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Items: 1 to 50 of 122

1.

Bioorthogonal oncometabolite ligation.

Briney CA, Najera S, Meier JL.

Methods Enzymol. 2019;622:431-448. doi: 10.1016/bs.mie.2019.02.037. Epub 2019 Mar 14.

PMID:
31155064
2.

Nucleotide resolution sequencing of N4-acetylcytidine in RNA.

Thomas JM, Bryson KM, Meier JL.

Methods Enzymol. 2019;621:31-51. doi: 10.1016/bs.mie.2019.02.022. Epub 2019 Mar 12.

PMID:
31128786
3.

Epigenetic regulation by endogenous metabolite pharmacology.

Kulkarni RA, Montgomery DC, Meier JL.

Curr Opin Chem Biol. 2019 Aug;51:30-39. doi: 10.1016/j.cbpa.2019.02.002. Epub 2019 Mar 15. Review.

PMID:
30884380
4.

Nucleotide Resolution Comparison of Transcription of Human Cytomegalovirus and Host Genomes Reveals Universal Use of RNA Polymerase II Elongation Control Driven by Dissimilar Core Promoter Elements.

Parida M, Nilson KA, Li M, Ball CB, Fuchs HA, Lawson CK, Luse DS, Meier JL, Price DH.

MBio. 2019 Feb 12;10(1). pii: e02047-18. doi: 10.1128/mBio.02047-18.

5.

The Effect of Proton Pump Inhibitors on Glycemic Control in Patients with Type 2 Diabetes.

Villegas K, Meier JL, Long M, Lopez J, Swislocki A.

Metab Syndr Relat Disord. 2019 May;17(4):192-196. doi: 10.1089/met.2018.0138. Epub 2019 Feb 7.

PMID:
30730235
6.

A chemoproteomic portrait of the oncometabolite fumarate.

Kulkarni RA, Bak DW, Wei D, Bergholtz SE, Briney CA, Shrimp JH, Alpsoy A, Thorpe AL, Bavari AE, Crooks DR, Levy M, Florens L, Washburn MP, Frizzell N, Dykhuizen EC, Weerapana E, Linehan WM, Meier JL.

Nat Chem Biol. 2019 Apr;15(4):391-400. doi: 10.1038/s41589-018-0217-y. Epub 2019 Feb 4.

7.

Metabolic Regulation of the Epitranscriptome.

Thomas JM, Batista PJ, Meier JL.

ACS Chem Biol. 2019 Mar 15;14(3):316-324. doi: 10.1021/acschembio.8b00951. Epub 2019 Feb 1.

PMID:
30653309
8.

Acetylation of Cytidine in mRNA Promotes Translation Efficiency.

Arango D, Sturgill D, Alhusaini N, Dillman AA, Sweet TJ, Hanson G, Hosogane M, Sinclair WR, Nanan KK, Mandler MD, Fox SD, Zengeya TT, Andresson T, Meier JL, Coller J, Oberdoerffer S.

Cell. 2018 Dec 13;175(7):1872-1886.e24. doi: 10.1016/j.cell.2018.10.030. Epub 2018 Nov 15.

PMID:
30449621
9.

Photoinducible Oncometabolite Detection.

Kulkarni RA, Briney CA, Crooks DR, Bergholtz SE, Mushti C, Lockett SJ, Lane AN, Fan TW, Swenson RE, Marston Linehan W, Meier JL.

Chembiochem. 2019 Feb 1;20(3):360-365. doi: 10.1002/cbic.201800651. Epub 2018 Dec 13.

PMID:
30358041
10.

A Chemical Signature for Cytidine Acetylation in RNA.

Thomas JM, Briney CA, Nance KD, Lopez JE, Thorpe AL, Fox SD, Bortolin-Cavaille ML, Sas-Chen A, Arango D, Oberdoerffer S, Cavaille J, Andresson T, Meier JL.

J Am Chem Soc. 2018 Oct 10;140(40):12667-12670. doi: 10.1021/jacs.8b06636. Epub 2018 Sep 25.

PMID:
30252461
11.

Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation.

Bruning U, Morales-Rodriguez F, Kalucka J, Goveia J, Taverna F, Queiroz KCS, Dubois C, Cantelmo AR, Chen R, Loroch S, Timmerman E, Caixeta V, Bloch K, Conradi LC, Treps L, Staes A, Gevaert K, Tee A, Dewerchin M, Semenkovich CF, Impens F, Schilling B, Verdin E, Swinnen JV, Meier JL, Kulkarni RA, Sickmann A, Ghesquière B, Schoonjans L, Li X, Mazzone M, Carmeliet P.

Cell Metab. 2018 Dec 4;28(6):866-880.e15. doi: 10.1016/j.cmet.2018.07.019. Epub 2018 Aug 23.

PMID:
30146486
12.

