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Items: 1 to 50 of 102

1.

A reassessment of DNA-immunoprecipitation-based genomic profiling.

Lentini A, Lagerwall C, Vikingsson S, Mjoseng HK, Douvlataniotis K, Vogt H, Green H, Meehan RR, Benson M, Nestor CE.

Nat Methods. 2018 Jul;15(7):499-504. doi: 10.1038/s41592-018-0038-7. Epub 2018 Jun 25.

PMID:
29941872
2.

Modelling non-alcoholic fatty liver disease in human hepatocyte-like cells.

Lyall MJ, Cartier J, Thomson JP, Cameron K, Meseguer-Ripolles J, O'Duibhir E, Szkolnicka D, Villarin BL, Wang Y, Blanco GR, Dunn WB, Meehan RR, Hay DC, Drake AJ.

Philos Trans R Soc Lond B Biol Sci. 2018 Jul 5;373(1750). pii: 20170362. doi: 10.1098/rstb.2017.0362.

3.

Methyl donor deficient diets cause distinct alterations in lipid metabolism but are poorly representative of human NAFLD.

Lyall MJ, Cartier J, Richards JA, Cobice D, Thomson JP, Meehan RR, Anderton SM, Drake AJ.

Wellcome Open Res. 2017 Aug 22;2:67. doi: 10.12688/wellcomeopenres.12199.1. eCollection 2017.

4.

Investigation into the role of the germline epigenome in the transmission of glucocorticoid-programmed effects across generations.

Cartier J, Smith T, Thomson JP, Rose CM, Khulan B, Heger A, Meehan RR, Drake AJ.

Genome Biol. 2018 Apr 10;19(1):50. doi: 10.1186/s13059-018-1422-4.

5.

Corrigendum: Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration.

Raven A, Lu WY, Man TY, Ferreira-Gonzalez S, O'Duibhir E, Dwyer BJ, Thomson JP, Meehan RR, Bogorad R, Koteliansky V, Kotelevtsev Y, Ffrench-Constant C, Boulter L, Forbes SJ.

Nature. 2018 Mar 14;555(7696):402. doi: 10.1038/nature25996.

PMID:
29542689
6.

DNA methylation as a genomic marker of exposure to chemical and environmental agents.

Meehan RR, Thomson JP, Lentini A, Nestor CE, Pennings S.

Curr Opin Chem Biol. 2018 Aug;45:48-56. doi: 10.1016/j.cbpa.2018.02.006. Epub 2018 Mar 2. Review.

7.

Affinity-Based Enrichment Techniques for the Genome-Wide Analysis of 5-Hydroxymethylcytosine.

Thomson JP, Meehan RR.

Methods Mol Biol. 2018;1708:679-696. doi: 10.1007/978-1-4939-7481-8_35.

PMID:
29224170
8.

Shoring up DNA methylation and H3K27me3 domain demarcation at developmental genes.

Meehan RR, Pennings S.

EMBO J. 2017 Dec 1;36(23):3407-3408. doi: 10.15252/embj.201798498. Epub 2017 Nov 22. No abstract available.

PMID:
29167195
9.

Defining baseline epigenetic landscapes in the rat liver.

Thomson JP, Ottaviano R, Buesen R, Moggs JG, Schwarz M, Meehan RR.

Epigenomics. 2017 Dec;9(12):1503-1527. doi: 10.2217/epi-2017-0029. Epub 2017 Nov 13.

10.

Mobilization of LINE-1 retrotransposons is restricted by Tex19.1 in mouse embryonic stem cells.

MacLennan M, García-Cañadas M, Reichmann J, Khazina E, Wagner G, Playfoot CJ, Salvador-Palomeque C, Mann AR, Peressini P, Sanchez L, Dobie K, Read D, Hung CC, Eskeland R, Meehan RR, Weichenrieder O, García-Pérez JL, Adams IR.

Elife. 2017 Aug 14;6. pii: e26152. doi: 10.7554/eLife.26152.

11.

Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration.

Raven A, Lu WY, Man TY, Ferreira-Gonzalez S, O'Duibhir E, Dwyer BJ, Thomson JP, Meehan RR, Bogorad R, Koteliansky V, Kotelevtsev Y, Ffrench-Constant C, Boulter L, Forbes SJ.

Nature. 2017 Jul 20;547(7663):350-354. doi: 10.1038/nature23015. Epub 2017 Jul 12. Erratum in: Nature. 2018 Mar 14;555(7696):402.

