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Items: 1 to 50 of 65

1.

Non-enzymatic cleavage of Hsp90 by oxidative stress leads to actin aggregate formation: A novel gain-of-function mechanism.

Castro JP, Fernando R, Reeg S, Meinl W, Almeida H, Grune T.

Redox Biol. 2019 Feb;21:101108. doi: 10.1016/j.redox.2019.101108. Epub 2019 Jan 11.

PMID:
30660959
2.

Strong impact of sulfotransferases on DNA adduct formation by 4-aminobiphenyl in bladder and liver in mice.

Li Y, Chen Z, Paonessa JD, Meinl W, Bhattacharya A, Glatt H, Vouros P, Zhang Y.

Cancer Med. 2018 Nov;7(11):5604-5610. doi: 10.1002/cam4.1779. Epub 2018 Oct 10.

PMID:
30306738
3.

Hemoglobin adducts of furfuryl alcohol in genetically modified mouse models: Role of endogenous sulfotransferases 1a1 and 1d1 and transgenic human sulfotransferases 1A1/1A2.

Monien BH, Sachse B, Meinl W, Abraham K, Lampen A, Glatt H.

Toxicol Lett. 2018 Oct 1;295:173-178. doi: 10.1016/j.toxlet.2018.06.008. Epub 2018 Jun 13.

PMID:
29908303
4.

Methyleugenol DNA adducts in human liver are associated with SULT1A1 copy number variations and expression levels.

Tremmel R, Herrmann K, Engst W, Meinl W, Klein K, Glatt H, Zanger UM.

Arch Toxicol. 2017 Oct;91(10):3329-3339. doi: 10.1007/s00204-017-1955-4. Epub 2017 Mar 22.

PMID:
28326452
5.

Erratum to: Comparison of in vitro test systems using bacterial and mammalian cells for genotoxicity assessment within the health-related indication value (HRIV) concept.

Prantl EM, Kramer M, Schmidt CK, Knauer M, Gartiser S, Shuliakevich A, Milas J, Glatt H, Meinl W, Hollert H.

Environ Sci Pollut Res Int. 2018 Feb;25(5):4011. doi: 10.1007/s11356-017-8464-0. No abstract available.

PMID:
28127693
6.

Comparison of in vitro test systems using bacterial and mammalian cells for genotoxicity assessment within the "health-related indication value (HRIV) concept.

Prantl EM, Kramer M, Schmidt CK, Knauer M, Gartiser S, Shuliakevich A, Milas J, Glatt H, Meinl W, Hollert H.

Environ Sci Pollut Res Int. 2018 Feb;25(5):3996-4010. doi: 10.1007/s11356-016-8166-z. Epub 2016 Dec 8. Erratum in: Environ Sci Pollut Res Int. 2017 Jan 27;:.

PMID:
27928753
7.

Impact of genetic modulation of SULT1A enzymes on DNA adduct formation by aristolochic acids and 3-nitrobenzanthrone.

Arlt VM, Meinl W, Florian S, Nagy E, Barta F, Thomann M, Mrizova I, Krais AM, Liu M, Richards M, Mirza A, Kopka K, Phillips DH, Glatt H, Stiborova M, Schmeiser HH.

Arch Toxicol. 2017 Apr;91(4):1957-1975. doi: 10.1007/s00204-016-1808-6. Epub 2016 Aug 24.

PMID:
27557898
8.

Use of genetically manipulated Salmonella typhimurium strains to evaluate the role of human sulfotransferases in the bioactivation of nitro- and aminotoluenes.

Glatt H, Sabbioni G, Monien BH, Meinl W.

Environ Mol Mutagen. 2016 May;57(4):299-311. doi: 10.1002/em.22005. Epub 2016 Feb 29.

PMID:
26924705
9.

The influence of the SULT1A status - wild-type, knockout or humanized - on the DNA adduct formation by methyleugenol in extrahepatic tissues of mice.

Herrmann K, Engst W, Florian S, Lampen A, Meinl W, Glatt HR.

Toxicol Res (Camb). 2016 Feb 12;5(3):808-815. doi: 10.1039/c5tx00358j. eCollection 2016 May 1.

