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Items: 1 to 50 of 76

1.

Author Correction: The responses of cancer cells to PLK1 inhibitors reveal a novel protective role for p53 in maintaining centrosome separation.

Smith L, Farzan R, Ali S, Buluwela L, T Saurin A, Meek DW.

Sci Rep. 2018 Mar 22;8(1):5237. doi: 10.1038/s41598-018-23384-5.

2.

The responses of cancer cells to PLK1 inhibitors reveal a novel protective role for p53 in maintaining centrosome separation.

Smith L, Farzan R, Ali S, Buluwela L, Saurin AT, Meek DW.

Sci Rep. 2017 Nov 23;7(1):16115. doi: 10.1038/s41598-017-16394-2. Erratum in: Sci Rep. 2018 Mar 22;8(1):5237.

3.

p53 controls expression of the DNA deaminase APOBEC3B to limit its potential mutagenic activity in cancer cells.

Periyasamy M, Singh AK, Gemma C, Kranjec C, Farzan R, Leach DA, Navaratnam N, Pálinkás HL, Vértessy BG, Fenton TR, Doorbar J, Fuller-Pace F, Meek DW, Coombes RC, Buluwela L, Ali S.

Nucleic Acids Res. 2017 Nov 2;45(19):11056-11069. doi: 10.1093/nar/gkx721.

4.

A functional SUMO-motif in the active site of PIM1 promotes its degradation via RNF4, and stimulates protein kinase activity.

Iyer RS, Chatham L, Sleigh R, Meek DW.

Sci Rep. 2017 Jun 15;7(1):3598. doi: 10.1038/s41598-017-03775-w.

5.

LRH-1 drives colon cancer cell growth by repressing the expression of the CDKN1A gene in a p53-dependent manner.

Kramer HB, Lai CF, Patel H, Periyasamy M, Lin ML, Feller SM, Fuller-Pace FV, Meek DW, Ali S, Buluwela L.

Nucleic Acids Res. 2016 Jan 29;44(2):582-94. doi: 10.1093/nar/gkv948. Epub 2015 Sep 22.

6.

Regulation of the p53 response and its relationship to cancer.

Meek DW.

Biochem J. 2015 Aug 1;469(3):325-46. doi: 10.1042/BJ20150517. Review.

PMID:
26205489
7.

MAGE-A Cancer/Testis Antigens Inhibit MDM2 Ubiquitylation Function and Promote Increased Levels of MDM4.

Marcar L, Ihrig B, Hourihan J, Bray SE, Quinlan PR, Jordan LB, Thompson AM, Hupp TR, Meek DW.

PLoS One. 2015 May 22;10(5):e0127713. doi: 10.1371/journal.pone.0127713. eCollection 2015.

8.

Critical role for p53-serine 15 phosphorylation in stimulating transactivation at p53-responsive promoters.

Loughery J, Cox M, Smith LM, Meek DW.

Nucleic Acids Res. 2014 Jul;42(12):7666-80. doi: 10.1093/nar/gku501. Epub 2014 Jun 13.

9.
10.

The RNA helicase p68 (DDX5) is selectively required for the induction of p53-dependent p21 expression and cell-cycle arrest after DNA damage.

Nicol SM, Bray SE, Black HD, Lorimore SA, Wright EG, Lane DP, Meek DW, Coates PJ, Fuller-Pace FV.

Oncogene. 2013 Jul 18;32(29):3461-9. doi: 10.1038/onc.2012.426. Epub 2012 Sep 17.

11.

MAGE-A antigens as targets in tumour therapy.

Meek DW, Marcar L.

Cancer Lett. 2012 Nov 28;324(2):126-32. doi: 10.1016/j.canlet.2012.05.011. Epub 2012 May 23. Review.

PMID:
22634429
12.

Immunohistochemical detection of Polo-like kinase-1 (PLK1) in primary breast cancer is associated with TP53 mutation and poor clinical outcom.

King SI, Purdie CA, Bray SE, Quinlan PR, Jordan LB, Thompson AM, Meek DW.

Breast Cancer Res. 2012 Mar 8;14(2):R40.

13.

Induction and activation of the p53 pathway: a role for the protein kinase CK2?

Meek DW, Cox M.

