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Items: 41


Cadherin-Mediated Cell Coupling Coordinates Chemokine Sensing across Collectively Migrating Cells.

Colak-Champollion T, Lan L, Jadhav AR, Yamaguchi N, Venkiteswaran G, Patel H, Cammer M, Meier-Schellersheim M, Knaut H.

Curr Biol. 2019 Aug 5;29(15):2570-2579.e7. doi: 10.1016/j.cub.2019.06.061.


Using Python for Spatially Resolved Modeling with Simmune.

Angermann BR, Meier-Schellersheim M.

Methods Mol Biol. 2019;1945:161-177. doi: 10.1007/978-1-4939-9102-0_7.


Anosmin1 Shuttles Fgf to Facilitate Its Diffusion, Increase Its Local Concentration, and Induce Sensory Organs.

Wang J, Yin Y, Lau S, Sankaran J, Rothenberg E, Wohland T, Meier-Schellersheim M, Knaut H.

Dev Cell. 2018 Sep 24;46(6):751-766.e12. doi: 10.1016/j.devcel.2018.07.015. Epub 2018 Aug 16.


SBML Level 3 package: Multistate, Multicomponent and Multicompartment Species, Version 1, Release 1.

Zhang F, Meier-Schellersheim M.

J Integr Bioinform. 2018 Apr 20;15(1). pii: /j/jib.2018.15.issue-1/jib-2017-0077/jib-2017-0077.xml. doi: 10.1515/jib-2017-0077.


A hierarchy of affinities between cytokine receptors and the common gamma chain leads to pathway cross-talk.

Gonnord P, Angermann BR, Sadtler K, Gombos E, Chappert P, Meier-Schellersheim M, Varma R.

Sci Signal. 2018 Apr 3;11(524). pii: eaal1253. doi: 10.1126/scisignal.aal1253.


Migrating Myeloid Cells Sense Temporal Dynamics of Chemoattractant Concentrations.

Petrie Aronin CE, Zhao YM, Yoon JS, Morgan NY, Prüstel T, Germain RN, Meier-Schellersheim M.

Immunity. 2017 Nov 21;47(5):862-874.e3. doi: 10.1016/j.immuni.2017.10.020.


Unified path integral approach to theories of diffusion-influenced reactions.

Prüstel T, Meier-Schellersheim M.

Phys Rev E. 2017 Aug;96(2-1):022151. doi: 10.1103/PhysRevE.96.022151. Epub 2017 Aug 25.


Distinct NF-κB and MAPK Activation Thresholds Uncouple Steady-State Microbe Sensing from Anti-pathogen Inflammatory Responses.

Gottschalk RA, Martins AJ, Angermann BR, Dutta B, Ng CE, Uderhardt S, Tsang JS, Fraser ID, Meier-Schellersheim M, Germain RN.

Cell Syst. 2016 Jun 22;2(6):378-90. doi: 10.1016/j.cels.2016.04.016. Epub 2016 May 26.


Targeted Proteomics-Driven Computational Modeling of Macrophage S1P Chemosensing.

Manes NP, Angermann BR, Koppenol-Raab M, An E, Sjoelund VH, Sun J, Ishii M, Germain RN, Meier-Schellersheim M, Nita-Lazar A.

Mol Cell Proteomics. 2015 Oct;14(10):2661-81. doi: 10.1074/mcp.M115.048918. Epub 2015 Jul 21.


Rate coefficients, binding probabilities, and related quantities for area reactivity models.

Prüstel T, Meier-Schellersheim M.

J Chem Phys. 2014 Nov 21;141(19):194115. doi: 10.1063/1.4901115.


NetworkViewer: visualizing biochemical reaction networks with embedded rendering of molecular interaction rules.

Cheng HC, Angermann BR, Zhang F, Meier-Schellersheim M.

BMC Syst Biol. 2014 Jun 16;8:70. doi: 10.1186/1752-0509-8-70.


The area reactivity model of geminate recombination.

Prüstel T, Meier-Schellersheim M.

J Chem Phys. 2014 Mar 21;140(11):114106. doi: 10.1063/1.4868554.


Inflammation-induced interstitial migration of effector CD4⁺ T cells is dependent on integrin αV.

Overstreet MG, Gaylo A, Angermann BR, Hughson A, Hyun YM, Lambert K, Acharya M, Billroth-Maclurg AC, Rosenberg AF, Topham DJ, Yagita H, Kim M, Lacy-Hulbert A, Meier-Schellersheim M, Fowell DJ.

