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Items: 1 to 50 of 91

1.

Ammonia-Induced Brain Edema Requires Macrophage and T Cell Expression of Toll-Like Receptor 9.

Manakkat Vijay GK, Hu C, Peng J, Garcia-Martinez I, Hoque R, Verghis RM, Ma Y, Mehal WZ, Shawcross DL, Wen L.

Cell Mol Gastroenterol Hepatol. 2019;8(4):609-623. doi: 10.1016/j.jcmgh.2019.08.002. Epub 2019 Aug 8.

2.

Incorporating Weight Loss Medications Into Hepatology Practice for Nonalcoholic Steatohepatitis.

Do A, Kuszewski EJ, Langberg KA, Mehal WZ.

Hepatology. 2019 Oct;70(4):1443-1456. doi: 10.1002/hep.30658. Review.

PMID:
30991446
3.

The Intestinal Microbiome, Plasma Metabolome, and Liver Transcriptome: A Conspiracy Driving Hepatic Steatosis.

Mehal WZ, Loomba R.

Hepatology. 2019 Aug;70(2):741-744. doi: 10.1002/hep.30577. Epub 2019 Apr 11. No abstract available.

PMID:
30779368
4.

Acetyl-Coenzyme A carboxylase inhibition Delivers, as Anticipated, for Patients With Nonalcoholic Steatohepatitis.

Mehal WZ.

Gastroenterology. 2018 Nov;155(5):1304-1306. doi: 10.1053/j.gastro.2018.10.013. Epub 2018 Oct 8. No abstract available.

PMID:
30308191
5.

The multi-dimensional role of intestinal HIFs in liver pathobiology.

Ouyang X, Mehal WZ.

J Hepatol. 2018 Oct;69(4):772-773. doi: 10.1016/j.jhep.2018.07.012. Epub 2018 Aug 10. No abstract available.

PMID:
30104025
6.

Digoxin Suppresses Pyruvate Kinase M2-Promoted HIF-1α Transactivation in Steatohepatitis.

Ouyang X, Han SN, Zhang JY, Dioletis E, Nemeth BT, Pacher P, Feng D, Bataller R, Cabezas J, Stärkel P, Caballeria J, LePine Pongratz R, Cai SY, Schnabl B, Hoque R, Chen Y, Yang WH, Garcia-Martinez I, Wang FS, Gao B, Torok NJ, Kibbey RG, Mehal WZ.

Cell Metab. 2018 May 1;27(5):1156. doi: 10.1016/j.cmet.2018.04.007. No abstract available.

7.

β-Hydroxybutyrate protects from alcohol-induced liver injury via a Hcar2-cAMP dependent pathway.

Chen Y, Ouyang X, Hoque R, Garcia-Martinez I, Yousaf MN, Tonack S, Offermanns S, Dubuquoy L, Louvet A, Mathurin P, Massey V, Schnabl B, Bataller RA, Mehal WZ.

J Hepatol. 2018 Sep;69(3):687-696. doi: 10.1016/j.jhep.2018.04.004. Epub 2018 Apr 27.

8.

Dysregulation of serum bile acids and FGF19 in alcoholic hepatitis.

Brandl K, Hartmann P, Jih LJ, Pizzo DP, Argemi J, Ventura-Cots M, Coulter S, Liddle C, Ling L, Rossi SJ, DePaoli AM, Loomba R, Mehal WZ, Fouts DE, Lucey MR, Bosques-Padilla F, Mathurin P, Louvet A, Garcia-Tsao G, Verna EC, Abraldes JG, Brown RS Jr, Vargas V, Altamirano J, Caballería J, Shawcross D, Stärkel P, Ho SB, Bataller R, Schnabl B.

J Hepatol. 2018 Aug;69(2):396-405. doi: 10.1016/j.jhep.2018.03.031. Epub 2018 Apr 12.

9.

A leukocyte activation test identifies food items which induce release of DNA by innate immune peripheral blood leucocytes.

Garcia-Martinez I, Weiss TR, Yousaf MN, Ali A, Mehal WZ.

Nutr Metab (Lond). 2018 Apr 11;15:26. doi: 10.1186/s12986-018-0260-4. eCollection 2018.

10.

Digoxin Suppresses Pyruvate Kinase M2-Promoted HIF-1α Transactivation in Steatohepatitis.

Ouyang X, Han SN, Zhang JY, Dioletis E, Nemeth BT, Pacher P, Feng D, Bataller R, Cabezas J, Stärkel P, Caballeria J, Pongratz RL, Cai SY, Schnabl B, Hoque R, Chen Y, Yang WH, Garcia-Martinez I, Wang FS, Gao B, Torok NJ, Kibbey RG, Mehal WZ.

