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Items: 1 to 50 of 119

1.

Kinetics of dextromethorphan-O-demethylase activity and distribution of CYP2D in four commonly-used subcellular fractions of rat brain.

DuBois BN, Amirrad F, Mehvar R.

Xenobiotica. 2018 Nov 5:1-33. doi: 10.1080/00498254.2018.1539782. [Epub ahead of print]

PMID:
30392427
2.

UPLC-MS/MS analysis of dextromethorphan-O-demethylation kinetics in rat brain microsomes.

DuBois BN, Mehvar R.

J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Oct 1;1096:66-72. doi: 10.1016/j.jchromb.2018.08.011. Epub 2018 Aug 18.

PMID:
30149296
3.

Brain Uptake of [13C] and [14C]Sucrose Quantified by Microdialysis and Whole Tissue Analysis in Mice.

Alqahtani F, Chowdhury EA, Bhattacharya R, Noorani B, Mehvar R, Bickel U.

Drug Metab Dispos. 2018 Nov;46(11):1514-1518. doi: 10.1124/dmd.118.082909. Epub 2018 Aug 16.

PMID:
30115645
4.

Clearance Concepts: Fundamentals and Application to Pharmacokinetic Behavior of Drugs.

Mehvar R.

J Pharm Pharm Sci. 2018;21(1s):88s-102s. doi: 10.18433/jpps29896.

5.
6.

Simultaneous UPLC-MS/MS analysis of two stable isotope labeled versions of sucrose in mouse plasma and brain samples as markers of blood-brain barrier permeability and brain vascular space.

Chowdhury EA, Alqahtani F, Bhattacharya R, Mehvar R, Bickel U.

J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jan 15;1073:19-26. doi: 10.1016/j.jchromb.2017.12.007. Epub 2017 Dec 6.

PMID:
29232607
7.

Effects of hepatic ischemia-reperfusion injury on the blood-brain barrier permeability to [14C] and [13C]sucrose.

Miah MK, Bickel U, Mehvar R.

Metab Brain Dis. 2017 Dec;32(6):1903-1912. doi: 10.1007/s11011-017-0069-2. Epub 2017 Aug 4.

8.

Why Every Aspect of an Academic Pharmacy Career Should Be Viewed Through the Lens of Scholarship.

Mehvar R.

Am J Pharm Educ. 2017 Feb 25;81(1):2. doi: 10.5688/ajpe8112. No abstract available.

9.

Evaluation of [14C] and [13C]Sucrose as Blood-Brain Barrier Permeability Markers.

Miah MK, Chowdhury EA, Bickel U, Mehvar R.

J Pharm Sci. 2017 Jun;106(6):1659-1669. doi: 10.1016/j.xphs.2017.02.011. Epub 2017 Feb 24.

10.

Development and validation of a sensitive UPLC-MS/MS method for the quantitation of [(13)C]sucrose in rat plasma, blood, and brain: Its application to the measurement of blood-brain barrier permeability.

Miah MK, Bickel U, Mehvar R.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Mar 15;1015-1016:105-110. doi: 10.1016/j.jchromb.2016.02.017. Epub 2016 Feb 16.

11.
12.

Effects of Pringle maneuver and partial hepatectomy on the pharmacokinetics and blood-brain barrier permeability of sodium fluorescein in rats.

Miah MK, Shaik IH, Bickel U, Mehvar R.

Brain Res. 2015 Aug 27;1618:249-60. doi: 10.1016/j.brainres.2015.05.038. Epub 2015 Jun 5.

13.

Fractional clearance for verapamil N-demethylation in the isolated rat liver preparation.

Mehvar R.

Drug Metab Dispos. 2015 Jul;43(7):1056-7. doi: 10.1124/dmd.115.064691. Epub 2015 May 11. No abstract available.

PMID:
25964424
14.

UHPLC-MS/MS analysis of arachidonic acid and 10 of its major cytochrome P450 metabolites as free acids in rat livers: effects of hepatic ischemia.

Edpuganti V, Mehvar R.

