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Dry powder inhalers: a brief overview of the drug detachment techniques.

Mehta PP.

Ther Deliv. 2020 Jan 9. doi: 10.4155/tde-2019-0087. [Epub ahead of print] No abstract available.


Dry powder inhalers: upcoming platform technologies for formulation development.

Mehta PP.

Ther Deliv. 2019 Sep;10(9):551-554. doi: 10.4155/tde-2019-0062. Epub 2019 Oct 14. No abstract available.


Retraction notice to "A novel class of specific Hsp90 small molecule inhibitors demonstrate in vitro and in vivo anti-tumor activity in human melanoma cells".

Mehta PP, Kung PP, Yamazaki S, Walls M, Shen A, Nguyen L, Gehring MR, Los G, Smeal T, Yin MJ.

Cancer Lett. 2018 May 28;422:132. doi: 10.1016/j.canlet.2018.03.019. No abstract available.


Dileucine-like motifs in the C-terminal tail of connexin32 control its endocytosis and assembly into gap junctions.

Ray A, Katoch P, Jain N, Mehta PP.

J Cell Sci. 2018 Mar 2;131(5). pii: jcs207340. doi: 10.1242/jcs.207340.


An update on minding the gap in cancer.

Mesnil M, Aasen T, Boucher J, Chépied A, Cronier L, Defamie N, Kameritsch P, Laird DW, Lampe PD, Lathia JD, Leithe E, Mehta PP, Monvoisin A, Pogoda K, Sin WC, Tabernero A, Yamasaki H, Yeh ES, Dagli MLZ, Naus CC.

Biochim Biophys Acta Biomembr. 2018 Jan;1860(1):237-243. doi: 10.1016/j.bbamem.2017.06.015. Epub 2017 Jun 24. Review.


Primary Care Continuity Improves Diabetic Health Outcomes: From Free Clinics to Federally Qualified Health Centers.

Mehta PP, Santiago-Torres JE, Wisely CE, Hartmann K, Makadia FA, Welker MJ, Habash DL.

J Am Board Fam Med. 2016 May-Jun;29(3):318-24. doi: 10.3122/jabfm.2016.03.150256.


Capnographic Monitoring in Routine EGD and Colonoscopy With Moderate Sedation: A Prospective, Randomized, Controlled Trial.

Mehta PP, Kochhar G, Albeldawi M, Kirsh B, Rizk M, Putka B, John B, Wang Y, Breslaw N, Lopez R, Vargo JJ.

Am J Gastroenterol. 2016 Mar;111(3):395-404. doi: 10.1038/ajg.2015.437. Epub 2016 Feb 23.


Efavirenz Self-Nano-Emulsifying Drug Delivery System: In Vitro and In Vivo Evaluation.

Kamble RN, Mehta PP, Kumar A.

AAPS PharmSciTech. 2016 Oct;17(5):1240-7. doi: 10.1208/s12249-015-0446-2. Epub 2015 Nov 16.


ErbB-2 signaling plays a critical role in regulating androgen-sensitive and castration-resistant androgen receptor-positive prostate cancer cells.

Muniyan S, Chen SJ, Lin FF, Wang Z, Mehta PP, Batra SK, Lin MF.

Cell Signal. 2015 Nov;27(11):2261-71. doi: 10.1016/j.cellsig.2015.08.002. Epub 2015 Aug 6.


The carboxyl tail of connexin32 regulates gap junction assembly in human prostate and pancreatic cancer cells.

Katoch P, Mitra S, Ray A, Kelsey L, Roberts BJ, Wahl JK 3rd, Johnson KR, Mehta PP.

J Biol Chem. 2015 Feb 20;290(8):4647-62. doi: 10.1074/jbc.M114.586057. Epub 2014 Dec 29.


Vitamin D3 regulates the formation and degradation of gap junctions in androgen-responsive human prostate cancer cells.

Kelsey L, Katoch P, Ray A, Mitra S, Chakraborty S, Lin MF, Mehta PP.

PLoS One. 2014 Sep 4;9(9):e106437. doi: 10.1371/journal.pone.0106437. eCollection 2014.


A rare cause of gastro-intestinal hemorrhage in a patient with a Roux-en-Y gastric bypass.

Cartabuke RH, Mehta PP, El-Hayek K, Henderson JM, Burke CA.

Gastroenterol Rep (Oxf). 2016 Feb;4(1):84-6. doi: 10.1093/gastro/gou056. Epub 2014 Aug 24.


Features of patients with gastrointestinal bleeding after implantation of ventricular assist devices.

Singh G, Albeldawi M, Kalra SS, Mehta PP, Lopez R, Vargo JJ.

Clin Gastroenterol Hepatol. 2015 Jan;13(1):107-14.e1. doi: 10.1016/j.cgh.2014.05.012. Epub 2014 May 21.


