonov A, Wagle N, Brown M, Meissner A, Sicinski P, Jaffe JD, Jeselsohn R, Gimelbrant AA, Michor F, Polyak K.

Cancer Cell. 2019 Feb 11;35(2):330-332. doi: 10.1016/j.ccell.2019.01.012. No abstract available.

PMID:
30753830
2.

T-Cell Accumulation in the Hypertensive Brain: A Role for Sphingosine-1-Phosphate-Mediated Chemotaxis.

Don-Doncow N, Vanherle L, Zhang Y, Meissner A.

Int J Mol Sci. 2019 Jan 28;20(3). pii: E537. doi: 10.3390/ijms20030537.

3.

Use of Fertility Preservation Among a Cohort of Transgirls in the Netherlands.

Brik T, Vrouenraets LJJJ, Schagen SEE, Meissner A, de Vries MC, Hannema SE.

J Adolesc Health. 2019 Jan 25. pii: S1054-139X(18)30793-6. doi: 10.1016/j.jadohealth.2018.11.008. [Epub ahead of print]

PMID:
30691936
4.

Prognostic factors in 264 adults with invasive Scedosporium spp. and Lomentospora prolificans infection reported in the literature and FungiScope®.

Seidel D, Meißner A, Lackner M, Piepenbrock E, Salmanton-García J, Stecher M, Mellinghoff S, Hamprecht A, Durán Graeff L, Köhler P, Cheng MP, Denis J, Chedotal I, Chander J, Pakstis DL, Los-Arcos I, Slavin M, Montagna MT, Caggiano G, Mares M, Trauth J, Aurbach U, Vehreschild MJGT, Vehreschild JJ, Duarte RF, Herbrecht R, Wisplinghoff H, Cornely OA.

Crit Rev Microbiol. 2019 Jan 10:1-21. doi: 10.1080/1040841X.2018.1514366. [Epub ahead of print] Erratum in: Crit Rev Microbiol. 2019 Feb 18;:1.

PMID:
30628529
5.

Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer's human brains.

Klein HU, McCabe C, Gjoneska E, Sullivan SE, Kaskow BJ, Tang A, Smith RV, Xu J, Pfenning AR, Bernstein BE, Meissner A, Schneider JA, Mostafavi S, Tsai LH, Young-Pearse TL, Bennett DA, De Jager PL.

Nat Neurosci. 2019 Jan;22(1):37-46. doi: 10.1038/s41593-018-0291-1. Epub 2018 Dec 17.

PMID:
30559478
6.

KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance.

Hinohara K, Wu HJ, Vigneau S, McDonald TO, Igarashi KJ, Yamamoto KN, Madsen T, Fassl A, Egri SB, Papanastasiou M, Ding L, Peluffo G, Cohen O, Kales SC, Lal-Nag M, Rai G, Maloney DJ, Jadhav A, Simeonov A, Wagle N, Brown M, Meissner A, Sicinski P, Jaffe JD, Jeselsohn R, Gimelbrant AA, Michor F, Polyak K.

Cancer Cell. 2018 Dec 10;34(6):939-953.e9. doi: 10.1016/j.ccell.2018.10.014. Epub 2018 Nov 21. Erratum in: Cancer Cell. 2019 Feb 11;35(2):330-332.

PMID:
30472020
7.

Targets and genomic constraints of ectopic Dnmt3b expression.

Zhang Y, Charlton J, Karnik R, Beerman I, Smith ZD, Gu H, Boyle P, Mi X, Clement K, Pop R, Gnirke A, Rossi DJ, Meissner A.

Elife. 2018 Nov 23;7. pii: e40757. doi: 10.7554/eLife.40757.

8.

Paying PIs from grants blocks talent and diversity.

Bernstein E, Meissner A, Ramalho-Santos M.

Nature. 2018 Nov;563(7731):325. doi: 10.1038/d41586-018-07382-1. No abstract available.

PMID:
30429558
9.

Orchidopexy for bilateral undescended testes: A multicentre study on its effects on fertility and comparison of two fixation techniques.

Uijldert M, Meißner A, Kuijper CF, Repping S, de Jong TPVM, Chrzan RJ.

Andrologia. 2018 Nov 8:e13194. doi: 10.1111/and.13194. [Epub ahead of print]

PMID:
30411395
10.

Comparative genomic analysis of embryonic, lineage-converted and stem cell-derived motor neurons.

Ichida JK, Staats KA, Davis-Dusenbery BN, Clement K, Galloway KE, Babos KN, Shi Y, Son EY, Kiskinis E, Atwater N, Gu H, Gnirke A, Meissner A, Eggan K.

