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Items: 1 to 50 of 389

1.

[b]-Annulated Halogen-Substituted Indoles as Potential DYRK1A Inhibitors.

Lechner C, Flaßhoff M, Falke H, Preu L, Loaëc N, Meijer L, Knapp S, Chaikuad A, Kunick C.

Molecules. 2019 Nov 13;24(22). pii: E4090. doi: 10.3390/molecules24224090.

2.

Decrease in p3-Alcβ37 and p3-Alcβ40, products of Alcadein β generated by γ-secretase cleavages, in aged monkeys and patients with Alzheimer's disease.

Hata S, Omori C, Kimura A, Saito H, Kimura N, Gupta V, Pedrini S, Hone E, Chatterjee P, Taddei K, Kasuga K, Ikeuchi T, Waragai M, Nishimura M, Hu A, Nakaya T, Meijer L, Maeda M, Yamamoto T, Masters CL, Rowe CC, Ames D, Yamamoto K, Martins RN, Gandy S, Suzuki T.

Alzheimers Dement (N Y). 2019 Nov 7;5:740-750. doi: 10.1016/j.trci.2019.09.015. eCollection 2019.

3.

Tumor microbiome: Pancreatic cancer and duodenal fluids contain multitudes, …but do they contradict themselves?

Meijer LL, Zwart ES, Brandt BW, Mebius R, Deng D, Giovannetti E, Zaura E, Kazemier G.

Crit Rev Oncol Hematol. 2019 Dec;144:102824. doi: 10.1016/j.critrevonc.2019.102824. Epub 2019 Nov 2. No abstract available.

PMID:
31731215
4.

A Collection of Bioactive Nitrogen-Containing Molecules from the Marine Sponge Acanthostrongylophora ingens.

Esposito G, Mai LH, Longeon A, Mangoni A, Durieu E, Meijer L, Van Soest R, Costantino V, Bourguet-Kondracki ML.

Mar Drugs. 2019 Aug 15;17(8). pii: E472. doi: 10.3390/md17080472.

5.

Unravelling the Diagnostic Dilemma: A MicroRNA Panel of Circulating MiR-16 and MiR-877 as A Diagnostic Classifier for Distal Bile Duct Tumors.

Meijer LL, Puik JR, Le Large TYS, Heger M, Dijk F, Funel N, Wurdinger T, Garajová I, van Grieken NCT, van de Wiel MA, Giovannetti E, Kazemier G.

Cancers (Basel). 2019 Aug 15;11(8). pii: E1181. doi: 10.3390/cancers11081181.

6.

Crossing borders: A systematic review with quantitative analysis of genetic mutations of carcinomas of the biliary tract.

Roos E, Soer EC, Klompmaker S, Meijer LL, Besselink MG, Giovannetti E, Heger M, Kazemier G, Klümpen HJ, Takkenberg RB, Wilmink H, Würdinger T, Dijk F, van Gulik TM, Verheij J, van de Vijver MJ.

Crit Rev Oncol Hematol. 2019 Aug;140:8-16. doi: 10.1016/j.critrevonc.2019.05.011. Epub 2019 May 24.

PMID:
31158800
7.

Trajectories of traumatic stress reactions in children exposed to intimate partner violence.

Meijer L, Finkenauer C, Tierolf B, Lünnemann M, Steketee M.

Child Abuse Negl. 2019 Jul;93:170-181. doi: 10.1016/j.chiabu.2019.04.017. Epub 2019 May 17.

8.

Structural analogues of roscovitine rescue the intracellular traffic and the function of ER-retained ABCB4 variants in cell models.

Vauthier V, Ben Saad A, Elie J, Oumata N, Durand-Schneider AM, Bruneau A, Delaunay JL, Housset C, Aït-Slimane T, Meijer L, Falguières T.

Sci Rep. 2019 Apr 30;9(1):6653. doi: 10.1038/s41598-019-43111-y.

9.

