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Items: 1 to 50 of 98

1.

Depletion of B cells rejuvenates the peripheral B-cell compartment but is insufficient to restore immune competence in aging.

Avivi I, Zisman-Rozen S, Naor S, Dai I, Benhamou D, Shahaf G, Tabibian-Keissar H, Rosenthal N, Rakovsky A, Hanna A, Shechter A, Peled E, Benyamini N, Dmitrukha E, Barshack I, Mehr R, Melamed D.

Aging Cell. 2019 Aug;18(4):e12959. doi: 10.1111/acel.12959. Epub 2019 May 6.

2.

Editorial: Integrative Computational Systems Biology Approaches in Immunology and Medicine.

Kaderali L, Theis F, Ganusov VV, Ciupe SM, Mehr R, Ribeiro RM, Hernandez-Vargas EA.

Front Microbiol. 2019 Jan 23;9:3338. doi: 10.3389/fmicb.2018.03338. eCollection 2018. No abstract available.

3.

Transforming growth factor-β1 mediated CHST11 and CHSY1 mRNA expression is ROS dependent in vascular smooth muscle cells.

Mohamed R, Dayati P, Mehr RN, Kamato D, Seif F, Babaahmadi-Rezaei H, Little PJ.

J Cell Commun Signal. 2019 Jun;13(2):225-233. doi: 10.1007/s12079-018-0495-x. Epub 2018 Nov 11.

4.

A Critical Role for HlgA in Staphylococcus aureus Pathogenesis Revealed by A Switch in the SaeRS Two-Component Regulatory System.

Venkatasubramaniam A, Kanipakala T, Ganjbaksh N, Mehr R, Mukherjee I, Krishnan S, Bae T, Aman MJ, Adhikari RP.

Toxins (Basel). 2018 Sep 18;10(9). pii: E377. doi: 10.3390/toxins10090377.

5.

Efficiency of piezotome-corticision assisted orthodontics in alleviating mandibular anterior crowding-a randomized clinical trial.

Uribe F, Davoody L, Mehr R, Jayaratne YSN, Almas K, Sobue T, Allareddy V, Nanda R.

Eur J Orthod. 2017 Nov 30;39(6):595-600. doi: 10.1093/ejo/cjw091.

PMID:
28371882
6.

Limited clonal relatedness between gut IgA plasma cells and memory B cells after oral immunization.

Bemark M, Hazanov H, Strömberg A, Komban R, Holmqvist J, Köster S, Mattsson J, Sikora P, Mehr R, Lycke NY.

Nat Commun. 2016 Sep 6;7:12698. doi: 10.1038/ncomms12698.

7.

Corrigendum: Long-lived antigen-induced IgM plasma cells demonstrate somatic mutations and contribute to long-term protection.

Bohannon C, Powers R, Satyabhama L, Cui A, Tipton C, Michaeli M, Skountzou I, Mittler RS, Kleinstein SH, Mehr R, Lee FE, Sanz I, Jacob J.

Nat Commun. 2016 Aug 16;7:12687. doi: 10.1038/ncomms12687. No abstract available.

8.

Long-lived antigen-induced IgM plasma cells demonstrate somatic mutations and contribute to long-term protection.

Bohannon C, Powers R, Satyabhama L, Cui A, Tipton C, Michaeli M, Skountzou I, Mittler RS, Kleinstein SH, Mehr R, Lee FE, Sanz I, Jacob J.

Nat Commun. 2016 Jun 7;7:11826. doi: 10.1038/ncomms11826. Erratum in: Nat Commun. 2016 Aug 16;7:12687. Lee, Francis Eun-Hyung [Lee, Frances Eun-Hyung].

9.

B Cell Development in the Bone Marrow Is Regulated by Homeostatic Feedback Exerted by Mature B Cells.

Shahaf G, Zisman-Rozen S, Benhamou D, Melamed D, Mehr R.