Development. 2018 Nov 21;145(22). pii: dev168617. doi: 10.1242/dev.168617.

PMID:
30337375
11.

Aligning Single-Cell Developmental and Reprogramming Trajectories Identifies Molecular Determinants of Myogenic Reprogramming Outcome.

Cacchiarelli D, Qiu X, Srivatsan S, Manfredi A, Ziller M, Overbey E, Grimaldi A, Grimsby J, Pokharel P, Livak KJ, Li S, Meissner A, Mikkelsen TS, Rinn JL, Trapnell C.

Cell Syst. 2018 Sep 26;7(3):258-268.e3. doi: 10.1016/j.cels.2018.07.006. Epub 2018 Sep 5.

12.

Reduced MEK inhibition preserves genomic stability in naive human embryonic stem cells.

Di Stefano B, Ueda M, Sabri S, Brumbaugh J, Huebner AJ, Sahakyan A, Clement K, Clowers KJ, Erickson AR, Shioda K, Gygi SP, Gu H, Shioda T, Meissner A, Takashima Y, Plath K, Hochedlinger K.

Nat Methods. 2018 Sep;15(9):732-740. doi: 10.1038/s41592-018-0104-1. Epub 2018 Aug 20.

13.

Chromatin-dependent allosteric regulation of DNMT3A activity by MeCP2.

Rajavelu A, Lungu C, Emperle M, Dukatz M, Bröhm A, Broche J, Hanelt I, Parsa E, Schiffers S, Karnik R, Meissner A, Carell T, Rathert P, Jurkowska RZ, Jeltsch A.

Nucleic Acids Res. 2018 Sep 28;46(17):9044-9056. doi: 10.1093/nar/gky715.

14.

Development of NASH in Obese Mice is Confounded by Adipose Tissue Increase in Inflammatory NOV and Oxidative Stress.

Sacerdoti D, Singh SP, Schragenheim J, Bellner L, Vanella L, Raffaele M, Meissner A, Grant I, Favero G, Rezzani R, Rodella LF, Bamshad D, Lebovics E, Abraham NG.

Int J Hepatol. 2018 Jul 2;2018:3484107. doi: 10.1155/2018/3484107. eCollection 2018.

15.

Prospective Isolation of Poised iPSC Intermediates Reveals Principles of Cellular Reprogramming.

Schwarz BA, Cetinbas M, Clement K, Walsh RM, Cheloufi S, Gu H, Langkabel J, Kamiya A, Schorle H, Meissner A, Sadreyev RI, Hochedlinger K.

Cell Stem Cell. 2018 Aug 2;23(2):289-305.e5. doi: 10.1016/j.stem.2018.06.013. Epub 2018 Jul 12.

PMID:
30017590
16.

The emerging alliance of sphingosine-1-phosphate signalling and immune cells: from basic mechanisms to implications in hypertension.

Don-Doncow N, Zhang Y, Matuskova H, Meissner A.

Br J Pharmacol. 2018 Jun 1. doi: 10.1111/bph.14381. [Epub ahead of print] Review.

PMID:
29856066
17.

An Intermediate Pluripotent State Controlled by MicroRNAs Is Required for the Naive-to-Primed Stem Cell Transition.

Du P, Pirouz M, Choi J, Huebner AJ, Clement K, Meissner A, Hochedlinger K, Gregory RI.

Cell Stem Cell. 2018 Jun 1;22(6):851-864.e5. doi: 10.1016/j.stem.2018.04.021. Epub 2018 May 24.

PMID:
29804889
18.

Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission.

Nehme R, Zuccaro E, Ghosh SD, Li C, Sherwood JL, Pietilainen O, Barrett LE, Limone F, Worringer KA, Kommineni S, Zang Y, Cacchiarelli D, Meissner A, Adolfsson R, Haggarty S, Madison J, Muller M, Arlotta P, Fu Z, Feng G, Eggan K.

Cell Rep. 2018 May 22;23(8):2509-2523. doi: 10.1016/j.celrep.2018.04.066.

19.

EET enhances renal function in obese mice resulting in restoration of HO-1-Mfn1/2 signaling, and decrease in hypertension through inhibition of sodium chloride co-transporter.

Schragenheim J, Bellner L, Cao J, Singh SP, Bamshad D, McClung JA, Maayan O, Meissner A, Grant I, Stier CT Jr, Abraham NG.

Prostaglandins Other Lipid Mediat. 2018 Jul;137:30-39. doi: 10.1016/j.prostaglandins.2018.05.008. Epub 2018 May 19.

20.

