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Repurposed quinacrine synergizes with cisplatin, reducing the effective dose required for treatment of head and neck squamous cell carcinoma.

Bryant J, Batis N, Franke AC, Clancey G, Hartley M, Ryan G, Brooks J, Southam AD, Barnes N, Parish J, Roberts S, Khanim F, Spruce R, Mehanna H.

Oncotarget. 2019 Aug 27;10(50):5229-5244. doi: 10.18632/oncotarget.27156. eCollection 2019 Aug 27.


Circulating Tumour Cell Biomarkers in Head and Neck Cancer: Current Progress and Future Prospects.

Payne K, Brooks J, Spruce R, Batis N, Taylor G, Nankivell P, Mehanna H.

Cancers (Basel). 2019 Aug 5;11(8). pii: E1115. doi: 10.3390/cancers11081115. Review.


The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC).

Cohen EEW, Bell RB, Bifulco CB, Burtness B, Gillison ML, Harrington KJ, Le QT, Lee NY, Leidner R, Lewis RL, Licitra L, Mehanna H, Mell LK, Raben A, Sikora AG, Uppaluri R, Whitworth F, Zandberg DP, Ferris RL.

J Immunother Cancer. 2019 Jul 15;7(1):184. doi: 10.1186/s40425-019-0662-5.


Oropharyngeal Cancers in the East and the West - Implications of Aetiopathogenesis on Prognosis and Research.

Chatterjee S, Ghosh Laskar S, Mehanna H, Nutting CM, Mallick I.

Clin Oncol (R Coll Radiol). 2019 Aug;31(8):510-519. doi: 10.1016/j.clon.2019.05.017. Epub 2019 Jun 11.


Development and Validation of a Combined Hypoxia and Immune Prognostic Classifier for Head and Neck Cancer.

Brooks JM, Menezes AN, Ibrahim M, Archer L, Lal N, Bagnall CJ, von Zeidler SV, Valentine HR, Spruce RJ, Batis N, Bryant JL, Hartley M, Kaul B, Ryan GB, Bao R, Khattri A, Lee SP, Ogbureke KUE, Middleton G, Tennant DA, Beggs AD, Deeks J, West CML, Cazier JB, Willcox BE, Seiwert TY, Mehanna H.

Clin Cancer Res. 2019 Sep 1;25(17):5315-5328. doi: 10.1158/1078-0432.CCR-18-3314. Epub 2019 Jun 10.


Modelling human papillomavirus biology in oropharyngeal keratinocytes.

Roberts S, Evans D, Mehanna H, Parish JL.

Philos Trans R Soc Lond B Biol Sci. 2019 May 27;374(1773):20180289. doi: 10.1098/rstb.2018.0289.


Transoral tongue base mucosectomy for the identification of the primary site in the work-up of cancers of unknown origin: Systematic review and meta-analysis.

Farooq S, Khandavilli S, Dretzke J, Moore D, Nankivell PC, Sharma N, Almeida JR, Winter SC, Simon C, Paleri V, De M, Siddiq S, Holsinger C, Ferris RL, Mehanna H.

Oral Oncol. 2019 Apr;91:97-106. doi: 10.1016/j.oraloncology.2019.02.018. Epub 2019 Mar 6. Review.


International validation of the revised European Organisation for Research and Treatment of Cancer Head and Neck Cancer Module, the EORTC QLQ-HN43: Phase IV.

Singer S, Amdal CD, Hammerlid E, Tomaszewska IM, Castro Silva J, Mehanna H, Santos M, Inhestern J, Brannan C, Yarom N, Fullerton A, Pinto M, Arraras JI, Kiyota N, Bonomo P, Sherman AC, Baumann I, Galalae R, Fernandez Gonzalez L, Nicolatou-Galitis O, Abdel-Hafeez Z, Raber-Durlacher J, Schmalz C, Zotti P, Boehm A, Hofmeister D, Krejovic Trivic S, Loo S, Chie WC, Bjordal K, Brokstad Herlofson B, Grégoire V, Licitra L; EORTC Quality of Life and the EORTC Head and Neck Cancer Groups.

Head Neck. 2019 Jun;41(6):1725-1737. doi: 10.1002/hed.25609. Epub 2019 Jan 12.


Evidence for the approach to the diagnostic evaluation of squamous cell carcinoma occult primary tumors of the head and neck.

Golusinski P, Di Maio P, Pehlivan B, Colley S, Nankivell P, Kong A, Hartley A, Mehanna H.

Oral Oncol. 2019 Jan;88:145-152. doi: 10.1016/j.oraloncology.2018.11.020. Epub 2018 Nov 30. Review.


