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Loss-of-Huntingtin in Medial and Lateral Ganglionic Lineages Differentially Disrupts Regional Interneuron and Projection Neuron Subtypes and Promotes Huntington's Disease-Associated Behavioral, Cellular, and Pathological Hallmarks.

Mehler MF, Petronglo JR, Arteaga-Bracho EE, Gulinello ME, Winchester ML, Pichamoorthy N, Young SK, DeJesus CD, Ishtiaq H, Gokhan S, Molero AE.

J Neurosci. 2019 Mar 6;39(10):1892-1909. doi: 10.1523/JNEUROSCI.2443-18.2018. Epub 2019 Jan 9.


Epigenetic mechanisms underlying nervous system diseases.

Qureshi IA, Mehler MF.

Handb Clin Neurol. 2018;147:43-58. doi: 10.1016/B978-0-444-63233-3.00005-1. Review.


Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease.

Pera M, Larrea D, Guardia-Laguarta C, Montesinos J, Velasco KR, Agrawal RR, Xu Y, Chan RB, Di Paolo G, Mehler MF, Perumal GS, Macaluso FP, Freyberg ZZ, Acin-Perez R, Enriquez JA, Schon EA, Area-Gomez E.

EMBO J. 2017 Nov 15;36(22):3356-3371. doi: 10.15252/embj.201796797. Epub 2017 Oct 10.


Author response: A dedicated scholarly research program in an adult and pediatric neurology residency program.

Robbins MS, Mehler MF.

Neurology. 2017 Sep 5;89(10):1095-1096. doi: 10.1212/WNL.0000000000004348. No abstract available.


A dedicated scholarly research program in an adult and pediatric neurology residency program.

Robbins MS, Haut SR, Lipton RB, Milstein MJ, Ocava LC, Ballaban-Gil K, Moshé SL, Mehler MF.

Neurology. 2017 Apr 4;88(14):1366-1370. doi: 10.1212/WNL.0000000000003626. Epub 2017 Feb 22.


Shining a light on early stress responses and late-onset disease vulnerability.

Mehler MF.

Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2109-2111. doi: 10.1073/pnas.1700323114. Epub 2017 Feb 8. No abstract available.


Postnatal and adult consequences of loss of huntingtin during development: Implications for Huntington's disease.

Arteaga-Bracho EE, Gulinello M, Winchester ML, Pichamoorthy N, Petronglo JR, Zambrano AD, Inocencio J, De Jesus CD, Louie JO, Gokhan S, Mehler MF, Molero AE.

Neurobiol Dis. 2016 Dec;96:144-155. doi: 10.1016/j.nbd.2016.09.006. Epub 2016 Sep 10.


Selective expression of mutant huntingtin during development recapitulates characteristic features of Huntington's disease.

Molero AE, Arteaga-Bracho EE, Chen CH, Gulinello M, Winchester ML, Pichamoorthy N, Gokhan S, Khodakhah K, Mehler MF.

Proc Natl Acad Sci U S A. 2016 May 17;113(20):5736-41. doi: 10.1073/pnas.1603871113. Epub 2016 May 2.


Emerging Roles for CSF-1 Receptor and its Ligands in the Nervous System.

Chitu V, Gokhan Ş, Nandi S, Mehler MF, Stanley ER.

Trends Neurosci. 2016 Jun;39(6):378-393. doi: 10.1016/j.tins.2016.03.005. Epub 2016 Apr 12. Review.


Hippocampal-dependent neurocognitive impairment following cranial irradiation observed in pre-clinical models: current knowledge and possible future directions.

Tomé WA, Gökhan Ş, Gulinello ME, Brodin NP, Heard J, Mehler MF, Guha C.

Br J Radiol. 2016;89(1057):20150762. doi: 10.1259/bjr.20150762. Epub 2015 Oct 30. Review.


A mouse model replicating hippocampal sparing cranial irradiation in humans: A tool for identifying new strategies to limit neurocognitive decline.

Tomé WA, Gökhan Ş, Brodin NP, Gulinello ME, Heard J, Mehler MF, Guha C.

Sci Rep. 2015 Sep 24;5:14384. doi: 10.1038/srep14384.


Epigenetics and therapeutic targets mediating neuroprotection.

Qureshi IA, Mehler MF.

Brain Res. 2015 Dec 2;1628(Pt B):265-272. doi: 10.1016/j.brainres.2015.07.034. Epub 2015 Jul 30. Review.


Animal extremists' threats to neurologic research continue: Neuroreality II.

Beversdorf DQ, Roos RP, Hauser WA, Lennon VA, Mehler MF.

Neurology. 2015 Aug 25;85(8):730-4. doi: 10.1212/WNL.0000000000001764. Epub 2015 Jul 8. Review. No abstract available.


Phenotypic characterization of a Csf1r haploinsufficient mouse model of adult-onset leukodystrophy with axonal spheroids and pigmented glia (ALSP).

Chitu V, Gokhan S, Gulinello M, Branch CA, Patil M, Basu R, Stoddart C, Mehler MF, Stanley ER.

