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Items: 1 to 50 of 124

1.

Intergenic Splicing between Four Adjacent UGT Genes (2B15, 2B29P2, 2B17, 2B29P1) Gives Rise to Variant UGT Proteins That Inhibit Glucuronidation via Protein-Protein Interactions.

Hu DG, Hulin JA, Wijayakumara DD, McKinnon RA, Mackenzie PI, Meech R.

Mol Pharmacol. 2018 Sep;94(3):938-952. doi: 10.1124/mol.118.111773. Epub 2018 Jun 29.

PMID:
29959221
2.

Cooperative Regulation of Intestinal UDP-Glucuronosyltransferases 1A8, -1A9, and 1A10 by CDX2 and HNF4α Is Mediated by a Novel Composite Regulatory Element.

Mubarokah N, Hulin JA, Mackenzie PI, McKinnon RA, Haines AZ, Hu DG, Meech R.

Mol Pharmacol. 2018 May;93(5):541-552. doi: 10.1124/mol.117.110619. Epub 2018 Mar 8.

PMID:
29519853
3.

Regulation of UDP-Glucuronosyltransferase 2B15 by miR-331-5p in Prostate Cancer Cells Involves Canonical and Noncanonical Target Sites.

Wijayakumara DD, Mackenzie PI, McKinnon RA, Hu DG, Meech R.

J Pharmacol Exp Ther. 2018 Apr;365(1):48-59. doi: 10.1124/jpet.117.245936. Epub 2018 Jan 24.

PMID:
29367276
4.

Exemestane and Its Active Metabolite 17-Hydroexemestane Induce UDP-Glucuronosyltransferase (UGT) 2B17 Expression in Breast Cancer Cells.

Chanawong A, Mackenzie PI, McKinnon RA, Hu DG, Meech R.

J Pharmacol Exp Ther. 2017 Jun;361(3):482-491. doi: 10.1124/jpet.117.240317. Epub 2017 Apr 12.

5.

Regulation of UDP-Glucuronosyltransferases UGT2B4 and UGT2B7 by MicroRNAs in Liver Cancer Cells.

Wijayakumara DD, Mackenzie PI, McKinnon RA, Hu DG, Meech R.

J Pharmacol Exp Ther. 2017 Jun;361(3):386-397. doi: 10.1124/jpet.116.239707. Epub 2017 Apr 7.

6.

Lacrimal Gland Repair Using Progenitor Cells.

Gromova A, Voronov DA, Yoshida M, Thotakura S, Meech R, Dartt DA, Makarenkova HP.

Stem Cells Transl Med. 2017 Jan;6(1):88-98. doi: 10.5966/sctm.2016-0191. Epub 2016 Aug 15.

7.

Novel Nine-Exon AR Transcripts (Exon 1/Exon 1b/Exons 2-8) in Normal and Cancerous Breast and Prostate Cells.

Hu DG, McKinnon RA, Hulin JA, Mackenzie PI, Meech R.

Int J Mol Sci. 2016 Dec 27;18(1). pii: E40. doi: 10.3390/ijms18010040.

8.

Reduced DNA methylation of sphingosine-1 phosphate receptor 5 in alveolar macrophages in COPD: A potential link to failed efferocytosis.

Barnawi J, Jersmann H, Haberberger R, Hodge S, Meech R.

Respirology. 2017 Feb;22(2):315-321. doi: 10.1111/resp.12949. Epub 2016 Nov 20.

PMID:
27868302
9.

Androgen and Estrogen Receptors in Breast Cancer Coregulate Human UDP-Glucuronosyltransferases 2B15 and 2B17.

Hu DG, Selth LA, Tarulli GA, Meech R, Wijayakumara D, Chanawong A, Russell R, Caldas C, Robinson JL, Carroll JS, Tilley WD, Mackenzie PI, Hickey TE.

Cancer Res. 2016 Oct 1;76(19):5881-5893. Epub 2016 Aug 5.

10.

Barx2 and Pax7 Regulate Axin2 Expression in Myoblasts by Interaction with β-Catenin and Chromatin Remodelling.

Hulin JA, Nguyen TD, Cui S, Marri S, Yu RT, Downes M, Evans RM, Makarenkova H, Meech R.

Stem Cells. 2016 Aug;34(8):2169-82. doi: 10.1002/stem.2396. Epub 2016 Jun 6.