Human Papillomavirus (HPV) Vaccine Effectiveness and Potential Herd Immunity for Reducing Oncogenic Oropharyngeal HPV-16 Prevalence in the United Kingdom: A Cross-sectional Study.

Mehanna H, Bryant TS, Babrah J, Louie K, Bryant JL, Spruce RJ, Batis N, Olaleye O, Jones J, Struijk L, Molijn A, Vorsters A, Rosillon D, Taylor S, D'Souza G.

Clin Infect Dis. 2019 Sep 27;69(8):1296-1302. doi: 10.1093/cid/ciy1081.


Association between loss of Y chromosome and poor prognosis in male head and neck squamous cell carcinoma.

Hollows R, Wei W, Cazier JB, Mehanna H, Parry G, Halford G, Murray P.

Head Neck. 2019 Apr;41(4):993-1006. doi: 10.1002/hed.25537. Epub 2018 Dec 23.


Radiotherapy plus cisplatin or cetuximab in low-risk human papillomavirus-positive oropharyngeal cancer (De-ESCALaTE HPV): an open-label randomised controlled phase 3 trial.

Mehanna H, Robinson M, Hartley A, Kong A, Foran B, Fulton-Lieuw T, Dalby M, Mistry P, Sen M, O'Toole L, Al Booz H, Dyker K, Moleron R, Whitaker S, Brennan S, Cook A, Griffin M, Aynsley E, Rolles M, De Winton E, Chan A, Srinivasan D, Nixon I, Grumett J, Leemans CR, Buter J, Henderson J, Harrington K, McConkey C, Gray A, Dunn J; De-ESCALaTE HPV Trial Group.

Lancet. 2019 Jan 5;393(10166):51-60. doi: 10.1016/S0140-6736(18)32752-1. Epub 2018 Nov 15.


Safety and Efficacy of Durvalumab With or Without Tremelimumab in Patients With PD-L1-Low/Negative Recurrent or Metastatic HNSCC: The Phase 2 CONDOR Randomized Clinical Trial.

Siu LL, Even C, Mesía R, Remenar E, Daste A, Delord JP, Krauss J, Saba NF, Nabell L, Ready NE, Braña I, Kotecki N, Zandberg DP, Gilbert J, Mehanna H, Bonomi M, Jarkowski A, Melillo G, Armstrong JM, Wildsmith S, Fayette J.

JAMA Oncol. 2019 Feb 1;5(2):195-203. doi: 10.1001/jamaoncol.2018.4628.


Toxicity Reduction in the Treatment of HPV Positive Oropharyngeal Cancer: Emerging Combined Modality Approaches.

Deschuymer S, Mehanna H, Nuyts S.

Front Oncol. 2018 Oct 9;8:439. doi: 10.3389/fonc.2018.00439. eCollection 2018. Review.


Surveillance of HPV-Positive Head and Neck Squamous Cell Carcinoma with Circulating and Salivary DNA Biomarkers.

Borsetto D, Cheng J, Payne K, Nankivell P, Batis N, Rao K, Bhide S, Li F, Kim Y, Mehanna H, Wong D.

Crit Rev Oncog. 2018;23(3-4):235-245. doi: 10.1615/CritRevOncog.2018027689. Review.


Surgical quality assurance in head and neck cancer trials: an EORTC Head and Neck Cancer Group position paper based on the EORTC 1420 'Best of' and 24954 'larynx preservation' study.

Simon C, Caballero C, Gregoire V, Thurnher D, Koivunen P, Ceruse P, Spriano G, Nicolai P, Licitra L, Machiels JP, Hamoir M, Andry G, Mehanna H, Hunter KD, Dietz A, René Leemans C.

Eur J Cancer. 2018 Nov;103:69-77. doi: 10.1016/j.ejca.2018.07.140. Epub 2018 Sep 11. Review.


PTTG and PBF Functionally Interact with p53 and Predict Overall Survival in Head and Neck Cancer.

Read ML, Modasia B, Fletcher A, Thompson RJ, Brookes K, Rae PC, Nieto HR, Poole VL, Roberts S, Campbell MJ, Boelaert K, Turnell AS, Smith VE, Mehanna H, McCabe CJ.

Cancer Res. 2018 Oct 15;78(20):5863-5876. doi: 10.1158/0008-5472.CAN-18-0855. Epub 2018 Aug 28.


In Regard to Beadle and Anderson.

Le QT, Yom SS, Wee JTS, Lee AWM, Grau C, Grégoire V, Porceddu S, Welch JJ, Mehanna H.