Mol Cell Biochem. 2011 Oct;356(1-2):133-8. doi: 10.1007/s11010-011-0966-3. Epub 2011 Jul 19. Review.

PMID:
21769452
14.

Mage-A cancer/testis antigens inhibit p53 function by blocking its interaction with chromatin.

Marcar L, Maclaine NJ, Hupp TR, Meek DW.

Cancer Res. 2010 Dec 15;70(24):10362-70. doi: 10.1158/0008-5472.CAN-10-1341. Epub 2010 Nov 5.

15.

Soil-test N recommendations augmented with PEST-optimized RZWQM simulations.

Malone RW, Jaynes DB, Ma L, Nolan BT, Meek DW, Karlen DL.

J Environ Qual. 2010 Sep-Oct;39(5):1711-23.

PMID:
21043276
16.

p53-dependent repression of polo-like kinase-1 (PLK1).

McKenzie L, King S, Marcar L, Nicol S, Dias SS, Schumm K, Robertson P, Bourdon JC, Perkins N, Fuller-Pace F, Meek DW.

Cell Cycle. 2010 Oct 15;9(20):4200-12. Epub 2010 Oct 4.

17.

Posttranslational modification of p53: cooperative integrators of function.

Meek DW, Anderson CW.

Cold Spring Harb Perspect Biol. 2009 Dec;1(6):a000950. doi: 10.1101/cshperspect.a000950. Epub 2009 Oct 28. Review.

18.

Phosphorylation of serine 392 in p53 is a common and integral event during p53 induction by diverse stimuli.

Cox ML, Meek DW.

Cell Signal. 2010 Mar;22(3):564-71. doi: 10.1016/j.cellsig.2009.11.014.

PMID:
19932175
19.

The regulation of MDM2 by multisite phosphorylation--opportunities for molecular-based intervention to target tumours?

Meek DW, Hupp TR.

Semin Cancer Biol. 2010 Feb;20(1):19-28. doi: 10.1016/j.semcancer.2009.10.005. Epub 2009 Nov 6. Review.

PMID:
19897041
20.

Polo-like kinase-1 phosphorylates MDM2 at Ser260 and stimulates MDM2-mediated p53 turnover.

Dias SS, Hogan C, Ochocka AM, Meek DW.

FEBS Lett. 2009 Nov 19;583(22):3543-8. doi: 10.1016/j.febslet.2009.09.057. Epub 2009 Oct 13.

21.

CK1alpha plays a central role in mediating MDM2 control of p53 and E2F-1 protein stability.

Huart AS, MacLaine NJ, Meek DW, Hupp TR.

J Biol Chem. 2009 Nov 20;284(47):32384-94. doi: 10.1074/jbc.M109.052647. Epub 2009 Sep 15.

22.

Tumour suppression by p53: a role for the DNA damage response?

Meek DW.

Nat Rev Cancer. 2009 Oct;9(10):714-23. doi: 10.1038/nrc2716. Epub 2009 Sep 4. Review.

PMID:
19730431
23.

Nitrogen fertilizer effects on soil carbon balances in midwestern U.S. agricultural systems.

Russell AE, Cambardella CA, Laird DA, Jaynes DB, Meek DW.

Ecol Appl. 2009 Jul;19(5):1102-13.

PMID:
19688919
24.

Heat shock factor-1 modulates p53 activity in the transcriptional response to DNA damage.

Logan IR, McNeill HV, Cook S, Lu X, Meek DW, Fuller-Pace FV, Lunec J, Robson CN.

Nucleic Acids Res. 2009 May;37(9):2962-73. doi: 10.1093/nar/gkp180. Epub 2009 Mar 18.

25.

14-3-3 Binding to Pim-phosphorylated Ser166 and Ser186 of human Mdm2--Potential interplay with the PKB/Akt pathway and p14(ARF).

Wood NT, Meek DW, Mackintosh C.

FEBS Lett. 2009 Feb 18;583(4):615-20. doi: 10.1016/j.febslet.2009.01.003. Epub 2009 Jan 21.

26.

A central role for CK1 in catalyzing phosphorylation of the p53 transactivation domain at serine 20 after HHV-6B viral infection.

MacLaine NJ, Oster B, Bundgaard B, Fraser JA, Buckner C, Lazo PA, Meek DW, Höllsberg P, Hupp TR.

