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Items: 46


Experimental Approaches to Identify Host Factors Important for Influenza Virus.

Schaack GA, Mehle A.

Cold Spring Harb Perspect Med. 2019 Dec 30. pii: a038521. doi: 10.1101/cshperspect.a038521. [Epub ahead of print]


EPS8 Facilitates Uncoating of Influenza A Virus.

Larson GP, Tran V, Yú S, Caì Y, Higgins CA, Smith DM, Baker SF, Radoshitzky SR, Kuhn JH, Mehle A.

Cell Rep. 2019 Nov 19;29(8):2175-2183.e4. doi: 10.1016/j.celrep.2019.10.064.


The Extracellular Domain of the β2 Integrin β Subunit (CD18) Is Sufficient for Escherichia coli Hemolysin and Aggregatibacter actinomycetemcomitans Leukotoxin Cytotoxic Activity.

Ristow LC, Tran V, Schwartz KJ, Pankratz L, Mehle A, Sauer JD, Welch RA.

mBio. 2019 Jul 9;10(4). pii: e01459-19. doi: 10.1128/mBio.01459-19.


ANP32B, or not to be, that is the question for influenza virus.

Baker SF, Mehle A.

Elife. 2019 Jun 10;8. pii: e48084. doi: 10.7554/eLife.48084.


In-Line Film Coating Thickness Estimation of Minitablets in a Fluid-Bed Coating Equipment.

Podrekar G, Kitak D, Mehle A, Lavrič Z, Likar B, Tomaževič D, Dreu R.

AAPS PharmSciTech. 2018 Nov;19(8):3440-3453. doi: 10.1208/s12249-018-1186-x. Epub 2018 Oct 2.


Flu's cues: Exploiting host post-translational modifications to direct the influenza virus replication cycle.

Dawson AR, Mehle A.

PLoS Pathog. 2018 Sep 20;14(9):e1007205. doi: 10.1371/journal.ppat.1007205. eCollection 2018 Sep. Review. No abstract available.


Differential Splicing of ANP32A in Birds Alters Its Ability to Stimulate RNA Synthesis by Restricted Influenza Polymerase.

Baker SF, Ledwith MP, Mehle A.

Cell Rep. 2018 Sep 4;24(10):2581-2588.e4. doi: 10.1016/j.celrep.2018.08.012.


Measuring Influenza Virus Infection Using Bioluminescent Reporter Viruses for In Vivo Imaging and In Vitro Replication Assays.

Karlsson EA, Meliopoulos VA, Tran V, Savage C, Livingston B, Schultz-Cherry S, Mehle A.

Methods Mol Biol. 2018;1836:431-459. doi: 10.1007/978-1-4939-8678-1_21.


Photocatalytic disinfection of surfaces with copper doped Ti02 nanotube coatings illuminated by ceiling mounted fluorescent light.

Koklic T, Pintarič Š, Zdovc I, Golob M, Umek P, Mehle A, Dobeic M, Štrancar J.

PLoS One. 2018 May 16;13(5):e0197308. doi: 10.1371/journal.pone.0197308. eCollection 2018.


In-line agglomeration degree estimation in fluidized bed pellet coating processes using visual imaging.

Mehle A, Kitak D, Podrekar G, Likar B, Tomaževič D.

Int J Pharm. 2018 Jul 30;546(1-2):78-85. doi: 10.1016/j.ijpharm.2018.05.024. Epub 2018 May 9.


Influenza virus recruits host protein kinase C to control assembly and activity of its replication machinery.

Mondal A, Dawson AR, Potts GK, Freiberger EC, Baker SF, Moser LA, Bernard KA, Coon JJ, Mehle A.

Elife. 2017 Jul 31;6. pii: e26910. doi: 10.7554/eLife.26910.


In Vivo Imaging of Influenza Virus Infection in Immunized Mice.

Czakó R, Vogel L, Lamirande EW, Bock KW, Moore IN, Ellebedy AH, Ahmed R, Mehle A, Subbarao K.

mBio. 2017 May 30;8(3). pii: e00714-17. doi: 10.1128/mBio.00714-17.


Ubiquitination Upregulates Influenza Virus Polymerase Function.

Kirui J, Mondal A, Mehle A.

J Virol. 2016 Nov 14;90(23):10906-10914. doi: 10.1128/JVI.01829-16. Print 2016 Dec 1.


Obesity Outweighs Protection Conferred by Adjuvanted Influenza Vaccination.

Karlsson EA, Hertz T, Johnson C, Mehle A, Krammer F, Schultz-Cherry S.

mBio. 2016 Aug 2;7(4). pii: e01144-16. doi: 10.1128/mBio.01144-16.


The Avian Influenza Virus Polymerase Brings ANP32A Home to Roost.