Metabolism and Disposition of Siponimod, a Novel Selective S1P1/S1P5 Agonist, in Healthy Volunteers and In Vitro Identification of Human Cytochrome P450 Enzymes Involved in Its Oxidative Metabolism.

Glaenzel U, Jin Y, Nufer R, Li W, Schroer K, Adam-Stitah S, Peter van Marle S, Legangneux E, Borell H, James AD, Meissner A, Camenisch G, Gardin A.

Drug Metab Dispos. 2018 Jul;46(7):1001-1013. doi: 10.1124/dmd.117.079574. Epub 2018 May 7.

PMID:
29735753
21.

[Heart Failure Despite Low BNP-Level: Paradoxon or Pathfinder? - - A Case of Pericarditis constrictiva].

Dopp H, Maagh P, Meissner A.

Dtsch Med Wochenschr. 2018 May;143(10):731-734. doi: 10.1055/a-0600-1645. Epub 2018 May 4. German.

PMID:
29727888
22.

The risk of TESE-induced hypogonadism: a systematic review and meta-analysis.

Eliveld J, van Wely M, Meißner A, Repping S, van der Veen F, van Pelt AMM.

Hum Reprod Update. 2018 Jul 1;24(4):442-454. doi: 10.1093/humupd/dmy015. Review.

23.

X Chromosome Dosage Influences DNA Methylation Dynamics during Reprogramming to Mouse iPSCs.

Pasque V, Karnik R, Chronis C, Petrella P, Langerman J, Bonora G, Song J, Vanheer L, Sadhu Dimashkie A, Meissner A, Plath K.

Stem Cell Reports. 2018 May 8;10(5):1537-1550. doi: 10.1016/j.stemcr.2018.03.019. Epub 2018 Apr 19.

24.

Cancer-Germline Antigen Expression Discriminates Clinical Outcome to CTLA-4 Blockade.

Shukla SA, Bachireddy P, Schilling B, Galonska C, Zhan Q, Bango C, Langer R, Lee PC, Gusenleitner D, Keskin DB, Babadi M, Mohammad A, Gnirke A, Clement K, Cartun ZJ, Van Allen EM, Miao D, Huang Y, Snyder A, Merghoub T, Wolchok JD, Garraway LA, Meissner A, Weber JS, Hacohen N, Neuberg D, Potts PR, Murphy GF, Lian CG, Schadendorf D, Hodi FS, Wu CJ.

Cell. 2018 Apr 19;173(3):624-633.e8. doi: 10.1016/j.cell.2018.03.026. Epub 2018 Apr 12.

PMID:
29656892
25.

A CLK3-HMGA2 Alternative Splicing Axis Impacts Human Hematopoietic Stem Cell Molecular Identity throughout Development.

Cesana M, Guo MH, Cacchiarelli D, Wahlster L, Barragan J, Doulatov S, Vo LT, Salvatori B, Trapnell C, Clement K, Cahan P, Tsanov KM, Sousa PM, Tazon-Vega B, Bolondi A, Giorgi FM, Califano A, Rinn JL, Meissner A, Hirschhorn JN, Daley GQ.

Cell Stem Cell. 2018 Apr 5;22(4):575-588.e7. doi: 10.1016/j.stem.2018.03.012.

PMID:
29625070
26.

Author Correction: Global delay in nascent strand DNA methylation.

Charlton J, Downing TL, Smith ZD, Gu H, Clement K, Pop R, Akopian V, Klages S, Santos DP, Tsankov AM, Timmermann B, Ziller MJ, Kiskinis E, Gnirke A, Meissner A.

Nat Struct Mol Biol. 2018 Apr;25(4):355. doi: 10.1038/s41594-018-0055-3.

PMID:
29581568
27.

Dissecting the Functional Consequences of De Novo DNA Methylation Dynamics in Human Motor Neuron Differentiation and Physiology.

Ziller MJ, Ortega JA, Quinlan KA, Santos DP, Gu H, Martin EJ, Galonska C, Pop R, Maidl S, Di Pardo A, Huang M, Meltzer HY, Gnirke A, Heckman CJ, Meissner A, Kiskinis E.

Cell Stem Cell. 2018 Apr 5;22(4):559-574.e9. doi: 10.1016/j.stem.2018.02.012. Epub 2018 Mar 15.

PMID:
29551301
28.

Global delay in nascent strand DNA methylation.

Charlton J, Downing TL, Smith ZD, Gu H, Clement K, Pop R, Akopian V, Klages S, Santos DP, Tsankov AM, Timmermann B, Ziller MJ, Kiskinis E, Gnirke A, Meissner A.

