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Items: 1 to 50 of 156

1.

Netrin-1 and its receptor DCC are causally implicated in melanoma progression.

Boussouar A, Tortereau A, Manceau A, Paradisi A, Gadot N, Vial J, Neves D, Larue L, Battistella M, Leboeuf C, Lebbé C, Janin A, Mehlen P.

Cancer Res. 2019 Dec 5. pii: canres.1590.2018. doi: 10.1158/0008-5472.CAN-18-1590. [Epub ahead of print]

PMID:
31806640
2.

Cancer-Associated Fibroblasts Produce Netrin-1 to Control Cancer Cell Plasticity.

Sung PJ, Rama N, Imbach J, Fiore S, Ducarouge B, Neves D, Chen HW, Bernard D, Yang PC, Bernet A, Depil S, Mehlen P.

Cancer Res. 2019 Jul 15;79(14):3651-3661. doi: 10.1158/0008-5472.CAN-18-2952. Epub 2019 May 14.

PMID:
31088838
3.

Synergistic Activity of Floor-Plate- and Ventricular-Zone-Derived Netrin-1 in Spinal Cord Commissural Axon Guidance.

Moreno-Bravo JA, Roig Puiggros S, Mehlen P, Chédotal A.

Neuron. 2019 Feb 20;101(4):625-634.e3. doi: 10.1016/j.neuron.2018.12.024. Epub 2019 Jan 17.

PMID:
30661739
4.

Ultrasound molecular imaging as a non-invasive companion diagnostic for netrin-1 interference therapy in breast cancer.

Wischhusen J, Wilson KE, Delcros JG, Molina-Peña R, Gibert B, Jiang S, Ngo J, Goldschneider D, Mehlen P, Willmann JK, Padilla F.

Theranostics. 2018 Oct 6;8(18):5126-5142. doi: 10.7150/thno.27221. eCollection 2018.

5.

The Proto-oncogene c-Kit Inhibits Tumor Growth by Behaving as a Dependence Receptor.

Wang H, Boussouar A, Mazelin L, Tauszig-Delamasure S, Sun Y, Goldschneider D, Paradisi A, Mehlen P.

Mol Cell. 2018 Nov 1;72(3):413-425.e5. doi: 10.1016/j.molcel.2018.08.040. Epub 2018 Oct 4.

6.

Notch Signaling in the Tumor Microenvironment.

Meurette O, Mehlen P.

Cancer Cell. 2018 Oct 8;34(4):536-548. doi: 10.1016/j.ccell.2018.07.009. Epub 2018 Aug 23. Review.

7.

The dependence receptor TrkC regulates the number of sensory neurons during DRG development.

Ménard M, Costechareyre C, Coelho-Aguiar JM, Jarrosson-Wuilleme L, Rama N, Blachier J, Kindbeiter K, Bozon M, Cabrera JR, Dupin E, Le Douarin N, Mehlen P, Tauszig-Delamasure S.

Dev Biol. 2018 Oct 15;442(2):249-261. doi: 10.1016/j.ydbio.2018.07.022. Epub 2018 Jul 31.

8.

The Ectodysplasin receptor EDAR acts as a tumor suppressor in melanoma by conditionally inducing cell death.

Vial J, Royet A, Cassier P, Tortereau A, Dinvaut S, Maillet D, Gratadou-Hupon L, Creveaux M, Sadier A, Tondeur G, Léon S, Depaepe L, Pantalacci S, de la Fouchardière A, Micheau O, Dalle S, Laudet V, Mehlen P, Castets M.

Cell Death Differ. 2019 Mar;26(3):443-454. doi: 10.1038/s41418-018-0128-1. Epub 2018 May 31.

PMID:
29855541
9.

Dependence receptors - the dark side awakens.

Negulescu AM, Mehlen P.

FEBS J. 2018 Nov;285(21):3909-3924. doi: 10.1111/febs.14507. Epub 2018 May 31. Review.

10.

Hey1- and p53-dependent TrkC proapoptotic activity controls neuroblastoma growth.

Ménard M, Costechareyre C, Ichim G, Blachier J, Neves D, Jarrosson-Wuilleme L, Depping R, Koster J, Saintigny P, Mehlen P, Tauszig-Delamasure S.

PLoS Biol. 2018 May 11;16(5):e2002912. doi: 10.1371/journal.pbio.2002912. eCollection 2018 May.

11.

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G.

