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Items: 38


Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes.

Limbocker R, Chia S, Ruggeri FS, Perni M, Cascella R, Heller GT, Meisl G, Mannini B, Habchi J, Michaels TCT, Challa PK, Ahn M, Casford ST, Fernando N, Xu CK, Kloss ND, Cohen SIA, Kumita JR, Cecchi C, Zasloff M, Linse S, Knowles TPJ, Chiti F, Vendruscolo M, Dobson CM.

Nat Commun. 2019 Jan 15;10(1):225. doi: 10.1038/s41467-018-07699-5.


Physical Determinants of Amyloid Assembly in Biofilm Formation.

Andreasen M, Meisl G, Taylor JD, Michaels TCT, Levin A, Otzen DE, Chapman MR, Dobson CM, Matthews SJ, Knowles TPJ.

MBio. 2019 Jan 8;10(1). pii: e02279-18. doi: 10.1128/mBio.02279-18.


Direct Observation of Murine Prion Protein Replication in Vitro.

Sang JC, Meisl G, Thackray AM, Hong L, Ponjavic A, Knowles TPJ, Bujdoso R, Klenerman D.

J Am Chem Soc. 2018 Nov 7;140(44):14789-14798. doi: 10.1021/jacs.8b08311. Epub 2018 Oct 23.


Origin of metastable oligomers and their effects on amyloid fibril self-assembly.

Hasecke F, Miti T, Perez C, Barton J, Schölzel D, Gremer L, Grüning CSR, Matthews G, Meisl G, Knowles TPJ, Willbold D, Neudecker P, Heise H, Ullah G, Hoyer W, Muschol M.

Chem Sci. 2018 Jun 13;9(27):5937-5948. doi: 10.1039/c8sc01479e. eCollection 2018 Jul 21.


Extrinsic Amyloid-Binding Dyes for Detection of Individual Protein Aggregates in Solution.

Taylor CG, Meisl G, Horrocks MH, Zetterberg H, Knowles TPJ, Klenerman D.

Anal Chem. 2018 Sep 4;90(17):10385-10393. doi: 10.1021/acs.analchem.8b02226. Epub 2018 Aug 13.


Secondary nucleation in amyloid formation.

Törnquist M, Michaels TCT, Sanagavarapu K, Yang X, Meisl G, Cohen SIA, Knowles TPJ, Linse S.

Chem Commun (Camb). 2018 Aug 2;54(63):8667-8684. doi: 10.1039/c8cc02204f. Review.


Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine.

Perni M, Flagmeier P, Limbocker R, Cascella R, Aprile FA, Galvagnion C, Heller GT, Meisl G, Chen SW, Kumita JR, Challa PK, Kirkegaard JB, Cohen SIA, Mannini B, Barbut D, Nollen EAA, Cecchi C, Cremades N, Knowles TPJ, Chiti F, Zasloff M, Vendruscolo M, Dobson CM.

ACS Chem Biol. 2018 Aug 17;13(8):2308-2319. doi: 10.1021/acschembio.8b00466. Epub 2018 Jun 28.


Oligomer Diversity during the Aggregation of the Repeat Region of Tau.

Kjaergaard M, Dear AJ, Kundel F, Qamar S, Meisl G, Knowles TPJ, Klenerman D.

ACS Chem Neurosci. 2018 Jul 17. doi: 10.1021/acschemneuro.8b00250. [Epub ahead of print]


Kinetic barriers to α-synuclein protofilament formation and conversion into mature fibrils.

Brown JWP, Meisl G, Knowles TPJ, Buell AK, Dobson CM, Galvagnion C.

Chem Commun (Camb). 2018 Jul 10;54(56):7854-7857. doi: 10.1039/c8cc03002b.


On the role of sidechain size and charge in the aggregation of Aβ42 with familial mutations.

Yang X, Meisl G, Frohm B, Thulin E, Knowles TPJ, Linse S.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):E5849-E5858. doi: 10.1073/pnas.1803539115. Epub 2018 Jun 12.


Kinetic Analysis of Amyloid Formation.

Meisl G, Michaels TCT, Linse S, Knowles TPJ.

Methods Mol Biol. 2018;1779:181-196. doi: 10.1007/978-1-4939-7816-8_12.


On-chip measurements of protein unfolding from direct observations of micron-scale diffusion.

Zhang Y, Yates EV, Hong L, Saar KL, Meisl G, Dobson CM, Knowles TPJ.

Chem Sci. 2018 Feb 9;9(14):3503-3507. doi: 10.1039/c7sc04331g. eCollection 2018 Apr 14.


Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading.

Kundel F, Hong L, Falcon B, McEwan WA, Michaels TCT, Meisl G, Esteras N, Abramov AY, Knowles TJP, Goedert M, Klenerman D.

