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Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation.

Rahman A, Henry KM, Herman KD, Thompson AA, Isles HM, Tulotta C, Sammut D, Rougeot JJ, Khoshaein N, Reese AE, Higgins K, Tabor C, Sabroe I, Zuercher WJ, Savage CO, Meijer AH, Whyte MK, Dockrell DH, Renshaw SA, Prince LR.

Elife. 2019 Oct 15;8. pii: e50990. doi: 10.7554/eLife.50990.


Role of β-glucosidase 2 in aberrant glycosphingolipid metabolism: model of glucocerebrosidase deficiency in zebrafish.

Lelieveld LT, Mirzaian M, Kuo CL, Artola M, Ferraz MJ, Peter REA, Akiyama H, Greimel P, van den Berg RJBHN, Overkleeft HS, Boot RG, Meijer AH, Aerts JMFG.

J Lipid Res. 2019 Nov;60(11):1851-1867. doi: 10.1194/jlr.RA119000154. Epub 2019 Sep 27.


Frontline Science: Antagonism between regular and atypical Cxcr3 receptors regulates macrophage migration during infection and injury in zebrafish.

Sommer F, Torraca V, Kamel SM, Lombardi A, Meijer AH.

J Leukoc Biol. 2019 Sep 17. doi: 10.1002/JLB.2HI0119-006R. [Epub ahead of print]


Aspergillus fumigatus establishes infection in zebrafish by germination of phagocytized conidia, while Aspergillus niger relies on extracellular germination.

Koch BEV, Hajdamowicz NH, Lagendijk E, Ram AFJ, Meijer AH.

Sci Rep. 2019 Sep 5;9(1):12791. doi: 10.1038/s41598-019-49284-w.


Zebrafish in Inflammasome Research.

Forn-Cuní G, Meijer AH, Varela M.

Cells. 2019 Aug 15;8(8). pii: E901. doi: 10.3390/cells8080901. Review.


Rubicon-Dependent Lc3 Recruitment to Salmonella-Containing Phagosomes Is a Host Defense Mechanism Triggered Independently From Major Bacterial Virulence Factors.

Masud S, van der Burg L, Storm L, Prajsnar TK, Meijer AH.

Front Cell Infect Microbiol. 2019 Aug 2;9:279. doi: 10.3389/fcimb.2019.00279. eCollection 2019.


RNAseq Profiling of Leukocyte Populations in Zebrafish Larvae Reveals a cxcl11 Chemokine Gene as a Marker of Macrophage Polarization During Mycobacterial Infection.

Rougeot J, Torraca V, Zakrzewska A, Kanwal Z, Jansen HJ, Sommer F, Spaink HP, Meijer AH.

Front Immunol. 2019 Apr 17;10:832. doi: 10.3389/fimmu.2019.00832. eCollection 2019.


Glucocorticoids inhibit macrophage differentiation towards a pro-inflammatory phenotype upon wounding without affecting their migration.

Xie Y, Tolmeijer S, Oskam JM, Tonkens T, Meijer AH, Schaaf MJM.

Dis Model Mech. 2019 May 30;12(5). pii: dmm037887. doi: 10.1242/dmm.037887.


The selective autophagy receptors Optineurin and p62 are both required for zebrafish host resistance to mycobacterial infection.

Zhang R, Varela M, Vallentgoed W, Forn-Cuni G, van der Vaart M, Meijer AH.

PLoS Pathog. 2019 Feb 28;15(2):e1007329. doi: 10.1371/journal.ppat.1007329. eCollection 2019 Feb.


CXCR4 signaling regulates metastatic onset by controlling neutrophil motility and response to malignant cells.

Tulotta C, Stefanescu C, Chen Q, Torraca V, Meijer AH, Snaar-Jagalska BE.

Sci Rep. 2019 Feb 20;9(1):2399. doi: 10.1038/s41598-019-38643-2.