Front Immunol. 2016 Mar 22;7:77. doi: 10.3389/fimmu.2016.00077. eCollection 2016.

10.

Murine peripheral NK-cell populations originate from site-specific immature NK cells more than from BM-derived NK cells.

Pinhas N, Sternberg-Simon M, Chiossone L, Shahaf G, Walzer T, Vivier E, Mehr R.

Eur J Immunol. 2016 May;46(5):1258-70. doi: 10.1002/eji.201545847. Epub 2016 Mar 31.

11.

Aging affects B-cell antigen receptor repertoire diversity in primary and secondary lymphoid tissues.

Tabibian-Keissar H, Hazanov L, Schiby G, Rosenthal N, Rakovsky A, Michaeli M, Shahaf GL, Pickman Y, Rosenblatt K, Melamed D, Dunn-Walters D, Mehr R, Barshack I.

Eur J Immunol. 2016 Feb;46(2):480-92. doi: 10.1002/eji.201545586. Epub 2015 Dec 20.

12.

Failure rates of mini-implants placed in the infrazygomatic region.

Uribe F, Mehr R, Mathur A, Janakiraman N, Allareddy V.

Prog Orthod. 2015;16:31. doi: 10.1186/s40510-015-0100-2. Epub 2015 Sep 15.

13.

High Throughput Sequencing Analysis of the Immunoglobulin Heavy Chain Gene from Flow-Sorted B Cell Sub-Populations Define the Dynamics of Follicular Lymphoma Clonal Evolution.

Carlotti E, Wrench D, Rosignoli G, Marzec J, Sangaralingam A, Hazanov L, Michaeli M, Hallam S, Chaplin T, Iqbal S, Calaminici M, Young B, Mehr R, Campbell P, Fitzgibbon J, Gribben JG.

PLoS One. 2015 Sep 1;10(9):e0134833. doi: 10.1371/journal.pone.0134833. eCollection 2015.

14.

Antioxidant activity of different parts of Pistacia khinjuk Stocks fruit and its correlation to phenolic composition.

Hatamnia AA, Rostamzad A, Malekzadeh P, Darvishzadeh R, Abbaspour N, Hosseini M, Nourollahi K, Mehr RS.

Nat Prod Res. 2016 Jun;30(12):1445-50. doi: 10.1080/14786419.2015.1060593. Epub 2015 Jul 13.

PMID:
26166043
15.

Diversification of memory B cells drives the continuous adaptation of secretory antibodies to gut microbiota.

Lindner C, Thomsen I, Wahl B, Ugur M, Sethi MK, Friedrichsen M, Smoczek A, Ott S, Baumann U, Suerbaum S, Schreiber S, Bleich A, Gaboriau-Routhiau V, Cerf-Bensussan N, Hazanov H, Mehr R, Boysen P, Rosenstiel P, Pabst O.

Nat Immunol. 2015 Aug;16(8):880-8. doi: 10.1038/ni.3213. Epub 2015 Jun 29.

PMID:
26147688
16.

Diversity, cellular origin and autoreactivity of antibody-secreting cell population expansions in acute systemic lupus erythematosus.

Tipton CM, Fucile CF, Darce J, Chida A, Ichikawa T, Gregoretti I, Schieferl S, Hom J, Jenks S, Feldman RJ, Mehr R, Wei C, Lee FE, Cheung WC, Rosenberg AF, Sanz I.

Nat Immunol. 2015 Jul;16(7):755-65. doi: 10.1038/ni.3175. Epub 2015 May 25.

17.

Immune system modeling and analysis.

Mehr R.

Front Immunol. 2014 Dec 19;5:644. doi: 10.3389/fimmu.2014.00644. eCollection 2014. No abstract available.

18.

Old questions, new tools: does next-generation sequencing hold the key to unraveling intestinal B-cell responses?

Pabst O, Hazanov H, Mehr R.