11.

D-methionine (D-met) significantly reduces kanamycin-induced ototoxicity in pigmented guinea pigs.

Campbell KC, Martin SM, Meech RP, Hargrove TL, Verhulst SJ, Fox DJ.

Int J Audiol. 2016;55(5):273-8. doi: 10.3109/14992027.2016.1143980. Epub 2016 Mar 10.

PMID:
26963517
12.

Genetic polymorphisms of human UDP-glucuronosyltransferase (UGT) genes and cancer risk.

Hu DG, Mackenzie PI, McKinnon RA, Meech R.

Drug Metab Rev. 2016;48(1):47-69. doi: 10.3109/03602532.2015.1131292. Epub 2016 Feb 1. Review.

PMID:
26828111
13.

Potential Link between the Sphingosine-1-Phosphate (S1P) System and Defective Alveolar Macrophage Phagocytic Function in Chronic Obstructive Pulmonary Disease (COPD).

Barnawi J, Tran H, Jersmann H, Pitson S, Roscioli E, Hodge G, Meech R, Haberberger R, Hodge S.

PLoS One. 2015 Oct 20;10(10):e0122771. doi: 10.1371/journal.pone.0122771. eCollection 2015.

14.

Insights into the UDP-sugar selectivities of human UDP-glycosyltransferases (UGT): a molecular modeling perspective.

Nair PC, Meech R, Mackenzie PI, McKinnon RA, Miners JO.

Drug Metab Rev. 2015 Aug;47(3):335-45. doi: 10.3109/03602532.2015.1071835. Epub 2015 Aug 3. Review.

PMID:
26289097
15.

Insights into the UDP-sugar selectivities of human UDP-glycosyltransferases (UGT): a molecular modeling perspective.

Nair PC, Meech R, Mackenzie PI, McKinnon RA, Miners JO.

Drug Metab Rev. 2015 Aug 3:1-11. [Epub ahead of print]

PMID:
26234632
16.

d-Methionine reduces tobramycin-induced ototoxicity without antimicrobial interference in animal models.

Fox DJ, Cooper MD, Speil CA, Roberts MH, Yanik SC, Meech RP, Hargrove TL, Verhulst SJ, Rybak LP, Campbell KC.

J Cyst Fibros. 2016 Jul;15(4):518-30. doi: 10.1016/j.jcf.2015.06.005. Epub 2015 Jul 10.

17.

Regulation of Human UGT2B15 and UGT2B17 by miR-376c in Prostate Cancer Cell Lines.

Wijayakumara DD, Hu DG, Meech R, McKinnon RA, Mackenzie PI.

J Pharmacol Exp Ther. 2015 Sep;354(3):417-25. doi: 10.1124/jpet.115.226118. Epub 2015 Jul 10.

18.

Induction of UDP-glucuronosyltransferase 2B15 gene expression by the major active metabolites of tamoxifen, 4-hydroxytamoxifen and endoxifen, in breast cancer cells.

Chanawong A, Hu DG, Meech R, Mackenzie PI, McKinnon RA.

Drug Metab Dispos. 2015 Jun;43(6):889-97. doi: 10.1124/dmd.114.062935. Epub 2015 Mar 20.

19.

Induction of human UDP-Glucuronosyltransferase 2B7 gene expression by cytotoxic anticancer drugs in liver cancer HepG2 cells.

Hu DG, Mackenzie PI, Lu L, Meech R, McKinnon RA.

Drug Metab Dispos. 2015 May;43(5):660-8. doi: 10.1124/dmd.114.062380. Epub 2015 Feb 23.

20.

Electrogenesis in the lower Metazoa and implications for neuronal integration.

Meech RW.

J Exp Biol. 2015 Feb 15;218(Pt 4):537-50. doi: 10.1242/jeb.111955. Review.

21.

A novel function for UDP glycosyltransferase 8: galactosidation of bile acids.

Meech R, Mubarokah N, Shivasami A, Rogers A, Nair PC, Hu DG, McKinnon RA, Mackenzie PI.

Mol Pharmacol. 2015;87(3):442-50. doi: 10.1124/mol.114.093823. Epub 2014 Dec 17.

22.

Transcriptional regulation of human UDP-glucuronosyltransferase genes.

Hu DG, Meech R, McKinnon RA, Mackenzie PI.