Macrophages target Salmonella by Lc3-associated phagocytosis in a systemic infection model.

Masud S, Prajsnar TK, Torraca V, Lamers GEM, Benning M, Van Der Vaart M, Meijer AH.

Autophagy. 2019 May;15(5):796-812. doi: 10.1080/15548627.2019.1569297. Epub 2019 Jan 24.


Ras-Induced miR-146a and 193a Target Jmjd6 to Regulate Melanoma Progression.

Anelli V, Ordas A, Kneitz S, Sagredo LM, Gourain V, Schartl M, Meijer AH, Mione M.

Front Genet. 2018 Dec 18;9:675. doi: 10.3389/fgene.2018.00675. eCollection 2018.


Deep learning image recognition enables efficient genome editing in zebrafish by automated injections.

Cordero-Maldonado ML, Perathoner S, van der Kolk KJ, Boland R, Heins-Marroquin U, Spaink HP, Meijer AH, Crawford AD, de Sonneville J.

PLoS One. 2019 Jan 7;14(1):e0202377. doi: 10.1371/journal.pone.0202377. eCollection 2019.


In vivo inactivation of glycosidases by conduritol B epoxide and cyclophellitol as revealed by activity-based protein profiling.

Kuo CL, Kallemeijn WW, Lelieveld LT, Mirzaian M, Zoutendijk I, Vardi A, Futerman AH, Meijer AH, Spaink HP, Overkleeft HS, Aerts JMFG, Artola M.

FEBS J. 2019 Feb;286(3):584-600. doi: 10.1111/febs.14744. Epub 2019 Feb 2.


Hif-1α-Induced Expression of Il-1β Protects against Mycobacterial Infection in Zebrafish.

Ogryzko NV, Lewis A, Wilson HL, Meijer AH, Renshaw SA, Elks PM.

J Immunol. 2019 Jan 15;202(2):494-502. doi: 10.4049/jimmunol.1801139. Epub 2018 Dec 14.


Functional analysis of the HD-Zip transcription factor genes Oshox12 and Oshox14 in rice.

Shao J, Haider I, Xiong L, Zhu X, Hussain RMF, Övernäs E, Meijer AH, Zhang G, Wang M, Bouwmeester HJ, Ouwerkerk PBF.

PLoS One. 2018 Jul 20;13(7):e0199248. doi: 10.1371/journal.pone.0199248. eCollection 2018.


The Difference between White and Red Ginseng: Variations in Ginsenosides and Immunomodulation.

He M, Huang X, Liu S, Guo C, Xie Y, Meijer AH, Wang M.

Planta Med. 2018 Aug;84(12-13):845-854. doi: 10.1055/a-0641-6240. Epub 2018 Jun 20. Review.


Ultrastructural Imaging of Salmonella-Host Interactions Using Super-resolution Correlative Light-Electron Microscopy of Bioorthogonal Pathogens.

van Elsland DM, Pujals S, Bakkum T, Bos E, Oikonomeas-Koppasis N, Berlin I, Neefjes J, Meijer AH, Koster AJ, Albertazzi L, van Kasteren SI.

Chembiochem. 2018 Jun 5. doi: 10.1002/cbic.201800230. [Epub ahead of print]


Microbiota promote secretory cell determination in the intestinal epithelium by modulating host Notch signaling.

Troll JV, Hamilton MK, Abel ML, Ganz J, Bates JM, Stephens WZ, Melancon E, van der Vaart M, Meijer AH, Distel M, Eisen JS, Guillemin K.

Development. 2018 Feb 23;145(4). pii: dev155317. doi: 10.1242/dev.155317.


Correction: Macrophages, but not neutrophils, are critical for proliferation of Burkholderia cenocepacia and ensuing host-damaging inflammation.

Mesureur J, Feliciano JR, Wagner N, Gomes MC, Zhang L, Blanco-Gonzalez M, van der Vaart M, O'Callaghan D, Meijer AH, Vergunst AC.

