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Items: 1 to 50 of 202

1.

Glucose metabolism mediates disease tolerance in cerebral malaria.

Wang A, Huen SC, Luan HH, Baker K, Rinder H, Booth CJ, Medzhitov R.

Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):11042-11047. doi: 10.1073/pnas.1806376115. Epub 2018 Oct 5.

PMID:
30291189
2.

Emerging Principles of Gene Expression Programs and Their Regulation.

Pope SD, Medzhitov R.

Mol Cell. 2018 Aug 2;71(3):389-397. doi: 10.1016/j.molcel.2018.07.017. Review.

PMID:
30075140
3.

Endocytosis as a stabilizing mechanism for tissue homeostasis.

Adler M, Mayo A, Zhou X, Franklin RA, Jacox JB, Medzhitov R, Alon U.

Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):E1926-E1935. doi: 10.1073/pnas.1714377115. Epub 2018 Feb 2.

4.

Circuit Design Features of a Stable Two-Cell System.

Zhou X, Franklin RA, Adler M, Jacox JB, Bailis W, Shyer JA, Flavell RA, Mayo A, Alon U, Medzhitov R.

Cell. 2018 Feb 8;172(4):744-757.e17. doi: 10.1016/j.cell.2018.01.015. Epub 2018 Feb 1.

PMID:
29398113
5.

Inflammation: Memory beyond immunity.

Dai X, Medzhitov R.

Nature. 2017 Oct 26;550(7677):460-461. doi: 10.1038/nature24154. Epub 2017 Oct 18. No abstract available.

PMID:
29045392
6.

Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus.

Karimy JK, Zhang J, Kurland DB, Theriault BC, Duran D, Stokum JA, Furey CG, Zhou X, Mansuri MS, Montejo J, Vera A, DiLuna ML, Delpire E, Alper SL, Gunel M, Gerzanich V, Medzhitov R, Simard JM, Kahle KT.

Nat Med. 2017 Aug;23(8):997-1003. doi: 10.1038/nm.4361. Epub 2017 Jul 10.

PMID:
28692063
7.

Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages.

Ip WKE, Hoshi N, Shouval DS, Snapper S, Medzhitov R.

Science. 2017 May 5;356(6337):513-519. doi: 10.1126/science.aal3535.

8.

Mitochondrial protein Fus1/Tusc2 in premature aging and age-related pathologies: critical roles of calcium and energy homeostasis.

Uzhachenko R, Boyd K, Olivares-Villagomez D, Zhu Y, Goodwin JS, Rana T, Shanker A, Tan WJ, Bondar T, Medzhitov R, Ivanova AV.

Aging (Albany NY). 2017 Mar 26;9(3):627-649. doi: 10.18632/aging.101213.

9.

Food Fight: Role of Itaconate and Other Metabolites in Antimicrobial Defense.

Luan HH, Medzhitov R.

Cell Metab. 2016 Sep 13;24(3):379-387. doi: 10.1016/j.cmet.2016.08.013. Review.

10.

Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation.

Wang A, Huen SC, Luan HH, Yu S, Zhang C, Gallezot JD, Booth CJ, Medzhitov R.

Cell. 2016 Sep 8;166(6):1512-1525.e12. doi: 10.1016/j.cell.2016.07.026.

11.

GENE EXPRESSION. Unwinding inducible gene expression.

Pope SD, Medzhitov R.

Science. 2016 May 27;352(6289):1058-9. doi: 10.1126/science.aag0365. No abstract available.

PMID:
27230367
12.

Wormhole Travel for Macrophages.

Okabe Y, Medzhitov R.

Cell. 2016 Apr 21;165(3):518-9. doi: 10.1016/j.cell.2016.04.005.

13.

The Effect of Sustained Inflammation on Hepatic Mevalonate Pathway Results in Hyperglycemia.

Okin D, Medzhitov R.

Cell. 2016 Apr 7;165(2):343-56. doi: 10.1016/j.cell.2016.02.023. Epub 2016 Mar 17.

14.

Training the next generation of biomedical investigators in glycosciences.

Agre P, Bertozzi C, Bissell M, Campbell KP, Cummings RD, Desai UR, Estes M, Flotte T, Fogleman G, Gage F, Ginsburg D, Gordon JI, Hart G, Hascall V, Kiessling L, Kornfeld S, Lowe J, Magnani J, Mahal LK, Medzhitov R, Roberts RJ, Sackstein R, Sarkar R, Schnaar R, Schwartz N, Varki A, Walt D, Weissman I.

J Clin Invest. 2016 Feb;126(2):405-8. doi: 10.1172/JCI85905. Epub 2016 Feb 1. Review.

15.

Editorial overview: Innate immunity.

Vivier E, Medzhitov R.

Curr Opin Immunol. 2016 Feb;38:v-vii. doi: 10.1016/j.coi.2015.12.005. Epub 2015 Dec 28. No abstract available.

PMID:
26739338
16.

Tissue biology perspective on macrophages.