J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Aug 1;964:153-63. doi: 10.1016/j.jchromb.2013.08.008. Epub 2013 Aug 14.

15.
16.

Effects of short-term portacaval anastomosis on the peripheral and brain disposition of the blood-brain barrier permeability marker sodium fluorescein in rats.

Shaik IH, Miah MK, Bickel U, Mehvar R.

Brain Res. 2013 Sep 19;1531:84-93. doi: 10.1016/j.brainres.2013.07.040. Epub 2013 Jul 31.

17.

Inhaled PLGA particles of prostaglandin E₁ ameliorate symptoms and progression of pulmonary hypertension at a reduced dosing frequency.

Gupta V, Gupta N, Shaik IH, Mehvar R, Nozik-Grayck E, McMurtry IF, Oka M, Komatsu M, Ahsan F.

Mol Pharm. 2013 May 6;10(5):1655-67. doi: 10.1021/mp300426u. Epub 2013 Mar 26.

18.

Liposomal fasudil, a rho-kinase inhibitor, for prolonged pulmonary preferential vasodilation in pulmonary arterial hypertension.

Gupta V, Gupta N, Shaik IH, Mehvar R, McMurtry IF, Oka M, Nozik-Grayck E, Komatsu M, Ahsan F.

J Control Release. 2013 Apr 28;167(2):189-99. doi: 10.1016/j.jconrel.2013.01.011. Epub 2013 Jan 23.

19.

Preface. State of Current Clinical Pharmacology.

Mehvar R.

Curr Clin Pharmacol. 2013 Feb 1;8(1):1-2. No abstract available.

PMID:
23237639
21.

Hepatic immunosuppressive effects of systemically administered novel dextran-methylprednisolone prodrugs with peptide linkers in rats.

Shaik IH, Agarwal HK, Parang K, Mehvar R.

J Pharm Sci. 2012 Oct;101(10):4003-12. doi: 10.1002/jps.23274. Epub 2012 Jul 24.

24.

Effects of transient overexpression or knockdown of cytochrome P450 reductase on reactive oxygen species generation and hypoxia reoxygenation injury in liver cells.

Pillai VC, Snyder RO, Gumaste U, Thekkumkara TJ, Mehvar R.

Clin Exp Pharmacol Physiol. 2011 Dec;38(12):846-53. doi: 10.1111/j.1440-1681.2011.05622.x.

PMID:
21973081
25.
26.
29.
30.

Rate and extent of drug accumulation after multiple dosing revisited.

Brocks DR, Mehvar R.

Clin Pharmacokinet. 2010 Jul;49(7):421-38. doi: 10.2165/11531190-000000000-00000. Review.

PMID:
20528003
31.

Cytochrome P450 induction by phenobarbital exacerbates warm hepatic ischemia-reperfusion injury in rat livers.

Shaik IH, Mehvar R.

Free Radic Res. 2010 Apr;44(4):441-53. doi: 10.3109/10715761003610729.

PMID:
20166883
32.

Delivery of NADPH-cytochrome P450 reductase antisense oligos using avidin-biotin approach.

Pillai VC, Yesudas R, Shaik IH, Thekkumkara TJ, Bickel U, Srivenugopal KS, Mehvar R.

Bioconjug Chem. 2010 Feb 17;21(2):203-7. doi: 10.1021/bc900449b.

PMID:
20063878
33.

Plasma pharmacokinetics and tissue disposition of novel dextran-methylprednisolone conjugates with peptide linkers in rats.

Penugonda S, Agarwal HK, Parang K, Mehvar R.

J Pharm Sci. 2010 Mar;99(3):1626-37. doi: 10.1002/jps.21934.

34.

Updated guidelines for manuscripts describing instructional design and assessment: the IDEAS format.

Poirier T, Crouch M, MacKinnon G, Mehvar R, Monk-Tutor M; American Association of Colleges of Pharmacy.

Am J Pharm Educ. 2009 May 27;73(3):55. Review. No abstract available.

35.