Mucosal Immunol. 2015 Jan;8(1):29-37. doi: 10.1038/mi.2014.103. Epub 2014 Nov 12. Review.

PMID:
25389035
19.

Frequency and phenotype of B cell subpopulations in young and aged HIV-1 infected patients receiving ART.

Amu S, Lavy-Shahaf G, Cagigi A, Hejdeman B, Nozza S, Lopalco L, Mehr R, Chiodi F.

Retrovirology. 2014 Sep 11;11:76. doi: 10.1186/s12977-014-0076-x.

20.

Immunoglobulin gene repertoire diversification and selection in the stomach - from gastritis to gastric lymphomas.

Michaeli M, Tabibian-Keissar H, Schiby G, Shahaf G, Pickman Y, Hazanov L, Rosenblatt K, Dunn-Walters DK, Barshack I, Mehr R.

Front Immunol. 2014 Jun 3;5:264. doi: 10.3389/fimmu.2014.00264. eCollection 2014.

21.

The V(H) repertoire and clonal diversification of B cells in inflammatory myopathies.

McIntyre D, Zuckerman NS, Field M, Mehr R, Stott DI.

Eur J Immunol. 2014 Feb;44(2):585-96. doi: 10.1002/eji.201343315. Epub 2014 Jan 16.

22.

Automated analysis of immunoglobulin genes from high-throughput sequencing: life without a template.

Michaeli M, Barak M, Hazanov L, Noga H, Mehr R.

J Clin Bioinforma. 2013 Aug 27;3(1):15. doi: 10.1186/2043-9113-3-15.

23.

BCR CDR3 length distributions differ between blood and spleen and between old and young patients, and TCR distributions can be used to detect myelodysplastic syndrome.

Pickman Y, Dunn-Walters D, Mehr R.

Phys Biol. 2013 Oct;10(5):056001. doi: 10.1088/1478-3975/10/5/056001. Epub 2013 Aug 22.

PMID:
23965732
24.

[B lymphocyte clonal evolution of human reactive lymph nodes revealed by lineage tree analysis].

Tabibian-Keissar H, Schiby G, Azogui-Rosenthal N, Hazanov H, Rakovsky AS, Michaeli M, Rosenblatt K, Mehr R, Barshack I.

Harefuah. 2013 Jun;152(6):330-3, 369. Hebrew.

PMID:
23885464
25.

Natural killer cell inhibitory receptor expression in humans and mice: a closer look.

Sternberg-Simon M, Brodin P, Pickman Y, Onfelt B, Kärre K, Malmberg KJ, Höglund P, Mehr R.

Front Immunol. 2013 Mar 26;4:65. doi: 10.3389/fimmu.2013.00065. eCollection 2013.

26.

Automated cleaning and pre-processing of immunoglobulin gene sequences from high-throughput sequencing.

Michaeli M, Noga H, Tabibian-Keissar H, Barshack I, Mehr R.

Front Immunol. 2012 Dec 28;3:386. doi: 10.3389/fimmu.2012.00386. eCollection 2012.

27.

Classification of human natural killer cells based on migration behavior and cytotoxic response.

Vanherberghen B, Olofsson PE, Forslund E, Sternberg-Simon M, Khorshidi MA, Pacouret S, Guldevall K, Enqvist M, Malmberg KJ, Mehr R, Önfelt B.

Blood. 2013 Feb 21;121(8):1326-34. doi: 10.1182/blood-2012-06-439851. Epub 2013 Jan 3.

PMID:
23287857
28.

Understanding natural killer cell regulation by mathematical approaches.

Watzl C, Sternberg-Simon M, Urlaub D, Mehr R.

Front Immunol. 2012 Dec 12;3:359. doi: 10.3389/fimmu.2012.00359. eCollection 2012.

29.

PCR amplification and high throughput sequencing of immunoglobulin heavy chain genes from formalin-fixed paraffin-embedded human biopsies.