Okabe Y, Medzhitov R.

Nat Immunol. 2016 Jan;17(1):9-17. doi: 10.1038/ni.3320. Review.

PMID:
26681457
17.

Bringing Warburg to lymphocytes.

Medzhitov R.

Nat Rev Immunol. 2015 Oct;15(10):598. doi: 10.1038/nri3918. No abstract available.

PMID:
26403193
18.
19.

Integrated innate mechanisms involved in airway allergic inflammation to the serine protease subtilisin.

Florsheim E, Yu S, Bragatto I, Faustino L, Gomes E, Ramos RN, Barbuto JA, Medzhitov R, Russo M.

J Immunol. 2015 May 15;194(10):4621-30. doi: 10.4049/jimmunol.1402493. Epub 2015 Apr 15.

20.

Control of adaptive immunity by the innate immune system.

Iwasaki A, Medzhitov R.

Nat Immunol. 2015 Apr;16(4):343-53. doi: 10.1038/ni.3123. Review.

21.

Homeostasis, inflammation, and disease susceptibility.

Kotas ME, Medzhitov R.

Cell. 2015 Feb 26;160(5):816-827. doi: 10.1016/j.cell.2015.02.010. Review.

22.

Analysis of gene-environment interactions in postnatal development of the mammalian intestine.

Rakoff-Nahoum S, Kong Y, Kleinstein SH, Subramanian S, Ahern PP, Gordon JI, Medzhitov R.

Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):1929-36. doi: 10.1073/pnas.1424886112.

23.

Two-signal requirement for growth-promoting function of Yap in hepatocytes.

Su T, Bondar T, Zhou X, Zhang C, He H, Medzhitov R.

Elife. 2015 Feb 10;4. doi: 10.7554/eLife.02948.

24.

Signaling pathways activated by a protease allergen in basophils.

Rosenstein RK, Bezbradica JS, Yu S, Medzhitov R.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):E4963-71. doi: 10.1073/pnas.1418959111. Epub 2014 Nov 4.

25.

ART and immunology.

Rivas FV, Chervonsky AV, Medzhitov R.

Trends Immunol. 2014 Oct;35(10):451. doi: 10.1016/j.it.2014.09.002. Epub 2014 Sep 23. No abstract available.

PMID:
25261059
26.

How the immune system spots tumors.

Okabe Y, Medzhitov R.

Elife. 2014 Sep 24;3:e04476. doi: 10.7554/eLife.04476.

27.

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid.

Colegio OR, Chu NQ, Szabo AL, Chu T, Rhebergen AM, Jairam V, Cyrus N, Brokowski CE, Eisenbarth SC, Phillips GM, Cline GW, Phillips AJ, Medzhitov R.

Nature. 2014 Sep 25;513(7519):559-63. doi: 10.1038/nature13490. Epub 2014 Jul 13.

28.

T cell-intrinsic role of IL-6 signaling in primary and memory responses.

Nish SA, Schenten D, Wunderlich FT, Pope SD, Gao Y, Hoshi N, Yu S, Yan X, Lee HK, Pasman L, Brodsky I, Yordy B, Zhao H, Brüning J, Medzhitov R.

Elife. 2014 May 19;3:e01949. doi: 10.7554/eLife.01949.

29.

Tissue-specific signals control reversible program of localization and functional polarization of macrophages.

Okabe Y, Medzhitov R.

Cell. 2014 May 8;157(4):832-44. doi: 10.1016/j.cell.2014.04.016. Epub 2014 May 1.

30.

Stress, inflammation, and defense of homeostasis.

Chovatiya R, Medzhitov R.

Mol Cell. 2014 Apr 24;54(2):281-8. doi: 10.1016/j.molcel.2014.03.030. Review.

31.

A role for the ITAM signaling module in specifying cytokine-receptor functions.

Bezbradica JS, Rosenstein RK, DeMarco RA, Brodsky I, Medzhitov R.

Nat Immunol. 2014 Apr;15(4):333-42. doi: 10.1038/ni.2845. Epub 2014 Mar 9.

32.

Signaling through the adaptor molecule MyD88 in CD4+ T cells is required to overcome suppression by regulatory T cells.

Schenten D, Nish SA, Yu S, Yan X, Lee HK, Brodsky I, Pasman L, Yordy B, Wunderlich FT, Brüning JC, Zhao H, Medzhitov R.

Immunity. 2014 Jan 16;40(1):78-90. doi: 10.1016/j.immuni.2013.10.023. Erratum in: Immunity. 2014 May 15;40(5):814.

33.

The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition.

Chang PV, Hao L, Offermanns S, Medzhitov R.

Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2247-52. doi: 10.1073/pnas.1322269111. Epub 2014 Jan 3.

34.

Fus1/Tusc2 is a novel regulator of mitochondrial calcium handling, Ca2+-coupled mitochondrial processes, and Ca2+-dependent NFAT and NF-κB pathways in CD4+ T cells.

Uzhachenko R, Ivanov SV, Yarbrough WG, Shanker A, Medzhitov R, Ivanova AV.