PLoS Pathog. 2017 Dec 20;13(12):e1006795. doi: 10.1371/journal.ppat.1006795. eCollection 2017 Dec.


COMICS: Cartoon Visualization of Omics Data in Spatial Context Using Anatomical Ontologies.

Travin D, Popov I, Guler AT, Medvedev D, van der Plas-Duivesteijn S, Varela M, Kolder ICRM, Meijer AH, Spaink HP, Palmblad M.

J Proteome Res. 2018 Jan 5;17(1):739-744. doi: 10.1021/acs.jproteome.7b00615. Epub 2017 Nov 13.


Macrophages as drivers of an opportunistic infection.

Vergunst AC, Carranza NL, Zhang L, Gomes MC, Tasrini Y, Meijer AH, O'Callaghan D.

Microb Cell. 2017 Sep 13;4(10):362-364. doi: 10.15698/mic2017.10.595.


Adverse outcome pathways: opportunities, limitations and open questions.

Leist M, Ghallab A, Graepel R, Marchan R, Hassan R, Bennekou SH, Limonciel A, Vinken M, Schildknecht S, Waldmann T, Danen E, van Ravenzwaay B, Kamp H, Gardner I, Godoy P, Bois FY, Braeuning A, Reif R, Oesch F, Drasdo D, Höhme S, Schwarz M, Hartung T, Braunbeck T, Beltman J, Vrieling H, Sanz F, Forsby A, Gadaleta D, Fisher C, Kelm J, Fluri D, Ecker G, Zdrazil B, Terron A, Jennings P, van der Burg B, Dooley S, Meijer AH, Willighagen E, Martens M, Evelo C, Mombelli E, Taboureau O, Mantovani A, Hardy B, Koch B, Escher S, van Thriel C, Cadenas C, Kroese D, van de Water B, Hengstler JG.

Arch Toxicol. 2017 Nov;91(11):3477-3505. doi: 10.1007/s00204-017-2045-3. Epub 2017 Oct 19. Review.


Bacterial size matters: Multiple mechanisms controlling septum cleavage and diplococcus formation are critical for the virulence of the opportunistic pathogen Enterococcus faecalis.

Salamaga B, Prajsnar TK, Jareño-Martinez A, Willemse J, Bewley MA, Chau F, Ben Belkacem T, Meijer AH, Dockrell DH, Renshaw SA, Mesnage S.

PLoS Pathog. 2017 Jul 24;13(7):e1006526. doi: 10.1371/journal.ppat.1006526. eCollection 2017 Jul.


Studying Autophagy in Zebrafish.

Mathai BJ, Meijer AH, Simonsen A.

Cells. 2017 Jul 9;6(3). pii: E21. doi: 10.3390/cells6030021. Review.


Expression and regulation of drug transporters in vertebrate neutrophils.

Foulkes MJ, Henry KM, Rougeot J, Hooper-Greenhill E, Loynes CA, Jeffrey P, Fleming A, Savage CO, Meijer AH, Jones S, Renshaw SA.

Sci Rep. 2017 Jul 10;7(1):4967. doi: 10.1038/s41598-017-04785-4.


Macrophages, but not neutrophils, are critical for proliferation of Burkholderia cenocepacia and ensuing host-damaging inflammation.

Mesureur J, Feliciano JR, Wagner N, Gomes MC, Zhang L, Blanco-Gonzalez M, van der Vaart M, O'Callaghan D, Meijer AH, Vergunst AC.

PLoS Pathog. 2017 Jun 26;13(6):e1006437. doi: 10.1371/journal.ppat.1006437. eCollection 2017 Jun. Erratum in: PLoS Pathog. 2017 Dec 20;13(12 ):e1006795.


Modeling Infectious Diseases in the Context of a Developing Immune System.

Masud S, Torraca V, Meijer AH.

Curr Top Dev Biol. 2017;124:277-329. doi: 10.1016/bs.ctdb.2016.10.006. Epub 2016 Dec 19. Review.