Association of procedure length on outcomes and adverse events of endoscopic retrograde cholangiopancreatography.

Mehta PP, Sanaka MR, Parsi MA, Albeldawi MJ, Dumot JA, Lopez R, Zuccaro G, Vargo JJ.

Gastroenterol Rep (Oxf). 2014 May;2(2):140-4. doi: 10.1093/gastro/gou009. Epub 2014 Mar 12.


miR-122 regulates tumorigenesis in hepatocellular carcinoma by targeting AKT3.

Nassirpour R, Mehta PP, Yin MJ.

PLoS One. 2013 Nov 7;8(11):e79655. doi: 10.1371/journal.pone.0079655. eCollection 2013. Retraction in: PLoS One. 2017 Sep 8;12 (9):e0184778.


Targeting small cell lung cancer harboring PIK3CA mutation with a selective oral PI3K inhibitor PF-4989216.

Walls M, Baxi SM, Mehta PP, Liu KK, Zhu J, Estrella H, Li C, Zientek M, Zong Q, Smeal T, Yin MJ.

Clin Cancer Res. 2014 Feb 1;20(3):631-43. doi: 10.1158/1078-0432.CCR-13-1663. Epub 2013 Nov 15. Retraction in: Clin Cancer Res. 2017 Aug 1;23 (15):4523.


Can a validated sleep apnea scoring system predict cardiopulmonary events using propofol sedation for routine EGD or colonoscopy? A prospective cohort study.

Mehta PP, Kochhar G, Kalra S, Maurer W, Tetzlaff J, Singh G, Lopez R, Sanaka MR, Vargo JJ.

Gastrointest Endosc. 2014 Mar;79(3):436-44. doi: 10.1016/j.gie.2013.09.022. Epub 2013 Nov 9.


miR-221 promotes tumorigenesis in human triple negative breast cancer cells.

Nassirpour R, Mehta PP, Baxi SM, Yin MJ.

PLoS One. 2013 Apr 24;8(4):e62170. doi: 10.1371/journal.pone.0062170. Print 2013. Retraction in: PLoS One. 2017 Apr 10;12 (4):e0175869.


Colonoscopies by nurse practitioners: too premature to support their role.

Navaneethan U, Mehta PP, Sanaka MR.

Clin Gastroenterol Hepatol. 2013 Jul;11(7):879. doi: 10.1016/j.cgh.2013.03.009. Epub 2013 Mar 21. No abstract available.


Phosphorylation on Ser-279 and Ser-282 of connexin43 regulates endocytosis and gap junction assembly in pancreatic cancer cells.

Johnson KE, Mitra S, Katoch P, Kelsey LS, Johnson KR, Mehta PP.

Mol Biol Cell. 2013 Mar;24(6):715-33. doi: 10.1091/mbc.E12-07-0537. Epub 2013 Jan 30.


Retinoids regulate the formation and degradation of gap junctions in androgen-responsive human prostate cancer cells.

Kelsey L, Katoch P, Johnson KE, Batra SK, Mehta PP.

PLoS One. 2012;7(4):e32846. doi: 10.1371/journal.pone.0032846. Epub 2012 Apr 13.


Decreased nNOS in the PVN leads to increased sympathoexcitation in chronic heart failure: role for CAPON and Ang II.

Sharma NM, Zheng H, Mehta PP, Li YF, Patel KP.

Cardiovasc Res. 2011 Nov 1;92(2):348-57. doi: 10.1093/cvr/cvr217. Epub 2011 Aug 10.


Effect of the time of day on the success and adverse events of ERCP.

Mehta PP, Sanaka MR, Parsi MA, Zuccaro G, Dumot JA, Lopez R, Vargo JJ.

Gastrointest Endosc. 2011 Aug;74(2):303-8. doi: 10.1016/j.gie.2011.04.006.


PF-04691502, a potent and selective oral inhibitor of PI3K and mTOR kinases with antitumor activity.

Yuan J, Mehta PP, Yin MJ, Sun S, Zou A, Chen J, Rafidi K, Feng Z, Nickel J, Engebretsen J, Hallin J, Blasina A, Zhang E, Nguyen L, Sun M, Vogt PK, McHarg A, Cheng H, Christensen JG, Kan JL, Bagrodia S.

Mol Cancer Ther. 2011 Nov;10(11):2189-99. doi: 10.1158/1535-7163.MCT-11-0185. Epub 2011 Jul 12.


Effective targeting of triple-negative breast cancer cells by PF-4942847, a novel oral inhibitor of Hsp 90.

Mehta PP, Whalen P, Baxi SM, Kung PP, Yamazaki S, Yin MJ.

