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Items: 1 to 50 of 60

1.

Aging phenotype(s) in kidneys of diabetic mice are p66ShcA dependent.

Vashistha H, Marrero L, Reiss K, Cohen AJ, Malhotra A, Javed T, Bradley A, Abbruscato F, Giusti S, Jimenez A, Mehra S, Kaushal D, Giorgio M, Pelicci PG, Kakoki M, Singhal PC, Bunnell B, Meggs LG.

Am J Physiol Renal Physiol. 2018 Dec 1;315(6):F1833-F1842. doi: 10.1152/ajprenal.00608.2017. Epub 2018 Sep 12.

PMID:
30207172
2.

Modulation of apolipoprotein L1-microRNA-193a axis prevents podocyte dedifferentiation in high-glucose milieu.

Mishra A, Ayasolla K, Kumar V, Lan X, Vashistha H, Aslam R, Hussain A, Chowdhary S, Marashi Shoshtari S, Paliwal N, Popik W, Saleem MA, Malhotra A, Meggs LG, Skorecki K, Singhal PC.

Am J Physiol Renal Physiol. 2018 May 1;314(5):F832-F843. doi: 10.1152/ajprenal.00541.2017. Epub 2018 Jan 10.

3.

AT1R blockade in adverse milieus: role of SMRT and corepressor complexes.

Singh T, Ayasolla K, Rai P, Chandel N, Haque S, Lederman R, Husain M, Vethantham V, Chawla A, Vashistha H, Saleem MA, Ding G, Chander PN, Malhotra A, Meggs LG, Singhal PC.

Am J Physiol Renal Physiol. 2015 Aug 1;309(3):F189-203. doi: 10.1152/ajprenal.00476.2014. Epub 2015 Jun 17.

4.

Polycyclic aromatic hydrocarbons-induced ROS accumulation enhances mutagenic potential of T-antigen from human polyomavirus JC.

Wilk A, Walig├│rski P, Lassak A, Vashistha H, Lirette D, Tate D, Zea AH, Koochekpour S, Rodriguez P, Meggs LG, Estrada JJ, Ochoa A, Reiss K.

J Cell Physiol. 2013 Nov;228(11):2127-38. doi: 10.1002/jcp.24375.

5.

Diabetic nephropathy: lessons from the mouse.

Vashistha H, Meggs L.

Ochsner J. 2013 Spring;13(1):140-6.

6.

Deficit of p66ShcA restores redox-sensitive stress response program in cisplatin-induced acute kidney injury.

Rattanavich R, Plagov A, Kumar D, Rai P, Lederman R, Salhan D, Vashistha H, Malhotra A, Meggs LG, Singhal PC.

Exp Mol Pathol. 2013 Jun;94(3):445-52. doi: 10.1016/j.yexmp.2013.03.001. Epub 2013 Mar 16.

7.

Null mutations at the p66 and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney.

Vashistha H, Singhal PC, Malhotra A, Husain M, Mathieson P, Saleem MA, Kuriakose C, Seshan S, Wilk A, Delvalle L, Peruzzi F, Giorgio M, Pelicci PG, Smithies O, Kim HS, Kakoki M, Reiss K, Meggs LG.

Am J Physiol Renal Physiol. 2012 Dec 15;303(12):F1629-40. doi: 10.1152/ajprenal.00246.2012. Epub 2012 Sep 26.

8.

HIV gene expression deactivates redox-sensitive stress response program in mouse tubular cells both in vitro and in vivo.

Salhan D, Pathak S, Husain M, Tandon P, Kumar D, Malhotra A, Meggs LG, Singhal PC.

Am J Physiol Renal Physiol. 2012 Jan 1;302(1):F129-40. doi: 10.1152/ajprenal.00024.2011. Epub 2011 Oct 12.

9.

Insulin-like growth factor-I-forkhead box O transcription factor 3a counteracts high glucose/tumor necrosis factor-╬▒-mediated neuronal damage: implications for human immunodeficiency virus encephalitis.

Wilk A, Urbanska K, Yang S, Wang JY, Amini S, Del Valle L, Peruzzi F, Meggs L, Reiss K.