Tabibian-Keissar H, Schibby G, Michaeli M, Rakovsky-Shapira A, Azogui-Rosenthal N, Dunn-Walters DK, Rosenblatt K, Mehr R, Barshack I.

Exp Mol Pathol. 2013 Feb;94(1):182-7. doi: 10.1016/j.yexmp.2012.08.002. Epub 2012 Aug 27.

PMID:
22944223
30.

Models and methods for analysis of lymphocyte repertoire generation, development, selection and evolution.

Mehr R, Sternberg-Simon M, Michaeli M, Pickman Y.

Immunol Lett. 2012 Nov-Dec;148(1):11-22. doi: 10.1016/j.imlet.2012.08.002. Epub 2012 Aug 10. Review.

PMID:
22902400
31.

Re-utilization of germinal centers in multiple Peyer's patches results in highly synchronized, oligoclonal, and affinity-matured gut IgA responses.

Bergqvist P, Stensson A, Hazanov L, Holmberg A, Mattsson J, Mehr R, Bemark M, Lycke NY.

Mucosal Immunol. 2013 Jan;6(1):122-35. doi: 10.1038/mi.2012.56. Epub 2012 Jul 11.

PMID:
22785230
32.

Lyn deficiency affects B-cell maturation as well as survival.

Shahaf G, Gross AJ, Sternberg-Simon M, Kaplan D, DeFranco AL, Mehr R.

Eur J Immunol. 2012 Feb;42(2):511-21. doi: 10.1002/eji.201141940. Epub 2011 Dec 14.

33.

Human NK cells differ more in their KIR2DL1-dependent thresholds for HLA-Cw6-mediated inhibition than in their maximal killing capacity.

Almeida CR, Ashkenazi A, Shahaf G, Kaplan D, Davis DM, Mehr R.

PLoS One. 2011;6(9):e24927. doi: 10.1371/journal.pone.0024927. Epub 2011 Sep 19.

34.

Chronic B cell deficiency from birth prevents age-related alterations in the B lineage.

Keren Z, Averbuch D, Shahaf G, Zisman-Rozen S, Golan K, Itkin T, Lapidot T, Mehr R, Melamed D.

J Immunol. 2011 Sep 1;187(5):2140-7. doi: 10.4049/jimmunol.1100999. Epub 2011 Aug 1.

35.

Immunology in Israel: society and research.

Mehr R.

Eur J Immunol. 2011 Aug;41(8):2133-6. doi: 10.1002/eji.201190048. No abstract available.

36.

Simulations of the NK cell immune synapse reveal that activation thresholds can be established by inhibitory receptors acting locally.

Kaplan A, Kotzer S, Almeida CR, Kohen R, Halpert G, Salmon-Divon M, Köhler K, Höglund P, Davis DM, Mehr R.

J Immunol. 2011 Jul 15;187(2):760-73. doi: 10.4049/jimmunol.1002208. Epub 2011 Jun 20.

37.

Reversing B cell aging.

Mehr R, Melamed D.

Aging (Albany NY). 2011 Apr;3(4):438-43.

38.

Factors important in evolutionary shaping of immunoglobulin gene loci.

Barak M, Eilat G, Unger R, Mehr R.

Immunome Res. 2010 Dec 6;6:13. doi: 10.1186/1745-7580-6-13.

39.

Ig gene diversification and selection in follicular lymphoma, diffuse large B cell lymphoma and primary central nervous system lymphoma revealed by lineage tree and mutation analyses.

Zuckerman NS, McCann KJ, Ottensmeier CH, Barak M, Shahaf G, Edelman H, Dunn-Walters D, Abraham RS, Stevenson FK, Mehr R.

Int Immunol. 2010 Nov;22(11):875-87. doi: 10.1093/intimm/dxq441. Epub 2010 Nov 8.

PMID:
21059768
40.

Natural killer cell tolerance persists despite significant reduction of self MHC class I on normal target cells in mice.