Cell Death Differ. 2018 Mar;25(3):486-541. doi: 10.1038/s41418-017-0012-4. Epub 2018 Jan 23. Review.

12.

Commissural neurons transgress the CNS/PNS boundary in absence of ventricular zone-derived netrin 1.

Moreno-Bravo JA, Roig Puiggros S, Blockus H, Dominici C, Zelina P, Mehlen P, Chédotal A.

Development. 2018 Jan 17;145(2). pii: dev159400. doi: 10.1242/dev.159400.

13.

Hepatocellular carcinoma-associated depletion of the netrin-1 receptor Uncoordinated Phenotype-5A (UNC5A) skews the hepatic unfolded protein response towards prosurvival outcomes.

Barnault R, Lahlali T, Plissonnier ML, Romero-López C, Laverdure N, Ducarouge B, Rivoire M, Mehlen P, Zoulim F, Parent R.

Biochem Biophys Res Commun. 2018 Jan 22;495(4):2425-2431. doi: 10.1016/j.bbrc.2017.12.129. Epub 2017 Dec 24.

PMID:
29277614
14.

DNA methylation signal has a major role in the response of human breast cancer cells to the microenvironment.

Mathot P, Grandin M, Devailly G, Souaze F, Cahais V, Moran S, Campone M, Herceg Z, Esteller M, Juin P, Mehlen P, Dante R.

Oncogenesis. 2017 Oct 23;6(10):e390. doi: 10.1038/oncsis.2017.88.

15.

Alu RNA accumulation induces epithelial-to-mesenchymal transition by modulating miR-566 and is associated with cancer progression.

Di Ruocco F, Basso V, Rivoire M, Mehlen P, Ambati J, De Falco S, Tarallo V.

Oncogene. 2018 Feb 1;37(5):627-637. doi: 10.1038/onc.2017.369. Epub 2017 Oct 9.

16.

p53-dependent programmed necrosis controls germ cell homeostasis during spermatogenesis.

Napoletano F, Gibert B, Yacobi-Sharon K, Vincent S, Favrot C, Mehlen P, Girard V, Teil M, Chatelain G, Walter L, Arama E, Mollereau B.

PLoS Genet. 2017 Sep 25;13(9):e1007024. doi: 10.1371/journal.pgen.1007024. eCollection 2017 Sep.

17.

Reciprocal antagonism between the netrin-1 receptor uncoordinated-phenotype-5A (UNC5A) and the hepatitis C virus.

Plissonnier ML, Lahlali T, Raab M, Michelet M, Romero-López C, Rivoire M, Strebhardt K, Durantel D, Levrero M, Mehlen P, Zoulim F, Parent R.

Oncogene. 2017 Nov 30;36(48):6712-6724. doi: 10.1038/onc.2017.271. Epub 2017 Aug 7.

PMID:
28783179
18.

Non-canonical NOTCH3 signalling limits tumour angiogenesis.

Lin S, Negulescu A, Bulusu S, Gibert B, Delcros JG, Ducarouge B, Rama N, Gadot N, Treilleux I, Saintigny P, Meurette O, Mehlen P.

Nat Commun. 2017 Jul 18;8:16074. doi: 10.1038/ncomms16074.

19.

Molecular characterization of Netrin-1 and APP receptor binding: New leads to block the progression of senile plaques in Alzheimer's disease.

Borel F, Marzocca F, Delcros JG, Rama N, Mehlen P, Ferrer JL.

Biochem Biophys Res Commun. 2017 Jul 1;488(3):466-470. doi: 10.1016/j.bbrc.2017.05.056. Epub 2017 May 10.

PMID:
28501620
20.

Floor-plate-derived netrin-1 is dispensable for commissural axon guidance.

Dominici C, Moreno-Bravo JA, Puiggros SR, Rappeneau Q, Rama N, Vieugue P, Bernet A, Mehlen P, Chédotal A.

Nature. 2017 May 18;545(7654):350-354. doi: 10.1038/nature22331. Epub 2017 Apr 26.

21.

Ephrin-B3 supports glioblastoma growth by inhibiting apoptosis induced by the dependence receptor EphA4.

Royet A, Broutier L, Coissieux MM, Malleval C, Gadot N, Maillet D, Gratadou-Hupon L, Bernet A, Nony P, Treilleux I, Honnorat J, Liebl D, Pelletier L, Berger F, Meyronet D, Castets M, Mehlen P.

Oncotarget. 2017 Apr 4;8(14):23750-23759. doi: 10.18632/oncotarget.16077.