Nat Struct Mol Biol. 2018 Apr;25(4):327-332. doi: 10.1038/s41594-018-0046-4. Epub 2018 Mar 12. Erratum in: Nat Struct Mol Biol. 2018 Mar 26;:.

29.

Zika Virus Alters DNA Methylation of Neural Genes in an Organoid Model of the Developing Human Brain.

Janssens S, Schotsaert M, Karnik R, Balasubramaniam V, Dejosez M, Meissner A, García-Sastre A, Zwaka TP.

mSystems. 2018 Feb 6;3(1). pii: e00219-17. doi: 10.1128/mSystems.00219-17. eCollection 2018 Jan-Feb.

30.

Genome-wide tracking of dCas9-methyltransferase footprints.

Galonska C, Charlton J, Mattei AL, Donaghey J, Clement K, Gu H, Mohammad AW, Stamenova EK, Cacchiarelli D, Klages S, Timmermann B, Cantz T, Schöler HR, Gnirke A, Ziller MJ, Meissner A.

Nat Commun. 2018 Feb 9;9(1):597. doi: 10.1038/s41467-017-02708-5.

31.

Genetic determinants and epigenetic effects of pioneer-factor occupancy.

Donaghey J, Thakurela S, Charlton J, Chen JS, Smith ZD, Gu H, Pop R, Clement K, Stamenova EK, Karnik R, Kelley DR, Gifford CA, Cacchiarelli D, Rinn JL, Gnirke A, Ziller MJ, Meissner A.

Nat Genet. 2018 Feb;50(2):250-258. doi: 10.1038/s41588-017-0034-3. Epub 2018 Jan 22.

PMID:
29358654
32.

Point-by-point versus multisite electrode mapping in VT ablation: does freedom from VT recurrences depend on mapping catheter? An observational study.

Maagh P, Christoph A, Müller MS, Dopp H, Plehn G, Meissner A.

J Interv Card Electrophysiol. 2018 Mar;51(2):169-181. doi: 10.1007/s10840-018-0311-9. Epub 2018 Jan 22.

PMID:
29356922
33.

High-Density Mapping in Ventricular Tachycardia Ablation: A PentaRay® Study.

Maagh P, Christoph A, Dopp H, Mueller MS, Plehn G, Meissner A.

Cardiol Res. 2017 Dec;8(6):293-303. doi: 10.14740/cr636w. Epub 2017 Dec 22.

34.

Is wrist splint more effective than forearm band for lateral epicondylitis?

Meissner A, Vives MI, Román J, Meissner A.

Medwave. 2017 Dec 28;17(9):e7124. doi: 10.5867/medwave.2017.09.7124. Review. Spanish, English.

PMID:
29286358
36.

Development of the testis in pre-pubertal boys with cancer after biopsy for fertility preservation.

Uijldert M, Meißner A, de Melker AA, van Pelt AMM, van de Wetering MD, van Rijn RR, van Wely M, van der Veen F, Repping S.

Hum Reprod. 2017 Dec 1;32(12):2366-2372. doi: 10.1093/humrep/dex306.

PMID:
29040511
37.

Epigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer.

Smith ZD, Shi J, Gu H, Donaghey J, Clement K, Cacchiarelli D, Gnirke A, Michor F, Meissner A.

Nature. 2017 Sep 28;549(7673):543-547. doi: 10.1038/nature23891. Epub 2017 Sep 20.

38.

Interconversion Rates between Conformational States as Rationale for the Membrane Permeability of Cyclosporines.

Witek J, Mühlbauer M, Keller BG, Blatter M, Meissner A, Wagner T, Riniker S.

Chemphyschem. 2017 Dec 6;18(23):3309-3314. doi: 10.1002/cphc.201700995. Epub 2017 Nov 2.

PMID:
28921848
39.

Correction to Kinetic Models of Cyclosporin A in Polar and Apolar Environments Reveal Multiple Congruent Conformational States.

Witek J, Keller BG, Blatter M, Meissner A, Wagner T, Riniker S.

J Chem Inf Model. 2017 Sep 25;57(9):2393. doi: 10.1021/acs.jcim.7b00502. Epub 2017 Sep 12. No abstract available.

PMID:
28898064
40.

Ablation of adipose-HO-1 expression increases white fat over beige fat through inhibition of mitochondrial fusion and of PGC1α in female mice.

Singh SP, Grant I, Meissner A, Kappas A, Abraham NG.

Horm Mol Biol Clin Investig. 2017 Aug 1;31(1). pii: /j/hmbci.2017.31.issue-1/hmbci-2017-0027/hmbci-2017-0027.xml. doi: 10.1515/hmbci-2017-0027.