12.

Corrigendum: SMCHD1 mutations associated with a rare muscular dystrophy can also cause isolated arhinia and Bosma arhinia microphthalmia syndrome.

Shaw ND, Brand H, Kupchinsky ZA, Bengani H, Plummer L, Jones TI, Erdin S, Williamson KA, Rainger J, Stortchevoi A, Samocha K, Currall BB, Dunican DS, Collins RL, Willer JR, Lek A, Lek M, Nassan M, Pereira S, Kammin T, Lucente D, Silva A, Seabra CM, Chiang C, An Y, Ansari M, Rainger JK, Joss S, Smith JC, Lippincott MF, Singh SS, Patel N, Jing JW, Law JR, Ferraro N, Verloes A, Rauch A, Steindl K, Zweier M, Scheer I, Sato D, Okamoto N, Jacobsen C, Tryggestad J, Chernausek S, Schimmenti LA, Brasseur B, Cesaretti C, García-Ortiz JE, Buitrago TP, Silva OP, Hoffman JD, Mühlbauer W, Ruprecht KW, Loeys BL, Shino M, Kaindl AM, Cho CH, Morton CC, Meehan RR, van Heyningen V, Liao EC, Balasubramanian R, Hall JE, Seminara SB, Macarthur D, Moore SA, Yoshiura KI, Gusella JF, Marsh JA, Graham JM Jr, Lin AE, Katsanis N, Jones PL, Crowley WF Jr, Davis EE, FitzPatrick DR, Talkowski ME.

Nat Genet. 2017 May 26;49(6):969. doi: 10.1038/ng0617-969c. No abstract available.

PMID:
28546579
13.

Hypoxia determines survival outcomes of bacterial infection through HIF-1alpha dependent re-programming of leukocyte metabolism.

Thompson AA, Dickinson RS, Murphy F, Thomson JP, Marriott HM, Tavares A, Willson J, Williams L, Lewis A, Mirchandani A, Dos Santos Coelho P, Doherty C, Ryan E, Watts E, Morton NM, Forbes S, Stimson RH, Hameed AG, Arnold N, Preston JA, Lawrie A, Finisguerra V, Mazzone M, Sadiku P, Goveia J, Taverna F, Carmeliet P, Foster SJ, Chilvers ER, Cowburn AS, Dockrell DH, Johnson RS, Meehan RR, Whyte MK, Walmsley SR.

Sci Immunol. 2017 Feb 10;2(8). pii: eaal2861. doi: 10.1126/sciimmunol.aal2861.

14.

Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions.

Cole JJ, Robertson NA, Rather MI, Thomson JP, McBryan T, Sproul D, Wang T, Brock C, Clark W, Ideker T, Meehan RR, Miller RA, Brown-Borg HM, Adams PD.

Genome Biol. 2017 Mar 28;18(1):58. doi: 10.1186/s13059-017-1185-3.

15.

Decoupling of DNA methylation and activity of intergenic LINE-1 promoters in colorectal cancer.

Vafadar-Isfahani N, Parr C, McMillan LE, Sanner J, Yeo Z, Saddington S, Peacock O, Cruickshanks HA, Meehan RR, Lund JN, Tufarelli C.

Epigenetics. 2017 Jun 3;12(6):465-475. doi: 10.1080/15592294.2017.1300729. Epub 2017 Mar 16.

16.

SMCHD1 mutations associated with a rare muscular dystrophy can also cause isolated arhinia and Bosma arhinia microphthalmia syndrome.

Shaw ND, Brand H, Kupchinsky ZA, Bengani H, Plummer L, Jones TI, Erdin S, Williamson KA, Rainger J, Stortchevoi A, Samocha K, Currall BB, Dunican DS, Collins RL, Willer JR, Lek A, Lek M, Nassan M, Pereira S, Kammin T, Lucente D, Silva A, Seabra CM, Chiang C, An Y, Ansari M, Rainger JK, Joss S, Smith JC, Lippincott MF, Singh SS, Patel N, Jing JW, Law JR, Ferraro N, Verloes A, Rauch A, Steindl K, Zweier M, Scheer I, Sato D, Okamoto N, Jacobsen C, Tryggestad J, Chernausek S, Schimmenti LA, Brasseur B, Cesaretti C, García-Ortiz JE, Buitrago TP, Silva OP, Hoffman JD, Mühlbauer W, Ruprecht KW, Loeys BL, Shino M, Kaindl AM, Cho CH, Morton CC, Meehan RR, van Heyningen V, Liao EC, Balasubramanian R, Hall JE, Seminara SB, Macarthur D, Moore SA, Yoshiura KI, Gusella JF, Marsh JA, Graham JM Jr, Lin AE, Katsanis N, Jones PL, Crowley WF Jr, Davis EE, FitzPatrick DR, Talkowski ME.