Histone Acetyltransferase Assays in Drug and Chemical Probe Discovery.

Gadhia S, Shrimp JH, Meier JL, McGee JE, Dahlin JL.

In: Sittampalam GS, Grossman A, Brimacombe K, Arkin M, Auld D, Austin C, Baell J, Bejcek B, Caaveiro JMM, Chung TDY, Coussens NP, Dahlin JL, Devanaryan V, Foley TL, Glicksman M, Hall MD, Haas JV, Hoare SRJ, Inglese J, Iversen PW, Kahl SD, Kales SC, Kirshner S, Lal-Nag M, Li Z, McGee J, McManus O, Riss T, Trask OJ Jr., Weidner JR, Wildey MJ, Xia M, Xu X, editors. Assay Guidance Manual [Internet]. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences; 2004-.
2017 Jul 26 [updated 2018 Jul 1].

13.

Bioorthogonal pro-metabolites for profiling short chain fatty acylation.

Sinclair WR, Shrimp JH, Zengeya TT, Kulkarni RA, Garlick JM, Luecke H, Worth AJ, Blair IA, Snyder NW, Meier JL.

Chem Sci. 2017 Dec 8;9(5):1236-1241. doi: 10.1039/c7sc00247e. eCollection 2018 Feb 7.

14.

A chemically stable fluorescent marker of the ureter.

Cha J, Nani RR, Luciano MP, Kline G, Broch A, Kim K, Namgoong JM, Kulkarni RA, Meier JL, Kim P, Schnermann MJ.

Bioorg Med Chem Lett. 2018 Sep 1;28(16):2741-2745. doi: 10.1016/j.bmcl.2018.02.040. Epub 2018 Feb 24.

15.

Pharmacology by Chemical Biology.

Meier JL, Schnermann MJ.

Mol Pharm. 2018 Mar 5;15(3):703-704. doi: 10.1021/acs.molpharmaceut.8b00067. No abstract available.

16.

Chemical Control of a CRISPR-Cas9 Acetyltransferase.

Shrimp JH, Grose C, Widmeyer SRT, Thorpe AL, Jadhav A, Meier JL.

ACS Chem Biol. 2018 Feb 16;13(2):455-460. doi: 10.1021/acschembio.7b00883. Epub 2018 Jan 17.

17.

Defining Metabolic and Nonmetabolic Regulation of Histone Acetylation by NSAID Chemotypes.

Shrimp JH, Garlick JM, Tezil T, Sorum AW, Worth AJ, Blair IA, Verdin E, Snyder NW, Meier JL.

Mol Pharm. 2018 Mar 5;15(3):729-736. doi: 10.1021/acs.molpharmaceut.7b00943. Epub 2017 Dec 29.

18.

Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors.

Dahlin JL, Nelson KM, Strasser JM, Barsyte-Lovejoy D, Szewczyk MM, Organ S, Cuellar M, Singh G, Shrimp JH, Nguyen N, Meier JL, Arrowsmith CH, Brown PJ, Baell JB, Walters MA.

Nat Commun. 2017 Nov 15;8(1):1527. doi: 10.1038/s41467-017-01657-3.

19.

Profiling Cytidine Acetylation with Specific Affinity and Reactivity.

Sinclair WR, Arango D, Shrimp JH, Zengeya TT, Thomas JM, Montgomery DC, Fox SD, Andresson T, Oberdoerffer S, Meier JL.

ACS Chem Biol. 2017 Dec 15;12(12):2922-2926. doi: 10.1021/acschembio.7b00734. Epub 2017 Oct 17.

PMID:
29039931
20.

Oxidative stress rapidly stabilizes promoter-proximal paused Pol II across the human genome.

Nilson KA, Lawson CK, Mullen NJ, Ball CB, Spector BM, Meier JL, Price DH.

Nucleic Acids Res. 2017 Nov 2;45(19):11088-11105. doi: 10.1093/nar/gkx724.

21.

Variable Effects of Autophagy Induction by Trehalose on Herpesviruses Depending on Conditions of Infection.

Meier JL, Grose C.

Yale J Biol Med. 2017 Mar 29;90(1):25-33. eCollection 2017 Mar.

22.

Discovering Targets of Non-enzymatic Acylation by Thioester Reactivity Profiling.

Kulkarni RA, Worth AJ, Zengeya TT, Shrimp JH, Garlick JM, Roberts AM, Montgomery DC, Sourbier C, Gibbs BK, Mesaros C, Tsai YC, Das S, Chan KC, Zhou M, Andresson T, Weissman AM, Linehan WM, Blair IA, Snyder NW, Meier JL.

Cell Chem Biol. 2017 Feb 16;24(2):231-242. doi: 10.1016/j.chembiol.2017.01.002. Epub 2017 Feb 2.

23.