Novel Mouse Tauopathy Model for Repetitive Mild Traumatic Brain Injury: Evaluation of Long-Term Effects on Cognition and Biomarker Levels After Therapeutic Inhibition of Tau Phosphorylation.

Rubenstein R, Sharma DR, Chang B, Oumata N, Cam M, Vaucelle L, Lindberg MF, Chiu A, Wisniewski T, Wang KKW, Meijer L.

Front Neurol. 2019 Mar 11;10:124. doi: 10.3389/fneur.2019.00124. eCollection 2019.

10.

Inhibition of DYRK1A proteolysis modifies its kinase specificity and rescues Alzheimer phenotype in APP/PS1 mice.

Souchet B, Audrain M, Billard JM, Dairou J, Fol R, Orefice NS, Tada S, Gu Y, Dufayet-Chaffaud G, Limanton E, Carreaux F, Bazureau JP, Alves S, Meijer L, Janel N, Braudeau J, Cartier N.

Acta Neuropathol Commun. 2019 Mar 18;7(1):46. doi: 10.1186/s40478-019-0678-6.

11.

Prenatal exposure to organohalogen compounds and children's mental and motor development at 18 and 30 months of age.

Ruel MVM, Bos AF, Soechitram SD, Meijer L, Sauer PJJ, Berghuis SA.

Neurotoxicology. 2019 May;72:6-14. doi: 10.1016/j.neuro.2019.01.003. Epub 2019 Jan 18.

12.

Challenges in measuring interprofessional-interorganisational collaboration with a questionnaire.

Meijer LJ, de Groot E, van Smeden M, Schellevis FG, Damoiseaux RA.

BJGP Open. 2018 Apr 21;2(1):bjgpopen18X101385. doi: 10.3399/bjgpopen18X101385. eCollection 2018 Apr.

13.

Monitoring cognitive change in multiple sclerosis using a computerized cognitive battery.

De Meijer L, Merlo D, Skibina O, Grobbee EJ, Gale J, Haartsen J, Maruff P, Darby D, Butzkueven H, Van der Walt A.

Mult Scler J Exp Transl Clin. 2018 Dec 10;4(4):2055217318815513. doi: 10.1177/2055217318815513. eCollection 2018 Oct-Dec.

14.

Incidence of cardiovascular disease in familial combined hyperlipidemia: A 15-year follow-up study.

Luijten J, van Greevenbroek MMJ, Schaper NC, Meex SJR, van der Steen C, Meijer LJ, de Boer D, de Graaf J, Stehouwer CDA, Brouwers MCGJ.

Atherosclerosis. 2019 Jan;280:1-6. doi: 10.1016/j.atherosclerosis.2018.11.013. Epub 2018 Nov 8.

PMID:
30448567
15.

Chemical modulation of autophagy as an adjunct to chemotherapy in childhood and adolescent brain tumors.

Servante J, Estranero J, Meijer L, Layfield R, Grundy R.

Oncotarget. 2018 Oct 16;9(81):35266-35277. doi: 10.18632/oncotarget.26186. eCollection 2018 Oct 16. Review.

16.

Plasma miR-181a-5p Downregulation Predicts Response and Improved Survival After FOLFIRINOX in Pancreatic Ductal Adenocarcinoma.

Meijer LL, Garajová I, Caparello C, Le Large TYS, Frampton AE, Vasile E, Funel N, Kazemier G, Giovannetti E.

Ann Surg. 2018 Dec 9. doi: 10.1097/SLA.0000000000003084. [Epub ahead of print]

PMID:
30394883
17.

The microbiome of pancreatic cancer: from molecular diagnostics to new therapeutic approaches to overcome chemoresistance caused by metabolic inactivation of gemcitabine.

Choy ATF, Carnevale I, Coppola S, Meijer LL, Kazemier G, Zaura E, Deng D, Giovannetti E.