Nat Genet. 2017 Feb;49(2):238-248. doi: 10.1038/ng.3743. Epub 2017 Jan 9. Erratum in: Nat Genet. 2017 May 26;49(6):969.

17.

The application of genome-wide 5-hydroxymethylcytosine studies in cancer research.

Thomson JP, Meehan RR.

Epigenomics. 2017 Jan;9(1):77-91. doi: 10.2217/epi-2016-0122. Epub 2016 Dec 12. Review.

18.

A Mutant Form of MeCP2 Protein Associated with Human Rett Syndrome Cannot Be Displaced from Methylated DNA by Notch in Xenopus Embryos.

Stancheva I, Collins AL, Van den Veyver IB, Zoghbi H, Meehan RR.

Mol Cell. 2016 Jul 7;63(1):179. doi: 10.1016/j.molcel.2016.06.007. No abstract available.

19.

5-Hydroxymethylcytosine Remodeling Precedes Lineage Specification during Differentiation of Human CD4(+) T Cells.

Nestor CE, Lentini A, Hägg Nilsson C, Gawel DR, Gustafsson M, Mattson L, Wang H, Rundquist O, Meehan RR, Klocke B, Seifert M, Hauck SM, Laumen H, Zhang H, Benson M.

Cell Rep. 2016 Jul 12;16(2):559-570. doi: 10.1016/j.celrep.2016.05.091. Epub 2016 Jun 23.

20.

Loss of Tet1-Associated 5-Hydroxymethylcytosine Is Concomitant with Aberrant Promoter Hypermethylation in Liver Cancer.

Thomson JP, Ottaviano R, Unterberger EB, Lempiäinen H, Muller A, Terranova R, Illingworth RS, Webb S, Kerr AR, Lyall MJ, Drake AJ, Wolf CR, Moggs JG, Schwarz M, Meehan RR.

Cancer Res. 2016 May 15;76(10):3097-108. doi: 10.1158/0008-5472.CAN-15-1910. Epub 2016 Apr 6.

21.

Lsh Is Essential for Maintaining Global DNA Methylation Levels in Amphibia and Fish and Interacts Directly with Dnmt1.

Dunican DS, Pennings S, Meehan RR.

Biomed Res Int. 2015;2015:740637. doi: 10.1155/2015/740637. Epub 2015 Sep 28.

22.

Importance of investigating epigenetic alterations for industry and regulators: An appraisal of current efforts by the Health and Environmental Sciences Institute.

Miousse IR, Currie R, Datta K, Ellinger-Ziegelbauer H, French JE, Harrill AH, Koturbash I, Lawton M, Mann D, Meehan RR, Moggs JG, O'Lone R, Rasoulpour RJ, Pera RA, Thompson K.

Toxicology. 2015 Sep 1;335:11-9. doi: 10.1016/j.tox.2015.06.009. Epub 2015 Jun 29.

23.

5-Hydroxymethylcytosine Profiling in Human DNA.

Thomson JP, Nestor CE, Meehan RR.

Methods Mol Biol. 2017;1589:89-98. doi: 10.1007/7651_2015_268.

PMID:
26126447
24.

DNA immunoprecipitation semiconductor sequencing (DIP-SC-seq) as a rapid method to generate genome wide epigenetic signatures.

Thomson JP, Fawkes A, Ottaviano R, Hunter JM, Shukla R, Mjoseng HK, Clark R, Coutts A, Murphy L, Meehan RR.

Sci Rep. 2015 May 14;5:9778. doi: 10.1038/srep09778.

25.

Rapid reprogramming of epigenetic and transcriptional profiles in mammalian culture systems.

Nestor CE, Ottaviano R, Reinhardt D, Cruickshanks HA, Mjoseng HK, McPherson RC, Lentini A, Thomson JP, Dunican DS, Pennings S, Anderton SM, Benson M, Meehan RR.

Genome Biol. 2015 Feb 4;16:11. doi: 10.1186/s13059-014-0576-y.

26.

Epigenetic modification of the PD-1 (Pdcd1) promoter in effector CD4(+) T cells tolerized by peptide immunotherapy.