Int J Radiat Oncol Biol Phys. 2018 Sep 1;102(1):229-230. doi: 10.1016/j.ijrobp.2018.05.015. Epub 2018 Aug 8. No abstract available.


Considerations for a head and neck smoking cessation support programme; A qualitative study of the challenges in quitting smoking after treatment for head and neck cancer.

Abdelrahim A, Balmer C, Jones J, Mehanna H, Dunn J.

Eur J Oncol Nurs. 2018 Aug;35:54-61. doi: 10.1016/j.ejon.2018.05.003. Epub 2018 Jun 6.


Laryngeal dysplasia and narrow band imaging: Secondary analysis of published data supports the role in patient follow-up.

Paleri V, Sawant R, Mehanna H, Ainsworth H, Stocken D.

Clin Otolaryngol. 2018 Dec;43(6):1439-1442. doi: 10.1111/coa.13182. Epub 2018 Aug 7. Review.


Revised Modelling of the Addition of Synchronous Chemotherapy to Radiotherapy in Squamous Cell Carcinoma of the Head and Neck-A Low α/β?

Best J, Fong C, Benghiat H, Mehanna H, Glaholm J, Hartley A.

Medicines (Basel). 2018 Jun 13;5(2). pii: E54. doi: 10.3390/medicines5020054.


Provision of physiotherapy rehabilitation following neck dissection in the UK.

Robinson M, Ward L, Mehanna H, Paleri V, Winter SC.

J Laryngol Otol. 2018 Jul;132(7):624-627. doi: 10.1017/S0022215118000671. Epub 2018 Jun 13.


Development and external validation of nomograms in oropharyngeal cancer patients with known HPV-DNA status: a European Multicentre Study (OroGrams).

Grønhøj C, Jensen DH, Dehlendorff C, Marklund L, Wagner S, Mehanna H, Munck-Wikland E, Ramqvist T, Näsman A, Wittekindt C, Würdemann N, Sharma SJ, Gattenlöhner S, Kiss K, Andersen E, Spruce R, Batis N, Robinson M, Harrington K, Winter S, Jones TM, Klussmann JP, Dalianis T, Friborg J, von Buchwald C.

Br J Cancer. 2018 Jun;118(12):1672-1681. doi: 10.1038/s41416-018-0107-9. Epub 2018 May 24.


The Clinical Utility of Cell-Free DNA Measurement in Differentiated Thyroid Cancer: A Systematic Review.

Fussey JM, Bryant JL, Batis N, Spruce RJ, Hartley A, Good JS, McCabe CJ, Boelaert K, Sharma N, Mehanna H.

Front Oncol. 2018 Apr 30;8:132. doi: 10.3389/fonc.2018.00132. eCollection 2018.


Circulating tumor DNA as a biomarker and liquid biopsy in head and neck squamous cell carcinoma.

Payne K, Spruce R, Beggs A, Sharma N, Kong A, Martin T, Parmar S, Praveen P, Nankivell P, Mehanna H.

Head Neck. 2018 Jul;40(7):1598-1604. doi: 10.1002/hed.25140. Epub 2018 Mar 15. Review.


Feasibility of Dose-escalated Hypofractionated Chemoradiation in Human Papilloma Virus-negative or Smoking-associated Oropharyngeal Cancer.

Meade S, Gaunt P, Hartley A, Robinson M, Harrop V, Cashmore J, Wagstaff L, Babrah J, Bowden SJ, Mehanna H, Sanghera P.

Clin Oncol (R Coll Radiol). 2018 Jun;30(6):366-374. doi: 10.1016/j.clon.2018.01.015. Epub 2018 Mar 2.


Unsupervised morphological segmentation of tissue compartments in histopathological images.

Fouad S, Randell D, Galton A, Mehanna H, Landini G.

PLoS One. 2017 Nov 30;12(11):e0188717. doi: 10.1371/journal.pone.0188717. eCollection 2017.


Cost-effectiveness analysis of PET-CT-guided management for locally advanced head and neck cancer.

Smith AF, Hall PS, Hulme CT, Dunn JA, McConkey CC, Rahman JK, McCabe C, Mehanna H.

Eur J Cancer. 2017 Nov;85:6-14. doi: 10.1016/j.ejca.2017.07.054. Epub 2017 Sep 4.


Formation of an international intergroup to coordinate clinical trials in head and neck cancers: HNCIG.

Le QT, Welch JJ, Vermorken JB, Rischin D, Mehanna H; all HNCIG investigators.