Cell Metab. 2018 Feb 6;27(2):339-350.e3. doi: 10.1016/j.cmet.2018.01.007. Erratum in: Cell Metab. 2018 May 1;27(5):1156.

11.

Efficacy of individualised diets in patients with irritable bowel syndrome: a randomised controlled trial.

Ali A, Weiss TR, McKee D, Scherban A, Khan S, Fields MR, Apollo D, Mehal WZ.

BMJ Open Gastroenterol. 2017 Sep 20;4(1):e000164. doi: 10.1136/bmjgast-2017-000164. eCollection 2017.

12.

Intestinal fungi contribute to development of alcoholic liver disease.

Yang AM, Inamine T, Hochrath K, Chen P, Wang L, Llorente C, Bluemel S, Hartmann P, Xu J, Koyama Y, Kisseleva T, Torralba MG, Moncera K, Beeri K, Chen CS, Freese K, Hellerbrand C, Lee SM, Hoffman HM, Mehal WZ, Garcia-Tsao G, Mutlu EA, Keshavarzian A, Brown GD, Ho SB, Bataller R, Stärkel P, Fouts DE, Schnabl B.

J Clin Invest. 2017 Jun 30;127(7):2829-2841. doi: 10.1172/JCI90562. Epub 2017 May 22.

13.

Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response.

Cai SY, Ouyang X, Chen Y, Soroka CJ, Wang J, Mennone A, Wang Y, Mehal WZ, Jain D, Boyer JL.

JCI Insight. 2017 Mar 9;2(5):e90780. doi: 10.1172/jci.insight.90780.

14.

The novel TLR9 antagonist COV08-0064 protects from ischemia/reperfusion injury in non-steatotic and steatotic mice livers.

Shaker ME, Trawick BN, Mehal WZ.

Biochem Pharmacol. 2016 Jul 15;112:90-101. doi: 10.1016/j.bcp.2016.05.003. Epub 2016 May 6.

PMID:
27157410
15.

Targeting Cell Death and Sterile Inflammation Loop for the Treatment of Nonalcoholic Steatohepatitis.

Wree A, Mehal WZ, Feldstein AE.

Semin Liver Dis. 2016 Feb;36(1):27-36. doi: 10.1055/s-0035-1571272. Epub 2016 Feb 12. Review.

16.

Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9.

Garcia-Martinez I, Santoro N, Chen Y, Hoque R, Ouyang X, Caprio S, Shlomchik MJ, Coffman RL, Candia A, Mehal WZ.

J Clin Invest. 2016 Mar 1;126(3):859-64. doi: 10.1172/JCI83885. Epub 2016 Jan 25.

17.

Caspase-12, but Not Caspase-11, Inhibits Obesity and Insulin Resistance.

Skeldon AM, Morizot A, Douglas T, Santoro N, Kursawe R, Kozlitina J, Caprio S, Mehal WZ, Saleh M.

J Immunol. 2016 Jan 1;196(1):437-47. doi: 10.4049/jimmunol.1501529. Epub 2015 Nov 18.

18.

We are not in Kansas anymore: The unfamiliar landscape of NASH.

Mehal WZ.

Hepatology. 2016 Mar;63(3):682-4. doi: 10.1002/hep.28348. Epub 2016 Jan 5. No abstract available.

PMID:
26567082
19.

CELLS ON FIRE.

Mehal WZ.

Sci Am. 2015 Jun;312(6):44-9. No abstract available.

PMID:
26336685
20.

Therapeutic Opportunities in Damage-Associated Molecular Pattern-Driven Metabolic Diseases.

Garcia-Martinez I, Shaker ME, Mehal WZ.

Antioxid Redox Signal. 2015 Dec 10;23(17):1305-15. doi: 10.1089/ars.2015.6383. Epub 2015 Jul 27. Review.

21.

Antifibrotic therapies in the liver.

Mehal WZ, Schuppan D.

Semin Liver Dis. 2015 May;35(2):184-98. doi: 10.1055/s-0035-1550055. Epub 2015 May 14. Review.

22.

Systemic inflammatory response and serum lipopolysaccharide levels predict multiple organ failure and death in alcoholic hepatitis.

Michelena J, Altamirano J, Abraldes JG, Affò S, Morales-Ibanez O, Sancho-Bru P, Dominguez M, García-Pagán JC, Fernández J, Arroyo V, Ginès P, Louvet A, Mathurin P, Mehal WZ, Caballería J, Bataller R.

Hepatology. 2015 Sep;62(3):762-72. doi: 10.1002/hep.27779. Epub 2015 Apr 13.

23.