J Neurosci Res. 2011 Feb;89(2):183-98. doi: 10.1002/jnr.22542. Epub 2010 Dec 8.

10.

Inhibition of p66ShcA longevity gene rescues podocytes from HIV-1-induced oxidative stress and apoptosis.

Husain M, Meggs LG, Vashistha H, Simoes S, Griffiths KO, Kumar D, Mikulak J, Mathieson PW, Saleem MA, Del Valle L, Pina-Oviedo S, Wang JY, Seshan SV, Malhotra A, Reiss K, Singhal PC.

J Biol Chem. 2009 Jun 12;284(24):16648-58. doi: 10.1074/jbc.M109.008482. Epub 2009 Apr 21.

11.

Inhibition of p66ShcA redox activity in cardiac muscle cells attenuates hyperglycemia-induced oxidative stress and apoptosis.

Malhotra A, Vashistha H, Yadav VS, Dube MG, Kalra SP, Abdellatif M, Meggs LG.

Am J Physiol Heart Circ Physiol. 2009 Feb;296(2):H380-8. doi: 10.1152/ajpheart.00225.2008. Epub 2008 Dec 5.

12.

Overexpression of Gsalpha compensates for myocyte loss in diabetic cardiomyopathy.

Malhotra A, Kang BP, Vashistha H, Yadav VS, Meggs LG.

Can J Physiol Pharmacol. 2008 Mar;86(3):122-30. doi: 10.1139/y08-015.

PMID:
18418439
13.

Inhibition of wild-type p66ShcA in mesangial cells prevents glycooxidant-dependent FOXO3a regulation and promotes the survival phenotype.

Chintapalli J, Yang S, Opawumi D, Goyal SR, Shamsuddin N, Malhotra A, Reiss K, Meggs LG.

Am J Physiol Renal Physiol. 2007 Feb;292(2):F523-30. Epub 2006 Oct 31.

14.

Activated IGF-1R inhibits hyperglycemia-induced DNA damage and promotes DNA repair by homologous recombination.

Yang S, Chintapalli J, Sodagum L, Baskin S, Malhotra A, Reiss K, Meggs LG.

Am J Physiol Renal Physiol. 2005 Nov;289(5):F1144-52. Epub 2005 Jun 14.

15.

PKC-{epsilon}-dependent survival signals in diabetic hearts.

Malhotra A, Begley R, Kang BP, Rana I, Liu J, Yang G, Mochly-Rosen D, Meggs LG.

Am J Physiol Heart Circ Physiol. 2005 Oct;289(4):H1343-50. Epub 2005 May 13.

16.

PKCepsilon inhibits the hyperglycemia-induced apoptosis signal in adult rat ventricular myocytes.

Malhotra A, Kang BP, Hashmi S, Meggs LG.

Mol Cell Biochem. 2005 Jan;268(1-2):169-73.

PMID:
15724450
17.

Glycation end-product cross-link breaker reduces collagen and improves cardiac function in aging diabetic heart.

Liu J, Masurekar MR, Vatner DE, Jyothirmayi GN, Regan TJ, Vatner SF, Meggs LG, Malhotra A.

Am J Physiol Heart Circ Physiol. 2003 Dec;285(6):H2587-91. Epub 2003 Aug 28.

18.

IGF-1 inhibits the mitochondrial apoptosis program in mesangial cells exposed to high glucose.

Kang BP, Urbonas A, Baddoo A, Baskin S, Malhotra A, Meggs LG.

Am J Physiol Renal Physiol. 2003 Nov;285(5):F1013-24. Epub 2003 Jul 22.

19.

High glucose promotes mesangial cell apoptosis by oxidant-dependent mechanism.

Kang BP, Frencher S, Reddy V, Kessler A, Malhotra A, Meggs LG.

Am J Physiol Renal Physiol. 2003 Mar;284(3):F455-66. Epub 2002 Nov 5.

20.

Molecular biology of protein kinase C signaling in cardiac myocytes.

Malhotra A, Kang BP, Opawumi D, Belizaire W, Meggs LG.

Mol Cell Biochem. 2001 Sep;225(1-):97-107. Review.

