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Items: 16


Deficiency in SIRP-α cytoplasmic recruitment confers protection from acute kidney injury.

Ghimire K, Chiba T, Minhas N, Meijles DN, Lu B, O'Connell P, Rogers NM.

FASEB J. 2019 Oct;33(10):11528-11540. doi: 10.1096/fj.201900583R. Epub 2019 Aug 1.


NADPH oxidase 2 inhibitors CPP11G and CPP11H attenuate endothelial cell inflammation & vessel dysfunction and restore mouse hind-limb flow.

Li Y, Cifuentes-Pagano E, DeVallance ER, de Jesus DS, Sahoo S, Meijles DN, Koes D, Camacho CJ, Ross M, St Croix C, Pagano PJ.

Redox Biol. 2019 Apr;22:101143. doi: 10.1016/j.redox.2019.101143. Epub 2019 Feb 15.


The cardiomyocyte "redox rheostat": Redox signalling via the AMPK-mTOR axis and regulation of gene and protein expression balancing survival and death.

Meijles DN, Zoumpoulidou G, Markou T, Rostron KA, Patel R, Lay K, Handa BS, Wong B, Sugden PH, Clerk A.

J Mol Cell Cardiol. 2019 Apr;129:118-129. doi: 10.1016/j.yjmcc.2019.02.006. Epub 2019 Feb 13.


The matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1.

Meijles DN, Sahoo S, Al Ghouleh I, Amaral JH, Bienes-Martinez R, Knupp HE, Attaran S, Sembrat JC, Nouraie SM, Rojas MM, Novelli EM, Gladwin MT, Isenberg JS, Cifuentes-Pagano E, Pagano PJ.

Sci Signal. 2017 Oct 17;10(501). pii: eaaj1784. doi: 10.1126/scisignal.aaj1784.


Endothelial Nox1 oxidase assembly in human pulmonary arterial hypertension; driver of Gremlin1-mediated proliferation.

Ghouleh IA, Sahoo S, Meijles DN, Amaral JH, de Jesus DS, Sembrat J, Rojas M, Goncharov DA, Goncharova EA, Pagano PJ.

Clin Sci (Lond). 2017 Jul 16;131(15):2019-2035. doi: 10.1042/CS20160812. Print 2017 Aug 1.


CD47 and Nox1 Mediate Dynamic Fluid-Phase Macropinocytosis of Native LDL.

Csányi G, Feck DM, Ghoshal P, Singla B, Lin H, Nagarajan S, Meijles DN, Al Ghouleh I, Cantu-Medellin N, Kelley EE, Mateuszuk L, Isenberg JS, Watkins S, Pagano PJ.

Antioxid Redox Signal. 2017 Jun 1;26(16):886-901. doi: 10.1089/ars.2016.6834. Epub 2017 Jan 31.


Binding of EBP50 to Nox organizing subunit p47phox is pivotal to cellular reactive species generation and altered vascular phenotype.

Al Ghouleh I, Meijles DN, Mutchler S, Zhang Q, Sahoo S, Gorelova A, Henrich Amaral J, Rodríguez AI, Mamonova T, Song GJ, Bisello A, Friedman PA, Cifuentes-Pagano ME, Pagano PJ.

Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):E5308-17. doi: 10.1073/pnas.1514161113. Epub 2016 Aug 18.


p22phox C242T Single-Nucleotide Polymorphism Inhibits Inflammatory Oxidative Damage to Endothelial Cells and Vessels.

Meijles DN, Fan LM, Ghazaly MM, Howlin B, Krönke M, Brooks G, Li JM.

Circulation. 2016 Jun 14;133(24):2391-403. doi: 10.1161/CIRCULATIONAHA.116.021993. Epub 2016 May 9.


MEF2C-MYOCD and Leiomodin1 Suppression by miRNA-214 Promotes Smooth Muscle Cell Phenotype Switching in Pulmonary Arterial Hypertension.

Sahoo S, Meijles DN, Al Ghouleh I, Tandon M, Cifuentes-Pagano E, Sembrat J, Rojas M, Goncharova E, Pagano PJ.

PLoS One. 2016 May 4;11(5):e0153780. doi: 10.1371/journal.pone.0153780. eCollection 2016.


NADPH oxidases: key modulators in aging and age-related cardiovascular diseases?

Sahoo S, Meijles DN, Pagano PJ.

Clin Sci (Lond). 2016 Mar;130(5):317-35. doi: 10.1042/CS20150087. Review.


Nox and Inflammation in the Vascular Adventitia.

Meijles DN, Pagano PJ.

Hypertension. 2016 Jan;67(1):14-9. doi: 10.1161/HYPERTENSIONAHA.115.03622. Epub 2015 Nov 9. Review. No abstract available.


Nox Inhibitors & Therapies: Rational Design of Peptidic and Small Molecule Inhibitors.

Cifuentes-Pagano ME, Meijles DN, Pagano PJ.

Curr Pharm Des. 2015;21(41):6023-35. Review.


Selective inactivation of NADPH oxidase 2 causes regression of vascularization and the size and stability of atherosclerotic plaques.

Quesada IM, Lucero A, Amaya C, Meijles DN, Cifuentes ME, Pagano PJ, Castro C.

Atherosclerosis. 2015 Oct;242(2):469-75. doi: 10.1016/j.atherosclerosis.2015.08.011. Epub 2015 Aug 8.


Molecular insights of p47phox phosphorylation dynamics in the regulation of NADPH oxidase activation and superoxide production.

Meijles DN, Fan LM, Howlin BJ, Li JM.

J Biol Chem. 2014 Aug 15;289(33):22759-70. doi: 10.1074/jbc.M114.561159. Epub 2014 Jun 26.


The quest for selective nox inhibitors and therapeutics: challenges, triumphs and pitfalls.

Cifuentes-Pagano E, Meijles DN, Pagano PJ.

Antioxid Redox Signal. 2014 Jun 10;20(17):2741-54. doi: 10.1089/ars.2013.5620. Epub 2013 Dec 14. Review.


Consensus in silico computational modelling of the p22phox subunit of the NADPH oxidase.

Meijles DN, Howlin BJ, Li JM.

Comput Biol Chem. 2012 Aug;39:6-13. doi: 10.1016/j.compbiolchem.2012.05.001. Epub 2012 May 11.


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