Drug Metab Rev. 2014 Nov;46(4):421-58. doi: 10.3109/03602532.2014.973037. Epub 2014 Oct 22. Review.

PMID:
25336387
23.

Barx2 and Pax7 have antagonistic functions in regulation of wnt signaling and satellite cell differentiation.

Zhuang L, Hulin JA, Gromova A, Tran Nguyen TD, Yu RT, Liddle C, Downes M, Evans RM, Makarenkova HP, Meech R.

Stem Cells. 2014 Jun;32(6):1661-73. doi: 10.1002/stem.1674.

24.

Polymorphisms and haplotypes of the UDP-glucuronosyltransferase 2B7 gene promoter.

Hu DG, Meech R, Lu L, McKinnon RA, Mackenzie PI.

Drug Metab Dispos. 2014 May;42(5):854-62. doi: 10.1124/dmd.113.056630. Epub 2014 Feb 21.

25.

D-methionine pre-loading reduces both noise-induced permanent threshold shift and outer hair cell loss in the chinchilla.

Claussen AD, Fox DJ, Yu XC, Meech RP, Verhulst SJ, Hargrove TL, Campbell KC.

Int J Audiol. 2013 Dec;52(12):801-7. doi: 10.3109/14992027.2013.840933. Epub 2013 Oct 31.

PMID:
24175619
26.

Transcription factors Runx1 to 3 are expressed in the lacrimal gland epithelium and are involved in regulation of gland morphogenesis and regeneration.

Voronov D, Gromova A, Liu D, Zoukhri D, Medvinsky A, Meech R, Makarenkova HP.

Invest Ophthalmol Vis Sci. 2013 May 1;54(5):3115-25. doi: 10.1167/iovs.13-11791.

27.

A contribution to the history of the proton channel.

Meech R.

Wiley Interdiscip Rev Membr Transp Signal. 2012 Sep;1(5):533-557. Epub 2012 Aug 6.

28.

Shewanella algae causing lower limb soft tissue infection in New Zealand.

Leung B, Meech R, Lau N, Cunliffe R.

N Z Med J. 2012 Nov 9;125(1365):75-7.

PMID:
23254503
29.

Identification of residues that confer sugar selectivity to UDP-glycosyltransferase 3A (UGT3A) enzymes.

Meech R, Rogers A, Zhuang L, Lewis BC, Miners JO, Mackenzie PI.

J Biol Chem. 2012 Jul 13;287(29):24122-30. doi: 10.1074/jbc.M112.343608. Epub 2012 May 23.

30.

Barx homeobox family in muscle development and regeneration.

Makarenkova HP, Meech R.

Int Rev Cell Mol Biol. 2012;297:117-73. doi: 10.1016/B978-0-12-394308-8.00004-2. Review.

PMID:
22608559
31.

The glycosidation of xenobiotics and endogenous compounds: versatility and redundancy in the UDP glycosyltransferase superfamily.

Meech R, Miners JO, Lewis BC, Mackenzie PI.

Pharmacol Ther. 2012 May;134(2):200-18. doi: 10.1016/j.pharmthera.2012.01.009. Epub 2012 Feb 1. Review.

PMID:
22322248
32.

Barx2 is expressed in satellite cells and is required for normal muscle growth and regeneration.

Meech R, Gonzalez KN, Barro M, Gromova A, Zhuang L, Hulin JA, Makarenkova HP.

Stem Cells. 2012 Feb;30(2):253-65. doi: 10.1002/stem.777.

33.

D-methionine (D-met) significantly rescues noise-induced hearing loss: timing studies.

Campbell K, Claussen A, Meech R, Verhulst S, Fox D, Hughes L.

Hear Res. 2011 Dec;282(1-2):138-44. doi: 10.1016/j.heares.2011.08.003. Epub 2011 Sep 6.

PMID:
21924333
34.

Barx2 and Fgf10 regulate ocular glands branching morphogenesis by controlling extracellular matrix remodeling.

Tsau C, Ito M, Gromova A, Hoffman MP, Meech R, Makarenkova HP.

Development. 2011 Aug;138(15):3307-17. doi: 10.1242/dev.066241.

35.

The novel UDP glycosyltransferase 3A2: cloning, catalytic properties, and tissue distribution.

MacKenzie PI, Rogers A, Elliot DJ, Chau N, Hulin JA, Miners JO, Meech R.