PMID:
11716370
21.

Angiotensin II promotes glucose-induced activation of cardiac protein kinase C isozymes and phosphorylation of troponin I.

Malhotra A, Kang BP, Cheung S, Opawumi D, Meggs LG.

Diabetes. 2001 Aug;50(8):1918-26.

22.

Emerging concepts in antihypertensive therapy: the benefits of angiotensin II blockade.

Meggs LG, Kodali P.

J Assoc Acad Minor Phys. 1999;10(2):34-43. Review.

PMID:
10826007
23.

Overexpression of insulin-like growth factor-1 attenuates the myocyte renin-angiotensin system in transgenic mice.

Leri A, Liu Y, Wang X, Kajstura J, Malhotra A, Meggs LG, Anversa P.

Circ Res. 1999 Apr 16;84(7):752-62.

PMID:
10205143
24.

Angiotensin II activates programmed myocyte cell death in vitro.

Cigola E, Kajstura J, Li B, Meggs LG, Anversa P.

Exp Cell Res. 1997 Mar 15;231(2):363-71.

PMID:
9087178
25.

Angiotensin II induces apoptosis of adult ventricular myocytes in vitro.

Kajstura J, Cigola E, Malhotra A, Li P, Cheng W, Meggs LG, Anversa P.

J Mol Cell Cardiol. 1997 Mar;29(3):859-70.

PMID:
9152847
26.

Coronary artery stenosis in rats affects beta-adrenergic receptor signaling in myocytes.

Meggs LG, Huang HE, Li B, Li P, Coupet J, Hamby CV, Akanuma M, Ishikawa Y, Anversa P.

Cardiovasc Res. 1997 Jan;33(1):98-109.

PMID:
9059533
27.

Myocardial infarction alters myofilament calcium sensitivity and mechanical behavior of myocytes.

Li P, Hofmann PA, Li B, Malhotra A, Cheng W, Sonnenblick EH, Meggs LG, Anversa P.

Am J Physiol. 1997 Jan;272(1 Pt 2):H360-70.

PMID:
9038957
28.

Identification and activation of autocrine renin-angiotensin system in adult ventricular myocytes.

Zhang X, Dostal DE, Reiss K, Cheng W, Kajstura J, Li P, Huang H, Sonnenblick EH, Meggs LG, Baker KM, et al.

Am J Physiol. 1995 Nov;269(5 Pt 2):H1791-802.

PMID:
7503279
29.

Fibroblast proliferation during myocardial development in rats is regulated by IGF-1 receptors.

Reiss K, Cheng W, Kajstura J, Sonnenblick EH, Meggs LG, Anversa P.

Am J Physiol. 1995 Sep;269(3 Pt 2):H943-51.

PMID:
7573538
30.

Alterations in angiotensin II receptor mediated signal transduction shortly after coronary artery constriction in the rat.

Huang H, Li P, Hamby CV, Reiss K, Meggs LG, Anversa P.

Cardiovasc Res. 1994 Oct;28(10):1564-73.

PMID:
8001047
31.

Coronary artery constriction in rats affects the activation of alpha 1 adrenergic receptors in cardiac myocytes.

Cheng W, Coupet J, Li P, Reiss K, Hamby CV, Capasso JM, Meggs LG, Anversa P.

Cardiovasc Res. 1994 Jul;28(7):1070-82.

PMID:
7954594
32.

Efficacy of angiotensin-converting enzyme inhibition and AT1 receptor blockade on cardiac pump performance after myocardial infarction in rats.

Capasso JM, Li P, Meggs LG, Herman MV, Anversa P.

J Cardiovasc Pharmacol. 1994 Apr;23(4):584-93.

PMID:
7516008
33.

The cardiocyte as a target for parathyroid hormone in end-stage renal disease.

Meggs LG.

J Assoc Acad Minor Phys. 1994;5(2):59-61. Review.

PMID:
8032177
34.

Upregulation of IGF1, IGF1-receptor, and late growth related genes in ventricular myocytes acutely after infarction in rats.

Reiss K, Meggs LG, Li P, Olivetti G, Capasso JM, Anversa P.