ACS Chem Neurosci. 2018 Jun 20;9(6):1276-1282. doi: 10.1021/acschemneuro.8b00094. Epub 2018 Apr 8.


Chemical Kinetics for Bridging Molecular Mechanisms and Macroscopic Measurements of Amyloid Fibril Formation.

Michaels TCT, Šarić A, Habchi J, Chia S, Meisl G, Vendruscolo M, Dobson CM, Knowles TPJ.

Annu Rev Phys Chem. 2018 Apr 20;69:273-298. doi: 10.1146/annurev-physchem-050317-021322. Epub 2018 Feb 28. Review.


Microfluidic Diffusion Platform for Characterizing the Sizes of Lipid Vesicles and the Thermodynamics of Protein-Lipid Interactions.

Gang H, Galvagnion C, Meisl G, Müller T, Pfammatter M, Buell AK, Levin A, Dobson CM, Mu B, Knowles TPJ.

Anal Chem. 2018 Mar 6;90(5):3284-3290. doi: 10.1021/acs.analchem.7b04820. Epub 2018 Feb 13.


Secondary nucleation of monomers on fibril surface dominates α-synuclein aggregation and provides autocatalytic amyloid amplification.

Gaspar R, Meisl G, Buell AK, Young L, Kaminski CF, Knowles TPJ, Sparr E, Linse S.

Q Rev Biophys. 2017 Jan;50:e6. doi: 10.1017/S0033583516000172.


Scaling behaviour and rate-determining steps in filamentous self-assembly.

Meisl G, Rajah L, Cohen SAI, Pfammatter M, Šarić A, Hellstrand E, Buell AK, Aguzzi A, Linse S, Vendruscolo M, Dobson CM, Knowles TPJ.

Chem Sci. 2017 Oct 1;8(10):7087-7097. doi: 10.1039/c7sc01965c. Epub 2017 Aug 31.


Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the Aβ42 peptide and its variants.

Meisl G, Yang X, Dobson CM, Linse S, Knowles TPJ.

Chem Sci. 2017 Jun 1;8(6):4352-4362. doi: 10.1039/c7sc00215g. Epub 2017 Apr 26.


Absolute Quantification of Amyloid Propagons by Digital Microfluidics.

Pfammatter M, Andreasen M, Meisl G, Taylor CG, Adamcik J, Bolisetty S, Sánchez-Ferrer A, Klenerman D, Dobson CM, Mezzenga R, Knowles TPJ, Aguzzi A, Hornemann S.

Anal Chem. 2017 Nov 21;89(22):12306-12313. doi: 10.1021/acs.analchem.7b03279. Epub 2017 Nov 1.


Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication.

Munke A, Persson J, Weiffert T, De Genst E, Meisl G, Arosio P, Carnerup A, Dobson CM, Vendruscolo M, Knowles TPJ, Linse S.

Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):6444-6449. doi: 10.1073/pnas.1700407114. Epub 2017 Jun 5.


Acceleration of α-synuclein aggregation.

Gaspar R, Meisl G, Buell AK, Young L, Kaminski CF, Knowles TPJ, Sparr E, Linse S.

Amyloid. 2017 Mar;24(sup1):20-21. doi: 10.1080/13506129.2017.1292904. No abstract available.


Physical principles of filamentous protein self-assembly kinetics.

Michaels TC, Liu LX, Meisl G, Knowles TP.

J Phys Condens Matter. 2017 Apr 20;29(15):153002. doi: 10.1088/1361-648X/aa5f10. Epub 2017 Feb 7.


A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity.

Perni M, Galvagnion C, Maltsev A, Meisl G, Müller MB, Challa PK, Kirkegaard JB, Flagmeier P, Cohen SI, Cascella R, Chen SW, Limbocker R, Sormanni P, Heller GT, Aprile FA, Cremades N, Cecchi C, Chiti F, Nollen EA, Knowles TP, Vendruscolo M, Bax A, Zasloff M, Dobson CM.

Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E1009-E1017. doi: 10.1073/pnas.1610586114. Epub 2017 Jan 17. Erratum in: Proc Natl Acad Sci U S A. 2017 Mar 21;114(12 ):E2543. Limboker, Ryan [corrected to Limbocker, Ryan].


β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces.

Brown JW, Buell AK, Michaels TC, Meisl G, Carozza J, Flagmeier P, Vendruscolo M, Knowles TP, Dobson CM, Galvagnion C.

Sci Rep. 2016 Nov 3;6:36010. doi: 10.1038/srep36010.


Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregation.

Flagmeier P, Meisl G, Vendruscolo M, Knowles TP, Dobson CM, Buell AK, Galvagnion C.

Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):10328-33. doi: 10.1073/pnas.1604645113. Epub 2016 Aug 29.