McPherson RC, Konkel JE, Prendergast CT, Thomson JP, Ottaviano R, Leech MD, Kay O, Zandee SE, Sweenie CH, Wraith DC, Meehan RR, Drake AJ, Anderton SM.

Elife. 2014 Dec 29;3. doi: 10.7554/eLife.03416.

27.

Modules, networks and systems medicine for understanding disease and aiding diagnosis.

Gustafsson M, Nestor CE, Zhang H, Barabási AL, Baranzini S, Brunak S, Chung KF, Federoff HJ, Gavin AC, Meehan RR, Picotti P, Pujana MÀ, Rajewsky N, Smith KG, Sterk PJ, Villoslada P, Benson M.

Genome Med. 2014 Oct 17;6(10):82. doi: 10.1186/s13073-014-0082-6. eCollection 2014.

28.

MBD4 interacts with and recruits USP7 to heterochromatic foci.

Meng H, Harrison DJ, Meehan RR.

J Cell Biochem. 2015 Mar;116(3):476-85. doi: 10.1002/jcb.25001.

29.

Dynamic changes in DNA modification states during late gestation male germ line development in the rat.

Rose CM, van den Driesche S, Sharpe RM, Meehan RR, Drake AJ.

Epigenetics Chromatin. 2014 Aug 7;7:19. doi: 10.1186/1756-8935-7-19. eCollection 2014.

30.

Phenobarbital induces cell cycle transcriptional responses in mouse liver humanized for constitutive androstane and pregnane x receptors.

Luisier R, Lempiäinen H, Scherbichler N, Braeuning A, Geissler M, Dubost V, Müller A, Scheer N, Chibout SD, Hara H, Picard F, Theil D, Couttet P, Vitobello A, Grenet O, Grasl-Kraupp B, Ellinger-Ziegelbauer H, Thomson JP, Meehan RR, Elcombe CR, Henderson CJ, Wolf CR, Schwarz M, Moulin P, Terranova R, Moggs JG.

Toxicol Sci. 2014 Jun;139(2):501-11. doi: 10.1093/toxsci/kfu038. Epub 2014 Apr 1.

PMID:
24690595
31.

Lsh regulates LTR retrotransposon repression independently of Dnmt3b function.

Dunican DS, Cruickshanks HA, Suzuki M, Semple CA, Davey T, Arceci RJ, Greally J, Adams IR, Meehan RR.

Genome Biol. 2013 Dec 24;14(12):R146. doi: 10.1186/gb-2013-14-12-r146.

32.

5-hydroxymethylcytosine profiling as an indicator of cellular state.

Laird A, Thomson JP, Harrison DJ, Meehan RR.

Epigenomics. 2013 Dec;5(6):655-69. doi: 10.2217/epi.13.69. Review.

33.

DNA methylation reprogramming in cancer: does it act by re-configuring the binding landscape of Polycomb repressive complexes?

Reddington JP, Sproul D, Meehan RR.

Bioessays. 2014 Feb;36(2):134-40. doi: 10.1002/bies.201300130. Epub 2013 Nov 26.

34.

Senescent cells harbour features of the cancer epigenome.

Cruickshanks HA, McBryan T, Nelson DM, Vanderkraats ND, Shah PP, van Tuyn J, Singh Rai T, Brock C, Donahue G, Dunican DS, Drotar ME, Meehan RR, Edwards JR, Berger SL, Adams PD.

Nat Cell Biol. 2013 Dec;15(12):1495-506. doi: 10.1038/ncb2879. Epub 2013 Nov 24.

35.

LINE-1 activation and epigenetic silencing of suppressor genes in cancer: Causally related events?

Tufarelli C, Cruickshanks HA, Meehan RR.

Mob Genet Elements. 2013 Sep 1;3(5):e26832. Epub 2013 Oct 25.

36.

Comparative analysis of affinity-based 5-hydroxymethylation enrichment techniques.

Thomson JP, Hunter JM, Nestor CE, Dunican DS, Terranova R, Moggs JG, Meehan RR.

Nucleic Acids Res. 2013 Dec;41(22):e206. doi: 10.1093/nar/gkt1080. Epub 2013 Nov 7. Erratum in: Nucleic Acids Res. . 2014 Apr;42(6):4142.

37.

Hydroxymethylated DNA immunoprecipitation (hmeDIP).

Nestor CE, Meehan RR.

