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Items: 1 to 50 of 268

1.

Wnt/β-Catenin Signaling Drives Thioacetamide-Mediated Heteroprotection Against Acetaminophen-Induced Lethal Liver Injury.

Dadhania VP, Bhushan B, Apte U, Mehendale HM.

Dose Response. 2017 Jan 30;15(1):1559325817690287. doi: 10.1177/1559325817690287. eCollection 2017 Jan-Mar.

2.

Hepatic Overexpression of Annexin A1 and A2 in Thioacetamide-Primed Mice Protects Them Against Acetaminophen-Induced Liver Failure and Death.

Dadhania VP, Muskhelishvili L, Latendresse JR, Mehendale HM.

Int J Toxicol. 2016 Nov;35(6):654-665. Epub 2016 Jul 22.

PMID:
27451051
3.

Once initiated, how does toxic tissue injury expand?

Mehendale HM.

Trends Pharmacol Sci. 2012 Apr;33(4):200-6. doi: 10.1016/j.tips.2012.01.003. Epub 2012 Mar 21. Review.

PMID:
22443935
4.

Secretory phospholipase A₂-mediated progression of hepatotoxicity initiated by acetaminophen is exacerbated in the absence of hepatic COX-2.

Bhave VS, Donthamsetty S, Latendresse JR, Cunningham ML, Mehendale HM.

Toxicol Appl Pharmacol. 2011 Mar 15;251(3):173-80. doi: 10.1016/j.taap.2011.01.013. Epub 2011 Jan 26.

PMID:
21277885
5.

High fat diet-fed obese rats are highly sensitive to doxorubicin-induced cardiotoxicity.

Mitra MS, Donthamsetty S, White B, Mehendale HM.

Toxicol Appl Pharmacol. 2008 Sep 15;231(3):413-22. doi: 10.1016/j.taap.2008.05.006. Epub 2008 May 10.

PMID:
18674790
6.

Nonalcoholic steatohepatitic (NASH) mice are protected from higher hepatotoxicity of acetaminophen upon induction of PPARalpha with clofibrate.

Donthamsetty S, Bhave VS, Mitra MS, Latendresse JR, Mehendale HM.

Toxicol Appl Pharmacol. 2008 Aug 1;230(3):327-37. doi: 10.1016/j.taap.2008.02.031. Epub 2008 Mar 20.

PMID:
18501395
7.

The rat red blood cell proteome is altered by priming with 2-butoxyethanol.

Palkar PS, Kakhniashvili DG, Goodman SR, Mehendale HM.

Toxicol Appl Pharmacol. 2008 Aug 1;230(3):338-45. doi: 10.1016/j.taap.2008.03.005. Epub 2008 Mar 15.

PMID:
18436273
8.

Inhibition of cyclooxygenase-2 aggravates secretory phospholipase A2-mediated progression of acute liver injury.

Bhave VS, Donthamsetty S, Latendresse JR, Mehendale HM.

Toxicol Appl Pharmacol. 2008 Apr 15;228(2):239-46. doi: 10.1016/j.taap.2007.12.025. Epub 2008 Jan 4.

PMID:
18336855
9.

Secretory phospholipase A2 mediates progression of acute liver injury in the absence of sufficient cyclooxygenase-2.

Bhave VS, Donthamsetty S, Latendresse JR, Muskhelishvili L, Mehendale HM.

Toxicol Appl Pharmacol. 2008 Apr 15;228(2):225-38. doi: 10.1016/j.taap.2007.12.023. Epub 2008 Jan 3.

PMID:
18329682
10.

Renal and hepatic transporter expression in type 2 diabetic rats.

Nowicki MT, Aleksunes LM, Sawant SP, Dnyanmote AV, Mehendale HM, Manautou JE.

Drug Metab Lett. 2008 Jan;2(1):11-7.

PMID:
19356064
11.

Mechanism of protection of moderately diet restricted rats against doxorubicin-induced acute cardiotoxicity.

Mitra MS, Donthamsetty S, White B, Latendresse JR, Mehendale HM.

Toxicol Appl Pharmacol. 2007 Nov 15;225(1):90-101. Epub 2007 Aug 21.

PMID:
17904602
12.

Priming dose of phenylhydrazine protects against hemolytic and lethal effects of 2-butoxyethanol.