22.

Netrin-1 Protects Hepatocytes Against Cell Death Through Sustained Translation During the Unfolded Protein Response.

Lahlali T, Plissonnier ML, Romero-López C, Michelet M, Ducarouge B, Berzal-Herranz A, Zoulim F, Mehlen P, Parent R.

Cell Mol Gastroenterol Hepatol. 2016 Jan 9;2(3):281-301.e9. doi: 10.1016/j.jcmgh.2015.12.011. eCollection 2016 May.

23.

Structural decoding of netrin-4 reveals a regulatory function towards mature basement membranes.

Reuten R, Patel TR, McDougall M, Rama N, Nikodemus D, Gibert B, Delcros JG, Prein C, Meier M, Metzger S, Zhou Z, Kaltenberg J, McKee KK, Bald T, Tüting T, Zigrino P, Djonov V, Bloch W, Clausen-Schaumann H, Poschl E, Yurchenco PD, Ehrbar M, Mehlen P, Stetefeld J, Koch M.

Nat Commun. 2016 Nov 30;7:13515. doi: 10.1038/ncomms13515.

24.

[Hepatitis C, EGFR, cirrhosis and netrin-1: potential implications for HCC onset].

Plissonnier ML, Lahlali T, Mehlen P, Parent R.

Med Sci (Paris). 2016 Jun-Jul;32(6-7):566-8. doi: 10.1051/medsci/20163206013. Epub 2016 Jul 12. French. No abstract available.

25.

Inhibition of DNA methylation promotes breast tumor sensitivity to netrin-1 interference.

Grandin M, Mathot P, Devailly G, Bidet Y, Ghantous A, Favrot C, Gibert B, Gadot N, Puisieux I, Herceg Z, Delcros JG, Bernet A, Mehlen P, Dante R.

EMBO Mol Med. 2016 Aug 1;8(8):863-77. doi: 10.15252/emmm.201505945. Print 2016 Aug.

26.

Netrin-1 Interrupts Amyloid-β Amplification, Increases sAβPPα in vitro and in vivo, and Improves Cognition in a Mouse Model of Alzheimer's Disease.

Spilman PR, Corset V, Gorostiza O, Poksay KS, Galvan V, Zhang J, Rao R, Peters-Libeu C, Vincelette J, McGeehan A, Dvorak-Ewell M, Beyer J, Campagna J, Bankiewicz K, Mehlen P, John V, Bredesen DE.

J Alzheimers Dis. 2016 Mar 8;52(1):223-42. doi: 10.3233/JAD-151046.

PMID:
27060954
27.

Epidermal Growth Factor Receptor-Dependent Mutual Amplification between Netrin-1 and the Hepatitis C Virus.

Plissonnier ML, Lahlali T, Michelet M, Lebossé F, Cottarel J, Beer M, Neveu G, Durantel D, Bartosch B, Accardi R, Clément S, Paradisi A, Devouassoux-Shisheboran M, Einav S, Mehlen P, Zoulim F, Parent R.

PLoS Biol. 2016 Mar 31;14(3):e1002421. doi: 10.1371/journal.pbio.1002421. eCollection 2016 Mar.

28.

[The netrin-1 cue regulates somatic cell reprogramming to pluripotency].

Mehlen P, Lavial F.

Med Sci (Paris). 2016 Mar;32(3):241-4. doi: 10.1051/medsci/20163203005. Epub 2016 Mar 23. French. No abstract available.

29.

Targeting netrin-1/DCC interaction in diffuse large B-cell and mantle cell lymphomas.

Broutier L, Creveaux M, Vial J, Tortereau A, Delcros JG, Chazot G, McCarron MJ, Léon S, Pangault C, Gadot N, Colombe A, Boulland ML, Blachier J, Marie JC, Traverse-Glehen A, Donzé O, Chassagne-Clément C, Salles G, Tarte K, Mehlen P, Castets M.

EMBO Mol Med. 2016 Feb 1;8(2):96-104. doi: 10.15252/emmm.201505480.

30.

Structural Decoding of the Netrin-1/UNC5 Interaction and its Therapeutical Implications in Cancers.

Grandin M, Meier M, Delcros JG, Nikodemus D, Reuten R, Patel TR, Goldschneider D, Orriss G, Krahn N, Boussouar A, Abes R, Dean Y, Neves D, Bernet A, Depil S, Schneiders F, Poole K, Dante R, Koch M, Mehlen P, Stetefeld J.