Expert Rev Mol Diagn. 2018 Dec;18(12):1005-1009. doi: 10.1080/14737159.2018.1544495. Epub 2018 Nov 9.

PMID:
30392417
18.

ASO Author Reflections: Current Treatment Options for Duodenal Adenocarcinoma-A Call for Collaborative Studies.

Meijer LL, Kazemier G.

Ann Surg Oncol. 2018 Dec;25(Suppl 3):737-738. doi: 10.1245/s10434-018-6896-5. Epub 2018 Oct 16. No abstract available.

19.

A facile consensus ranking approach enhances virtual screening robustness and identifies a cell-active DYRK1α inhibitor.

Mavrogeni ME, Pronios F, Zareifi D, Vasilakaki S, Lozach O, Alexopoulos L, Meijer L, Myrianthopoulos V, Mikros E.

Future Med Chem. 2018 Oct;10(20):2411-2430. doi: 10.4155/fmc-2018-0198. Epub 2018 Oct 16.

20.

Development of Kinase Inhibitors via Metal-Catalyzed C⁻H Arylation of 8-Alkyl-thiazolo[5,4-f]-quinazolin-9-ones Designed by Fragment-Growing Studies.

Couly F, Harari M, Dubouilh-Benard C, Bailly L, Petit E, Diharce J, Bonnet P, Meijer L, Fruit C, Besson T.

Molecules. 2018 Aug 29;23(9). pii: E2181. doi: 10.3390/molecules23092181.

21.

Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A.

Nguyen TL, Duchon A, Manousopoulou A, Loaëc N, Villiers B, Pani G, Karatas M, Mechling AE, Harsan LA, Limanton E, Bazureau JP, Carreaux F, Garbis SD, Meijer L, Herault Y.

Dis Model Mech. 2018 Sep 27;11(9). pii: dmm035634. doi: 10.1242/dmm.035634.

22.
23.

Outcomes and Treatment Options for Duodenal Adenocarcinoma: A Systematic Review and Meta-Analysis.

Meijer LL, Alberga AJ, de Bakker JK, van der Vliet HJ, Le Large TYS, van Grieken NCT, de Vries R, Daams F, Zonderhuis BM, Kazemier G.

Ann Surg Oncol. 2018 Sep;25(9):2681-2692. doi: 10.1245/s10434-018-6567-6. Epub 2018 Jun 26.

24.

Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype.

Walter A, Chaikuad A, Helmer R, Loaëc N, Preu L, Ott I, Knapp S, Meijer L, Kunick C.

PLoS One. 2018 May 3;13(5):e0196761. doi: 10.1371/journal.pone.0196761. eCollection 2018.

25.

Genetic and pharmacological inhibition of Cdk1 provides neuroprotection towards ischemic neuronal death.

Marlier Q, Jibassia F, Verteneuil S, Linden J, Kaldis P, Meijer L, Nguyen L, Vandenbosch R, Malgrange B.

Cell Death Discov. 2018 Mar 16;4:43. doi: 10.1038/s41420-018-0044-7. eCollection 2018.

26.

Identification of Two Protein-Signaling States Delineating Transcriptionally Heterogeneous Human Medulloblastoma.

Zomerman WW, Plasschaert SLA, Conroy S, Scherpen FJ, Meeuwsen-de Boer TGJ, Lourens HJ, Guerrero Llobet S, Smit MJ, Slagter-Menkema L, Seitz A, Gidding CEM, Hulleman E, Wesseling P, Meijer L, van Kempen LC, van den Berg A, Warmerdam DO, Kruyt FAE, Foijer F, van Vugt MATM, den Dunnen WFA, Hoving EW, Guryev V, de Bont ESJM, Bruggeman SWM.

Cell Rep. 2018 Mar 20;22(12):3206-3216. doi: 10.1016/j.celrep.2018.02.089.

27.

Casein kinase 1ε and 1α as novel players in polycystic kidney disease and mechanistic targets for (R)-roscovitine and (S)-CR8.