Palkar PS, Philip BK, Reddy RN, Mehendale HM.

Toxicol Appl Pharmacol. 2007 Nov 15;225(1):102-12. Epub 2007 Jun 30.

PMID:
17850838
13.

NTP-CERHR expert panel report on the reproductive and developmental toxicity of hydroxyurea.

Liebelt EL, Balk SJ, Faber W, Fisher JW, Hughes CL, Lanzkron SM, Lewis KM, Marchetti F, Mehendale HM, Rogers JM, Shad AT, Skalko RG, Stanek EJ.

Birth Defects Res B Dev Reprod Toxicol. 2007 Aug;80(4):259-366. No abstract available.

PMID:
17712860
14.

Mechanisms and outcomes of drug- and toxicant-induced liver toxicity in diabetes.

Wang T, Shankar K, Ronis MJ, Mehendale HM.

Crit Rev Toxicol. 2007 Jun;37(5):413-59. Review.

PMID:
17612954
15.

Proteomics of S-(1, 2-dichlorovinyl)-L-cysteine-induced acute renal failure and autoprotection in mice.

Korrapati MC, Chilakapati J, Witzmann FA, Rao C, Lock EA, Mehendale HM.

Am J Physiol Renal Physiol. 2007 Oct;293(4):F994-F1006. Epub 2007 Jun 20.

16.

Measuring covalent binding in hepatotoxicity.

Devi SS, Palkar PS, Mehendale HM.

Curr Protoc Toxicol. 2007 May;Chapter 14:Unit14.6. doi: 10.1002/0471140856.tx1406s32.

PMID:
23045139
17.

Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework.

Calabrese EJ, Bachmann KA, Bailer AJ, Bolger PM, Borak J, Cai L, Cedergreen N, Cherian MG, Chiueh CC, Clarkson TW, Cook RR, Diamond DM, Doolittle DJ, Dorato MA, Duke SO, Feinendegen L, Gardner DE, Hart RW, Hastings KL, Hayes AW, Hoffmann GR, Ives JA, Jaworowski Z, Johnson TE, Jonas WB, Kaminski NE, Keller JG, Klaunig JE, Knudsen TB, Kozumbo WJ, Lettieri T, Liu SZ, Maisseu A, Maynard KI, Masoro EJ, McClellan RO, Mehendale HM, Mothersill C, Newlin DB, Nigg HN, Oehme FW, Phalen RF, Philbert MA, Rattan SI, Riviere JE, Rodricks J, Sapolsky RM, Scott BR, Seymour C, Sinclair DA, Smith-Sonneborn J, Snow ET, Spear L, Stevenson DE, Thomas Y, Tubiana M, Williams GM, Mattson MP.

Toxicol Appl Pharmacol. 2007 Jul 1;222(1):122-8. Epub 2007 Mar 7. Review.

18.

Mechanisms of inhibited liver tissue repair in toxicant challenged type 2 diabetic rats.

Sawant SP, Dnyanmote AV, Mehendale HM.

Toxicology. 2007 Apr 11;232(3):200-15. Epub 2007 Jan 14.

PMID:
17298859
19.

Impact of repeated exposure on toxicity of perchloroethylene in Swiss Webster mice.

Philip BK, Mumtaz MM, Latendresse JR, Mehendale HM.

Toxicology. 2007 Mar 22;232(1-2):1-14. Epub 2006 Dec 22.

PMID:
17267091
20.

Nonalcoholic fatty liver sensitizes rats to carbon tetrachloride hepatotoxicity.

Donthamsetty S, Bhave VS, Mitra MS, Latendresse JR, Mehendale HM.

Hepatology. 2007 Feb;45(2):391-403.

PMID:
17256749
21.

Role of CYP2E1 and saturation kinetics in the bioactivation of thioacetamide: Effects of diet restriction and phenobarbital.

Chilakapati J, Korrapati MC, Shankar K, Hill RA, Warbritton A, Latendresse JR, Mehendale HM.

Toxicol Appl Pharmacol. 2007 Feb 15;219(1):72-84. Epub 2006 Dec 8.

PMID:
17234228
22.

Toxicokinetics and toxicity of thioacetamide sulfoxide: a metabolite of thioacetamide.

Chilakapati J, Korrapati MC, Hill RA, Warbritton A, Latendresse JR, Mehendale HM.