Self-assembly of MPG1, a hydrophobin protein from the rice blast fungus that forms functional amyloid coatings, occurs by a surface-driven mechanism.

Pham CL, Rey A, Lo V, Soulès M, Ren Q, Meisl G, Knowles TP, Kwan AH, Sunde M.

Sci Rep. 2016 May 4;6:25288. doi: 10.1038/srep25288.


Electrostatically-guided inhibition of Curli amyloid nucleation by the CsgC-like family of chaperones.

Taylor JD, Hawthorne WJ, Lo J, Dear A, Jain N, Meisl G, Andreasen M, Fletcher C, Koch M, Darvill N, Scull N, Escalera-Maurer A, Sefer L, Wenman R, Lambert S, Jean J, Xu Y, Turner B, Kazarian SG, Chapman MR, Bubeck D, de Simone A, Knowles TP, Matthews SJ.

Sci Rep. 2016 Apr 21;6:24656. doi: 10.1038/srep24656.


An Environmentally Sensitive Fluorescent Dye as a Multidimensional Probe of Amyloid Formation.

Yates EV, Meisl G, Knowles TP, Dobson CM.

J Phys Chem B. 2016 Mar 10;120(9):2087-94. doi: 10.1021/acs.jpcb.5b09663. Epub 2016 Feb 29.


Quantitative analysis of intrinsic and extrinsic factors in the aggregation mechanism of Alzheimer-associated Aβ-peptide.

Meisl G, Yang X, Frohm B, Knowles TP, Linse S.

Sci Rep. 2016 Jan 13;6:18728. doi: 10.1038/srep18728.


Molecular mechanisms of protein aggregation from global fitting of kinetic models.

Meisl G, Kirkegaard JB, Arosio P, Michaels TC, Vendruscolo M, Dobson CM, Linse S, Knowles TP.

Nat Protoc. 2016 Feb;11(2):252-72. doi: 10.1038/nprot.2016.010. Epub 2016 Jan 7.


N-Terminal Extensions Retard Aβ42 Fibril Formation but Allow Cross-Seeding and Coaggregation with Aβ42.

Szczepankiewicz O, Linse B, Meisl G, Thulin E, Frohm B, Sala Frigerio C, Colvin MT, Jacavone AC, Griffin RG, Knowles T, Walsh DM, Linse S.

J Am Chem Soc. 2015 Nov 25;137(46):14673-85. doi: 10.1021/jacs.5b07849. Epub 2015 Nov 17.


The Aβ40 and Aβ42 peptides self-assemble into separate homomolecular fibrils in binary mixtures but cross-react during primary nucleation.

Cukalevski R, Yang X, Meisl G, Weininger U, Bernfur K, Frohm B, Knowles TPJ, Linse S.

Chem Sci. 2015 Jul 1;6(7):4215-4233. doi: 10.1039/c4sc02517b. Epub 2015 May 8.


Preventing peptide and protein misbehavior.

Arosio P, Meisl G, Andreasen M, Knowles TP.

Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5267-8. doi: 10.1073/pnas.1505170112. Epub 2015 Apr 20. No abstract available.


Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation.

Galvagnion C, Buell AK, Meisl G, Michaels TC, Vendruscolo M, Knowles TP, Dobson CM.

Nat Chem Biol. 2015 Mar;11(3):229-34. doi: 10.1038/nchembio.1750. Epub 2015 Feb 2.


Ostwald's rule of stages governs structural transitions and morphology of dipeptide supramolecular polymers.

Levin A, Mason TO, Adler-Abramovich L, Buell AK, Meisl G, Galvagnion C, Bram Y, Stratford SA, Dobson CM, Knowles TP, Gazit E.

Nat Commun. 2014 Nov 13;5:5219. doi: 10.1038/ncomms6219.


Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides.

Meisl G, Yang X, Hellstrand E, Frohm B, Kirkegaard JB, Cohen SI, Dobson CM, Linse S, Knowles TP.

Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9384-9. doi: 10.1073/pnas.1401564111. Epub 2014 Jun 17.


Diffuse transition state structure for the unfolding of a leucine-rich repeat protein.

Kelly SE, Meisl G, Rowling PJ, McLaughlin SH, Knowles T, Itzhaki LS.

Phys Chem Chem Phys. 2014 Apr 14;16(14):6448-59. doi: 10.1039/c3cp54818j. Epub 2014 Feb 18.


Solvent and conformation dependence of amide I vibrations in peptides and proteins containing proline.

Roy S, Lessing J, Meisl G, Ganim Z, Tokmakoff A, Knoester J, Jansen TL.

J Chem Phys. 2011 Dec 21;135(23):234507. doi: 10.1063/1.3665417.


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