Billot K, Coquil C, Villiers B, Josselin-Foll B, Desban N, Delehouzé C, Oumata N, Le Meur Y, Boletta A, Weimbs T, Grosch M, Witzgall R, Saunier S, Fischer E, Pontoglio M, Fautrel A, Mrug M, Wallace D, Tran PV, Trudel M, Bukanov N, Ibraghimov-Beskrovnaya O, Meijer L.

Am J Physiol Renal Physiol. 2018 Jul 1;315(1):F57-F73. doi: 10.1152/ajprenal.00489.2017. Epub 2018 Mar 14.

28.

Induction of Amyloid-β42 Production by Fipronil and Other Pyrazole Insecticides.

Cam M, Durieu E, Bodin M, Manousopoulou A, Koslowski S, Vasylieva N, Barnych B, Hammock BD, Bohl B, Koch P, Omori C, Yamamoto K, Hata S, Suzuki T, Karg F, Gizzi P, Erakovic Haber V, Bencetic Mihaljevic V, Tavcar B, Portelius E, Pannee J, Blennow K, Zetterberg H, Garbis SD, Auvray P, Gerber H, Fraering J, Fraering PC, Meijer L.

J Alzheimers Dis. 2018;62(4):1663-1681. doi: 10.3233/JAD-170875.

PMID:
29504531
29.

Indole-3-Carbonitriles as DYRK1A Inhibitors by Fragment-Based Drug Design.

Meine R, Becker W, Falke H, Preu L, Loaëc N, Meijer L, Kunick C.

Molecules. 2018 Jan 24;23(2). pii: E64. doi: 10.3390/molecules23020064.

30.

Workplace learning through collaboration in primary healthcare: A BEME realist review of what works, for whom and in what circumstances: BEME Guide No. 46.

Mertens F, de Groot E, Meijer L, Wens J, Gemma Cherry M, Deveugele M, Damoiseaux R, Stes A, Pype P.

Med Teach. 2018 Feb;40(2):117-134. doi: 10.1080/0142159X.2017.1390216. Epub 2017 Nov 2. Review.

PMID:
29094626
31.

Hierarchical control of enzymatic actuators using DNA-based switchable memories.

Meijer LHH, Joesaar A, Steur E, Engelen W, van Santen RA, Merkx M, de Greef TFA.

Nat Commun. 2017 Oct 24;8(1):1117. doi: 10.1038/s41467-017-01127-w.

32.

Marine-Derived 2-Aminoimidazolone Alkaloids. Leucettamine B-Related Polyandrocarpamines Inhibit Mammalian and Protozoan DYRK & CLK Kinases.

Loaëc N, Attanasio E, Villiers B, Durieu E, Tahtouh T, Cam M, Davis RA, Alencar A, Roué M, Bourguet-Kondracki ML, Proksch P, Limanton E, Guiheneuf S, Carreaux F, Bazureau JP, Klautau M, Meijer L.

Mar Drugs. 2017 Oct 17;15(10). pii: E316. doi: 10.3390/md15100316. Review.

33.

Combined Virtual and Experimental Screening for CK1 Inhibitors Identifies a Modulator of p53 and Reveals Important Aspects of in Silico Screening Performance.

Myrianthopoulos V, Lozach O, Zareifi D, Alexopoulos L, Meijer L, Gorgoulis VG, Mikros E.

Int J Mol Sci. 2017 Oct 6;18(10). pii: E2102. doi: 10.3390/ijms18102102.

34.

miRNA profiling for diagnosis, prognosis and stratification of cancer treatment in cholangiocarcinoma.

Puik JR, Meijer LL, Le Large TY, Prado MM, Frampton AE, Kazemier G, Giovannetti E.

Pharmacogenomics. 2017 Sep;18(14):1343-1358. doi: 10.2217/pgs-2017-0010. Epub 2017 Aug 23. Review.

PMID:
28832247
35.