Nat Immunol. 2013 Sep;14(9):949-58. doi: 10.1038/ni.2682. Epub 2013 Aug 11.


High production rates sustain in vivo levels of PD-1high simian immunodeficiency virus-specific CD8 T cells in the face of rapid clearance.

Petrovas C, Yamamoto T, Price DA, Rao SS, Klatt NR, Brenchley JM, Douek DC, Gostick E, Angermann BR, Grossman Z, Macallan DC, Meier-Schellersheim M, Koup RA.

J Virol. 2013 Sep;87(17):9836-44. doi: 10.1128/JVI.01001-13. Epub 2013 Jul 3.


Theory of reversible diffusion-influenced reactions with non-Markovian dissociation in two space dimensions.

Prüstel T, Meier-Schellersheim M.

J Chem Phys. 2013 Mar 14;138(10):104112. doi: 10.1063/1.4794311.


The Simmune Modeler visual interface for creating signaling networks based on bi-molecular interactions.

Zhang F, Angermann BR, Meier-Schellersheim M.

Bioinformatics. 2013 May 1;29(9):1229-30. doi: 10.1093/bioinformatics/btt134. Epub 2013 Mar 17.


Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines.

Junttila IS, Creusot RJ, Moraga I, Bates DL, Wong MT, Alonso MN, Suhoski MM, Lupardus P, Meier-Schellersheim M, Engleman EG, Utz PJ, Fathman CG, Paul WE, Garcia KC.

Nat Chem Biol. 2012 Dec;8(12):990-8. doi: 10.1038/nchembio.1096. Epub 2012 Oct 28.


Opposing roles for RhoH GTPase during T-cell migration and activation.

Baker CM, Comrie WA, Hyun YM, Chung HL, Fedorchuk CA, Lim K, Brakebusch C, McGrath JL, Waugh RE, Meier-Schellersheim M, Kim M.

Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10474-9. doi: 10.1073/pnas.1114214109. Epub 2012 Jun 11.


Computational modeling of cellular signaling processes embedded into dynamic spatial contexts.

Angermann BR, Klauschen F, Garcia AD, Prustel T, Zhang F, Germain RN, Meier-Schellersheim M.

Nat Methods. 2012 Jan 29;9(3):283-9. doi: 10.1038/nmeth.1861.


Feedback regulation of proliferation vs. differentiation rates explains the dependence of CD4 T-cell expansion on precursor number.

Bocharov G, Quiel J, Luzyanina T, Alon H, Chiglintsev E, Chereshnev V, Meier-Schellersheim M, Paul WE, Grossman Z.

Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3318-23. doi: 10.1073/pnas.1019706108. Epub 2011 Feb 3.


Systems biology in immunology: a computational modeling perspective.

Germain RN, Meier-Schellersheim M, Nita-Lazar A, Fraser ID.

Annu Rev Immunol. 2011;29:527-85. doi: 10.1146/annurev-immunol-030409-101317. Review.


Chemorepulsion by blood S1P regulates osteoclast precursor mobilization and bone remodeling in vivo.

Ishii M, Kikuta J, Shimazu Y, Meier-Schellersheim M, Germain RN.

J Exp Med. 2010 Dec 20;207(13):2793-8. doi: 10.1084/jem.20101474. Epub 2010 Dec 6.


Coupling mechanism of a GPCR and a heterotrimeric G protein during chemoattractant gradient sensing in Dictyostelium.

Xu X, Meckel T, Brzostowski JA, Yan J, Meier-Schellersheim M, Jin T.

Sci Signal. 2010 Sep 28;3(141):ra71. doi: 10.1126/scisignal.2000980.


Multiscale modeling for biologists.

Meier-Schellersheim M, Fraser IDC, Klauschen F.

Wiley Interdiscip Rev Syst Biol Med. 2009 Jul-Aug;1(1):4-14. doi: 10.1002/wsbm.33. Review.


Computational modeling of signaling networks for eukaryotic chemosensing.

Meier-Schellersheim M, Klauschen F, Angermann B.

Methods Mol Biol. 2009;571:507-26. doi: 10.1007/978-1-60761-198-1_33.


Quantifying cellular interaction dynamics in 3D fluorescence microscopy data.

Klauschen F, Ishii M, Qi H, Bajénoff M, Egen JG, Germain RN, Meier-Schellersheim M.