Mehle A.

Cell Host Microbe. 2016 Feb 10;19(2):137-8. doi: 10.1016/j.chom.2016.01.013.


Multi-Modal Imaging with a Toolbox of Influenza A Reporter Viruses.

Tran V, Poole DS, Jeffery JJ, Sheahan TP, Creech D, Yevtodiyenko A, Peat AJ, Francis KP, You S, Mehle A.

Viruses. 2015 Oct 13;7(10):5319-27. doi: 10.3390/v7102873.


Electrochemical and Electrophysiological Performance of Platinum Electrodes Within the Ninety-Nine-Electrode Stimulating Nerve Cuff.

Pečlin P, Mehle A, Karpe B, Rozman J.

Artif Organs. 2015 Oct;39(10):886-96. doi: 10.1111/aor.12625. Review.


Fiat Luc: Bioluminescence Imaging Reveals In Vivo Viral Replication Dynamics.

Mehle A.

PLoS Pathog. 2015 Sep 10;11(9):e1005081. doi: 10.1371/journal.ppat.1005081. eCollection 2015 Sep. No abstract available.


Assessment of the electrochemical effects of pulsed electric fields in a biological cell suspension.

Chafai DE, Mehle A, Tilmatine A, Maouche B, Miklavčič D.

Bioelectrochemistry. 2015 Dec;106(Pt B):249-57. doi: 10.1016/j.bioelechem.2015.08.002. Epub 2015 Aug 11.


Intramolecular ex vivo Fluorescence Resonance Energy Transfer (FRET) of Dihydropyridine Receptor (DHPR) β1a Subunit Reveals Conformational Change Induced by RYR1 in Mouse Skeletal Myotubes.

Bhattacharya D, Mehle A, Kamp TJ, Balijepalli RC.

PLoS One. 2015 Jun 26;10(6):e0131399. doi: 10.1371/journal.pone.0131399. eCollection 2015.


Phosphorylation at the homotypic interface regulates nucleoprotein oligomerization and assembly of the influenza virus replication machinery.

Mondal A, Potts GK, Dawson AR, Coon JJ, Mehle A.

PLoS Pathog. 2015 Apr 13;11(4):e1004826. doi: 10.1371/journal.ppat.1004826. eCollection 2015 Apr.


Visualizing real-time influenza virus infection, transmission and protection in ferrets.

Karlsson EA, Meliopoulos VA, Savage C, Livingston B, Mehle A, Schultz-Cherry S.

Nat Commun. 2015 Mar 6;6:6378. doi: 10.1038/ncomms7378.


Inhibitors of peptidyl proline isomerases as antivirals in hepatitis C and other viruses.

Striker R, Mehle A.

PLoS Pathog. 2014 Nov 6;10(11):e1004428. doi: 10.1371/journal.ppat.1004428. eCollection 2014 Nov. Review. No abstract available.


Unusual influenza A viruses in bats.

Mehle A.

Viruses. 2014 Sep 17;6(9):3438-49. doi: 10.3390/v6093438. Review.


Influenza A virus polymerase is a site for adaptive changes during experimental evolution in bat cells.

Poole DS, Yú S, Caì Y, Dinis JM, Müller MA, Jordan I, Friedrich TC, Kuhn JH, Mehle A.

J Virol. 2014 Nov;88(21):12572-85. doi: 10.1128/JVI.01857-14. Epub 2014 Aug 20.


Electrochemical performance of platinum electrodes within the multi-electrode spiral nerve cuff.

Rozman J, Pečlin P, Mehle A, Šala M.

Australas Phys Eng Sci Med. 2014 Sep;37(3):525-33. doi: 10.1007/s13246-014-0282-9. Epub 2014 Jun 18.


The nature of chlorine-inhibition of photocatalytic degradation of dichloroacetic acid in a TiO2-based microreactor.

Krivec M, Dillert R, Bahnemann DW, Mehle A, Štrancar J, Dražić G.

Phys Chem Chem Phys. 2014 Jul 28;16(28):14867-73. doi: 10.1039/c4cp01043d.


Conserved features of the PB2 627 domain impact influenza virus polymerase function and replication.

Kirui J, Bucci MD, Poole DS, Mehle A.

J Virol. 2014 Jun;88(11):5977-86. doi: 10.1128/JVI.00508-14. Epub 2014 Mar 12.


Highly sensitive real-time in vivo imaging of an influenza reporter virus reveals dynamics of replication and spread.

Tran V, Moser LA, Poole DS, Mehle A.

J Virol. 2013 Dec;87(24):13321-9. doi: 10.1128/JVI.02381-13. Epub 2013 Oct 2.


Fluorescence resonance energy transfer-based intracellular assay for the conformation of hepatitis C virus drug target NS5A.