Antioxid Redox Signal. 2014 Apr 1;20(10):1533-47. doi: 10.1089/ars.2013.5437. Epub 2014 Feb 4.

35.

Ruslan Medzhitov: Meet the winner of the Else Kröner-Fresenius Award in 2013.

Medzhitov R.

Eur J Immunol. 2013 Nov;43(11):2792-4. doi: 10.1002/eji.201370115. No abstract available.

36.

Septic shock: on the importance of being tolerant.

Medzhitov R.

Immunity. 2013 Nov 14;39(5):799-800. doi: 10.1016/j.immuni.2013.10.012.

37.

Bee venom phospholipase A2 induces a primary type 2 response that is dependent on the receptor ST2 and confers protective immunity.

Palm NW, Rosenstein RK, Yu S, Schenten DD, Florsheim E, Medzhitov R.

Immunity. 2013 Nov 14;39(5):976-85. doi: 10.1016/j.immuni.2013.10.006. Epub 2013 Oct 24.

38.

Pattern recognition theory and the launch of modern innate immunity.

Medzhitov R.

J Immunol. 2013 Nov 1;191(9):4473-4. doi: 10.4049/jimmunol.1302427. No abstract available.

39.

Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells.

Gao Y, Nish SA, Jiang R, Hou L, Licona-Limón P, Weinstein JS, Zhao H, Medzhitov R.

Immunity. 2013 Oct 17;39(4):722-32. doi: 10.1016/j.immuni.2013.08.028. Epub 2013 Sep 26.

40.

Honor thy Go(na)ds.

Chovatiya R, Medzhitov R.

Immunol Cell Biol. 2013 Nov-Dec;91(10):597-8. doi: 10.1038/icb.2013.50. Epub 2013 Sep 24. No abstract available.

PMID:
24060964
41.

The origins of tumor-promoting inflammation.

Bondar T, Medzhitov R.

Cancer Cell. 2013 Aug 12;24(2):143-4. doi: 10.1016/j.ccr.2013.07.016.

42.

The human papillomavirus type 16 E7 oncoprotein induces a transcriptional repressor complex on the Toll-like receptor 9 promoter.

Hasan UA, Zannetti C, Parroche P, Goutagny N, Malfroy M, Roblot G, Carreira C, Hussain I, Müller M, Taylor-Papadimitriou J, Picard D, Sylla BS, Trinchieri G, Medzhitov R, Tommasino M.

J Exp Med. 2013 Jul 1;210(7):1369-87. doi: 10.1084/jem.20122394. Epub 2013 Jun 10.

43.

Role of tissue protection in lethal respiratory viral-bacterial coinfection.

Jamieson AM, Pasman L, Yu S, Gamradt P, Homer RJ, Decker T, Medzhitov R.

Science. 2013 Jun 7;340(6137):1230-4. doi: 10.1126/science.1233632. Epub 2013 Apr 25.

44.

Signals via the adaptor MyD88 in B cells and DCs make distinct and synergistic contributions to immune activation and tissue damage in lupus.

Teichmann LL, Schenten D, Medzhitov R, Kashgarian M, Shlomchik MJ.

Immunity. 2013 Mar 21;38(3):528-40. doi: 10.1016/j.immuni.2012.11.017. Epub 2013 Mar 14.

45.

Role of caspase-1 in regulation of triglyceride metabolism.

Kotas ME, Jurczak MJ, Annicelli C, Gillum MP, Cline GW, Shulman GI, Medzhitov R.

Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4810-5. doi: 10.1073/pnas.1301996110. Epub 2013 Mar 4.

46.

Role of the inflammasome in defense against venoms.

Palm NW, Medzhitov R.

Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1809-14. doi: 10.1073/pnas.1221476110. Epub 2013 Jan 7.

47.

MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice.

Hoshi N, Schenten D, Nish SA, Walther Z, Gagliani N, Flavell RA, Reizis B, Shen Z, Fox JG, Iwasaki A, Medzhitov R.

Nat Commun. 2012;3:1120. doi: 10.1038/ncomms2113.

48.

Evolution of inflammatory diseases.

Okin D, Medzhitov R.

Curr Biol. 2012 Sep 11;22(17):R733-40. doi: 10.1016/j.cub.2012.07.029. Review.

49.

Semaphorin 7A contributes to West Nile virus pathogenesis through TGF-β1/Smad6 signaling.

Sultana H, Neelakanta G, Foellmer HG, Montgomery RR, Anderson JF, Koski RA, Medzhitov RM, Fikrig E.

J Immunol. 2012 Sep 15;189(6):3150-8. doi: 10.4049/jimmunol.1201140. Epub 2012 Aug 15.

50.

The human gut microbiota and undernutrition.

Gordon JI, Dewey KG, Mills DA, Medzhitov RM.

Sci Transl Med. 2012 Jun 6;4(137):137ps12. doi: 10.1126/scitranslmed.3004347.

PMID:
22674549

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