Nat Protoc. 2009;4(9):1305-11. doi: 10.1038/nprot.2009.129. Epub 2009 Aug 20.


Computational reconstruction of cell and tissue surfaces for modeling and data analysis.

Klauschen F, Qi H, Egen JG, Germain RN, Meier-Schellersheim M.

Nat Protoc. 2009;4(7):1006-12. doi: 10.1038/nprot.2009.94. Epub 2009 Jun 4.


Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis.

Ishii M, Egen JG, Klauschen F, Meier-Schellersheim M, Saeki Y, Vacher J, Proia RL, Germain RN.

Nature. 2009 Mar 26;458(7237):524-8. doi: 10.1038/nature07713. Epub 2009 Feb 8. Erratum in: Nature. 2010 Jun 17;465(7300):966.


Tuning sensitivity to IL-4 and IL-13: differential expression of IL-4Ralpha, IL-13Ralpha1, and gammac regulates relative cytokine sensitivity.

Junttila IS, Mizukami K, Dickensheets H, Meier-Schellersheim M, Yamane H, Donnelly RP, Paul WE.

J Exp Med. 2008 Oct 27;205(11):2595-608. doi: 10.1084/jem.20080452. Epub 2008 Oct 13.


Progressive CD4+ central memory T cell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infection.

Okoye A, Meier-Schellersheim M, Brenchley JM, Hagen SI, Walker JM, Rohankhedkar M, Lum R, Edgar JB, Planer SL, Legasse A, Sylwester AW, Piatak M Jr, Lifson JD, Maino VC, Sodora DL, Douek DC, Axthelm MK, Grossman Z, Picker LJ.

J Exp Med. 2007 Sep 3;204(9):2171-85. Epub 2007 Aug 27. Erratum in: J Exp Med. 2007 Oct;204(10):2493.


Understanding diseases by mouse click: the promise and potential of computational approaches in Systems Biology.

Klauschen F, Angermann BR, Meier-Schellersheim M.

Clin Exp Immunol. 2007 Sep;149(3):424-9. Epub 2007 Jul 30. Review.


Locally controlled inhibitory mechanisms are involved in eukaryotic GPCR-mediated chemosensing.

Xu X, Meier-Schellersheim M, Yan J, Jin T.

J Cell Biol. 2007 Jul 2;178(1):141-53.


Keratinocyte growth factor augments immune reconstitution after autologous hematopoietic progenitor cell transplantation in rhesus macaques.

Seggewiss R, Loré K, Guenaga FJ, Pittaluga S, Mattapallil J, Chow CK, Koup RA, Camphausen K, Nason MC, Meier-Schellersheim M, Donahue RE, Blazar BR, Dunbar CE, Douek DC.

Blood. 2007 Jul 1;110(1):441-9. Epub 2007 Mar 20.


Key role of local regulation in chemosensing revealed by a new molecular interaction-based modeling method.

Meier-Schellersheim M, Xu X, Angermann B, Kunkel EJ, Jin T, Germain RN.

PLoS Comput Biol. 2006 Jul 21;2(7):e82. Epub 2006 May 25.


Pathogenesis of HIV infection: what the virus spares is as important as what it destroys.

Grossman Z, Meier-Schellersheim M, Paul WE, Picker LJ.

Nat Med. 2006 Mar;12(3):289-95.


Concomitant regulation of T-cell activation and homeostasis.

Grossman Z, Min B, Meier-Schellersheim M, Paul WE.

Nat Rev Immunol. 2004 May;4(5):387-95. Review. No abstract available.


Spontaneous proliferation, a response of naive CD4 T cells determined by the diversity of the memory cell repertoire.

Min B, Foucras G, Meier-Schellersheim M, Paul WE.

Proc Natl Acad Sci U S A. 2004 Mar 16;101(11):3874-9. Epub 2004 Mar 4.


CD4 T cell depletion is linked directly to immune activation in the pathogenesis of HIV-1 and HIV-2 but only indirectly to the viral load.

Sousa AE, Carneiro J, Meier-Schellersheim M, Grossman Z, Victorino RM.

J Immunol. 2002 Sep 15;169(6):3400-6.


CD4+ T-cell depletion in HIV infection: are we closer to understanding the cause?

Grossman Z, Meier-Schellersheim M, Sousa AE, Victorino RM, Paul WE.

Nat Med. 2002 Apr;8(4):319-23. No abstract available.


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