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Items: 42

1.

Characterization of Lipid and Lipid Droplet Metabolism in Human HCC.

Berndt N, Eckstein J, Heucke N, Gajowski R, Stockmann M, Meierhofer D, Holzhütter HG.

Cells. 2019 May 27;8(5). pii: E512. doi: 10.3390/cells8050512.

2.

Genetic determinants of steatosis and fibrosis progression in paediatric non-alcoholic fatty liver disease.

Hudert CA, Selinski S, Rudolph B, Bläker H, Loddenkemper C, Thielhorn R, Berndt N, Golka K, Cadenas C, Reinders J, Henning S, Bufler P, Jansen PLM, Holzhütter HG, Meierhofer D, Hengstler JG, Wiegand S.

Liver Int. 2019 Mar;39(3):540-556. doi: 10.1111/liv.14006. Epub 2018 Dec 21.

PMID:
30444569
3.

HEPATOKIN1 is a biochemistry-based model of liver metabolism for applications in medicine and pharmacology.

Berndt N, Bulik S, Wallach I, Wünsch T, König M, Stockmann M, Meierhofer D, Holzhütter HG.

Nat Commun. 2018 Jun 19;9(1):2386. doi: 10.1038/s41467-018-04720-9.

4.

Are Hydroethidine-Based Probes Reliable for Reactive Oxygen Species Detection?

Xiao Y, Meierhofer D.

Antioxid Redox Signal. 2019 Aug 1;31(4):359-367. doi: 10.1089/ars.2018.7535. Epub 2018 Jun 22.

5.

A modular synthetic route to size-defined immunogenic Haemophilus influenzae b antigens is key to the identification of an octasaccharide lead vaccine candidate.

Baek JY, Geissner A, Rathwell DCK, Meierhofer D, Pereira CL, Seeberger PH.

Chem Sci. 2017 Dec 11;9(5):1279-1288. doi: 10.1039/c7sc04521b. eCollection 2018 Feb 7.

6.

Renal oncocytoma characterized by the defective complex I of the respiratory chain boosts the synthesis of the ROS scavenger glutathione.

Kürschner G, Zhang Q, Clima R, Xiao Y, Busch JF, Kilic E, Jung K, Berndt N, Bulik S, Holzhütter HG, Gasparre G, Attimonelli M, Babu M, Meierhofer D.

Oncotarget. 2017 Nov 11;8(62):105882-105904. doi: 10.18632/oncotarget.22413. eCollection 2017 Dec 1.

7.

Defining Human Tyrosine Kinase Phosphorylation Networks Using Yeast as an In Vivo Model Substrate.

Corwin T, Woodsmith J, Apelt F, Fontaine JF, Meierhofer D, Helmuth J, Grossmann A, Andrade-Navarro MA, Ballif BA, Stelzl U.

Cell Syst. 2017 Aug 23;5(2):128-139.e4. doi: 10.1016/j.cels.2017.08.001.

8.

Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation.

Torres-Odio S, Key J, Hoepken HH, Canet-Pons J, Valek L, Roller B, Walter M, Morales-Gordo B, Meierhofer D, Harter PN, Mittelbronn M, Tegeder I, Gispert S, Auburger G.

J Neuroinflammation. 2017 Aug 2;14(1):154. doi: 10.1186/s12974-017-0928-0.

9.

Efficient Prevention of Neurodegenerative Diseases by Depletion of Starvation Response Factor Ataxin-2.

Auburger G, Sen NE, Meierhofer D, Başak AN, Gitler AD.

Trends Neurosci. 2017 Aug;40(8):507-516. doi: 10.1016/j.tins.2017.06.004. Epub 2017 Jul 3. Review.

PMID:
28684172
10.

Transcriptomic and proteomic insight into the effects of a defined European mistletoe extract in Ewing sarcoma cells reveals cellular stress responses.

Twardziok M, Meierhofer D, Börno S, Timmermann B, Jäger S, Boral S, Eggert A, Delebinski CI, Seifert G.

BMC Complement Altern Med. 2017 Apr 28;17(1):237. doi: 10.1186/s12906-017-1715-2.

11.