PMID:
30090391
10.

Ethanol and 4-methylpyrazole increase DNA adduct formation of furfuryl alcohol in FVB/N wild-type mice and in mice expressing human sulfotransferases 1A1/1A2.

Sachse B, Meinl W, Glatt H, Monien BH.

Carcinogenesis. 2016 Mar;37(3):314-319. doi: 10.1093/carcin/bgw006. Epub 2016 Jan 16.

PMID:
26775039
11.

In Silico Prediction of Human Sulfotransferase 1E1 Activity Guided by Pharmacophores from Molecular Dynamics Simulations.

Rakers C, Schumacher F, Meinl W, Glatt H, Kleuser B, Wolber G.

J Biol Chem. 2016 Jan 1;291(1):58-71. doi: 10.1074/jbc.M115.685610. Epub 2015 Nov 5.

PMID:
26542807
12.

Conversion of Suspected Food Carcinogen 5-Hydroxymethylfurfural by Sulfotransferases and Aldehyde Dehydrogenases in Postmitochondrial Tissue Preparations of Humans, Mice, and Rats.

Sachse B, Meinl W, Glatt H, Monien BH.

Toxicol Sci. 2016 Jan;149(1):192-201. doi: 10.1093/toxsci/kfv228. Epub 2015 Oct 9.

PMID:
26454887
13.

Genotoxicity of three food processing contaminants in transgenic mice expressing human sulfotransferases 1A1 and 1A2 as assessed by the in vivo alkaline single cell gel electrophoresis assay.

Høie AH, Svendsen C, Brunborg G, Glatt H, Alexander J, Meinl W, Husøy T.

Environ Mol Mutagen. 2015 Oct;56(8):709-14. doi: 10.1002/em.21963. Epub 2015 Aug 13.

PMID:
26270892
14.

The glucosinolate metabolite 1-methoxy-3-indolylmethyl alcohol induces a gene expression profile in mouse liver similar to the expression signature caused by known genotoxic hepatocarcinogens.

Ehlers A, Florian S, Schumacher F, Meinl W, Lenze D, Hummel M, Heise T, Seidel A, Glatt H, Lampen A.

Mol Nutr Food Res. 2015 Apr;59(4):685-97. doi: 10.1002/mnfr.201400707. Epub 2015 Feb 9.

PMID:
25559983
15.

Bioactivation of food genotoxicants 5-hydroxymethylfurfural and furfuryl alcohol by sulfotransferases from human, mouse and rat: a comparative study.

Sachse B, Meinl W, Sommer Y, Glatt H, Seidel A, Monien BH.

Arch Toxicol. 2016 Jan;90(1):137-48. doi: 10.1007/s00204-014-1392-6. Epub 2014 Nov 5.

PMID:
25370010
16.

The effect of knockout of sulfotransferases 1a1 and 1d1 and of transgenic human sulfotransferases 1A1/1A2 on the formation of DNA adducts from furfuryl alcohol in mouse models.

Sachse B, Meinl W, Glatt H, Monien BH.

Carcinogenesis. 2014 Oct;35(10):2339-45. doi: 10.1093/carcin/bgu152. Epub 2014 Jul 22.

PMID:
25053625
17.

Determination of sulfotransferase forms involved in the metabolic activation of the genotoxicant 1-hydroxymethylpyrene using bacterially expressed enzymes and genetically modified mouse models.

Bendadani C, Meinl W, Monien B, Dobbernack G, Florian S, Engst W, Nolden T, Himmelbauer H, Glatt H.

Chem Res Toxicol. 2014 Jun 16;27(6):1060-9. doi: 10.1021/tx500129g. Epub 2014 May 22.

PMID:
24802129
18.

The carcinogen 1-methylpyrene forms benzylic DNA adducts in mouse and rat tissues in vivo via a reactive sulphuric acid ester.

Bendadani C, Meinl W, Monien BH, Dobbernack G, Glatt H.

Arch Toxicol. 2014 Mar;88(3):815-21. doi: 10.1007/s00204-013-1182-6. Epub 2013 Dec 13.

PMID:
24337722
19.