Oral Oncol. 2017 Aug;71:180-183. doi: 10.1016/j.oraloncology.2017.05.022. Epub 2017 Jun 22.


A Q methodology study to investigate the experiences of head and neck cancer patients from diagnosis to 1 year.

Reid KJ, Swift A, Mehanna H.

Eur J Cancer Care (Engl). 2017 Nov;26(6). doi: 10.1111/ecc.12694. Epub 2017 May 4.


PET-NECK: a multicentre randomised Phase III non-inferiority trial comparing a positron emission tomography-computerised tomography-guided watch-and-wait policy with planned neck dissection in the management of locally advanced (N2/N3) nodal metastases in patients with squamous cell head and neck cancer.

Mehanna H, McConkey CC, Rahman JK, Wong WL, Smith AF, Nutting C, Hartley AG, Hall P, Hulme C, Patel DK, Zeidler SV, Robinson M, Sanghera B, Fresco L, Dunn JA.

Health Technol Assess. 2017 Apr;21(17):1-122. doi: 10.3310/hta21170.


Management of neck metastases in head and neck cancer: United Kingdom National Multidisciplinary Guidelines.

Paleri V, Urbano TG, Mehanna H, Repanos C, Lancaster J, Roques T, Patel M, Sen M.

J Laryngol Otol. 2016 May;130(S2):S161-S169.


Recurrent head and neck cancer: United Kingdom National Multidisciplinary Guidelines.

Mehanna H, Kong A, Ahmed SK.

J Laryngol Otol. 2016 May;130(S2):S181-S190.


Oropharyngeal cancer: United Kingdom National Multidisciplinary Guidelines.

Mehanna H, Evans M, Beasley M, Chatterjee S, Dilkes M, Homer J, O'Hara J, Robinson M, Shaw R, Sloan P.

J Laryngol Otol. 2016 May;130(S2):S90-S96.


Long-term survival outcomes in patients with surgically treated oropharyngeal cancer and defined human papilloma virus status.

Dale OT, Sood S, Shah KA, Han C, Rapozo D, Mehanna H, Winter SC.

J Laryngol Otol. 2016 Nov;130(11):1048-1053.


HPV-Related Oropharynx Cancer in the United Kingdom: An Evolution in the Understanding of Disease Etiology.

Schache AG, Powell NG, Cuschieri KS, Robinson M, Leary S, Mehanna H, Rapozo D, Long A, Cubie H, Junor E, Monaghan H, Harrington KJ, Nutting CM, Schick U, Lau AS, Upile N, Sheard J, Brougham K, West CM, Oguejiofor K, Thomas S, Ness AR, Pring M, Thomas GJ, King EV, McCance DJ, James JA, Moran M, Sloan P, Shaw RJ, Evans M, Jones TM.

Cancer Res. 2016 Nov 15;76(22):6598-6606. doi: 10.1158/0008-5472.CAN-16-0633. Epub 2016 Aug 28.


Update on De-intensification and Intensification Studies in HPV.

Mehanna H.

Recent Results Cancer Res. 2017;206:251-256. Review.


Pro-invasive Effect of Proto-oncogene PBF Is Modulated by an Interaction with Cortactin.

Watkins RJ, Imruetaicharoenchoke W, Read ML, Sharma N, Poole VL, Gentilin E, Bansal S, Bosseboeuf E, Fletcher R, Nieto HR, Mallick U, Hackshaw A, Mehanna H, Boelaert K, Smith VE, McCabe CJ.

J Clin Endocrinol Metab. 2016 Dec;101(12):4551-4563. Epub 2016 Sep 7.


Management of Advanced Head and Neck Cancer.

Mehanna H, Wong WL, Dunn J.

N Engl J Med. 2016 Aug 4;375(5):492-3. doi: 10.1056/NEJMc1606211. No abstract available.


Efficacy, outcomes, and complication rates of different surgical and nonsurgical treatment modalities for recurrent/residual oropharyngeal carcinoma: A systematic review and meta-analysis.

Jayaram SC, Muzaffar SJ, Ahmed I, Dhanda J, Paleri V, Mehanna H.

Head Neck. 2016 Dec;38(12):1855-1861. doi: 10.1002/hed.24531. Epub 2016 Jul 13. Review.


PET-CT Surveillance versus Neck Dissection in Advanced Head and Neck Cancer.

Mehanna H, Wong WL, McConkey CC, Rahman JK, Robinson M, Hartley AG, Nutting C, Powell N, Al-Booz H, Robinson M, Junor E, Rizwanullah M, von Zeidler SV, Wieshmann H, Hulme C, Smith AF, Hall P, Dunn J; PET-NECK Trial Management Group.