The chemokine receptor CXCR4 promotes granuloma formation by sustaining a mycobacteria-induced angiogenesis programme.

Torraca V, Tulotta C, Snaar-Jagalska BE, Meijer AH.

Sci Rep. 2017 Mar 23;7:45061. doi: 10.1038/srep45061.


Functional analysis reveals no transcriptional role for the glucocorticoid receptor β-isoform in zebrafish.

Chatzopoulou A, Schoonheim PJ, Torraca V, Meijer AH, Spaink HP, Schaaf MJ.

Mol Cell Endocrinol. 2017 May 15;447:61-70. doi: 10.1016/j.mce.2017.02.036. Epub 2017 Feb 24.


The inflammatory chemokine Cxcl18b exerts neutrophil-specific chemotaxis via the promiscuous chemokine receptor Cxcr2 in zebrafish.

Torraca V, Otto NA, Tavakoli-Tameh A, Meijer AH.

Dev Comp Immunol. 2017 Feb;67:57-65. doi: 10.1016/j.dci.2016.10.014. Epub 2016 Nov 1.


Transcriptomic Approaches in the Zebrafish Model for Tuberculosis-Insights Into Host- and Pathogen-specific Determinants of the Innate Immune Response.

Benard EL, Rougeot J, Racz PI, Spaink HP, Meijer AH.

Adv Genet. 2016;95:217-51. doi: 10.1016/bs.adgen.2016.04.004. Epub 2016 Jun 14. Review.


Efferocytosis and extrusion of leukocytes determine the progression of early mycobacterial pathogenesis.

Hosseini R, Lamers GE, Soltani HM, Meijer AH, Spaink HP, Schaaf MJ.

J Cell Sci. 2016 Sep 15;129(18):3385-95. doi: 10.1242/jcs.135194. Epub 2016 Jul 28.


Imaging of Human Cancer Cell Proliferation, Invasion, and Micrometastasis in a Zebrafish Xenogeneic Engraftment Model.

Tulotta C, He S, Chen L, Groenewoud A, van der Ent W, Meijer AH, Spaink HP, Snaar-Jagalska BE.

Methods Mol Biol. 2016;1451:155-69. doi: 10.1007/978-1-4939-3771-4_11.


Glucocorticoid-Induced Attenuation of the Inflammatory Response in Zebrafish.

Chatzopoulou A, Heijmans JP, Burgerhout E, Oskam N, Spaink HP, Meijer AH, Schaaf MJ.

Endocrinology. 2016 Jul;157(7):2772-84. doi: 10.1210/en.2015-2050. Epub 2016 May 24.


Linking Smokers' Susceptibility to Tuberculosis with Lysosomal Storage Disorders.

Meijer AH, Aerts JM.

Dev Cell. 2016 Apr 18;37(2):112-3. doi: 10.1016/j.devcel.2016.04.004. Review.


Exploring the HIFs, buts and maybes of hypoxia signalling in disease: lessons from zebrafish models.

Elks PM, Renshaw SA, Meijer AH, Walmsley SR, van Eeden FJ.

Dis Model Mech. 2015 Nov;8(11):1349-60. doi: 10.1242/dmm.021865. Review.


Protection and pathology in TB: learning from the zebrafish model.

Meijer AH.

Semin Immunopathol. 2016 Mar;38(2):261-73. doi: 10.1007/s00281-015-0522-4. Epub 2015 Sep 1. Review.


Common and specific downstream signaling targets controlled by Tlr2 and Tlr5 innate immune signaling in zebrafish.

Yang S, Marín-Juez R, Meijer AH, Spaink HP.

BMC Genomics. 2015 Jul 25;16:547. doi: 10.1186/s12864-015-1740-9.


Matrix metalloproteinase 9 modulates collagen matrices and wound repair.