Swarm Intelligence-Enhanced Detection of Non-Small-Cell Lung Cancer Using Tumor-Educated Platelets.

Best MG, Sol N, In 't Veld SGJG, Vancura A, Muller M, Niemeijer AN, Fejes AV, Tjon Kon Fat LA, Huis In 't Veld AE, Leurs C, Le Large TY, Meijer LL, Kooi IE, Rustenburg F, Schellen P, Verschueren H, Post E, Wedekind LE, Bracht J, Esenkbrink M, Wils L, Favaro F, Schoonhoven JD, Tannous J, Meijers-Heijboer H, Kazemier G, Giovannetti E, Reijneveld JC, Idema S, Killestein J, Heger M, de Jager SC, Urbanus RT, Hoefer IE, Pasterkamp G, Mannhalter C, Gomez-Arroyo J, Bogaard HJ, Noske DP, Vandertop WP, van den Broek D, Ylstra B, Nilsson RJA, Wesseling P, Karachaliou N, Rosell R, Lee-Lewandrowski E, Lewandrowski KB, Tannous BA, de Langen AJ, Smit EF, van den Heuvel MM, Wurdinger T.

Cancer Cell. 2017 Aug 14;32(2):238-252.e9. doi: 10.1016/j.ccell.2017.07.004.

36.

Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.

Nguyen TL, Fruit C, Hérault Y, Meijer L, Besson T.

Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. doi: 10.1080/13543776.2017.1360285. Epub 2017 Aug 2. Review.

PMID:
28766366
37.

Harnessing Neutrophil Survival Mechanisms during Chronic Infection by Pseudomonas aeruginosa: Novel Therapeutic Targets to Dampen Inflammation in Cystic Fibrosis.

Marteyn BS, Burgel PR, Meijer L, Witko-Sarsat V.

Front Cell Infect Microbiol. 2017 Jun 30;7:243. doi: 10.3389/fcimb.2017.00243. eCollection 2017. Review.

38.

Stereotactic radiosurgery versus whole-brain radiotherapy after intracranial metastasis resection: a systematic review and meta-analysis.

Lamba N, Muskens IS, DiRisio AC, Meijer L, Briceno V, Edrees H, Aslam B, Minhas S, Verhoeff JJC, Kleynen CE, Smith TR, Mekary RA, Broekman ML.

Radiat Oncol. 2017 Jun 24;12(1):106. doi: 10.1186/s13014-017-0840-x. Review.

39.

Intracystic interferon-alpha in pediatric craniopharyngioma patients: an international multicenter assessment on behalf of SIOPE and ISPN.

Kilday JP, Caldarelli M, Massimi L, Chen RH, Lee YY, Liang ML, Parkes J, Naiker T, van Veelen ML, Michiels E, Mallucci C, Pettorini B, Meijer L, Dorfer C, Czech T, Diezi M, Schouten-van Meeteren AYN, Holm S, Gustavsson B, Benesch M, Müller HL, Hoffmann A, Rutkowski S, Flitsch J, Escherich G, Grotzer M, Spoudeas HA, Azquikina K, Capra M, Jiménez-Guerra R, MacDonald P, Johnston DL, Dvir R, Constantini S, Kuo MF, Yang SH, Bartels U.

Neuro Oncol. 2017 Oct 1;19(10):1398-1407. doi: 10.1093/neuonc/nox056.

40.

N-(1H-Pyrazol-3-yl)quinazolin-4-amines as a novel class of casein kinase 1δ/ε inhibitors: Synthesis, biological evaluation and molecular modeling studies.

Karthikeyan C, Jharia P, Waiker DK, Nusbaum AC, Amawi H, Kirwen EM, Christman R, Arudra SKC, Meijer L, Tiwari AK, Trivedi P.

Bioorg Med Chem Lett. 2017 Jun 15;27(12):2663-2667. doi: 10.1016/j.bmcl.2017.04.080. Epub 2017 Apr 27.

