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Items: 23

1.

Safety and efficacy of MIM-D3 ophthalmic solutions in a randomized, placebo-controlled Phase 2 clinical trial in patients with dry eye.

Meerovitch K, Torkildsen G, Lonsdale J, Goldfarb H, Lama T, Cumberlidge G, Ousler GW 3rd.

Clin Ophthalmol. 2013;7:1275-85. doi: 10.2147/OPTH.S44688. Epub 2013 Jun 26.

2.

An NGF mimetic, MIM-D3, stimulates conjunctival cell glycoconjugate secretion and demonstrates therapeutic efficacy in a rat model of dry eye.

Jain P, Li R, Lama T, Saragovi HU, Cumberlidge G, Meerovitch K.

Exp Eye Res. 2011 Oct;93(4):503-12. doi: 10.1016/j.exer.2011.06.014. Epub 2011 Jun 25.

PMID:
21726552
3.

Small-molecule ligands of GD2 ganglioside, designed from NMR studies, exhibit induced-fit binding and bioactivity.

Tong W, Gagnon M, Sprules T, Gilbert M, Chowdhury S, Meerovitch K, Hansford K, Purisima EO, Blankenship JW, Cheung NK, Gehring K, Lubell WD, Saragovi HU.

Chem Biol. 2010 Feb 26;17(2):183-94. doi: 10.1016/j.chembiol.2010.01.012.

4.

Alpha2-macroglobulin is a mediator of retinal ganglion cell death in glaucoma.

Shi Z, Rudzinski M, Meerovitch K, Lebrun-Julien F, Birman E, Di Polo A, Saragovi HU.

J Biol Chem. 2008 Oct 24;283(43):29156-65. doi: 10.1074/jbc.M802365200. Epub 2008 Aug 13.

5.

Hepatitis C virus NS2/3 processing is required for NS3 stability and viral RNA replication.

Welbourn S, Green R, Gamache I, Dandache S, Lohmann V, Bartenschlager R, Meerovitch K, Pause A.

J Biol Chem. 2005 Aug 19;280(33):29604-11. Epub 2005 Jun 24.

6.

Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 1. Structure-activity relationships of the 4-aryl group.

Kemnitzer W, Drewe J, Jiang S, Zhang H, Wang Y, Zhao J, Jia S, Herich J, Labreque D, Storer R, Meerovitch K, Bouffard D, Rej R, Denis R, Blais C, Lamothe S, Attardo G, Gourdeau H, Tseng B, Kasibhatla S, Cai SX.

J Med Chem. 2004 Dec 2;47(25):6299-310.

PMID:
15566300
7.

Discovery and mechanism of action of a novel series of apoptosis inducers with potential vascular targeting activity.

Kasibhatla S, Gourdeau H, Meerovitch K, Drewe J, Reddy S, Qiu L, Zhang H, Bergeron F, Bouffard D, Yang Q, Herich J, Lamothe S, Cai SX, Tseng B.

Mol Cancer Ther. 2004 Nov;3(11):1365-74.

8.

A novel RGD antagonist that targets both alphavbeta3 and alpha5beta1 induces apoptosis of angiogenic endothelial cells on type I collagen.

Meerovitch K, Bergeron F, Leblond L, Grouix B, Poirier C, Bubenik M, Chan L, Gourdeau H, Bowlin T, Attardo G.

Vascul Pharmacol. 2003 Feb;40(2):77-89.

PMID:
12646396
9.

Thiophene-based vitronectin receptor antagonists.

Bubenik M, Meerovitch K, Bergeron F, Attardo G, Chan L.

Bioorg Med Chem Lett. 2003 Feb 10;13(3):503-6.

PMID:
12565960
10.
11.
12.

Identification and characterization of 1,25-dihydroxyvitamin D3-responsive repressor sequences in the rat parathyroid hormone-related peptide gene.

Kremer R, Sebag M, Champigny C, Meerovitch K, Hendy GN, White J, Goltzman D.

J Biol Chem. 1996 Jul 5;271(27):16310-6.

13.

Internal translation initiation on poliovirus RNA: further characterization of La function in poliovirus translation in vitro.

Svitkin YV, Meerovitch K, Lee HS, Dholakia JN, Kenan DJ, Agol VI, Sonenberg N.

J Virol. 1994 Mar;68(3):1544-50.

14.

La autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate.

Meerovitch K, Svitkin YV, Lee HS, Lejbkowicz F, Kenan DJ, Chan EK, Agol VI, Keene JD, Sonenberg N.

J Virol. 1993 Jul;67(7):3798-807.

15.

Towards development of an in vitro translation test for poliovirus neurovirulence.

Svitkin YV, Alpatova GA, Lipskaya GA, Maslova SV, Agol VI, Kew O, Meerovitch K, Sonenberg N.

Dev Biol Stand. 1993;78:27-32.

PMID:
8388829
16.

Murine p53 inhibits the function but not the formation of SV40 T antigen hexamers and stimulates T antigen RNA helicase activity.

Friedman PN, Wang EH, Meerovitch K, Sonenberg N, Prives C.

Chromosoma. 1992;102(1 Suppl):S60-6.

PMID:
1337881
17.
18.
19.

Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F.

Rozen F, Edery I, Meerovitch K, Dever TE, Merrick WC, Sonenberg N.

Mol Cell Biol. 1990 Mar;10(3):1134-44.

20.

Translation of poliovirus mRNA.

Sonenberg N, Meerovitch K.

Enzyme. 1990;44(1-4):278-91. Review.

PMID:
1966842
21.
22.

Mechanisms regulating the level of IL-2 mRNA in T lymphocytes.

Shaw J, Meerovitch K, Bleackley RC, Paetkau V.

J Immunol. 1988 Apr 1;140(7):2243-8.

PMID:
3258332
23.

Induction, suppression and superinduction of lymphokine mRNA in T lymphocytes.

Shaw J, Meerovitch K, Elliott JF, Bleackley RC, Paetkau V.

Mol Immunol. 1987 May;24(5):409-19.

PMID:
3116404

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