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Items: 1 to 50 of 51

1.

Apocynin alleviates lung injury by suppressing NLRP3 inflammasome activation and NF-κB signaling in acute pancreatitis.

Jin HZ, Yang XJ, Zhao KL, Mei FC, Zhou Y, You YD, Wang WX.

Int Immunopharmacol. 2019 Oct;75:105821. doi: 10.1016/j.intimp.2019.105821. Epub 2019 Aug 19.

PMID:
31437787
2.

β-Cell-intrinsic β-arrestin 1 signaling enhances sulfonylurea-induced insulin secretion.

Barella LF, Rossi M, Zhu L, Cui Y, Mei FC, Cheng X, Chen W, Gurevich VV, Wess J.

J Clin Invest. 2019 Jun 11;130:3732-3737. doi: 10.1172/JCI126309.

3.

Inhibition of macrophage migration inhibitory factor attenuates inflammation and fetal kidney injury in a rat model of acute pancreatitis in pregnancy.

Li M, Yu J, Zhao L, Mei FC, Zhou Y, Hong YP, Zuo T, Wang WX.

Int Immunopharmacol. 2019 Mar;68:106-114. doi: 10.1016/j.intimp.2018.12.068. Epub 2019 Jan 7.

PMID:
30622028
4.

4-Phenylbutyric Acid Attenuates Endoplasmic Reticulum Stress-Mediated Intestinal Epithelial Cell Apoptosis in Rats with Severe Acute Pancreatitis.

You YD, Deng WH, Guo WY, Zhao L, Mei FC, Hong YP, Zhou Y, Yu J, Xu S, Wang WX.

Dig Dis Sci. 2019 Jun;64(6):1535-1547. doi: 10.1007/s10620-018-5437-1. Epub 2019 Jan 4.

PMID:
30607691
5.

Corrigendum to "4-Phenylbutyric Acid Attenuates Pancreatic Beta-Cell Injury in Rats with Experimental Severe Acute Pancreatitis".

Hong YP, Guo WY, Wang WX, Zhao L, Xiang MW, Mei FC, Abliz A, Hu P, Deng WH, Yu J.

Int J Endocrinol. 2018 Jan 9;2018:6307830. doi: 10.1155/2018/6307830. eCollection 2018.

6.

Serum thyroid hormones levels are significantly decreased in pregnant rats with acute pancreatitis.

Wang CY, Zhao L, Hong YP, Mei FC, Zhou Y, Shi Q, Guo WY, Deng WH, Chen C, Yu J, Wang WX.

Biochem Biophys Res Commun. 2018 Nov 2;505(3):657-663. doi: 10.1016/j.bbrc.2018.09.180. Epub 2018 Oct 2.

PMID:
30286956
7.

Inhibition of endoplasmic reticulum stress by 4-phenylbutyric acid prevents vital organ injury in rat acute pancreatitis.

Hong YP, Deng WH, Guo WY, Shi Q, Zhao L, You YD, Mei FC, Zhou Y, Wang CY, Chen C, Yu J, Wang WX.

Am J Physiol Gastrointest Liver Physiol. 2018 Nov 1;315(5):G838-G847. doi: 10.1152/ajpgi.00102.2018. Epub 2018 Aug 23.

8.

β cells can be generated from cytokeratin 5-positive cells after cerulein-induced pancreatitis in adult mice.

Shi Q, Hong YP, Zhang XY, Tao J, Wang CY, Zhao L, Mei FC, You YD, Xia H, Xiong XC, Wang GR, Wang WX.

Biochem Biophys Res Commun. 2018 Jan 29;496(1):114-119. doi: 10.1016/j.bbrc.2018.01.008. Epub 2018 Jan 4.

PMID:
29307825
9.

EPAC1 regulates endothelial annexin A2 cell surface translocation and plasminogen activation.

Yang W, Mei FC, Cheng X.

FASEB J. 2018 Apr;32(4):2212-2222. doi: 10.1096/fj.201701027R. Epub 2018 Jan 5.

10.

Structure-activity relationships of 2-substituted phenyl-N-phenyl-2-oxoacetohydrazonoyl cyanides as novel antagonists of exchange proteins directly activated by cAMP (EPACs).

Liu Z, Zhu Y, Chen H, Wang P, Mei FC, Ye N, Cheng X, Zhou J.

Bioorg Med Chem Lett. 2017 Dec 1;27(23):5163-5166. doi: 10.1016/j.bmcl.2017.10.056. Epub 2017 Oct 25.