Brodin P, Lakshmikanth T, Mehr R, Johansson MH, Duru AD, Achour A, Salmon-Divon M, Kärre K, Höglund P, Johansson S.

PLoS One. 2010 Oct 4;5(10). pii: e13174. doi: 10.1371/journal.pone.0013174.

41.

Somatic hypermutation and antigen-driven selection of B cells are altered in autoimmune diseases.

Zuckerman NS, Hazanov H, Barak M, Edelman H, Hess S, Shcolnik H, Dunn-Walters D, Mehr R.

J Autoimmun. 2010 Dec;35(4):325-35. doi: 10.1016/j.jaut.2010.07.004. Epub 2010 Aug 19.

PMID:
20727711
42.

Kinetic modeling reveals a common death niche for newly formed and mature B cells.

Shahaf G, Cancro MP, Mehr R.

PLoS One. 2010 Mar 2;5(3):e9497. doi: 10.1371/journal.pone.0009497.

43.

Ectopic GC in the thymus of myasthenia gravis patients show characteristics of normal GC.

Zuckerman NS, Howard WA, Bismuth J, Gibson K, Edelman H, Berrih-Aknin S, Dunn-Walters D, Mehr R.

Eur J Immunol. 2010 Apr;40(4):1150-61. doi: 10.1002/eji.200939914.

44.

Dental enamel: genes define biomechanics.

Rauth RJ, Potter KS, Ngan AY, Saad DM, Mehr R, Luong VQ, Schuetter VL, Miklus VG, Chang P, Paine ML, Lacruz RS, Snead ML, White SN.

J Calif Dent Assoc. 2009 Dec;37(12):863-8. Review.

45.

Expression and chromosomal organization of mouse meiotic genes.

Waldman Ben-Asher H, Shahar I, Yitzchak A, Mehr R, Don J.

Mol Reprod Dev. 2010 Mar;77(3):241-8. doi: 10.1002/mrd.21139.

PMID:
19953644
46.

Evidence for large diversity in the human transcriptome created by Alu RNA editing.

Barak M, Levanon EY, Eisenberg E, Paz N, Rechavi G, Church GM, Mehr R.

Nucleic Acids Res. 2009 Nov;37(20):6905-15. doi: 10.1093/nar/gkp729. Epub 2009 Sep 8.

47.

Probing natural killer cell education by Ly49 receptor expression analysis and computational modelling in single MHC class I mice.

Johansson S, Salmon-Divon M, Johansson MH, Pickman Y, Brodin P, Kärre K, Mehr R, Höglund P.

PLoS One. 2009 Jun 25;4(6):e6046. doi: 10.1371/journal.pone.0006046.

48.

B-cell clonal diversification and gut-lymph node trafficking in ulcerative colitis revealed using lineage tree analysis.

Tabibian-Keissar H, Zuckerman NS, Barak M, Dunn-Walters DK, Steiman-Shimony A, Chowers Y, Ofek E, Rosenblatt K, Schiby G, Mehr R, Barshack I.

Eur J Immunol. 2008 Sep;38(9):2600-9. doi: 10.1002/eji.200838333.

49.

Antigen-driven selection in germinal centers as reflected by the shape characteristics of immunoglobulin gene lineage trees: a large-scale simulation study.

Shahaf G, Barak M, Zuckerman NS, Swerdlin N, Gorfine M, Mehr R.

J Theor Biol. 2008 Nov 21;255(2):210-22. doi: 10.1016/j.jtbi.2008.08.005. Epub 2008 Aug 13.

PMID:
18786548
50.

IgTree: creating Immunoglobulin variable region gene lineage trees.

Barak M, Zuckerman NS, Edelman H, Unger R, Mehr R.

J Immunol Methods. 2008 Sep 30;338(1-2):67-74. doi: 10.1016/j.jim.2008.06.006. Epub 2008 Aug 14.

PMID:
18706908

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