Formation of hepatic DNA adducts by methyleugenol in mouse models: drastic decrease by Sult1a1 knockout and strong increase by transgenic human SULT1A1/2.

Herrmann K, Engst W, Meinl W, Florian S, Cartus AT, Schrenk D, Appel KE, Nolden T, Himmelbauer H, Glatt H.

Carcinogenesis. 2014 Apr;35(4):935-41. doi: 10.1093/carcin/bgt408. Epub 2013 Dec 6.

PMID:
24318996
20.

Highly selective bioactivation of 1- and 2-hydroxy-3-methylcholanthrene to mutagens by individual human and other mammalian sulphotransferases expressed in Salmonella typhimurium.

Meinl W, Tsoi C, Swedmark S, Tibbs ZE, Falany CN, Glatt H.

Mutagenesis. 2013 Sep;28(5):609-19. doi: 10.1093/mutage/get039. Epub 2013 Jul 26.

PMID:
23894158
21.

Sulfotransferase-independent genotoxicity of illudin S and its acylfulvene derivatives in bacterial and mammalian cells.

Glatt H, Pietsch KE, Sturla SJ, Meinl W.

Arch Toxicol. 2014 Jan;88(1):161-9. doi: 10.1007/s00204-013-1097-2. Epub 2013 Jul 24.

PMID:
23881331
22.

Study of 5-hydroxymethylfurfural and its metabolite 5-sulfooxymethylfurfural on induction of colonic aberrant crypt foci in wild-type mice and transgenic mice expressing human sulfotransferases 1A1 and 1A2.

Florian S, Bauer-Marinovic M, Taugner F, Dobbernack G, Monien BH, Meinl W, Glatt H.

Mol Nutr Food Res. 2012 Apr;56(4):593-600. doi: 10.1002/mnfr.201100574. Epub 2012 Feb 20.

PMID:
22351042
23.

Intestinal carcinogenesis of two food processing contaminants, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 5-hydroxymethylfurfural, in transgenic FVB min mice expressing human sulfotransferases.

Svendsen C, Meinl W, Glatt H, Alexander J, Knutsen HK, Hjertholm H, Rasmussen T, Husøy T.

Mol Carcinog. 2012 Dec;51(12):984-92. doi: 10.1002/mc.20869. Epub 2011 Oct 17.

PMID:
22006426
24.

Altered tissue distribution of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA adducts in mice transgenic for human sulfotransferases 1A1 and 1A2.

Dobbernack G, Meinl W, Schade N, Florian S, Wend K, Voigt I, Himmelbauer H, Gross M, Liehr T, Glatt H.

Carcinogenesis. 2011 Nov;32(11):1734-40. doi: 10.1093/carcin/bgr204. Epub 2011 Sep 7.

PMID:
21900212
25.

Hydroxymethyl-substituted furans: mutagenicity in Salmonella typhimurium strains engineered for expression of various human and rodent sulphotransferases.

Glatt H, Schneider H, Murkovic M, Monien BH, Meinl W.

Mutagenesis. 2012 Jan;27(1):41-8. doi: 10.1093/mutage/ger054. Epub 2011 Aug 8.

PMID:
21825114
26.

First chemical synthesis and in vitro characterization of the potential human metabolites 5-o-feruloylquinic acid 4'-sulfate and 4'-O-glucuronide.

Menozzi-Smarrito C, Wong CC, Meinl W, Glatt H, Fumeaux R, Munari C, Robert F, Williamson G, Barron D.

J Agric Food Chem. 2011 May 25;59(10):5671-6. doi: 10.1021/jf200272m. Epub 2011 Apr 21.

PMID:
21417257
27.

Constitutive expression of bioactivating enzymes in normal human prostate suggests a capability to activate pro-carcinogens to DNA-damaging metabolites.

Martin FL, Patel II, Sozeri O, Singh PB, Ragavan N, Nicholson CM, Frei E, Meinl W, Glatt H, Phillips DH, Arlt VM.

Prostate. 2010 Oct 1;70(14):1586-99. doi: 10.1002/pros.21194.

PMID:
20687231
28.