Clin Cancer Res. 2011 Aug 15;17(16):5432-42. doi: 10.1158/1078-0432.CCR-11-0592. Epub 2011 Jun 29. Retraction in: Clin Cancer Res. 2017 Jan 15;23 (2):612.


Pharmacokinetic-pharmacodynamic modeling of biomarker response and tumor growth inhibition to an orally available heat shock protein 90 inhibitor in a human tumor xenograft mouse model.

Yamazaki S, Nguyen L, Vekich S, Shen Z, Yin MJ, Mehta PP, Kung PP, Vicini P.

J Pharmacol Exp Ther. 2011 Sep;338(3):964-73. doi: 10.1124/jpet.111.181339. Epub 2011 Jun 16.


Design strategies to target crystallographic waters applied to the Hsp90 molecular chaperone.

Kung PP, Sinnema PJ, Richardson P, Hickey MJ, Gajiwala KS, Wang F, Huang B, McClellan G, Wang J, Maegley K, Bergqvist S, Mehta PP, Kania R.

Bioorg Med Chem Lett. 2011 Jun 15;21(12):3557-62. doi: 10.1016/j.bmcl.2011.04.130. Epub 2011 May 5.


Optimization of potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitors of heat shock protein 90. Identification of development candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide.

Zehnder L, Bennett M, Meng J, Huang B, Ninkovic S, Wang F, Braganza J, Tatlock J, Jewell T, Zhou JZ, Burke B, Wang J, Maegley K, Mehta PP, Yin MJ, Gajiwala KS, Hickey MJ, Yamazaki S, Smith E, Kang P, Sistla A, Dovalsantos E, Gehring MR, Kania R, Wythes M, Kung PP.

J Med Chem. 2011 May 12;54(9):3368-85. doi: 10.1021/jm200128m. Epub 2011 Apr 20.


Does anesthesiologist-directed sedation for ERCP improve deep cannulation and complication rates?

Mehta PP, Vargo JJ, Dumot JA, Parsi MA, Lopez R, Zuccaro G.

Dig Dis Sci. 2011 Jul;56(7):2185-90. doi: 10.1007/s10620-011-1568-3. Epub 2011 Jan 28.


RETRACTED: A novel class of specific Hsp90 small molecule inhibitors demonstrate in vitro and in vivo anti-tumor activity in human melanoma cells.

Mehta PP, Kung PP, Yamazaki S, Walls M, Shen A, Nguyen L, Gehring MR, Los G, Smeal T, Yin MJ.

Cancer Lett. 2011 Jan 1;300(1):30-9. doi: 10.1016/j.canlet.2010.09.002. Retraction in: Cancer Lett. 2018 May 28;422:132.


Assembly of connexin43 into gap junctions is regulated differentially by E-cadherin and N-cadherin in rat liver epithelial cells.

Govindarajan R, Chakraborty S, Johnson KE, Falk MM, Wheelock MJ, Johnson KR, Mehta PP.

Mol Biol Cell. 2010 Dec;21(23):4089-107. doi: 10.1091/mbc.E10-05-0403. Epub 2010 Sep 29.


PF-03732010: a fully human monoclonal antibody against P-cadherin with antitumor and antimetastatic activity.

Zhang CC, Yan Z, Zhang Q, Kuszpit K, Zasadny K, Qiu M, Painter CL, Wong A, Kraynov E, Arango ME, Mehta PP, Popoff I, Casperson GF, Los G, Bender S, Anderes K, Christensen JG, VanArsdale T.

Clin Cancer Res. 2010 Nov 1;16(21):5177-88. doi: 10.1158/1078-0432.CCR-10-1343. Epub 2010 Sep 9.


Orally active MMP-1 sparing α-tetrahydropyranyl and α-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease.

Becker DP, Barta TE, Bedell LJ, Boehm TL, Bond BR, Carroll J, Carron CP, Decrescenzo GA, Easton AM, Freskos JN, Funckes-Shippy CL, Heron M, Hockerman S, Howard CP, Kiefer JR, Li MH, Mathis KJ, McDonald JJ, Mehta PP, Munie GE, Sunyer T, Swearingen CA, Villamil CI, Welsch D, Williams JM, Yu Y, Yao J.

J Med Chem. 2010 Sep 23;53(18):6653-80. doi: 10.1021/jm100669j.


E-cadherin differentially regulates the assembly of Connexin43 and Connexin32 into gap junctions in human squamous carcinoma cells.

Chakraborty S, Mitra S, Falk MM, Caplan SH, Wheelock MJ, Johnson KR, Mehta PP.

J Biol Chem. 2010 Apr 2;285(14):10761-76. doi: 10.1074/jbc.M109.053348. Epub 2010 Jan 10.


Solution-phase parallel synthesis of Hsp90 inhibitors.