ρ⁰ Cells Feature De-Ubiquitination of SLC Transporters and Increased Levels and Fluxes of Amino Acids.

Medina AB, Banaszczak M, Ni Y, Aretz I, Meierhofer D.

Int J Mol Sci. 2017 Apr 20;18(4). pii: E879. doi: 10.3390/ijms18040879.

12.

Human iPSC-Derived Neural Progenitors Are an Effective Drug Discovery Model for Neurological mtDNA Disorders.

Lorenz C, Lesimple P, Bukowiecki R, Zink A, Inak G, Mlody B, Singh M, Semtner M, Mah N, Auré K, Leong M, Zabiegalov O, Lyras EM, Pfiffer V, Fauler B, Eichhorst J, Wiesner B, Huebner N, Priller J, Mielke T, Meierhofer D, Izsvák Z, Meier JC, Bouillaud F, Adjaye J, Schuelke M, Wanker EE, Lombès A, Prigione A.

Cell Stem Cell. 2017 May 4;20(5):659-674.e9. doi: 10.1016/j.stem.2016.12.013. Epub 2017 Jan 26.

13.

Quantitative Global Proteomics of Yeast PBP1 Deletion Mutants and Their Stress Responses Identifies Glucose Metabolism, Mitochondrial, and Stress Granule Changes.

Seidel G, Meierhofer D, Şen NE, Guenther A, Krobitsch S, Auburger G.

J Proteome Res. 2017 Feb 3;16(2):504-515. doi: 10.1021/acs.jproteome.6b00647. Epub 2016 Dec 22.

PMID:
27966978
14.

PHF13 is a molecular reader and transcriptional co-regulator of H3K4me2/3.

Chung HR, Xu C, Fuchs A, Mund A, Lange M, Staege H, Schubert T, Bian C, Dunkel I, Eberharter A, Regnard C, Klinker H, Meierhofer D, Cozzuto L, Winterpacht A, Di Croce L, Min J, Will H, Kinkley S.

Elife. 2016 May 25;5. pii: e10607. doi: 10.7554/eLife.10607.

15.

The long non-coding RNA PARROT is an upstream regulator of c-Myc and affects proliferation and translation.

Vučićević D, Gehre M, Dhamija S, Friis-Hansen L, Meierhofer D, Sauer S, Ørom UA.

Oncotarget. 2016 Jun 7;7(23):33934-47. doi: 10.18632/oncotarget.8985.

16.

Advantages and Pitfalls of Mass Spectrometry Based Metabolome Profiling in Systems Biology.

Aretz I, Meierhofer D.

Int J Mol Sci. 2016 Apr 27;17(5). pii: E632. doi: 10.3390/ijms17050632. Review.

17.

Serial interactome capture of the human cell nucleus.

Conrad T, Albrecht AS, de Melo Costa VR, Sauer S, Meierhofer D, Ørom UA.

Nat Commun. 2016 Apr 4;7:11212. doi: 10.1038/ncomms11212.

18.

Identification and characterization of DNA sequences that prevent glucocorticoid receptor binding to nearby response elements.

Telorac J, Prykhozhij SV, Schöne S, Meierhofer D, Sauer S, Thomas-Chollier M, Meijsing SH.

Nucleic Acids Res. 2016 Jul 27;44(13):6142-56. doi: 10.1093/nar/gkw203. Epub 2016 Mar 25.

19.

Mutations in Subunits of the Activating Signal Cointegrator 1 Complex Are Associated with Prenatal Spinal Muscular Atrophy and Congenital Bone Fractures.

Knierim E, Hirata H, Wolf NI, Morales-Gonzalez S, Schottmann G, Tanaka Y, Rudnik-Schöneborn S, Orgeur M, Zerres K, Vogt S, van Riesen A, Gill E, Seifert F, Zwirner A, Kirschner J, Goebel HH, Hübner C, Stricker S, Meierhofer D, Stenzel W, Schuelke M.

Am J Hum Genet. 2016 Mar 3;98(3):473-489. doi: 10.1016/j.ajhg.2016.01.006. Epub 2016 Feb 25.

20.