J Biol Chem. 2008 Oct 17;283(42):28563-73. doi: 10.1074/jbc.M804433200. Epub 2008 Jul 31.

27.

Transcription factor TAFII250 promotes Mdm2-dependent turnover of p53.

Allende-Vega N, Saville MK, Meek DW.

Oncogene. 2007 Jun 21;26(29):4234-42. Epub 2007 Jan 22.

28.

c-Abl phosphorylates Hdm2 at tyrosine 276 in response to DNA damage and regulates interaction with ARF.

Dias SS, Milne DM, Meek DW.

Oncogene. 2006 Oct 26;25(50):6666-71. Epub 2006 May 15.

PMID:
16702947
29.

Agricultural practices influence flow regimes of headwater streams in western Iowa.

Tomer MD, Meek DW, Kramer LA.

J Environ Qual. 2005 Aug 9;34(5):1547-58. Print 2005 Sep-Oct.

PMID:
16091607
30.

Nitrate leaching to subsurface drains as affected by drain spacing and changes in crop production system.

Kladivko EJ, Frankenberger JR, Jaynes DB, Meek DW, Jenkinson BJ, Fausey NR.

J Environ Qual. 2004 Sep-Oct;33(5):1803-13.

PMID:
15356241
31.

The p53 response to DNA damage.

Meek DW.

DNA Repair (Amst). 2004 Aug-Sep;3(8-9):1049-56. Review.

PMID:
15279792
32.

Using the late spring nitrate test to reduce nitrate loss within a watershed.

Jaynes DB, Dinnes DL, Meek DW, Karlen DL, Cambardella CA, Colvin TS.

J Environ Qual. 2004 Mar-Apr;33(2):669-77.

PMID:
15074819
33.

Posttranslational modification of MDM2.

Meek DW, Knippschild U.

Mol Cancer Res. 2003 Dec;1(14):1017-26. Review.

35.

Evaluation of nitrate nitrogen fluxes from a tile-drained watershed in central Iowa.

Tomer MD, Meek DW, Jaynes DB, Hatfield JL.

J Environ Qual. 2003 Mar-Apr;32(2):642-53.

PMID:
12708689
36.

p53 Induction: phosphorylation sites cooperate in regulating.

Meek DW.

Cancer Biol Ther. 2002 May-Jun;1(3):284-6. No abstract available.

PMID:
12432278
37.

Centrosomal anchoring of the protein kinase CK1delta mediated by attachment to the large, coiled-coil scaffolding protein CG-NAP/AKAP450.

Sillibourne JE, Milne DM, Takahashi M, Ono Y, Meek DW.

J Mol Biol. 2002 Sep 27;322(4):785-97.

PMID:
12270714
38.

Hypophosphorylation of Mdm2 augments p53 stability.

Blattner C, Hay T, Meek DW, Lane DP.

Mol Cell Biol. 2002 Sep;22(17):6170-82.

39.
40.

Nitrate loss in subsurface drainage as affected by nitrogen fertilizer rate.

Jaynes DB, Colvin TS, Karlen DL, Cambardella CA, Meek DW.

J Environ Qual. 2001 Jul-Aug;30(4):1305-14.

PMID:
11476509
41.
42.

IC261, a specific inhibitor of the protein kinases casein kinase 1-delta and -epsilon, triggers the mitotic checkpoint and induces p53-dependent postmitotic effects.

Behrend L, Milne DM, Stöter M, Deppert W, Campbell LE, Meek DW, Knippschild U.

Oncogene. 2000 Nov 9;19(47):5303-13.

44.

Analysis of multisite phosphorylation of the p53 tumor-suppressor protein by tryptic phosphopeptide mapping.

Meek DW, Milne DM.

Methods Mol Biol. 2000;99:447-63. Review. No abstract available.

PMID:
10909098
45.

The role of p53 in the response to mitotic spindle damage.

Meek DW.

Pathol Biol (Paris). 2000 Apr;48(3):246-54. Review.

PMID:
10858957
46.

Mechanisms of switching on p53: a role for covalent modification?

Meek DW.

Oncogene. 1999 Dec 13;18(53):7666-75. Review.

47.
50.

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