PMID:
28487075
41.

Nucleic acid detection using BRET-beacons based on bioluminescent protein-DNA hybrids.

Engelen W, van de Wiel KM, Meijer LHH, Saha B, Merkx M.

Chem Commun (Camb). 2017 Mar 2;53(19):2862-2865. doi: 10.1039/c6cc10032e.

42.

Antibody-controlled actuation of DNA-based molecular circuits.

Engelen W, Meijer LH, Somers B, de Greef TF, Merkx M.

Nat Commun. 2017 Feb 17;8:14473. doi: 10.1038/ncomms14473.

43.

Systematic high-resolution assessment of global hydropower potential.

Hoes OA, Meijer LJ, van der Ent RJ, van de Giesen NC.

PLoS One. 2017 Feb 8;12(2):e0171844. doi: 10.1371/journal.pone.0171844. eCollection 2017.

44.

Identification of CLK1 Inhibitors by a Fragment-linking Based Virtual Screening.

Walter A, Chaikuad A, Loaëc N, Preu L, Knapp S, Meijer L, Kunick C, Koch O.

Mol Inform. 2017 Apr;36(4). doi: 10.1002/minf.201600123. Epub 2016 Dec 21.

PMID:
28000414
45.

Chloromethylhalicyclamine B, a Marine-Derived Protein Kinase CK1δ/ε Inhibitor.

Esposito G, Bourguet-Kondracki ML, Mai LH, Longeon A, Teta R, Meijer L, Van Soest R, Mangoni A, Costantino V.

J Nat Prod. 2016 Nov 23;79(11):2953-2960. Epub 2016 Nov 9.

PMID:
27933894
46.

hENT-1 Expression and Localization Predict Outcome After Adjuvant Gemcitabine in Resected Cholangiocarcinoma Patients.

Meijer LL, Puik JR, Peters GJ, Kazemier G, Giovannetti E.

Oncologist. 2016 Dec;21(12):e4. Epub 2016 Nov 2. No abstract available.

47.

Reduction of ciliary length through pharmacologic or genetic inhibition of CDK5 attenuates polycystic kidney disease in a model of nephronophthisis.

Husson H, Moreno S, Smith LA, Smith MM, Russo RJ, Pitstick R, Sergeev M, Ledbetter SR, Bukanov NO, Lane M, Zhang K, Billot K, Carlson G, Shah J, Meijer L, Beier DR, Ibraghimov-Beskrovnaya O.

Hum Mol Genet. 2016 Jun 1;25(11):2245-2255. Epub 2016 Apr 5.

48.

Specific Triazine Herbicides Induce Amyloid-β42 Production.

Portelius E, Durieu E, Bodin M, Cam M, Pannee J, Leuxe C, Mabondzo A, Oumata N, Galons H, Lee JY, Chang YT, Stϋber K, Koch P, Fontaine G, Potier MC, Manousopoulou A, Garbis SD, Covaci A, Van Dam D, De Deyn P, Karg F, Flajolet M, Omori C, Hata S, Suzuki T, Blennow K, Zetterberg H, Meijer L.

J Alzheimers Dis. 2016 Oct 18;54(4):1593-1605.

PMID:
27589520
49.

Exploration of the imidazo[1,2-b]pyridazine scaffold as a protein kinase inhibitor.

Bendjeddou LZ, Loaëc N, Villiers B, Prina E, Späth GF, Galons H, Meijer L, Oumata N.

Eur J Med Chem. 2017 Jan 5;125:696-709. doi: 10.1016/j.ejmech.2016.09.064. Epub 2016 Sep 22.

PMID:
27721154
50.

Ten- to 15-year results of the Oxford Phase III mobile unicompartmental knee arthroplasty: a prospective study from a non-designer group.

Lisowski LA, Meijer LI, van den Bekerom MP, Pilot P, Lisowski AE.

Bone Joint J. 2016 Oct;98 B(10 Supple B):41-47.

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