PMID:
28763300
41.

Prolonged Mek1/2 suppression impairs the developmental potential of embryonic stem cells.

Choi J, Huebner AJ, Clement K, Walsh RM, Savol A, Lin K, Gu H, Di Stefano B, Brumbaugh J, Kim SY, Sharif J, Rose CM, Mohammad A, Odajima J, Charron J, Shioda T, Gnirke A, Gygi S, Koseki H, Sadreyev RI, Xiao A, Meissner A, Hochedlinger K.

Nature. 2017 Aug 10;548(7666):219-223. doi: 10.1038/nature23274. Epub 2017 Jul 26.

42.

Open-water and under-ice seasonal variations in trace element content and physicochemical associations in fluvial bed sediment.

Doig LE, Carr MK, Meissner AGN, Jardine TD, Jones PD, Bharadwaj L, Lindenschmidt KE.

Environ Toxicol Chem. 2017 Nov;36(11):2916-2924. doi: 10.1002/etc.3886. Epub 2017 Aug 3.

PMID:
28612479
43.

Pulmonary vein potential mapping in atrial fibrillation with high density and standard spiral (lasso) catheters: A comparative study.

Meissner A, Maagh P, Christoph A, Oernek A, Plehn G.

J Arrhythm. 2017 Jun;33(3):192-200. doi: 10.1016/j.joa.2016.10.562. Epub 2016 Nov 25.

44.

S1PR (Sphingosine-1-Phosphate Receptor) Signaling in the Regulation of Vascular Tone and Blood Pressure: Is S1PR1 Doing the Trick?

Meissner A.

Hypertension. 2017 Aug;70(2):232-234. doi: 10.1161/HYPERTENSIONAHA.117.09200. Epub 2017 Jun 12. No abstract available.

PMID:
28607129
45.

Comparison of 19F NMR and 14C Measurements for the Assessment of ADME of BYL719 (Alpelisib) in Humans.

James AD, Marvalin C, Luneau A, Meissner A, Camenisch G.

Drug Metab Dispos. 2017 Aug;45(8):900-907. doi: 10.1124/dmd.117.075424. Epub 2017 May 31.

PMID:
28566285
46.

Retraction Note to: Inotropic therapy for cardiac low output syndrome: comparison of hemodynamic effects of dopamine/dobutamine versus dopamine/dopexamine.

El Mokhtari NE, Arlt A, Meissner A, Lins M.

Eur J Med Res. 2017 May 16;22(1):16. doi: 10.1186/s40001-017-0256-y. No abstract available.

47.

Impact of High-Intensity-NIV on the heart in stable COPD: a randomised cross-over pilot study.

Duiverman ML, Maagh P, Magnet FS, Schmoor C, Arellano-Maric MP, Meissner A, Storre JH, Wijkstra PJ, Windisch W, Callegari J.

Respir Res. 2017 May 2;18(1):76. doi: 10.1186/s12931-017-0542-9.

48.

Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease.

Warren CR, O'Sullivan JF, Friesen M, Becker CE, Zhang X, Liu P, Wakabayashi Y, Morningstar JE, Shi X, Choi J, Xia F, Peters DT, Florido MHC, Tsankov AM, Duberow E, Comisar L, Shay J, Jiang X, Meissner A, Musunuru K, Kathiresan S, Daheron L, Zhu J, Gerszten RE, Deo RC, Vasan RS, O'Donnell CJ, Cowan CA.

Cell Stem Cell. 2017 Apr 6;20(4):547-557.e7. doi: 10.1016/j.stem.2017.01.010.

49.

DUSP9 Modulates DNA Hypomethylation in Female Mouse Pluripotent Stem Cells.

Choi J, Clement K, Huebner AJ, Webster J, Rose CM, Brumbaugh J, Walsh RM, Lee S, Savol A, Etchegaray JP, Gu H, Boyle P, Elling U, Mostoslavsky R, Sadreyev R, Park PJ, Gygi SP, Meissner A, Hochedlinger K.

Cell Stem Cell. 2017 May 4;20(5):706-719.e7. doi: 10.1016/j.stem.2017.03.002. Epub 2017 Mar 30.

50.

Pneumocystis jirovecii-induced chronic interstitial lung disease in Waldenström's macroglobulinemia.

Windisch W, Meissner A, Goßmann A, Brockmann M, Schildgen V, Schildgen O.

Future Microbiol. 2017 Mar;12:307-313. doi: 10.2217/fmb-2016-0188. Epub 2017 Feb 24.

PMID:
28287298

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