LeBert DC, Squirrell JM, Rindy J, Broadbridge E, Lui Y, Zakrzewska A, Eliceiri KW, Meijer AH, Huttenlocher A.

Development. 2015 Jun 15;142(12):2136-46. doi: 10.1242/dev.121160. Epub 2015 May 26.


Transcriptional and metabolic effects of glucocorticoid receptor α and β signaling in zebrafish.

Chatzopoulou A, Roy U, Meijer AH, Alia A, Spaink HP, Schaaf MJ.

Endocrinology. 2015 May;156(5):1757-69. doi: 10.1210/en.2014-1941. Epub 2015 Mar 10.


The CXCR3-CXCL11 signaling axis mediates macrophage recruitment and dissemination of mycobacterial infection.

Torraca V, Cui C, Boland R, Bebelman JP, van der Sar AM, Smit MJ, Siderius M, Spaink HP, Meijer AH.

Dis Model Mech. 2015 Mar;8(3):253-69. doi: 10.1242/dmm.017756. Epub 2015 Jan 8.


Analysis of RNAseq datasets from a comparative infectious disease zebrafish model using GeneTiles bioinformatics.

Veneman WJ, de Sonneville J, van der Kolk KJ, Ordas A, Al-Ars Z, Meijer AH, Spaink HP.

Immunogenetics. 2015 Mar;67(3):135-47. doi: 10.1007/s00251-014-0820-3. Epub 2014 Dec 13.


DRAM1 promotes the targeting of mycobacteria to selective autophagy.

Meijer AH, van der Vaart M.

Autophagy. 2014;10(12):2389-91. doi: 10.4161/15548627.2014.984280.


Testing tuberculosis drug efficacy in a zebrafish high-throughput translational medicine screen.

Ordas A, Raterink RJ, Cunningham F, Jansen HJ, Wiweger MI, Jong-Raadsen S, Bos S, Bates RH, Barros D, Meijer AH, Vreeken RJ, Ballell-Pages L, Dirks RP, Hankemeier T, Spaink HP.

Antimicrob Agents Chemother. 2015 Feb;59(2):753-62. doi: 10.1128/AAC.03588-14. Epub 2014 Nov 10.


Molecular and functional characterization of the scavenger receptor CD36 in zebrafish and common carp.

Fink IR, Benard EL, Hermsen T, Meijer AH, Forlenza M, Wiegertjes GF.

Mol Immunol. 2015 Feb;63(2):381-93. doi: 10.1016/j.molimm.2014.09.010. Epub 2014 Oct 11.


Macrophage-expressed perforins mpeg1 and mpeg1.2 have an anti-bacterial function in zebrafish.

Benard EL, Racz PI, Rougeot J, Nezhinsky AE, Verbeek FJ, Spaink HP, Meijer AH.

J Innate Immun. 2015;7(2):136-52. doi: 10.1159/000366103. Epub 2014 Sep 19.


RNA sequencing of FACS-sorted immune cell populations from zebrafish infection models to identify cell specific responses to intracellular pathogens.

Rougeot J, Zakrzewska A, Kanwal Z, Jansen HJ, Spaink HP, Meijer AH.

Methods Mol Biol. 2014;1197:261-74. doi: 10.1007/978-1-4939-1261-2_15.


Correlative light and electron microscopy imaging of autophagy in a zebrafish infection model.

Hosseini R, Lamers GE, Hodzic Z, Meijer AH, Schaaf MJ, Spaink HP.

Autophagy. 2014 Oct 1;10(10):1844-57. doi: 10.4161/auto.29992. Epub 2014 Aug 11.


Cellular visualization of macrophage pyroptosis and interleukin-1β release in a viral hemorrhagic infection in zebrafish larvae.

Varela M, Romero A, Dios S, van der Vaart M, Figueras A, Meijer AH, Novoa B.

J Virol. 2014 Oct;88(20):12026-40. doi: 10.1128/JVI.02056-14. Epub 2014 Aug 6.

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