11.

A preliminary study on fetal lung injury in a rat model of acute pancreatitis in pregnancy.

Zhao L, Zuo T, Shi Q, Mei FC, Hong YP, Deng WH, Yu J, Hu P, Wang WX.

Pathol Res Pract. 2017 Nov;213(11):1370-1377. doi: 10.1016/j.prp.2017.09.016. Epub 2017 Sep 18.

PMID:
29033186
12.

Identification of novel 2-(benzo[d]isoxazol-3-yl)-2-oxo-N-phenylacetohydrazonoyl cyanide analoguesas potent EPAC antagonists.

Ye N, Zhu Y, Liu Z, Mei FC, Chen H, Wang P, Cheng X, Zhou J.

Eur J Med Chem. 2017 Jul 7;134:62-71. doi: 10.1016/j.ejmech.2017.04.001. Epub 2017 Apr 4.

13.

Effects of Castanospermine on Inflammatory Response in a Rat Model of Experimental Severe Acute Pancreatitis.

Hong YP, Chen C, Guo WY, Zhao L, Mei FC, Xiang MW, Wang WX.

Arch Med Res. 2016 Aug;47(6):436-445. doi: 10.1016/j.arcmed.2016.11.007.

PMID:
27986123
14.

Inhibition of Epac1 suppresses mitochondrial fission and reduces neointima formation induced by vascular injury.

Wang H, Robichaux WG, Wang Z, Mei FC, Cai M, Du G, Chen J, Cheng X.

Sci Rep. 2016 Nov 10;6:36552. doi: 10.1038/srep36552.

15.
16.

4-Phenylbutyric Acid Attenuates Pancreatic Beta-Cell Injury in Rats with Experimental Severe Acute Pancreatitis.

Hong YP, Guo WY, Wang WX, Zhao L, Xiang MW, Mei FC, Abliz A, Hu P, Deng WH, Yu J.

Int J Endocrinol. 2016;2016:4592346. doi: 10.1155/2016/4592346. Epub 2016 Aug 30. Erratum in: Int J Endocrinol. 2018 Jan 9;2018:6307830.

17.

Role of Exchange Protein Directly Activated by Cyclic AMP Isoform 1 in Energy Homeostasis: Regulation of Leptin Expression and Secretion in White Adipose Tissue.

Hu Y, Robichaux WG 3rd, Mei FC, Kim ER, Wang H, Tong Q, Jin J, Xu M, Chen J, Cheng X.

Mol Cell Biol. 2016 Sep 12;36(19):2440-50. doi: 10.1128/MCB.01034-15. Print 2016 Oct 1.

18.

Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1.

Singhmar P, Huo X, Eijkelkamp N, Berciano SR, Baameur F, Mei FC, Zhu Y, Cheng X, Hawke D, Mayor F Jr, Murga C, Heijnen CJ, Kavelaars A.

Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3036-41. doi: 10.1073/pnas.1516036113. Epub 2016 Feb 29.

19.

The pleiotropic role of exchange protein directly activated by cAMP 1 (EPAC1) in cancer: implications for therapeutic intervention.

Almahariq M, Mei FC, Cheng X.

Acta Biochim Biophys Sin (Shanghai). 2016 Jan;48(1):75-81. doi: 10.1093/abbs/gmv115. Epub 2015 Nov 2. Review.

20.

Structure-Activity Relationship Studies of Substituted 2-(Isoxazol-3-yl)-2-oxo-N'-phenyl-acetohydrazonoyl Cyanide Analogues: Identification of Potent Exchange Proteins Directly Activated by cAMP (EPAC) Antagonists.

Ye N, Zhu Y, Chen H, Liu Z, Mei FC, Wild C, Chen H, Cheng X, Zhou J.

J Med Chem. 2015 Aug 13;58(15):6033-47. doi: 10.1021/acs.jmedchem.5b00635. Epub 2015 Jul 16.

21.

Relationship between expression of NADPH oxidase 2 and invasion and prognosis of human gastric cancer.

Wang P, Shi Q, Deng WH, Yu J, Zuo T, Mei FC, Wang WX.

World J Gastroenterol. 2015 May 28;21(20):6271-9. doi: 10.3748/wjg.v21.i20.6271.

22.

Pharmacological inhibition and genetic knockdown of exchange protein directly activated by cAMP 1 reduce pancreatic cancer metastasis in vivo.