Xanthohumol, a prenylated chalcone from hops, modulates hepatic expression of genes involved in thyroid hormone distribution and metabolism.

Radović B, Hussong R, Gerhäuser C, Meinl W, Frank N, Becker H, Köhrle J.

Mol Nutr Food Res. 2010 Jul;54 Suppl 2:S225-35. doi: 10.1002/mnfr.200900489.

PMID:
20461738
29.

Phase II metabolism of hesperetin by individual UDP-glucuronosyltransferases and sulfotransferases and rat and human tissue samples.

Brand W, Boersma MG, Bik H, Hoek-van den Hil EF, Vervoort J, Barron D, Meinl W, Glatt H, Williamson G, van Bladeren PJ, Rietjens IM.

Drug Metab Dispos. 2010 Apr;38(4):617-25. doi: 10.1124/dmd.109.031047. Epub 2010 Jan 7.

PMID:
20056724
30.

Comparison of murine and human estrogen sulfotransferase inhibition in vitro and in silico--implications for differences in activity, subunit dimerization and substrate inhibition.

Stjernschantz E, Reinen J, Meinl W, George BJ, Glatt H, Vermeulen NP, Oostenbrink C.

Mol Cell Endocrinol. 2010 Apr 12;317(1-2):127-40. doi: 10.1016/j.mce.2009.12.001. Epub 2009 Dec 16.

PMID:
20025931
31.

In vitro and in vivo conjugation of dietary hydroxycinnamic acids by UDP-glucuronosyltransferases and sulfotransferases in humans.

Wong CC, Meinl W, Glatt HR, Barron D, Stalmach A, Steiling H, Crozier A, Williamson G.

J Nutr Biochem. 2010 Nov;21(11):1060-8. doi: 10.1016/j.jnutbio.2009.09.001. Epub 2009 Dec 1.

PMID:
19954949
32.

Impact of gut microbiota on intestinal and hepatic levels of phase 2 xenobiotic-metabolizing enzymes in the rat.

Meinl W, Sczesny S, Brigelius-Flohé R, Blaut M, Glatt H.

Drug Metab Dispos. 2009 Jun;37(6):1179-86. doi: 10.1124/dmd.108.025916. Epub 2009 Mar 12.

PMID:
19282396
33.

Consumption of Brussels sprouts protects peripheral human lymphocytes against 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and oxidative DNA-damage: results of a controlled human intervention trial.

Hoelzl C, Glatt H, Meinl W, Sontag G, Haidinger G, Kundi M, Simic T, Chakraborty A, Bichler J, Ferk F, Angelis K, Nersesyan A, Knasmüller S.

Mol Nutr Food Res. 2008 Mar;52(3):330-41. doi: 10.1002/mnfr.200700406.

PMID:
18293303
34.

Oxidation of alcohols and reduction of aldehydes derived from methyl- and dimethylpyrenes by cDNA-expressed human alcohol dehydrogenases.

Kollock R, Frank H, Seidel A, Meinl W, Glatt H.

Toxicology. 2008 Mar 12;245(1-2):65-75. doi: 10.1016/j.tox.2007.12.012. Epub 2007 Dec 23.

PMID:
18242813
35.

Sulfotransferase forms expressed in human intestinal Caco-2 and TC7 cells at varying stages of differentiation and role in benzo[a]pyrene metabolism.

Meinl W, Ebert B, Glatt H, Lampen A.

Drug Metab Dispos. 2008 Feb;36(2):276-83. Epub 2007 Oct 29.

PMID:
17967930
36.

SULT1C3, an orphan sequence of the human genome, encodes an enzyme activating various promutagens.

Meinl W, Donath C, Schneider H, Sommer Y, Glatt H.

Food Chem Toxicol. 2008 Apr;46(4):1249-56. Epub 2007 Sep 6.

PMID:
17936463
37.

Phytoestrogens and xenoestrogens: the contribution of diet and environment to endocrine disruption.

Waring RH, Ayers S, Gescher AJ, Glatt HR, Meinl W, Jarratt P, Kirk CJ, Pettitt T, Rea D, Harris RM.