Methods Mol Biol. 2014;1094:259-67. doi: 10.1007/978-1-62703-706-8_20.

PMID:
24162994
38.

Investigating 5-hydroxymethylcytosine (5hmC): the state of the art.

Nestor CE, Reddington JP, Benson M, Meehan RR.

Methods Mol Biol. 2014;1094:243-58. doi: 10.1007/978-1-62703-706-8_19. Review.

PMID:
24162993
39.

Defending the genome from the enemy within: mechanisms of retrotransposon suppression in the mouse germline.

Crichton JH, Dunican DS, Maclennan M, Meehan RR, Adams IR.

Cell Mol Life Sci. 2014 May;71(9):1581-605. doi: 10.1007/s00018-013-1468-0. Epub 2013 Sep 18. Review.

40.

Epigenetic profiles as defined signatures of xenobiotic exposure.

Thomson JP, Moggs JG, Wolf CR, Meehan RR.

Mutat Res Genet Toxicol Environ Mutagen. 2014 Apr;764-765:3-9. doi: 10.1016/j.mrgentox.2013.08.007. Epub 2013 Aug 31. Review.

PMID:
24001620
41.

Deep C diving: mapping the low-abundance modifications of the DNA demethylation pathway.

Thomson JP, Hunter JM, Meehan RR.

Genome Biol. 2013 May 29;14(5):118. doi: 10.1186/gb-2013-14-5-118.

42.

From paramutation to paradigm.

Adams IR, Meehan RR.

PLoS Genet. 2013 May;9(5):e1003537. doi: 10.1371/journal.pgen.1003537. Epub 2013 May 23. No abstract available.

43.

The CXXC-TET bridge--mind the methylation gap!

Dunican DS, Pennings S, Meehan RR.

Cell Res. 2013 Aug;23(8):973-4. doi: 10.1038/cr.2013.71. Epub 2013 May 28.

44.

Expression of a large LINE-1-driven antisense RNA is linked to epigenetic silencing of the metastasis suppressor gene TFPI-2 in cancer.

Cruickshanks HA, Vafadar-Isfahani N, Dunican DS, Lee A, Sproul D, Lund JN, Meehan RR, Tufarelli C.

Nucleic Acids Res. 2013 Aug;41(14):6857-69. doi: 10.1093/nar/gkt438. Epub 2013 May 23.

45.

Epigenetic reprogramming: preparing the epigenome for the next generation.

Rose CM, van den Driesche S, Meehan RR, Drake AJ.

Biochem Soc Trans. 2013 Jun;41(3):809-14. doi: 10.1042/BST20120356. Review.

PMID:
23697942
46.

Dynamic changes in 5-hydroxymethylation signatures underpin early and late events in drug exposed liver.

Thomson JP, Hunter JM, Lempiäinen H, Müller A, Terranova R, Moggs JG, Meehan RR.

Nucleic Acids Res. 2013 Jun;41(11):5639-54. doi: 10.1093/nar/gkt232. Epub 2013 Apr 17.

47.

Redistribution of H3K27me3 upon DNA hypomethylation results in de-repression of Polycomb target genes.

Reddington JP, Perricone SM, Nestor CE, Reichmann J, Youngson NA, Suzuki M, Reinhardt D, Dunican DS, Prendergast JG, Mjoseng H, Ramsahoye BH, Whitelaw E, Greally JM, Adams IR, Bickmore WA, Meehan RR.

Genome Biol. 2013 Mar 25;14(3):R25. doi: 10.1186/gb-2013-14-3-r25.

48.

Non-canonical functions of the DNA methylome in gene regulation.

Reddington JP, Pennings S, Meehan RR.

Biochem J. 2013 Apr 1;451(1):13-23. doi: 10.1042/BJ20121585. Review.

PMID:
23489368
49.

The genome-defence gene Tex19.1 suppresses LINE-1 retrotransposons in the placenta and prevents intra-uterine growth retardation in mice.

Reichmann J, Reddington JP, Best D, Read D, Ollinger R, Meehan RR, Adams IR.

Hum Mol Genet. 2013 May 1;22(9):1791-806. doi: 10.1093/hmg/ddt029. Epub 2013 Jan 30.

50.

Genomic insights into cancer-associated aberrant CpG island hypermethylation.

Sproul D, Meehan RR.

Brief Funct Genomics. 2013 May;12(3):174-90. doi: 10.1093/bfgp/els063. Epub 2013 Jan 21. Review.

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