Cancer Cell. 2016 Feb 8;29(2):173-85. doi: 10.1016/j.ccell.2016.01.001.

31.

Dependence Receptors and Cancer: Addiction to Trophic Ligands.

Gibert B, Mehlen P.

Cancer Res. 2015 Dec 15;75(24):5171-5. doi: 10.1158/0008-5472.CAN-14-3652. Epub 2015 Dec 1. Review.

32.

Unraveling the Role of Huntingtin in Breast Cancer Metastasis.

Thion MS, McGuire JR, Sousa CM, Fuhrmann L, Fitamant J, Leboucher S, Vacher S, du Montcel ST, Bièche I, Bernet A, Mehlen P, Vincent-Salomon A, Humbert S.

J Natl Cancer Inst. 2015 Aug 20;107(10). pii: djv208. doi: 10.1093/jnci/djv208. Print 2015 Oct.

PMID:
26293574
33.

ϒ-secretase and LARG mediate distinct RGMa activities to control appropriate layer targeting within the optic tectum.

Banerjee P, Harada H, Tassew NG, Charish J, Goldschneider D, Wallace VA, Sugita S, Mehlen P, Monnier PP.

Cell Death Differ. 2016 Mar;23(3):442-53. doi: 10.1038/cdd.2015.111. Epub 2015 Aug 21.

34.

Netrin-1 regulates somatic cell reprogramming and pluripotency maintenance.

Ozmadenci D, Féraud O, Markossian S, Kress E, Ducarouge B, Gibert B, Ge J, Durand I, Gadot N, Plateroti M, Bennaceur-Griscelli A, Scoazec JY, Gil J, Deng H, Bernet A, Mehlen P, Lavial F.

Nat Commun. 2015 Jul 8;6:7398. doi: 10.1038/ncomms8398.

35.

[Quinze questions importantes à se poser en oncologie en 2015].

Blay JY, Tredan O, Ray-Coquard I, Rivoire M, Mehlen P, Puisieux A, Bachelot T.

Bull Cancer. 2015 Jun;102(6 Suppl 1):S22-6. doi: 10.1016/S0007-4551(15)31214-5. Review. French.

PMID:
26118872
36.

Dynamics of MBD2 deposition across methylated DNA regions during malignant transformation of human mammary epithelial cells.

Devailly G, Grandin M, Perriaud L, Mathot P, Delcros JG, Bidet Y, Morel AP, Bignon JY, Puisieux A, Mehlen P, Dante R.

Nucleic Acids Res. 2015 Jul 13;43(12):5838-54. doi: 10.1093/nar/gkv508. Epub 2015 May 24.

37.

Regulation by miR181 family of the dependence receptor CDON tumor suppressive activity in neuroblastoma.

Gibert B, Delloye-Bourgeois C, Gattolliat CH, Meurette O, Le Guernevel S, Fombonne J, Ducarouge B, Lavial F, Bouhallier F, Creveaux M, Negulescu AM, Bénard J, Janoueix-Lerosey I, Harel-Bellan A, Delattre O, Mehlen P.

J Natl Cancer Inst. 2014 Oct 13;106(11). pii: dju318. doi: 10.1093/jnci/dju318. Print 2014 Nov.

PMID:
25313246
38.

Sonic Hedgehog promotes the survival of neural crest cells by limiting apoptosis induced by the dependence receptor CDON during branchial arch development.

Delloye-Bourgeois C, Rama N, Brito J, Le Douarin N, Mehlen P.

Biochem Biophys Res Commun. 2014 Sep 26;452(3):655-60. doi: 10.1016/j.bbrc.2014.08.134. Epub 2014 Sep 1.

PMID:
25193697
39.

Dependence receptors and colorectal cancer.

Mehlen P, Tauszig-Delamasure S.

Gut. 2014 Nov;63(11):1821-9. doi: 10.1136/gutjnl-2013-306704. Epub 2014 Aug 27. Review.

PMID:
25163468
40.

Patched-1 proapoptotic activity is downregulated by modification of K1413 by the E3 ubiquitin-protein ligase Itchy homolog.

Chen XL, Chinchilla P, Fombonne J, Ho L, Guix C, Keen JH, Mehlen P, Riobo NA.

Mol Cell Biol. 2014 Oct;34(20):3855-66. doi: 10.1128/MCB.00960-14. Epub 2014 Aug 4.

41.