Toxicology. 2007 Feb 12;230(2-3):105-16. Epub 2006 Nov 17.

PMID:
17187915
23.

Prior administration of a low dose of thioacetamide protects type 1 diabetic rats from subsequent administration of lethal dose of thioacetamide.

Devi SS, Philip BK, Warbritton A, Latendresse JR, Mehendale HM.

Toxicology. 2006 Sep 21;226(2-3):107-17. Epub 2006 Jun 16.

PMID:
16901604
24.

Upregulation of calpastatin in regenerating and developing rat liver: role in resistance against hepatotoxicity.

Limaye PB, Bhave VS, Palkar PS, Apte UM, Sawant SP, Yu S, Latendresse JR, Reddy JK, Mehendale HM.

Hepatology. 2006 Aug;44(2):379-88.

PMID:
16871587
25.

Subchronic chloroform priming protects mice from a subsequently administered lethal dose of chloroform.

Philip BK, Anand SS, Palkar PS, Mumtaz MM, Latendresse JR, Mehendale HM.

Toxicol Appl Pharmacol. 2006 Oct 1;216(1):108-21. Epub 2006 Jul 3.

PMID:
16815507
26.

Adaptive tolerance in mice upon subchronic exposure to chloroform: Increased exhalation and target tissue regeneration.

Anand SS, Philip BK, Palkar PS, Mumtaz MM, Latendresse JR, Mehendale HM.

Toxicol Appl Pharmacol. 2006 Jun 15;213(3):267-81. Epub 2006 Apr 21.

PMID:
16630638
27.

Calpastatin overexpression prevents progression of S-1,2-dichlorovinyl-l-cysteine (DCVC)-initiated acute renal injury and renal failure (ARF) in diabetes.

Dnyanmote AV, Sawant SP, Lock EA, Latendresse JR, Warbritton AA, Mehendale HM.

Toxicol Appl Pharmacol. 2006 Sep 1;215(2):146-57. Epub 2006 Mar 20.

PMID:
16546232
28.

Preplaced cell division: a critical mechanism of autoprotection against S-1,2-dichlorovinyl-L-cysteine-induced acute renal failure and death in mice.

Korrapati MC, Chilakapati J, Lock EA, Latendresse JR, Warbritton A, Mehendale HM.

Am J Physiol Renal Physiol. 2006 Aug;291(2):F439-55. Epub 2006 Feb 21.

29.

Colchicine antimitosis causes progression of S-(1,2-dichlorovinyl)-L-cysteine-induced injury leading to acute renal failure and death in mice.

Reddy RN, Latendresse JR, Mehendale HM.

Toxicology. 2006 Mar 15;220(2-3):147-59. Epub 2006 Feb 7.

PMID:
16457931
30.
31.

Microarray analysis of thioacetamide-treated type 1 diabetic rats.

Devi SS, Mehendale HM.

Toxicol Appl Pharmacol. 2006 Apr 1;212(1):69-78. Epub 2005 Nov 17.

PMID:
16297948
32.

The role of NF-kappaB signaling in impaired liver tissue repair in thioacetamide-treated type 1 diabetic rats.

Devi SS, Mehendale HM.

Eur J Pharmacol. 2005 Oct 31;523(1-3):127-36. Epub 2005 Oct 24.

PMID:
16246324
33.

Protective effect of type 2 diabetes on acetaminophen-induced hepatotoxicity in male Swiss-Webster mice.

Sawant SP, Dnyanmote AV, Mitra MS, Chilakapati J, Warbritton A, Latendresse JR, Mehendale HM.

J Pharmacol Exp Ther. 2006 Feb;316(2):507-19. Epub 2005 Oct 5.

PMID:
16207833
34.

Saturation toxicokinetics of thioacetamide: role in initiation of liver injury.

Chilakapati J, Shankar K, Korrapati MC, Hill RA, Mehendale HM.

Drug Metab Dispos. 2005 Dec;33(12):1877-85. Epub 2005 Sep 23.

PMID:
16183780
35.

Type 2 diabetic rats are sensitive to thioacetamide hepatotoxicity.

Sawant SP, Dnyanmote AV, Warbritton A, Latendresse JR, Mehendale HM.

Toxicol Appl Pharmacol. 2006 Mar 15;211(3):221-32. Epub 2005 Sep 8.

PMID:
16153671
36.