Impact of a High-fat Diet on Tissue Acyl-CoA and Histone Acetylation Levels.

Carrer A, Parris JL, Trefely S, Henry RA, Montgomery DC, Torres A, Viola JM, Kuo YM, Blair IA, Meier JL, Andrews AJ, Snyder NW, Wellen KE.

J Biol Chem. 2017 Feb 24;292(8):3312-3322. doi: 10.1074/jbc.M116.750620. Epub 2017 Jan 11.

24.

Co-opting a Bioorthogonal Reaction for Oncometabolite Detection.

Zengeya TT, Garlick JM, Kulkarni RA, Miley M, Roberts AM, Yang Y, Crooks DR, Sourbier C, Linehan WM, Meier JL.

J Am Chem Soc. 2016 Dec 14;138(49):15813-15816. Epub 2016 Nov 30.

25.

Structural and Biochemical Analysis of Protein-Protein Interactions Between the Acyl-Carrier Protein and Product Template Domain.

Barajas JF, Finzel K, Valentic TR, Shakya G, Gamarra N, Martinez D, Meier JL, Vagstad AL, Newman AG, Townsend CA, Burkart MD, Tsai SC.

Angew Chem Int Ed Engl. 2016 Oct 10;55(42):13005-13009. doi: 10.1002/anie.201605401.

26.

Mapping Lysine Acetyltransferase-Ligand Interactions by Activity-Based Capture.

Montgomery DC, Meier JL.

Methods Enzymol. 2016;574:105-123. doi: 10.1016/bs.mie.2016.01.006. Epub 2016 Feb 16.

PMID:
27423859
27.

Global Profiling of Acetyltransferase Feedback Regulation.

Montgomery DC, Garlick JM, Kulkarni RA, Kennedy S, Allali-Hassani A, Kuo YM, Andrews AJ, Wu H, Vedadi M, Meier JL.

J Am Chem Soc. 2016 May 25;138(20):6388-91. doi: 10.1021/jacs.6b03036. Epub 2016 May 17.

28.

Characterizing the Covalent Targets of a Small Molecule Inhibitor of the Lysine Acetyltransferase P300.

Shrimp JH, Sorum AW, Garlick JM, Guasch L, Nicklaus MC, Meier JL.

ACS Med Chem Lett. 2015 Oct 31;7(2):151-5. doi: 10.1021/acsmedchemlett.5b00385. eCollection 2016 Feb 11.

29.

High-throughput single-molecule screen for small-molecule perturbation of splicing and transcription kinetics.

Day CR, Chen H, Coulon A, Meier JL, Larson DR.

Methods. 2016 Mar 1;96:59-68. doi: 10.1016/j.ymeth.2015.11.025. Epub 2015 Nov 30.

30.

Microfluidic Mobility Shift Profiling of Lysine Acetyltransferases Enables Screening and Mechanistic Analysis of Cellular Acetylation Inhibitors.

Sorum AW, Shrimp JH, Roberts AM, Montgomery DC, Tiwari NK, Lal-Nag M, Simeonov A, Jadhav A, Meier JL.

ACS Chem Biol. 2016 Mar 18;11(3):734-41. doi: 10.1021/acschembio.5b00709. Epub 2015 Oct 14.

31.

Differentiation-Coupled Induction of Human Cytomegalovirus Replication by Union of the Major Enhancer Retinoic Acid, Cyclic AMP, and NF-κB Response Elements.

Yuan J, Li M, Torres YR, Galle CS, Meier JL.

J Virol. 2015 Dec;89(24):12284-98. doi: 10.1128/JVI.00965-15. Epub 2015 Sep 30.

32.

Metabolic Regulation of Histone Acetyltransferases by Endogenous Acyl-CoA Cofactors.

Montgomery DC, Sorum AW, Guasch L, Nicklaus MC, Meier JL.

Chem Biol. 2015 Aug 20;22(8):1030-1039. doi: 10.1016/j.chembiol.2015.06.015. Epub 2015 Jul 16.

33.

Differential Survival for Men and Women with HIV/AIDS-Related Neurologic Diagnoses.

Carvour ML, Harms JP, Lynch CF, Mayer RR, Meier JL, Liu D, Torner JC.

PLoS One. 2015 Jun 24;10(6):e0123119. doi: 10.1371/journal.pone.0123119. eCollection 2015.

34.

Modular synthesis of cell-permeating 2-ketoglutarate esters.

Zengeya TT, Kulkarni RA, Meier JL.

Org Lett. 2015 May 15;17(10):2326-9. doi: 10.1021/acs.orglett.5b00737. Epub 2015 Apr 27.

35.

Paring Down cytomegalovirus's role in acute respiratory distress syndrome outcome*.

Meier JL.

Crit Care Med. 2015 Feb;43(2):498-9. doi: 10.1097/CCM.0000000000000828. No abstract available.