Inflammasomes in pancreatic physiology and disease.

Hoque R, Mehal WZ.

Am J Physiol Gastrointest Liver Physiol. 2015 Apr 15;308(8):G643-51. doi: 10.1152/ajpgi.00388.2014. Epub 2015 Feb 19. Review.

24.

DNA: adding injury to insult.

Garcia-Martinez I, Mehal WZ.

Hepatology. 2015 Jan;61(1):35-6. doi: 10.1002/hep.27398. Epub 2014 Nov 26. No abstract available.

PMID:
25145786
25.

Activation of N-methyl-d-aspartate receptor downregulates inflammasome activity and liver inflammation via a β-arrestin-2 pathway.

Farooq A, Hoque R, Ouyang X, Farooq A, Ghani A, Ahsan K, Guerra M, Mehal WZ.

Am J Physiol Gastrointest Liver Physiol. 2014 Oct 1;307(7):G732-40. doi: 10.1152/ajpgi.00073.2014. Epub 2014 Aug 7.

26.

The inflammasome in liver injury and non-alcoholic fatty liver disease.

Mehal WZ.

Dig Dis. 2014;32(5):507-15. doi: 10.1159/000360495. Epub 2014 Jul 14. Review.

27.

Activation of adenosine receptor A2A increases HSC proliferation and inhibits death and senescence by down-regulation of p53 and Rb.

Ahsan MK, Mehal WZ.

Front Pharmacol. 2014 Apr 10;5:69. doi: 10.3389/fphar.2014.00069. eCollection 2014.

28.

Who is the scientist in bio-medical research, the author or the reviewer?

Mehal WZ.

Front Pharmacol. 2014 Mar 26;5:50. doi: 10.3389/fphar.2014.00050. eCollection 2014. No abstract available.

29.

Lactate reduces liver and pancreatic injury in Toll-like receptor- and inflammasome-mediated inflammation via GPR81-mediated suppression of innate immunity.

Hoque R, Farooq A, Ghani A, Gorelick F, Mehal WZ.

Gastroenterology. 2014 Jun;146(7):1763-74. doi: 10.1053/j.gastro.2014.03.014. Epub 2014 Mar 20.

30.

Adenosine is required for sustained inflammasome activation via the A₂A receptor and the HIF-1α pathway.

Ouyang X, Ghani A, Malik A, Wilder T, Colegio OR, Flavell RA, Cronstein BN, Mehal WZ.

Nat Commun. 2013;4:2909. doi: 10.1038/ncomms3909.

31.

The Gordian Knot of dysbiosis, obesity and NAFLD.

Mehal WZ.

Nat Rev Gastroenterol Hepatol. 2013 Nov;10(11):637-44. doi: 10.1038/nrgastro.2013.146. Epub 2013 Aug 20. Review.

PMID:
23958600
32.

Constitutive NLRP3 activation: too much of a bad thing.

Mehal WZ.

Hepatology. 2014 Mar;59(3):761-3. doi: 10.1002/hep.26674. Epub 2014 Jan 13. No abstract available.

PMID:
23929761
33.

Sterile inflammation in the liver and pancreas.

Hoque R, Farooq A, Mehal WZ.

J Gastroenterol Hepatol. 2013 Aug;28 Suppl 1:61-7. doi: 10.1111/jgh.12018. Review.

34.

Inflammasome biology in fibrogenesis.

Ouyang X, Ghani A, Mehal WZ.

Biochim Biophys Acta. 2013 Jul;1832(7):979-88. doi: 10.1016/j.bbadis.2013.03.020. Epub 2013 Apr 3.

35.

Nilotinib induces apoptosis and autophagic cell death of activated hepatic stellate cells via inhibition of histone deacetylases.

Shaker ME, Ghani A, Shiha GE, Ibrahim TM, Mehal WZ.

Biochim Biophys Acta. 2013 Aug;1833(8):1992-2003. doi: 10.1016/j.bbamcr.2013.02.033. Epub 2013 Mar 13.

36.

Sterile inflammation in the liver.

Kubes P, Mehal WZ.

Gastroenterology. 2012 Nov;143(5):1158-1172. doi: 10.1053/j.gastro.2012.09.008. Epub 2012 Sep 13. Review.

PMID:
22982943
37.

Pathogenesis of liver injury in acute liver failure.

Chung RT, Stravitz RT, Fontana RJ, Schiodt FV, Mehal WZ, Reddy KR, Lee WM.

Gastroenterology. 2012 Sep;143(3):e1-e7. doi: 10.1053/j.gastro.2012.07.011. Epub 2012 Jul 13. No abstract available.

38.

Gaucher disease gene GBA functions in immune regulation.