Bhattacharya D, Ansari IH, Mehle A, Striker R.

J Virol. 2012 Aug;86(15):8277-86. doi: 10.1128/JVI.00645-12. Epub 2012 May 23.


Reassortment and mutation of the avian influenza virus polymerase PA subunit overcome species barriers.

Mehle A, Dugan VG, Taubenberger JK, Doudna JA.

J Virol. 2012 Feb;86(3):1750-7. doi: 10.1128/JVI.06203-11. Epub 2011 Nov 16.


Single particle analysis of tau oligomer formation induced by metal ions and organic solvents.

Bader B, Nübling G, Mehle A, Nobile S, Kretzschmar H, Giese A.

Biochem Biophys Res Commun. 2011 Jul 22;411(1):190-6. doi: 10.1016/j.bbrc.2011.06.135. Epub 2011 Jun 24.


A host of factors regulating influenza virus replication.

Mehle A, Doudna JA.

Viruses. 2010 Feb;2(2):566-73. doi: 10.3390/v2020566. Epub 2010 Feb 5.


Female mice and rats exhibit species-specific metabolic and behavioral responses to ovariectomy.

Witte MM, Resuehr D, Chandler AR, Mehle AK, Overton JM.

Gen Comp Endocrinol. 2010 May 1;166(3):520-8. doi: 10.1016/j.ygcen.2010.01.006. Epub 2010 Jan 11.


Adaptive strategies of the influenza virus polymerase for replication in humans.

Mehle A, Doudna JA.

Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21312-6. doi: 10.1073/pnas.0911915106. Epub 2009 Dec 7.


An inhibitory activity in human cells restricts the function of an avian-like influenza virus polymerase.

Mehle A, Doudna JA.

Cell Host Microbe. 2008 Aug 14;4(2):111-22. doi: 10.1016/j.chom.2008.06.007.


Identification of an APOBEC3G binding site in human immunodeficiency virus type 1 Vif and inhibitors of Vif-APOBEC3G binding.

Mehle A, Wilson H, Zhang C, Brazier AJ, McPike M, Pery E, Gabuzda D.

J Virol. 2007 Dec;81(23):13235-41. Epub 2007 Sep 26.


Changes in the V3 region of gp120 contribute to unusually broad coreceptor usage of an HIV-1 isolate from a CCR5 Delta32 heterozygote.

Gorry PR, Dunfee RL, Mefford ME, Kunstman K, Morgan T, Moore JP, Mascola JR, Agopian K, Holm GH, Mehle A, Taylor J, Farzan M, Wang H, Ellery P, Willey SJ, Clapham PR, Wolinsky SM, Crowe SM, Gabuzda D.

Virology. 2007 May 25;362(1):163-78. Epub 2007 Jan 18.


A zinc-binding region in Vif binds Cul5 and determines cullin selection.

Mehle A, Thomas ER, Rajendran KS, Gabuzda D.

J Biol Chem. 2006 Jun 23;281(25):17259-65. Epub 2006 Apr 24.


Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradation.

Mehle A, Goncalves J, Santa-Marta M, McPike M, Gabuzda D.

Genes Dev. 2004 Dec 1;18(23):2861-6.


Vif overcomes the innate antiviral activity of APOBEC3G by promoting its degradation in the ubiquitin-proteasome pathway.

Mehle A, Strack B, Ancuta P, Zhang C, McPike M, Gabuzda D.

J Biol Chem. 2004 Feb 27;279(9):7792-8. Epub 2003 Dec 13.


Fractalkine preferentially mediates arrest and migration of CD16+ monocytes.

Ancuta P, Rao R, Moses A, Mehle A, Shaw SK, Luscinskas FW, Gabuzda D.

J Exp Med. 2003 Jun 16;197(12):1701-7.


Increased CCR5 affinity and reduced CCR5/CD4 dependence of a neurovirulent primary human immunodeficiency virus type 1 isolate.

Gorry PR, Taylor J, Holm GH, Mehle A, Morgan T, Cayabyab M, Farzan M, Wang H, Bell JE, Kunstman K, Moore JP, Wolinsky SM, Gabuzda D.

J Virol. 2002 Jun;76(12):6277-92.



Mehle AL, Nedorost S, Camisa C.

Int J Dermatol. 1990 Oct;29(8):567-70.


Perforating pilomatricoma: a case report.

Lo JS, Guitart J, Bergfeld WF, Benedetto EA, Mehle AL.

Cutis. 1989 Aug;44(2):130-2. Review. No abstract available.


Optimal use of an occlusive dressing to enhance healing. Effect of delayed application and early removal on wound healing.

Eaglstein WH, Davis SC, Mehle AL, Mertz PM.

Arch Dermatol. 1988 Mar;124(3):392-5.


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