Bioenergetic cues shift FXR splicing towards FXRα2 to modulate hepatic lipolysis and fatty acid metabolism.

Correia JC, Massart J, de Boer JF, Porsmyr-Palmertz M, Martínez-Redondo V, Agudelo LZ, Sinha I, Meierhofer D, Ribeiro V, Björnholm M, Sauer S, Dahlman-Wright K, Zierath JR, Groen AK, Ruas JL.

Mol Metab. 2015 Sep 26;4(12):891-902. doi: 10.1016/j.molmet.2015.09.005. eCollection 2015 Dec.

21.

An Impaired Respiratory Electron Chain Triggers Down-regulation of the Energy Metabolism and De-ubiquitination of Solute Carrier Amino Acid Transporters.

Aretz I, Hardt C, Wittig I, Meierhofer D.

Mol Cell Proteomics. 2016 May;15(5):1526-38. doi: 10.1074/mcp.M115.053181. Epub 2016 Feb 6.

22.

Ataxin-2 (Atxn2)-Knock-Out Mice Show Branched Chain Amino Acids and Fatty Acids Pathway Alterations.

Meierhofer D, Halbach M, Şen NE, Gispert S, Auburger G.

Mol Cell Proteomics. 2016 May;15(5):1728-39. doi: 10.1074/mcp.M115.056770. Epub 2016 Feb 5.

23.

Phosphorylation of the chromatin remodeling factor DPF3a induces cardiac hypertrophy through releasing HEY repressors from DNA.

Cui H, Schlesinger J, Schoenhals S, Tönjes M, Dunkel I, Meierhofer D, Cano E, Schulz K, Berger MF, Haack T, Abdelilah-Seyfried S, Bulyk ML, Sauer S, Sperling SR.

Nucleic Acids Res. 2016 Apr 7;44(6):2538-53. doi: 10.1093/nar/gkv1244. Epub 2015 Nov 17.

24.

Recurrent De Novo Mutations Affecting Residue Arg138 of Pyrroline-5-Carboxylate Synthase Cause a Progeroid Form of Autosomal-Dominant Cutis Laxa.

Fischer-Zirnsak B, Escande-Beillard N, Ganesh J, Tan YX, Al Bughaili M, Lin AE, Sahai I, Bahena P, Reichert SL, Loh A, Wright GD, Liu J, Rahikkala E, Pivnick EK, Choudhri AF, Krüger U, Zemojtel T, van Ravenswaaij-Arts C, Mostafavi R, Stolte-Dijkstra I, Symoens S, Pajunen L, Al-Gazali L, Meierhofer D, Robinson PN, Mundlos S, Villarroel CE, Byers P, Masri A, Robertson SP, Schwarze U, Callewaert B, Reversade B, Kornak U.

Am J Hum Genet. 2015 Sep 3;97(3):483-92. doi: 10.1016/j.ajhg.2015.08.001. Epub 2015 Aug 27.

25.

GORAB Missense Mutations Disrupt RAB6 and ARF5 Binding and Golgi Targeting.

Egerer J, Emmerich D, Fischer-Zirnsak B, Chan WL, Meierhofer D, Tuysuz B, Marschner K, Sauer S, Barr FA, Mundlos S, Kornak U.

J Invest Dermatol. 2015 Oct;135(10):2368-2376. doi: 10.1038/jid.2015.192. Epub 2015 May 22.

26.
27.

Metabolome and proteome profiling of complex I deficiency induced by rotenone.

Gielisch I, Meierhofer D.

J Proteome Res. 2015 Jan 2;14(1):224-35. doi: 10.1021/pr500894v. Epub 2014 Nov 12.

PMID:
25361611
29.

Transcriptomics assisted proteomic analysis of Nicotiana occidentalis infected by Candidatus Phytoplasma mali strain AT.

Luge T, Kube M, Freiwald A, Meierhofer D, Seemüller E, Sauer S.

Proteomics. 2014 Aug;14(16):1882-9. doi: 10.1002/pmic.201300551. Epub 2014 Jul 28.

PMID:
24920314
30.

Comprehensive proteomic data sets for studying adipocyte-macrophage cell-cell communication.