Cho-Schultz S, Patten MJ, Huang B, Elleraas J, Gajiwala KS, Hickey MJ, Wang J, Mehta PP, Kang P, Gehring MR, Kung PP, Sutton SC.

J Comb Chem. 2009 Sep-Oct;11(5):860-74. doi: 10.1021/cc900056d.


MUC4 mucin interacts with and stabilizes the HER2 oncoprotein in human pancreatic cancer cells.

Chaturvedi P, Singh AP, Chakraborty S, Chauhan SC, Bafna S, Meza JL, Singh PK, Hollingsworth MA, Mehta PP, Batra SK.

Cancer Res. 2008 Apr 1;68(7):2065-70. doi: 10.1158/0008-5472.CAN-07-6041. Erratum in: Cancer Res. 2008 May 1;68(9):3550.


Improvement of cytotoxic effects induced by mitoxantrone on hormone-refractory metastatic prostate cancer cells by co-targeting epidermal growth factor receptor and hedgehog signaling cascades.

Mimeault M, Mehta PP, Hauke R, Henichart JP, Depreux P, Lin MF, Batra SK.

Growth Factors. 2007 Dec;25(6):400-16. doi: 10.1080/08977190801930935.


Functions of normal and malignant prostatic stem/progenitor cells in tissue regeneration and cancer progression and novel targeting therapies.

Mimeault M, Mehta PP, Hauke R, Batra SK.

Endocr Rev. 2008 Apr;29(2):234-52. doi: 10.1210/er.2007-0040. Epub 2008 Feb 21. Review.


Introduction: a tribute to cell-to-cell channels.

Mehta PP.

J Membr Biol. 2007 Jun;217(1-3):5-12. Epub 2007 Sep 19. Review. No abstract available.


IFN-gamma-induced expression of MUC4 in pancreatic cancer cells is mediated by STAT-1 upregulation: a novel mechanism for IFN-gamma response.

Andrianifahanana M, Singh AP, Nemos C, Ponnusamy MP, Moniaux N, Mehta PP, Varshney GC, Batra SK.

Oncogene. 2007 Nov 8;26(51):7251-61. Epub 2007 May 21.


Androgen-regulated formation and degradation of gap junctions in androgen-responsive human prostate cancer cells.

Mitra S, Annamalai L, Chakraborty S, Johnson K, Song XH, Batra SK, Mehta PP.

Mol Biol Cell. 2006 Dec;17(12):5400-16. Epub 2006 Oct 18.


Synthesis and structure-activity relationships of beta- and alpha-piperidine sulfone hydroxamic acid matrix metalloproteinase inhibitors with oral antitumor efficacy.

Becker DP, Villamil CI, Barta TE, Bedell LJ, Boehm TL, Decrescenzo GA, Freskos JN, Getman DP, Hockerman S, Heintz R, Howard SC, Li MH, McDonald JJ, Carron CP, Funckes-Shippy CL, Mehta PP, Munie GE, Swearingen CA.

J Med Chem. 2005 Oct 20;48(21):6713-30.


Laparoscopic-assisted colon resections: long-term results and survival.

Mehta PP, Griffin J, Ganta S, Rangraj M, Steichen F.

JSLS. 2005 Apr-Jun;9(2):184-8.


Synergy between celecoxib and radiotherapy results from inhibition of cyclooxygenase-2-derived prostaglandin E2, a survival factor for tumor and associated vasculature.

Davis TW, O'Neal JM, Pagel MD, Zweifel BS, Mehta PP, Heuvelman DM, Masferrer JL.

Cancer Res. 2004 Jan 1;64(1):279-85.


Discovery of novel benzothiazolesulfonamides as potent inhibitors of HIV-1 protease.

Nagarajan SR, De Crescenzo GA, Getman DP, Lu HF, Sikorski JA, Walker JL, McDonald JJ, Houseman KA, Kocan GP, Kishore N, Mehta PP, Funkes-Shippy CL, Blystone L.

Bioorg Med Chem. 2003 Nov 3;11(22):4769-77.


Impaired trafficking of connexins in androgen-independent human prostate cancer cell lines and its mitigation by alpha-catenin.

Govindarajan R, Zhao S, Song XH, Guo RJ, Wheelock M, Johnson KR, Mehta PP.

J Biol Chem. 2002 Dec 20;277(51):50087-97. Epub 2002 Aug 29.


Identification, characterization, and differentiation of human prostate cells.

Mehta PP, Perez-Stable C, Roos BA, Nadji M.

Methods Mol Biol. 2000;137:317-35. No abstract available.


Suppression of human prostate cancer cell growth by forced expression of connexin genes.

Mehta PP, Perez-Stable C, Nadji M, Mian M, Asotra K, Roos BA.

Dev Genet. 1999;24(1-2):91-110.


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