Diabetic mice are protected from normally lethal nephrotoxicity of S-1,2-dichlorovinyl-L-cysteine (DCVC): role of nephrogenic tissue repair.

Dnyanmote AV, Sawant SP, Lock EA, Latendresse JR, Warbritton AA, Mehendale HM.

Toxicol Appl Pharmacol. 2006 Mar 1;211(2):133-47. Epub 2005 Aug 25.

PMID:
16125744
37.
38.

Dose-dependent liver regeneration in chloroform, trichloroethylene and allyl alcohol ternary mixture hepatotoxicity in rats.

Anand SS, Mumtaz MM, Mehendale HM.

Arch Toxicol. 2005 Nov;79(11):671-82. Epub 2005 Jun 7.

PMID:
15940471
39.

Dose-dependent liver tissue repair after chloroform plus trichloroethylene binary mixture.

Anand SS, Mumtaz MM, Mehendale HM.

Basic Clin Pharmacol Toxicol. 2005 Jun;96(6):436-44.

40.

Calpain: a death protein that mediates progression of liver injury.

Mehendale HM, Limaye PB.

Trends Pharmacol Sci. 2005 May;26(5):232-6. Review.

PMID:
15860369
41.

Tissue repair: an important determinant of final outcome of toxicant-induced injury.

Mehendale HM.

Toxicol Pathol. 2005;33(1):41-51. Review.

PMID:
15805055
42.

Molecular mechanisms of enhanced renal cell division in protection against S-1,2-dichlorovinyl-L-cysteine-induced acute renal failure and death.

Korrapati MC, Lock EA, Mehendale HM.

Am J Physiol Renal Physiol. 2005 Jul;289(1):F175-85. Epub 2005 Mar 1.

43.

Liver regeneration: a critical toxicodynamic response in predictive toxicology.

Anand SS, Mehendale HM.

Environ Toxicol Pharmacol. 2004 Nov;18(2):149-60. doi: 10.1016/j.etap.2004.02.011.

PMID:
21782744
44.

Dose-dependent liver tissue repair in chloroform plus thioacetamide acute hepatotoxicity.

Anand SS, Murthy SN, Mumtaz MM, Mehendale HM.

Environ Toxicol Pharmacol. 2004 Nov;18(2):143-8. doi: 10.1016/j.etap.2004.02.010.

PMID:
21782743
45.

Genetically modified foods: why the public frenzy? Role of mainstream news media.

Mehendale HM.

Int J Toxicol. 2004;23(5):279-80. No abstract available.

PMID:
15513828
46.

Mimetics of caloric restriction include agonists of lipid-activated nuclear receptors.

Corton JC, Apte U, Anderson SP, Limaye P, Yoon L, Latendresse J, Dunn C, Everitt JI, Voss KA, Swanson C, Kimbrough C, Wong JS, Gill SS, Chandraratna RA, Kwak MK, Kensler TW, Stulnig TM, Steffensen KR, Gustafsson JA, Mehendale HM.

J Biol Chem. 2004 Oct 29;279(44):46204-12. Epub 2004 Aug 9.

47.

Genetically modified foods get bad rap.

Mehendale HM.

Int J Toxicol. 2004 Mar-Apr;23(2):79-80. No abstract available.

PMID:
15204724
48.

Tolerance of aged Fischer 344 rats against chlordecone-amplified carbon tetrachloride toxicity.

Murali B, Korrapati MC, Warbritton A, Latendresse JR, Mehendale HM.

Mech Ageing Dev. 2004 Jun;125(6):421-35.

PMID:
15178132
49.

Potentiation of carbon tetrachloride hepatotoxicity and lethality in type 2 diabetic rats.

Sawant SP, Dnyanmote AV, Shankar K, Limaye PB, Latendresse JR, Mehendale HM.

J Pharmacol Exp Ther. 2004 Feb;308(2):694-704. Epub 2003 Nov 10.

PMID:
14610242
50.

Molecular mechanisms of renal tissue repair in survival from acute renal tubule necrosis: role of ERK1/2 pathway.

Vaidya VS, Shankar K, Lock EA, Dixon D, Mehendale HM.

Toxicol Pathol. 2003 Nov-Dec;31(6):604-18. Erratum in: Toxicol Pathol. 2004 Jan-Feb;32(1):168-9.

PMID:
14585728

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