Almahariq M, Chao C, Mei FC, Hellmich MR, Patrikeev I, Motamedi M, Cheng X.

Mol Pharmacol. 2015 Feb;87(2):142-9. doi: 10.1124/mol.114.095158. Epub 2014 Nov 10.

23.

Exchange protein directly activated by cAMP modulates regulatory T-cell-mediated immunosuppression.

Almahariq M, Mei FC, Wang H, Cao AT, Yao S, Soong L, Sun J, Cong Y, Chen J, Cheng X.

Biochem J. 2015 Jan 15;465(2):295-303. doi: 10.1042/BJ20140952.

24.

Cyclic AMP sensor EPAC proteins and energy homeostasis.

Almahariq M, Mei FC, Cheng X.

Trends Endocrinol Metab. 2014 Feb;25(2):60-71. doi: 10.1016/j.tem.2013.10.004. Epub 2013 Nov 12. Review.

25.

Exchange protein directly activated by cAMP plays a critical role in bacterial invasion during fatal rickettsioses.

Gong B, Shelite T, Mei FC, Ha T, Hu Y, Xu G, Chang Q, Wakamiya M, Ksiazek TG, Boor PJ, Bouyer DH, Popov VL, Chen J, Walker DH, Cheng X.

Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19615-20. doi: 10.1073/pnas.1314400110. Epub 2013 Nov 11.

26.

Identification and characterization of small molecules as potent and specific EPAC2 antagonists.

Chen H, Tsalkova T, Chepurny OG, Mei FC, Holz GG, Cheng X, Zhou J.

J Med Chem. 2013 Feb 14;56(3):952-62. doi: 10.1021/jm3014162. Epub 2013 Jan 15.

27.

Enhanced leptin sensitivity, reduced adiposity, and improved glucose homeostasis in mice lacking exchange protein directly activated by cyclic AMP isoform 1.

Yan J, Mei FC, Cheng H, Lao DH, Hu Y, Wei J, Patrikeev I, Hao D, Stutz SJ, Dineley KT, Motamedi M, Hommel JD, Cunningham KA, Chen J, Cheng X.

Mol Cell Biol. 2013 Mar;33(5):918-26. doi: 10.1128/MCB.01227-12. Epub 2012 Dec 21.

28.

Structural analyses of a constitutively active mutant of exchange protein directly activated by cAMP.

White MA, Li S, Tsalkova T, Mei FC, Liu T, Woods VL Jr, Cheng X.

PLoS One. 2012;7(11):e49932. doi: 10.1371/journal.pone.0049932. Epub 2012 Nov 26.

29.

Isoform-specific antagonists of exchange proteins directly activated by cAMP.

Tsalkova T, Mei FC, Li S, Chepurny OG, Leech CA, Liu T, Holz GG, Woods VL Jr, Cheng X.

Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18613-8. doi: 10.1073/pnas.1210209109. Epub 2012 Oct 22.

30.

A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion.

Almahariq M, Tsalkova T, Mei FC, Chen H, Zhou J, Sastry SK, Schwede F, Cheng X.

Mol Pharmacol. 2013 Jan;83(1):122-8. doi: 10.1124/mol.112.080689. Epub 2012 Oct 11.

31.

5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP.

Chen H, Tsalkova T, Mei FC, Hu Y, Cheng X, Zhou J.

Bioorg Med Chem Lett. 2012 Jun 15;22(12):4038-43. doi: 10.1016/j.bmcl.2012.04.082. Epub 2012 Apr 26.

32.

A fluorescence-based high-throughput assay for the discovery of exchange protein directly activated by cyclic AMP (EPAC) antagonists.

Tsalkova T, Mei FC, Cheng X.

PLoS One. 2012;7(1):e30441. doi: 10.1371/journal.pone.0030441. Epub 2012 Jan 19.

33.

Mechanism of intracellular cAMP sensor Epac2 activation: cAMP-induced conformational changes identified by amide hydrogen/deuterium exchange mass spectrometry (DXMS).

Li S, Tsalkova T, White MA, Mei FC, Liu T, Wang D, Woods VL Jr, Cheng X.

J Biol Chem. 2011 May 20;286(20):17889-97. doi: 10.1074/jbc.M111.224535. Epub 2011 Mar 17.

34.

Epac, not PKA catalytic subunit, is required for 3T3-L1 preadipocyte differentiation.

