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Items: 21


Characterization of a novel AICARFT inhibitor which potently elevates ZMP and has anti-tumor activity in murine models.

Brooks HB, Meier TI, Geeganage S, Fales KR, Thrasher KJ, Konicek SA, Spencer CD, Thibodeaux S, Foreman RT, Hui YH, Roth KD, Qian YW, Wang T, Luo S, Torrado A, Si C, Toth JL, Mc Cowan JR, Frimpong K, Lee MR, Dally RD, Shepherd TA, Durham TB, Wang Y, Wu Z, Iversen PW, Njoroge FG.

Sci Rep. 2018 Oct 18;8(1):15458. doi: 10.1038/s41598-018-33453-4.


Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model.

Fales KR, Njoroge FG, Brooks HB, Thibodeaux S, Torrado A, Si C, Toth JL, Mc Cowan JR, Roth KD, Thrasher KJ, Frimpong K, Lee MR, Dally RD, Shepherd TA, Durham TB, Margolis BJ, Wu Z, Wang Y, Atwell S, Wang J, Hui YH, Meier TI, Konicek SA, Geeganage S.

J Med Chem. 2017 Dec 14;60(23):9599-9616. doi: 10.1021/acs.jmedchem.7b01046. Epub 2017 Nov 9.


A novel CDK9 inhibitor shows potent antitumor efficacy in preclinical hematologic tumor models.

Yin T, Lallena MJ, Kreklau EL, Fales KR, Carballares S, Torrres R, Wishart GN, Ajamie RT, Cronier DM, Iversen PW, Meier TI, Foreman RT, Zeckner D, Sissons SE, Halstead BW, Lin AB, Donoho GP, Qian Y, Li S, Wu S, Aggarwal A, Ye XS, Starling JJ, Gaynor RB, de Dios A, Du J.

Mol Cancer Ther. 2014 Jun;13(6):1442-56. doi: 10.1158/1535-7163.MCT-13-0849. Epub 2014 Mar 31.


Pharmacological inhibition of nicotinamide phosphoribosyltransferase (NAMPT), an enzyme essential for NAD+ biosynthesis, in human cancer cells: metabolic basis and potential clinical implications.

Tan B, Young DA, Lu ZH, Wang T, Meier TI, Shepard RL, Roth K, Zhai Y, Huss K, Kuo MS, Gillig J, Parthasarathy S, Burkholder TP, Smith MC, Geeganage S, Zhao G.

J Biol Chem. 2013 Feb 1;288(5):3500-11. doi: 10.1074/jbc.M112.394510. Epub 2012 Dec 13.


Identification and characterization of an inhibitor specific to bacterial NAD+-dependent DNA ligases.

Meier TI, Yan D, Peery RB, McAllister KA, Zook C, Peng SB, Zhao G.

FEBS J. 2008 Nov;275(21):5258-71. doi: 10.1111/j.1742-4658.2008.06652.x. Epub 2008 Sep 13.


The development of potent and selective bisarylmaleimide GSK3 inhibitors.

Engler TA, Malhotra S, Burkholder TP, Henry JR, Mendel D, Porter WJ, Furness K, Diefenbacher C, Marquart A, Reel JK, Li Y, Clayton J, Cunningham B, McLean J, O'toole JC, Brozinick J, Hawkins E, Misener E, Briere D, Brier RA, Wagner JR, Campbell RM, Anderson BD, Vaughn R, Bennett DB, Meier TI, Cook JA.

Bioorg Med Chem Lett. 2005 Feb 15;15(4):899-903.


Cloning, expression, purification, and characterization of the human Class Ia phosphoinositide 3-kinase isoforms.

Meier TI, Cook JA, Thomas JE, Radding JA, Horn C, Lingaraj T, Smith MC.

Protein Expr Purif. 2004 Jun;35(2):218-24.


Fluorescent Bocillins: synthesis and application in the detection of penicillin-binding proteins.

Gee KR, Kang HC, Meier TI, Zhao G, Blaszcak LC.

Electrophoresis. 2001 Mar;22(5):960-5.


Era GTPase of Escherichia coli: binding to 16S rRNA and modulation of GTPase activity by RNA and carbohydrates.

Meier TI, Peery RB, McAllister KA, Zhao G.

Microbiology. 2000 May;146 ( Pt 5):1071-83.


Gene disruption studies of penicillin-binding proteins 1a, 1b, and 2a in Streptococcus pneumoniae.

Hoskins J, Matsushima P, Mullen DL, Tang J, Zhao G, Meier TI, Nicas TI, Jaskunas SR.

J Bacteriol. 1999 Oct;181(20):6552-5.


16S rRNA is bound to era of Streptococcus pneumoniae.

Meier TI, Peery RB, Jaskunas SR, Zhao G.

J Bacteriol. 1999 Sep;181(17):5242-9.


BOCILLIN FL, a sensitive and commercially available reagent for detection of penicillin-binding proteins.

Zhao G, Meier TI, Kahl SD, Gee KR, Blaszczak LC.

Antimicrob Agents Chemother. 1999 May;43(5):1124-8.


Biochemical and molecular analyses of the C-terminal domain of Era GTPase from Streptococcus pneumoniae.

Zhao G, Meier TI, Peery RB, Matsushima P, Skatrud PL.

Microbiology. 1999 Apr;145 ( Pt 4):791-800.


Transcriptional pausing at +62 of the HIV-1 nascent RNA modulates formation of the TAR RNA structure.

Palangat M, Meier TI, Keene RG, Landick R.

Mol Cell. 1998 Jun;1(7):1033-42.


Discontinuous movements of DNA and RNA in RNA polymerase accompany formation of a paused transcription complex.

Wang D, Meier TI, Chan CL, Feng G, Lee DN, Landick R.

Cell. 1995 May 5;81(3):341-50.

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