Neurobiol Dis. 2015 Feb;74:219-28. doi: 10.1016/j.nbd.2014.12.001. Epub 2014 Dec 9.


Epigenetic mechanisms underlying the pathogenesis of neurogenetic diseases.

Qureshi IA, Mehler MF.

Neurotherapeutics. 2014 Oct;11(4):708-20. doi: 10.1007/s13311-014-0302-1. Review.


An evolving view of epigenetic complexity in the brain.

Qureshi IA, Mehler MF.

Philos Trans R Soc Lond B Biol Sci. 2014 Sep 26;369(1652). pii: 20130506. doi: 10.1098/rstb.2013.0506. Review.


Sex, epilepsy, and epigenetics.

Qureshi IA, Mehler MF.

Neurobiol Dis. 2014 Dec;72 Pt B:210-6. doi: 10.1016/j.nbd.2014.06.019. Epub 2014 Jul 4. Review.


The role of H1 linker histone subtypes in preserving the fidelity of elaboration of mesendodermal and neuroectodermal lineages during embryonic development.

Nguyen GD, Gokhan S, Molero AE, Yang SM, Kim BJ, Skoultchi AI, Mehler MF.

PLoS One. 2014 May 6;9(5):e96858. doi: 10.1371/journal.pone.0096858. eCollection 2014.


Epigenetics of sleep and chronobiology.

Qureshi IA, Mehler MF.

Curr Neurol Neurosci Rep. 2014 Mar;14(3):432. doi: 10.1007/s11910-013-0432-6. Review.


Developing epigenetic diagnostics and therapeutics for brain disorders.

Qureshi IA, Mehler MF.

Trends Mol Med. 2013 Dec;19(12):732-41. doi: 10.1016/j.molmed.2013.09.003. Epub 2013 Oct 18. Review.


Towards a 'systems'-level understanding of the nervous system and its disorders.

Qureshi IA, Mehler MF.

Trends Neurosci. 2013 Nov;36(11):674-84. doi: 10.1016/j.tins.2013.07.003. Epub 2013 Aug 27. Review.


Functions of huntingtin in germ layer specification and organogenesis.

Nguyen GD, Molero AE, Gokhan S, Mehler MF.

PLoS One. 2013 Aug 13;8(8):e72698. doi: 10.1371/journal.pone.0072698. eCollection 2013. Erratum in: PLoS One. 2013;8(9). doi:10.1371/annotation/edee8dfa-6b2a-44f4-866a-098f186e27f0.


Long non-coding RNAs: novel targets for nervous system disease diagnosis and therapy.

Qureshi IA, Mehler MF.

Neurotherapeutics. 2013 Oct;10(4):632-46. doi: 10.1007/s13311-013-0199-0. Review.


Receptor-type protein-tyrosine phosphatase ζ is a functional receptor for interleukin-34.

Nandi S, Cioce M, Yeung YG, Nieves E, Tesfa L, Lin H, Hsu AW, Halenbeck R, Cheng HY, Gokhan S, Mehler MF, Stanley ER.

J Biol Chem. 2013 Jul 26;288(30):21972-86. doi: 10.1074/jbc.M112.442731. Epub 2013 Jun 6.


Selective roles of normal and mutant huntingtin in neural induction and early neurogenesis.

Nguyen GD, Gokhan S, Molero AE, Mehler MF.

PLoS One. 2013 May 14;8(5):e64368. doi: 10.1371/journal.pone.0064368. Print 2013.


Understanding neurological disease mechanisms in the era of epigenetics.

Qureshi IA, Mehler MF.

JAMA Neurol. 2013 Jun;70(6):703-10. doi: 10.1001/jamaneurol.2013.1443. Review.


Development and neurodegeneration: turning HD pathogenesis on its head.

Marder K, Mehler MF.

Neurology. 2012 Aug 14;79(7):621-2. doi: 10.1212/WNL.0b013e3182648bfe. Epub 2012 Jul 18. No abstract available.


Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease.

Qureshi IA, Mehler MF.

Nat Rev Neurosci. 2012 Jul 20;13(8):528-41. doi: 10.1038/nrn3234. Review.


Epigenetic mechanisms governing the process of neurodegeneration.

Qureshi IA, Mehler MF.

Mol Aspects Med. 2013 Jul-Aug;34(4):875-82. doi: 10.1016/j.mam.2012.06.011. Epub 2012 Jul 7. Review.


The CSF-1 receptor ligands IL-34 and CSF-1 exhibit distinct developmental brain expression patterns and regulate neural progenitor cell maintenance and maturation.

Nandi S, Gokhan S, Dai XM, Wei S, Enikolopov G, Lin H, Mehler MF, Stanley ER.

Dev Biol. 2012 Jul 15;367(2):100-13. doi: 10.1016/j.ydbio.2012.03.026. Epub 2012 Apr 19.


Alu transcription: a rheostat for stem cell aging?

Qureshi IA, Mehler MF.