N Engl J Med. 2016 Apr 14;374(15):1444-54. doi: 10.1056/NEJMoa1514493. Epub 2016 Mar 23.


Management of advanced nodal disease in patients treated with primary chemoradiotherapy.

Mehanna H, Wong WL, Dunn J.

Curr Opin Oncol. 2016 May;28(3):201-4. doi: 10.1097/CCO.0000000000000283. Review.


HPV Involvement in Head and Neck Cancers: Comprehensive Assessment of Biomarkers in 3680 Patients.

Castellsagué X, Alemany L, Quer M, Halec G, Quirós B, Tous S, Clavero O, Alòs L, Biegner T, Szafarowski T, Alejo M, Holzinger D, Cadena E, Claros E, Hall G, Laco J, Poljak M, Benevolo M, Kasamatsu E, Mehanna H, Ndiaye C, Guimerà N, Lloveras B, León X, Ruiz-Cabezas JC, Alvarado-Cabrero I, Kang CS, Oh JK, Garcia-Rojo M, Iljazovic E, Ajayi OF, Duarte F, Nessa A, Tinoco L, Duran-Padilla MA, Pirog EC, Viarheichyk H, Morales H, Costes V, Félix A, Germar MJ, Mena M, Ruacan A, Jain A, Mehrotra R, Goodman MT, Lombardi LE, Ferrera A, Malami S, Albanesi EI, Dabed P, Molina C, López-Revilla R, Mandys V, González ME, Velasco J, Bravo IG, Quint W, Pawlita M, Muñoz N, de Sanjosé S, Xavier Bosch F; ICO International HPV in Head and Neck Cancer Study Group.

J Natl Cancer Inst. 2016 Jan 28;108(6):djv403. doi: 10.1093/jnci/djv403. Print 2016 Jun.


Geographic variation in human papillomavirus-related oropharyngeal cancer: Data from 4 multinational randomized trials.

Mehanna H, Franklin N, Compton N, Robinson M, Powell N, Biswas-Baldwin N, Paleri V, Hartley A, Fresco L, Al-Booz H, Junor E, El-Hariry I, Roberts S, Harrington K, Ang KK, Dunn J, Woodman C.

Head Neck. 2016 Apr;38 Suppl 1:E1863-9. doi: 10.1002/hed.24336. Epub 2016 Jan 8.


Features and prognostic utility of biopsy in oral squamous cell carcinoma.

Dhanda J, Uppal N, Chowlia H, Opie N, Al-Qamachi L, Shelat D, Aslam A, Yuffa A, Martin T, Risk J, Triantafyllou A, Shaw R, Parmar S, Mehanna H.

Head Neck. 2016 Apr;38 Suppl 1:E1857-62. doi: 10.1002/hed.24335. Epub 2015 Dec 24.


Postoperative Adjuvant Lapatinib and Concurrent Chemoradiotherapy Followed by Maintenance Lapatinib Monotherapy in High-Risk Patients With Resected Squamous Cell Carcinoma of the Head and Neck: A Phase III, Randomized, Double-Blind, Placebo-Controlled Study.

Harrington K, Temam S, Mehanna H, D'Cruz A, Jain M, D'Onofrio I, Manikhas G, Horvath Z, Sun Y, Dietzsch S, Dubinsky P, Holeckova P, El-Hariry I, Franklin N, Biswas-Baldwin N, Legenne P, Wissel P, Netherway T, Farrell J, Ellis C, Wang-Silvanto J, Amonkar M, Ahmed N, Santillana S, Bourhis J.

J Clin Oncol. 2015 Dec 10;33(35):4202-9. doi: 10.1200/JCO.2015.61.4370. Epub 2015 Nov 2.


External beam radiotherapy in differentiated thyroid carcinoma: A systematic review.

Fussey JM, Crunkhorn R, Tedla M, Weickert MO, Mehanna H.

Head Neck. 2016 Apr;38 Suppl 1:E2297-305. doi: 10.1002/hed.24218. Epub 2015 Sep 3. Review.


IGF-1R expression is associated with HPV-negative status and adverse survival in head and neck squamous cell cancer.

Dale OT, Aleksic T, Shah KA, Han C, Mehanna H, Rapozo DC, Sheard JD, Goodyear P, Upile NS, Robinson M, Jones TM, Winter S, Macaulay VM.

Carcinogenesis. 2015 Jun;36(6):648-55. doi: 10.1093/carcin/bgv053. Epub 2015 Apr 20.


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