J Cell Physiol. 1994 Jan;158(1):160-8.

PMID:
7505276
35.

Regulation of angiotensin II receptors on ventricular myocytes after myocardial infarction in rats.

Meggs LG, Coupet J, Huang H, Cheng W, Li P, Capasso JM, Homcy CJ, Anversa P.

Circ Res. 1993 Jun;72(6):1149-62.

PMID:
8495545
36.

Alterations in ANG II responsiveness in left and right myocardium after infarction-induced heart failure in rats.

Capasso JM, Li P, Zhang X, Meggs LG, Anversa P.

Am J Physiol. 1993 Jun;264(6 Pt 2):H2056-67.

PMID:
8322934
37.

Myocyte loss and left ventricular failure characterise the long term effects of coronary artery narrowing or renal hypertension in rats.

Li P, Zhang X, Capasso JM, Meggs LG, Sonnenblick EH, Anversa P.

Cardiovasc Res. 1993 Jun;27(6):1066-75.

PMID:
8221766
38.

ANG II receptors, c-myc, and c-jun in myocytes after myocardial infarction and ventricular failure.

Reiss K, Capasso JM, Huang HE, Meggs LG, Li P, Anversa P.

Am J Physiol. 1993 Mar;264(3 Pt 2):H760-9.

PMID:
8456979
39.

Re-expression of alpha skeletal actin and regulation of alpha 1 adrenoceptor signalling in DOCA-salt hypertension in rats.

Meggs LG, Huang H, Tillotson J, Capasso JM, Anversa P.

Cardiovasc Res. 1992 Sep;26(9):878-85.

PMID:
1333362
40.

Chronic coronary arterial stenosis impairs alpha 1-adrenoreceptor signaling and cardiac performance in rats.

Meggs LG, Huang H, Li P, Capasso JM, Anversa P.

Am J Physiol. 1992 Sep;263(3 Pt 2):H929-38.

PMID:
1329538
41.
42.

Association of asbestos exposure, retroperitoneal fibrosis, and acute renal failure.

Maguire GP, Meggs LG, Addonizio J, Del Guercio LR.

N Y State J Med. 1991 Aug;91(8):357-9. No abstract available.

PMID:
1945140
43.

Cellular basis of chronic ventricular remodeling after myocardial infarction in rats.

Olivetti G, Capasso JM, Meggs LG, Sonnenblick EH, Anversa P.

Circ Res. 1991 Mar;68(3):856-69.

PMID:
1742871
44.
45.

Myocyte cell loss and myocyte cellular hyperplasia in the hypertrophied aging rat heart.

Anversa P, Palackal T, Sonnenblick EH, Olivetti G, Meggs LG, Capasso JM.

Circ Res. 1990 Oct;67(4):871-85.

PMID:
2145091
46.

Adaptive myocardial hypertrophy in the renal ablation model.

Meggs LG, Ben-Ari J, Gammon D, Choudhury M, Goodman AI.

Am J Hypertens. 1990 Jan;3(1):33-8.

PMID:
2154238
47.

Left ventricular response to exercise and autonomic control mechanisms in end-stage renal disease.

Blake JW, Solangi KB, Herman MV, Goodman AA, Meggs LG.

Arch Intern Med. 1989 Feb;149(2):433-6.

PMID:
2916888
48.

Amelioration of systemic hypertension by converting enzyme inhibition in the renal ablation model.

Meggs LG, Garrick R, Chander P, Ben-Ari J, Gammon D, Goodman AI.

Am J Hypertens. 1988 Apr;1(2):190-2.

PMID:
2969741
49.

Upregulation of the vascular alpha-1 receptor in malignant DOCA-salt hypertension.

Meggs LG, Stitzel R, Ben-Ari J, Chander P, Gammon D, Goodman AI, Head R.

Clin Exp Hypertens A. 1988;10(2):229-47.

PMID:
2836114
50.

Myocardial hypertrophy: the effect of sodium and the role of sympathetic nervous system activity.

Meggs LG, Ben-Ari J, Gammon D, Goodman AI.

Am J Hypertens. 1988 Jan;1(1):11-5.

PMID:
2835963

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