Netrin-1 expression is an independent prognostic factor for poor patient survival in brain metastases.

Harter PN, Zinke J, Scholz A, Tichy J, Zachskorn C, Kvasnicka HM, Goeppert B, Delloye-Bourgeois C, Hattingen E, Senft C, Steinbach JP, Plate KH, Mehlen P, Schulte D, Mittelbronn M.

PLoS One. 2014 Mar 19;9(3):e92311. doi: 10.1371/journal.pone.0092311. eCollection 2014.

42.

Combining chemotherapeutic agents and netrin-1 interference potentiates cancer cell death.

Paradisi A, Creveaux M, Gibert B, Devailly G, Redoulez E, Neves D, Cleyssac E, Treilleux I, Klein C, Niederfellner G, Cassier PA, Bernet A, Mehlen P.

EMBO Mol Med. 2013 Dec;5(12):1821-34. doi: 10.1002/emmm.201302654. Epub 2013 Oct 8.

43.

[Dependence receptors: life or death choices].

Delcros JG, Mehlen P.

Bull Cancer. 2013 Dec;100(12):1261-74. doi: 10.1684/bdc.2013.1858. Review. French.

PMID:
24240434
44.

Semaphorin 3E suppresses tumor cell death triggered by the plexin D1 dependence receptor in metastatic breast cancers.

Luchino J, Hocine M, Amoureux MC, Gibert B, Bernet A, Royet A, Treilleux I, Lécine P, Borg JP, Mehlen P, Chauvet S, Mann F.

Cancer Cell. 2013 Nov 11;24(5):673-85. doi: 10.1016/j.ccr.2013.09.010. Epub 2013 Oct 17.

45.

Caspase-generated fragment of the Met receptor favors apoptosis via the intrinsic pathway independently of its tyrosine kinase activity.

Lefebvre J, Muharram G, Leroy C, Kherrouche Z, Montagne R, Ichim G, Tauszig-Delamasure S, Chotteau-Lelievre A, Brenner C, Mehlen P, Tulasne D.

Cell Death Dis. 2013 Oct 17;4:e871. doi: 10.1038/cddis.2013.377.

46.

The dependence receptor TrkC triggers mitochondria-dependent apoptosis upon Cobra-1 recruitment.

Ichim G, Genevois AL, Ménard M, Yu LY, Coelho-Aguiar JM, Llambi F, Jarrosson-Wuilleme L, Lefebvre J, Tulasne D, Dupin E, Le Douarin N, Arumäe U, Tauszig-Delamasure S, Mehlen P.

Mol Cell. 2013 Sep 12;51(5):632-46. doi: 10.1016/j.molcel.2013.08.021.

47.

Analysis of the dominant effects mediated by wild type or R120G mutant of αB-crystallin (HspB5) towards Hsp27 (HspB1).

Simon S, Dimitrova V, Gibert B, Virot S, Mounier N, Nivon M, Kretz-Remy C, Corset V, Mehlen P, Arrigo AP.

PLoS One. 2013 Aug 12;8(8):e70545. doi: 10.1371/journal.pone.0070545. eCollection 2013.

48.

Sonic Hedgehog promotes tumor cell survival by inhibiting CDON pro-apoptotic activity.

Delloye-Bourgeois C, Gibert B, Rama N, Delcros JG, Gadot N, Scoazec JY, Krauss R, Bernet A, Mehlen P.

PLoS Biol. 2013;11(8):e1001623. doi: 10.1371/journal.pbio.1001623. Epub 2013 Aug 6.

49.

Dependence receptor UNC5D mediates nerve growth factor depletion-induced neuroblastoma regression.

Zhu Y, Li Y, Haraguchi S, Yu M, Ohira M, Ozaki T, Nakagawa A, Ushijima T, Isogai E, Koseki H, Nakamura Y, Kong C, Mehlen P, Arakawa H, Nakagawara A.

J Clin Invest. 2013 Jul;123(7):2935-47. doi: 10.1172/JCI65988. Epub 2013 Jun 17.

50.

Dependence receptor TrkC is a putative colon cancer tumor suppressor.

Genevois AL, Ichim G, Coissieux MM, Lambert MP, Lavial F, Goldschneider D, Jarrosson-Wuilleme L, Lepinasse F, Gouysse G, Herceg Z, Scoazec JY, Tauszig-Delamasure S, Mehlen P.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3017-22. doi: 10.1073/pnas.1212333110. Epub 2013 Jan 22.

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