J Steroid Biochem Mol Biol. 2008 Feb;108(3-5):213-20. Epub 2007 Sep 7. Review.

PMID:
17933522
38.

Efficient oxidation of promutagenic hydroxymethylpyrenes by cDNA-expressed human alcohol dehydrogenase ADH2 and its inhibition by various agents.

Kollock R, Meinl W, Schneider H, Batke M, Frank H, Seidel A, Glatt H.

Biochem Pharmacol. 2008 Jan 15;75(2):527-37. Epub 2007 Sep 1.

PMID:
17920042
39.

Identification and localization of soluble sulfotransferases in the human gastrointestinal tract.

Teubner W, Meinl W, Florian S, Kretzschmar M, Glatt H.

Biochem J. 2007 Jun 1;404(2):207-15.

PMID:
17335415
40.

N-Acetyltransferase and sulfotransferase activity in human prostate: potential for carcinogen activation.

Al-Buheissi SZ, Patel HR, Meinl W, Hewer A, Bryan RL, Glatt H, Miller RA, Phillips DH.

Pharmacogenet Genomics. 2006 Jun;16(6):391-9.

PMID:
16708048
41.

Sulfotransferases and acetyltransferases in mutagenicity testing: technical aspects.

Glatt H, Meinl W.

Methods Enzymol. 2005;400:230-49.

PMID:
16399352
42.

Human sulphotransferases are involved in the activation of aristolochic acids and are expressed in renal target tissue.

Meinl W, Pabel U, Osterloh-Quiroz M, Hengstler JG, Glatt H.

Int J Cancer. 2006 Mar 1;118(5):1090-7.

PMID:
16161050
43.

Coffee diterpenes prevent the genotoxic effects of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and N-nitrosodimethylamine in a human derived liver cell line (HepG2).

Majer BJ, Hofer E, Cavin C, Lhoste E, Uhl M, Glatt HR, Meinl W, Knasmüller S.

Food Chem Toxicol. 2005 Mar;43(3):433-41.

PMID:
15680679
44.

Cohort analysis of a single nucleotide polymorphism on DNA chips.

Schwonbeck S, Krause-Griep A, Gajovic-Eichelmann N, Ehrentreich-Förster E, Meinl W, Glatt H, Bier FF.

Biosens Bioelectron. 2004 Nov 15;20(5):956-66.

PMID:
15530792
45.

Polymorphisms in sulfotransferases SULT1A1 and SULT1A2 are not related to colorectal cancer.

Moreno V, Glatt H, Guino E, Fisher E, Meinl W, Navarro M, Badosa JM, Boeing H; Bellvitge Colorectal Cancer Study Group.

Int J Cancer. 2005 Feb 10;113(4):683-6. No abstract available.

PMID:
15455379
46.

Investigation of the genotoxic effects of 2-amino-9H-pyrido[2,3-b]indole in different organs of rodents and in human derived cells.

Majer BJ, Kassie F, Sasaki Y, Pfau W, Glatt H, Meinl W, Darroudi F, Knasmüller S.

J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Mar 25;802(1):167-73.

PMID:
15036008
47.
48.

Bioactivation of the heterocyclic aromatic amine 2-amino-3-methyl-9H-pyrido [2,3-b]indole (MeAalphaC) in recombinant test systems expressing human xenobiotic-metabolizing enzymes.

Glatt H, Pabel U, Meinl W, Frederiksen H, Frandsen H, Muckel E.

Carcinogenesis. 2004 May;25(5):801-7. Epub 2004 Jan 16.

PMID:
14729582
49.

Pharmacogenetics of soluble sulfotransferases (SULTs).

Glatt H, Meinl W.

Naunyn Schmiedebergs Arch Pharmacol. 2004 Jan;369(1):55-68. Epub 2003 Nov 5. Review.

PMID:
14600802
50.

Characterization of rat iodothyronine sulfotransferases.

Kester MH, Kaptein E, Roest TJ, van Dijk CH, Tibboel D, Meinl W, Glatt H, Coughtrie MW, Visser TJ.

Am J Physiol Endocrinol Metab. 2003 Sep;285(3):E592-8. Epub 2003 May 28.

PMID:
12773305

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