Freiwald A, Weidner C, Witzke A, Huang SY, Meierhofer D, Sauer S.

Proteomics. 2013 Dec;13(23-24):3424-8.

PMID:
24174276
31.

Protein sets define disease states and predict in vivo effects of drug treatment.

Meierhofer D, Weidner C, Hartmann L, Mayr JA, Han CT, Schroeder FC, Sauer S.

Mol Cell Proteomics. 2013 Jul;12(7):1965-79. doi: 10.1074/mcp.M112.025031. Epub 2013 Apr 11.

32.

A Y2H-seq approach defines the human protein methyltransferase interactome.

Weimann M, Grossmann A, Woodsmith J, Özkan Z, Birth P, Meierhofer D, Benlasfer N, Valovka T, Timmermann B, Wanker EE, Sauer S, Stelzl U.

Nat Methods. 2013 Apr;10(4):339-42. doi: 10.1038/nmeth.2397. Epub 2013 Mar 3.

PMID:
23455924
33.

Lipoic acid synthetase deficiency causes neonatal-onset epilepsy, defective mitochondrial energy metabolism, and glycine elevation.

Mayr JA, Zimmermann FA, Fauth C, Bergheim C, Meierhofer D, Radmayr D, Zschocke J, Koch J, Sperl W.

Am J Hum Genet. 2011 Dec 9;89(6):792-7. doi: 10.1016/j.ajhg.2011.11.011.

34.

Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry.

Meierhofer D, Wang X, Huang L, Kaiser P.

J Proteome Res. 2008 Oct;7(10):4566-76. doi: 10.1021/pr800468j. Epub 2008 Sep 10.

35.

Loss of complex I due to mitochondrial DNA mutations in renal oncocytoma.

Mayr JA, Meierhofer D, Zimmermann F, Feichtinger R, Kögler C, Ratschek M, Schmeller N, Sperl W, Kofler B.

Clin Cancer Res. 2008 Apr 15;14(8):2270-5. doi: 10.1158/1078-0432.CCR-07-4131.

36.

Tandem affinity purification combined with mass spectrometry to identify components of protein complexes.

Kaiser P, Meierhofer D, Wang X, Huang L.

Methods Mol Biol. 2008;439:309-26. doi: 10.1007/978-1-59745-188-8_21.

37.

Multiplex primer extension analysis for rapid detection of major European mitochondrial haplogroups.

Wiesbauer M, Meierhofer D, Mayr JA, Sperl W, Paulweber B, Kofler B.

Electrophoresis. 2006 Oct;27(19):3864-8.

PMID:
16960846
38.

Mitochondrial DNA mutations in renal cell carcinomas revealed no general impact on energy metabolism.

Meierhofer D, Mayr JA, Fink K, Schmeller N, Kofler B, Sperl W.

Br J Cancer. 2006 Jan 30;94(2):268-74.

39.

Platelet transfusion can mimic somatic mtDNA mutations.

Meierhofer D, Ebner S, Mayr JA, Jones ND, Kofler B, Sperl W.

Leukemia. 2006 Feb;20(2):362-3. No abstract available.

PMID:
16357835
40.

Rapid screening of the entire mitochondrial DNA for low-level heteroplasmic mutations.

Meierhofer D, Mayr JA, Ebner S, Sperl W, Kofler B.

Mitochondrion. 2005 Aug;5(4):282-96.

PMID:
16050991
41.

Decrease of mitochondrial DNA content and energy metabolism in renal cell carcinoma.

Meierhofer D, Mayr JA, Foetschl U, Berger A, Fink K, Schmeller N, Hacker GW, Hauser-Kronberger C, Kofler B, Sperl W.

Carcinogenesis. 2004 Jun;25(6):1005-10. Epub 2004 Feb 4.

PMID:
14764459
42.

Severe depletion of mitochondrial DNA in spinal muscular atrophy.

Berger A, Mayr JA, Meierhofer D, Fötschl U, Bittner R, Budka H, Grethen C, Huemer M, Kofler B, Sperl W.

Acta Neuropathol. 2003 Mar;105(3):245-51. Epub 2002 Nov 14.

PMID:
12557011

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