Mol Pharmacol. 2011 Mar;79(3):472-8. doi: 10.1124/mol.110.069336. Epub 2010 Nov 18.

36.

The homeobox transcription factor Barx2 regulates plasticity of young primary myofibers.

Meech R, Gomez M, Woolley C, Barro M, Hulin JA, Walcott EC, Delgado J, Makarenkova HP.

PLoS One. 2010 Jul 15;5(7):e11612. doi: 10.1371/journal.pone.0011612.

37.

UGT3A: novel UDP-glycosyltransferases of the UGT superfamily.

Meech R, Mackenzie PI.

Drug Metab Rev. 2010 Feb;42(1):45-54. doi: 10.3109/03602530903205823.

PMID:
19814657
38.

Differential interactions of FGFs with heparan sulfate control gradient formation and branching morphogenesis.

Makarenkova HP, Hoffman MP, Beenken A, Eliseenkova AV, Meech R, Tsau C, Patel VN, Lang RA, Mohammadi M.

Sci Signal. 2009 Sep 15;2(88):ra55. doi: 10.1126/scisignal.2000304.

39.

Barx2 controls myoblast fusion and promotes MyoD-mediated activation of the smooth muscle alpha-actin gene.

Makarenkova HP, Gonzalez KN, Kiosses WB, Meech R.

J Biol Chem. 2009 May 29;284(22):14866-74. doi: 10.1074/jbc.M807208200. Epub 2009 Mar 5.

40.

Nerves in the endodermal canals of hydromedusae and their role in swimming inhibition.

Mackie GO, Meech RW.

Invert Neurosci. 2008 Dec;8(4):199-209. doi: 10.1007/s10158-008-0082-6. Epub 2008 Nov 11.

PMID:
19002509
41.

Identification of UDP glycosyltransferase 3A1 as a UDP N-acetylglucosaminyltransferase.

Mackenzie PI, Rogers A, Treloar J, Jorgensen BR, Miners JO, Meech R.

J Biol Chem. 2008 Dec 26;283(52):36205-10. doi: 10.1074/jbc.M807961200. Epub 2008 Nov 3.

42.

Non-neural reflexes: sponges and the origins of behaviour.

Meech RW.

Curr Biol. 2008 Jan 22;18(2):R70-2. doi: 10.1016/j.cub.2007.11.022.

43.

A conductive pathway generated from fragments of the human red cell anion exchanger AE1.

Parker MD, Young MT, Daly CM, Meech RW, Boron WF, Tanner MJ.

J Physiol. 2007 May 15;581(Pt 1):33-50. Epub 2007 Feb 22.

44.

Prevention of noise- and drug-induced hearing loss with D-methionine.

Campbell KC, Meech RP, Klemens JJ, Gerberi MT, Dyrstad SS, Larsen DL, Mitchell DL, El-Azizi M, Verhulst SJ, Hughes LF.

Hear Res. 2007 Apr;226(1-2):92-103. Epub 2007 Jan 16.

PMID:
17224251
46.

The homeobox transcription factor Barx2 regulates chondrogenesis during limb development.

Meech R, Edelman DB, Jones FS, Makarenkova HP.

Development. 2005 May;132(9):2135-46. Epub 2005 Mar 30.

47.

Effects of trypsin on large-conductance Ca(2+)-activated K(+) channels of guinea-pig outer hair cells.

Spreadbury IC, Kros CJ, Meech RW.

Hear Res. 2004 Apr;190(1-2):115-27.

PMID:
15051134
48.

Nitric oxide regulates swimming in the jellyfish Aglantha digitale.

Moroz LL, Meech RW, Sweedler JV, Mackie GO.

J Comp Neurol. 2004 Mar 22;471(1):26-36.

PMID:
14983473
49.

Identification of novel binding elements and gene targets for the homeodomain protein BARX2.

Stevens TA, Iacovoni JS, Edelman DB, Meech R.

J Biol Chem. 2004 Apr 9;279(15):14520-30. Epub 2004 Jan 26.

50.

The effect of D-methionine on cochlear oxidative state with and without cisplatin administration: mechanisms of otoprotection.

Campbell KC, Meech RP, Rybak LP, Hughes LF.

J Am Acad Audiol. 2003 Apr;14(3):144-56.

PMID:
12859139

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