Liu J, Halene S, Yang M, Iqbal J, Yang R, Mehal WZ, Chuang WL, Jain D, Yuen T, Sun L, Zaidi M, Mistry PK.

Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):10018-23. doi: 10.1073/pnas.1200941109. Epub 2012 Jun 4.

39.

Adenine induces differentiation of rat hepatic stellate cells.

Watanabe A, Sohail MA, Gautam S, Gomes DA, Mehal WZ.

Dig Dis Sci. 2012 Sep;57(9):2371-8. doi: 10.1007/s10620-012-2183-7. Epub 2012 May 10.

40.

Sterile inflammatory response in acute pancreatitis.

Hoque R, Malik AF, Gorelick F, Mehal WZ.

Pancreas. 2012 Apr;41(3):353-7. doi: 10.1097/MPA.0b013e3182321500. Review.

41.

The gut-liver axis: a busy two-way street.

Mehal WZ.

Hepatology. 2012 Jun;55(6):1647-9. doi: 10.1002/hep.25704. No abstract available.

PMID:
22407752
42.

P2X7 receptor-mediated purinergic signaling promotes liver injury in acetaminophen hepatotoxicity in mice.

Hoque R, Sohail MA, Salhanick S, Malik AF, Ghani A, Robson SC, Mehal WZ.

Am J Physiol Gastrointest Liver Physiol. 2012 May 15;302(10):G1171-9. doi: 10.1152/ajpgi.00352.2011. Epub 2012 Mar 1.

43.

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.

Henao-Mejia J, Elinav E, Jin C, Hao L, Mehal WZ, Strowig T, Thaiss CA, Kau AL, Eisenbarth SC, Jurczak MJ, Camporez JP, Shulman GI, Gordon JI, Hoffman HM, Flavell RA.

Nature. 2012 Feb 1;482(7384):179-85. doi: 10.1038/nature10809.

44.

Inflammasome components Asc and caspase-1 mediate biomaterial-induced inflammation and foreign body response.

Malik AF, Hoque R, Ouyang X, Ghani A, Hong E, Khan K, Moore LB, Ng G, Munro F, Flavell RA, Shi Y, Kyriakides TR, Mehal WZ.

Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20095-100. doi: 10.1073/pnas.1105152108. Epub 2011 Nov 22.

45.

HIF-1α is a major and complex player in alcohol induced liver diseases.

Mehal WZ.

J Hepatol. 2012 Feb;56(2):311-2. doi: 10.1016/j.jhep.2011.09.009. Epub 2011 Sep 29. No abstract available.

46.

Scraping fibrosis: expressway to the core of fibrosis.

Mehal WZ, Iredale J, Friedman SL.

Nat Med. 2011 May;17(5):552-3. doi: 10.1038/nm0511-552. Review. No abstract available.

47.

Comparison of imatinib, nilotinib and silymarin in the treatment of carbon tetrachloride-induced hepatic oxidative stress, injury and fibrosis.

Shaker ME, Zalata KR, Mehal WZ, Shiha GE, Ibrahim TM.

Toxicol Appl Pharmacol. 2011 Apr 15;252(2):165-75. doi: 10.1016/j.taap.2011.02.004. Epub 2011 Feb 24.

48.

Glucocerebrosidase gene-deficient mouse recapitulates Gaucher disease displaying cellular and molecular dysregulation beyond the macrophage.

Mistry PK, Liu J, Yang M, Nottoli T, McGrath J, Jain D, Zhang K, Keutzer J, Chuang WL, Mehal WZ, Zhao H, Lin A, Mane S, Liu X, Peng YZ, Li JH, Agrawal M, Zhu LL, Blair HC, Robinson LJ, Iqbal J, Sun L, Zaidi M.

Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19473-8. doi: 10.1073/pnas.1003308107. Epub 2010 Oct 20. Erratum in: Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):9220. Chuang, Wei-Lein [corrected to Chuang, Wei-Lien].

49.

A distinct nitric oxide and adenosine A1 receptor dependent hepatic artery vasodilatatory response in the CCl-cirrhotic liver.

Zipprich A, Mehal WZ, Ripoll C, Groszmann RJ.

Liver Int. 2010 Aug;30(7):988-94. doi: 10.1111/j.1478-3231.2010.02278.x. Epub 2010 May 24.

50.

Adenosine inhibits chemotaxis and induces hepatocyte-specific genes in bone marrow mesenchymal stem cells.

Mohamadnejad M, Sohail MA, Watanabe A, Krause DS, Swenson ES, Mehal WZ.

Hepatology. 2010 Mar;51(3):963-73. doi: 10.1002/hep.23389.

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