PMID:
25599483
36.

Defining the orphan functions of lysine acetyltransferases.

Montgomery DC, Sorum AW, Meier JL.

ACS Chem Biol. 2015 Jan 16;10(1):85-94. doi: 10.1021/cb500853p. Review.

37.

Chemical cryptology of cancer's histone code.

Kulkarni RA, Meier JL.

Chem Biol. 2014 Nov 20;21(11):1419-21. doi: 10.1016/j.chembiol.2014.11.003. Epub 2014 Nov 20.

38.

Consumer neuroscience to inform consumers-physiological methods to identify attitude formation related to over-consumption and environmental damage.

Walla P, Koller M, Meier JL.

Front Hum Neurosci. 2014 May 20;8:304. doi: 10.3389/fnhum.2014.00304. eCollection 2014. No abstract available.

39.

Chemoproteomic profiling of lysine acetyltransferases highlights an expanded landscape of catalytic acetylation.

Montgomery DC, Sorum AW, Meier JL.

J Am Chem Soc. 2014 Jun 18;136(24):8669-76. doi: 10.1021/ja502372j. Epub 2014 May 30.

40.

Design of sequence-specific DNA binding molecules for DNA methyltransferase inhibition.

Kang JS, Meier JL, Dervan PB.

J Am Chem Soc. 2014 Mar 5;136(9):3687-94. doi: 10.1021/ja500211z. Epub 2014 Feb 19.

41.

Metabolic mechanisms of epigenetic regulation.

Meier JL.

ACS Chem Biol. 2013 Dec 20;8(12):2607-21. doi: 10.1021/cb400689r. Epub 2013 Nov 14. Review.

42.

Animal toxicity of hairpin pyrrole-imidazole polyamides varies with the turn unit.

Yang F, Nickols NG, Li BC, Szablowski JO, Hamilton SR, Meier JL, Wang CM, Dervan PB.

J Med Chem. 2013 Sep 26;56(18):7449-57. doi: 10.1021/jm401100s. Epub 2013 Sep 9.

43.

A prospective noninterventional study to document implant success and survival of the Straumann Bone Level SLActive dental implant in daily dental practice.

Filippi A, Higginbottom FL, Lambrecht T, Levin BP, Meier JL, Rosen PS, Wallkamm B, Will C, Roccuzzo M.

Quintessence Int. 2013 Jul;44(7):499-512. doi: 10.3290/j.qi.a29611.

PMID:
23616977
44.

Molecular basis of antibiotic multiresistance transfer in Staphylococcus aureus.

Edwards JS, Betts L, Frazier ML, Pollet RM, Kwong SM, Walton WG, Ballentine WK 3rd, Huang JJ, Habibi S, Del Campo M, Meier JL, Dervan PB, Firth N, Redinbo MR.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2804-9. doi: 10.1073/pnas.1219701110. Epub 2013 Jan 28.

45.

Guiding the design of synthetic DNA-binding molecules with massively parallel sequencing.

Meier JL, Yu AS, Korf I, Segal DJ, Dervan PB.

J Am Chem Soc. 2012 Oct 24;134(42):17814-22. doi: 10.1021/ja308888c. Epub 2012 Oct 10.

46.

Pyrrole-imidazole polyamides distinguish between double-helical DNA and RNA.

Chenoweth DM, Meier JL, Dervan PB.

Angew Chem Int Ed Engl. 2013 Jan 2;52(1):415-8. doi: 10.1002/anie.201205775. Epub 2012 Sep 14.

47.

The antibiotic CJ-15,801 is an antimetabolite that hijacks and then inhibits CoA biosynthesis.

van der Westhuyzen R, Hammons JC, Meier JL, Dahesh S, Moolman WJ, Pelly SC, Nizet V, Burkart MD, Strauss E.

Chem Biol. 2012 May 25;19(5):559-71. doi: 10.1016/j.chembiol.2012.03.013.

48.

Characterization and solubilization of pyrrole-imidazole polyamide aggregates.

Hargrove AE, Raskatov JA, Meier JL, Montgomery DC, Dervan PB.

J Med Chem. 2012 Jun 14;55(11):5425-32. doi: 10.1021/jm300380a. Epub 2012 May 24.

49.

Modulation of NF-κB-dependent gene transcription using programmable DNA minor groove binders.

Raskatov JA, Meier JL, Puckett JW, Yang F, Ramakrishnan P, Dervan PB.

Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1023-8. doi: 10.1073/pnas.1118506109. Epub 2011 Dec 27.

50.

Enhancing the cellular uptake of Py-Im polyamides through next-generation aryl turns.

Meier JL, Montgomery DC, Dervan PB.

Nucleic Acids Res. 2012 Mar;40(5):2345-56. doi: 10.1093/nar/gkr970. Epub 2011 Nov 12.

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