Cell Cycle. 2011 Nov 15;10(22):3820-1. doi: 10.4161/cc.10.22.18194. Epub 2011 Nov 15. No abstract available.


Advances in epigenetics and epigenomics for neurodegenerative diseases.

Qureshi IA, Mehler MF.

Curr Neurol Neurosci Rep. 2011 Oct;11(5):464-73. doi: 10.1007/s11910-011-0210-2. Review.


Diagnosing and Treating Nervous System Disorders by Targeting Novel Classes of Non-coding RNAs.

Qureshi IA, Mehler MF.

Int Drug Discov. 2011 Jun-Jul;6(3):30-36. No abstract available.


Non-coding RNA networks underlying cognitive disorders across the lifespan.

Qureshi IA, Mehler MF.

Trends Mol Med. 2011 Jun;17(6):337-46. doi: 10.1016/j.molmed.2011.02.002. Epub 2011 Mar 15. Review.


The emerging role of epigenetics in stroke: III. Neural stem cell biology and regenerative medicine.

Qureshi IA, Mehler MF.

Arch Neurol. 2011 Mar;68(3):294-302. doi: 10.1001/archneurol.2011.6. Review.


Epigenetics, nervous system tumors, and cancer stem cells.

Qureshi IA, Mehler MF.

Cancers (Basel). 2011 Sep 13;3(3):3525-56. doi: 10.3390/cancers3033525.


The emerging role of epigenetics in stroke: II. RNA regulatory circuitry.

Qureshi IA, Mehler MF.

Arch Neurol. 2010 Dec;67(12):1435-41. doi: 10.1001/archneurol.2010.300. Review.


Genetic and epigenetic underpinnings of sex differences in the brain and in neurological and psychiatric disease susceptibility.

Qureshi IA, Mehler MF.

Prog Brain Res. 2010;186:77-95. doi: 10.1016/B978-0-444-53630-3.00006-3. Review.


REST and CoREST are transcriptional and epigenetic regulators of seminal neural fate decisions.

Qureshi IA, Gokhan S, Mehler MF.

Cell Cycle. 2010 Nov 15;9(22):4477-86. Epub 2010 Nov 15. Review.


Emerging role of epigenetics in stroke: part 1: DNA methylation and chromatin modifications.

Qureshi IA, Mehler MF.

Arch Neurol. 2010 Nov;67(11):1316-22. doi: 10.1001/archneurol.2010.275. Review.


Fate mapping analysis reveals that adult microglia derive from primitive macrophages.

Ginhoux F, Greter M, Leboeuf M, Nandi S, See P, Gokhan S, Mehler MF, Conway SJ, Ng LG, Stanley ER, Samokhvalov IM, Merad M.

Science. 2010 Nov 5;330(6005):841-5. doi: 10.1126/science.1194637. Epub 2010 Oct 21.


Impact of nuclear organization and dynamics on epigenetic regulation in the central nervous system: implications for neurological disease states.

Qureshi IA, Mehler MF.

Ann N Y Acad Sci. 2010 Sep;1204 Suppl:E20-37. doi: 10.1111/j.1749-6632.2010.05718.x. Review.


Epigenetics and neuropsychiatric diseases: introduction and meeting summary.

Mehler MF.

Ann N Y Acad Sci. 2010 Sep;1204 Suppl:E1-7. doi: 10.1111/j.1749-6632.2010.05717.x.


Corepressor for element-1-silencing transcription factor preferentially mediates gene networks underlying neural stem cell fate decisions.

Abrajano JJ, Qureshi IA, Gokhan S, Molero AE, Zheng D, Bergman A, Mehler MF.

Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16685-90. doi: 10.1073/pnas.0906917107. Epub 2010 Sep 7.


Emerging themes in epigenetics: implications for understanding and treating nervous system disorders.

Qureshi IA, Mehler MF.

Epigenomics. 2010 Jun;2(3):345-9. doi: 10.2217/epi.10.17. No abstract available.


Long non-coding RNAs in nervous system function and disease.

Qureshi IA, Mattick JS, Mehler MF.

Brain Res. 2010 Jun 18;1338:20-35. doi: 10.1016/j.brainres.2010.03.110. Epub 2010 Apr 7. Review.


Introduction: epigenetics and neuropsychiatric diseases.

Mehler MF.

Neurobiol Dis. 2010 Jul;39(1):1-2. doi: 10.1016/j.nbd.2010.02.006. Epub 2010 Feb 24. No abstract available.


Epigenetic mechanisms underlying human epileptic disorders and the process of epileptogenesis.

Qureshi IA, Mehler MF.

Neurobiol Dis. 2010 Jul;39(1):53-60. doi: 10.1016/j.nbd.2010.02.005. Epub 2010 Feb 24. Review.


Long noncoding RNAs in neuronal-glial fate specification and oligodendrocyte lineage maturation.

Mercer TR, Qureshi IA, Gokhan S, Dinger ME, Li G, Mattick JS, Mehler MF.

BMC Neurosci. 2010 Feb 5;11:14. doi: 10.1186/1471-2202-11-14.

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