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Items: 17

1.

Biochemical Characterization of Isoniazid-resistant Mycobacterium tuberculosis: Can the Analysis of Clonal Strains Reveal Novel Targetable Pathways?

Nieto R LM, Mehaffy C, Islam MN, Fitzgerald B, Belisle J, Prenni J, Dobos K.

Mol Cell Proteomics. 2018 Sep;17(9):1685-1701. doi: 10.1074/mcp.RA118.000821. Epub 2018 May 29.

PMID:
29844232
2.

Cytokine-Mediated Systemic Adverse Drug Reactions in a Drug-Drug Interaction Study of Dolutegravir With Once-Weekly Isoniazid and Rifapentine.

Brooks KM, George JM, Pau AK, Rupert A, Mehaffy C, De P, Dobos KM, Kellogg A, McLaughlin M, McManus M, Alfaro RM, Hadigan C, Kovacs JA, Kumar P.

Clin Infect Dis. 2018 Jul 2;67(2):193-201. doi: 10.1093/cid/ciy082.

PMID:
29415190
3.

Whole transcriptomic and proteomic analyses of an isogenic M. tuberculosis clinical strain with a naturally occurring 15 Kb genomic deletion.

Duncan C, Jamieson FB, Troudt J, Izzo L, Bielefeldt-Ohmann H, Izzo A, Mehaffy C.

PLoS One. 2017 Jun 26;12(6):e0179996. doi: 10.1371/journal.pone.0179996. eCollection 2017.

4.

Second generation multiple reaction monitoring assays for enhanced detection of ultra-low abundance Mycobacterium tuberculosis peptides in human serum.

Mehaffy C, Dobos KM, Nahid P, Kruh-Garcia NA.

Clin Proteomics. 2017 Jun 5;14:21. doi: 10.1186/s12014-017-9156-y. eCollection 2017.

5.

Virulence of Mycobacterium tuberculosis after Acquisition of Isoniazid Resistance: Individual Nature of katG Mutants and the Possible Role of AhpC.

Nieto R LM, Mehaffy C, Creissen E, Troudt J, Troy A, Bielefeldt-Ohmann H, Burgos M, Izzo A, Dobos KM.

PLoS One. 2016 Nov 28;11(11):e0166807. doi: 10.1371/journal.pone.0166807. eCollection 2016.

6.

Longitudinal whole genome analysis of pre and post drug treatment Mycobacterium tuberculosis isolates reveals progressive steps to drug resistance.

Datta G, Nieto LM, Davidson RM, Mehaffy C, Pederson C, Dobos KM, Strong M.

Tuberculosis (Edinb). 2016 May;98:50-5. doi: 10.1016/j.tube.2016.02.004. Epub 2016 Feb 26.

7.

Comparing isogenic strains of Beijing genotype Mycobacterium tuberculosis after acquisition of Isoniazid resistance: A proteomics approach.

Nieto R LM, Mehaffy C, Dobos KM.

Proteomics. 2016 May;16(9):1376-80. doi: 10.1002/pmic.201500403. Epub 2016 Apr 13.

8.

Preliminary evaluation of exome sequencing to identify genetic markers of susceptibility to tuberculosis disease.

Duncan C, Jamieson F, Mehaffy C.

BMC Res Notes. 2015 Dec 8;8:750. doi: 10.1186/s13104-015-1740-5.

9.
10.

Marked microevolution of a unique Mycobacterium tuberculosis strain in 17 years of ongoing transmission in a high risk population.

Mehaffy C, Guthrie JL, Alexander DC, Stuart R, Rea E, Jamieson FB.

PLoS One. 2014 Nov 18;9(11):e112928. doi: 10.1371/journal.pone.0112928. eCollection 2014.

11.
12.

Profiling of rpoB mutations and MICs for rifampin and rifabutin in Mycobacterium tuberculosis.

Jamieson FB, Guthrie JL, Neemuchwala A, Lastovetska O, Melano RG, Mehaffy C.

J Clin Microbiol. 2014 Jun;52(6):2157-62. doi: 10.1128/JCM.00691-14. Epub 2014 Apr 16.

13.

Upregulation of the phthiocerol dimycocerosate biosynthetic pathway by rifampin-resistant, rpoB mutant Mycobacterium tuberculosis.

Bisson GP, Mehaffy C, Broeckling C, Prenni J, Rifat D, Lun DS, Burgos M, Weissman D, Karakousis PC, Dobos K.

J Bacteriol. 2012 Dec;194(23):6441-52. doi: 10.1128/JB.01013-12. Epub 2012 Sep 21.

14.

Characterization of extensively drug-resistant tuberculosis cases from Valle del Cauca, Colombia.

Nieto LM, Ferro BE, Villegas SL, Mehaffy C, Forero L, Moreira C, Rastogi N, van Soolingen D.

J Clin Microbiol. 2012 Dec;50(12):4185-7. doi: 10.1128/JCM.01946-12. Epub 2012 Sep 19. No abstract available.

15.

Epidemiologic consequences of microvariation in Mycobacterium tuberculosis.

Mathema B, Kurepina N, Yang G, Shashkina E, Manca C, Mehaffy C, Bielefeldt-Ohmann H, Ahuja S, Fallows DA, Izzo A, Bifani P, Dobos K, Kaplan G, Kreiswirth BN.

J Infect Dis. 2012 Mar 15;205(6):964-74. doi: 10.1093/infdis/jir876. Epub 2012 Feb 7.

16.

Descriptive proteomic analysis shows protein variability between closely related clinical isolates of Mycobacterium tuberculosis.

Mehaffy C, Hess A, Prenni JE, Mathema B, Kreiswirth B, Dobos KM.

Proteomics. 2010 May;10(10):1966-84. doi: 10.1002/pmic.200900836.

17.

Identification of promoter-binding proteins of the fbp A and C genes in Mycobacterium tuberculosis.

Romero IC, Mehaffy C, Burchmore RJ, Dobos-Elder K, Brennan P, Walker J.

Tuberculosis (Edinb). 2010 Jan;90(1):25-30. doi: 10.1016/j.tube.2009.10.001. Epub 2009 Dec 3.

PMID:
19959397

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