Effects of cytochrome p450 inhibition by cimetidine on the warm hepatic ischemia-reperfusion injury in rats.

Shaik IH, Mehvar R.

J Surg Res. 2010 Apr;159(2):680-8. doi: 10.1016/j.jss.2008.09.016. Epub 2008 Oct 16.

PMID:
19500799
36.
37.

Role of TNF-alpha in liver ischaemia-reperfusion injury: new evidence or experimental artefact?

Mehvar R.

Eur J Clin Invest. 2009 Jun;39(6):527-8; author reply 529-30. doi: 10.1111/j.1365-2362.2009.02127.x. No abstract available.

PMID:
19490060
38.

Liquid chromatography-tandem mass spectrometry for the determination of methylprednisolone in rat plasma and liver after intravenous administration of its liver-targeted dextran prodrug.

Zhang SQ, Thorsheim HR, Penugonda S, Pillai VC, Smith QR, Mehvar R.

J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Apr 1;877(10):927-32. doi: 10.1016/j.jchromb.2009.02.028. Epub 2009 Feb 21.

39.

Hepatobiliary disposition of rhodamine 123 in isolated perfused rat livers.

Parasrampuria R, Mehvar R.

Xenobiotica. 2008 Oct;38(10):1263-73. doi: 10.1080/00498250802411421 .

PMID:
18798123
40.

Dependence of time to reach steady-state on the length of dosage interval.

Mehvar R.

Ann Pharmacother. 2008 Oct;42(10):1518-9. doi: 10.1345/aph.1L251. Epub 2008 Aug 26. No abstract available.

PMID:
18728101
41.

Protective effects of diallyl sulfide, a garlic constituent, on the warm hepatic ischemia-reperfusion injury in a rat model.

Shaik IH, George JM, Thekkumkara TJ, Mehvar R.

Pharm Res. 2008 Oct;25(10):2231-42. doi: 10.1007/s11095-008-9601-8. Epub 2008 Jul 15.

PMID:
18626753
42.

Effects of atazanavir/ritonavir or fosamprenavir/ritonavir on the pharmacokinetics of rosuvastatin.

Busti AJ, Bain AM, Hall RG 2nd, Bedimo RG, Leff RD, Meek C, Mehvar R.

J Cardiovasc Pharmacol. 2008 Jun;51(6):605-10. doi: 10.1097/FJC.0b013e31817b5b5a.

PMID:
18520949
43.

Enantioselective determination of tramadol and its main phase I metabolites in human plasma by high-performance liquid chromatography.

Ardakani YH, Mehvar R, Foroumadi A, Rouini MR.

J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Mar 15;864(1-2):109-15. doi: 10.1016/j.jchromb.2008.01.038. Epub 2008 Feb 3.

PMID:
18282749
44.

Synthesis, analysis, in vitro characterization, and in vivo disposition of a lamivudine-dextran conjugate for selective antiviral delivery to the liver.

Chimalakonda KC, Agarwal HK, Kumar A, Parang K, Mehvar R.

Bioconjug Chem. 2007 Nov-Dec;18(6):2097-108. Epub 2007 Oct 9.

PMID:
17922546
45.
47.

Metabolic bioactivation and toxicity of ethyl 4-hydroxybenzoate in human SK-MEL-28 melanoma cells.

Vad NM, Shaik IH, Mehvar R, Moridani MY.

J Pharm Sci. 2008 May;97(5):1934-45.

PMID:
17847068
48.

Stereospecific high-performance liquid chromatographic analysis of tramadol and its O-demethylated (M1) and N,O-demethylated (M5) metabolites in human plasma.

Mehvar R, Elliott K, Parasrampuria R, Eradiri O.

J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Jun 1;852(1-2):152-9. Epub 2007 Jan 13.

PMID:
17257910
49.

Route-dependent stereoselective pharmacokinetics of tramadol and its active O-demethylated metabolite in rats.

Parasrampuria R, Vuppugalla R, Elliott K, Mehvar R.

Chirality. 2007 Mar;19(3):190-6.

PMID:
17192836
50.

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