Ji Z, Mei FC, Cheng X.

Front Biosci (Elite Ed). 2010 Jan 1;2:392-8.

35.

Mechanism of Epac activation: structural and functional analyses of Epac2 hinge mutants with constitutive and reduced activities.

Tsalkova T, Blumenthal DK, Mei FC, White MA, Cheng X.

J Biol Chem. 2009 Aug 28;284(35):23644-51. doi: 10.1074/jbc.M109.024950. Epub 2009 Jun 24.

36.

Chemical genetic screening of KRAS-based synthetic lethal inhibitors for pancreatic cancer.

Ji Z, Mei FC, Lory PL, Gilbertson SR, Chen Y, Cheng X.

Front Biosci (Landmark Ed). 2009 Jan 1;14:2904-10.

37.

Protein kinase A (PKA) isoform RIIbeta mediates the synergistic killing effect of cAMP and glucocorticoid in acute lymphoblastic leukemia cells.

Ji Z, Mei FC, Miller AL, Thompson EB, Cheng X.

J Biol Chem. 2008 Aug 8;283(32):21920-5. doi: 10.1074/jbc.M803193200. Epub 2008 Jun 10.

38.

Protein kinase A, not Epac, suppresses hedgehog activity and regulates glucocorticoid sensitivity in acute lymphoblastic leukemia cells.

Ji Z, Mei FC, Johnson BH, Thompson EB, Cheng X.

J Biol Chem. 2007 Dec 28;282(52):37370-7. Epub 2007 Sep 25.

39.

Conformational analysis of Epac activation using amide hydrogen/deuterium exchange mass spectrometry.

Brock M, Fan F, Mei FC, Li S, Gessner C, Woods VL Jr, Cheng X.

J Biol Chem. 2007 Nov 2;282(44):32256-63. Epub 2007 Sep 4.

40.

Up-regulation of tumor susceptibility gene 101 conveys poor prognosis through suppression of p21 expression in ovarian cancer.

Young TW, Rosen DG, Mei FC, Li N, Liu J, Wang XF, Cheng X.

Clin Cancer Res. 2007 Jul 1;13(13):3848-54.

41.

Proteomics analyses of ovarian cancer using genetically defined human ovarian cancer models.

Cheng X, Young TW, Mei FC.

Front Biosci. 2007 Sep 1;12:5166-74.

PMID:
17569638
42.

Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells.

Ji Z, Mei FC, Xie J, Cheng X.

J Biol Chem. 2007 May 11;282(19):14048-55. Epub 2007 Mar 12.

43.

Up-regulation of tumor susceptibility gene 101 protein in ovarian carcinomas revealed by proteomics analyses.

Young TW, Mei FC, Rosen DG, Yang G, Li N, Liu J, Cheng X.

Mol Cell Proteomics. 2007 Feb;6(2):294-304. Epub 2006 Nov 16.

44.

Cyclic adenosine 5'-monophosphate-stimulated neurotensin secretion is mediated through Rap1 downstream of both Epac and protein kinase A signaling pathways.

Li J, O'Connor KL, Cheng X, Mei FC, Uchida T, Townsend CM Jr, Evers BM.

Mol Endocrinol. 2007 Jan;21(1):159-71. Epub 2006 Oct 26.

PMID:
17068197
45.

Interplay between exchange protein directly activated by cAMP (Epac) and microtubule cytoskeleton.

Mei FC, Cheng X.

Mol Biosyst. 2005 Oct;1(4):325-31. Epub 2005 Sep 26.

PMID:
16880999
46.

Comparative two-dimensional gel electrophoresis maps for promastigotes of Leishmania amazonensis and Leishmania major.

Brobey RK, Mei FC, Cheng X, Soong L.

Braz J Infect Dis. 2006 Feb;10(1):1-6. Epub 2006 Jun 2.

PMID:
16767307
47.

RAS-mediated epigenetic inactivation of OPCML in oncogenic transformation of human ovarian surface epithelial cells.

Mei FC, Young TW, Liu J, Cheng X.

FASEB J. 2006 Mar;20(3):497-9. Epub 2005 Dec 29.

PMID:
16384911
48.
49.
50.

Cell cycle-dependent subcellular localization of exchange factor directly activated by cAMP.

Qiao J, Mei FC, Popov VL, Vergara LA, Cheng X.

J Biol Chem. 2002 Jul 19;277(29):26581-6. Epub 2002 May 8.

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